GB1283331A - Pharmaceutical compositions - Google Patents
Pharmaceutical compositionsInfo
- Publication number
- GB1283331A GB1283331A GB33670A GB33670A GB1283331A GB 1283331 A GB1283331 A GB 1283331A GB 33670 A GB33670 A GB 33670A GB 33670 A GB33670 A GB 33670A GB 1283331 A GB1283331 A GB 1283331A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sodium
- sulphonate
- acid
- dichloro
- dichlorobenzene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- WIWQDBABYGRKEW-UHFFFAOYSA-N 3,4-dichlorobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=C(Cl)C(Cl)=C1 WIWQDBABYGRKEW-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 1
- JIDCYYWQSYSUPY-UHFFFAOYSA-M ClC1=C(C=CC(=C1Cl)I)S(=O)(=O)[O-].[Na+] Chemical compound ClC1=C(C=CC(=C1Cl)I)S(=O)(=O)[O-].[Na+] JIDCYYWQSYSUPY-UHFFFAOYSA-M 0.000 abstract 1
- SPKDRWVCPIRTGS-UHFFFAOYSA-M ClC=1C(=C(C=CC1Cl)S(=O)(=O)[O-])I.[K+] Chemical compound ClC=1C(=C(C=CC1Cl)S(=O)(=O)[O-])I.[K+] SPKDRWVCPIRTGS-UHFFFAOYSA-M 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- BFSMWENDZZIWPW-UHFFFAOYSA-N Isopropamide iodide Chemical compound [I-].C=1C=CC=CC=1C(C(N)=O)(CC[N+](C)(C(C)C)C(C)C)C1=CC=CC=C1 BFSMWENDZZIWPW-UHFFFAOYSA-N 0.000 abstract 1
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 abstract 1
- QLZHNIAADXEJJP-UHFFFAOYSA-N Phenylphosphonic acid Chemical compound OP(O)(=O)C1=CC=CC=C1 QLZHNIAADXEJJP-UHFFFAOYSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 abstract 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- JPKKQJKQTPNWTR-KQAYXBCTSA-N [(1r,5s)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2r)-3-hydroxy-2-phenylpropanoate;sulfuric acid;hydrate Chemical compound O.OS(O)(=O)=O.C1([C@H](CO)C(=O)OC2C[C@H]3CC[C@@H](C2)N3C)=CC=CC=C1.C1([C@H](CO)C(=O)OC2C[C@H]3CC[C@@H](C2)N3C)=CC=CC=C1 JPKKQJKQTPNWTR-KQAYXBCTSA-N 0.000 abstract 1
- 229940069428 antacid Drugs 0.000 abstract 1
- 239000003159 antacid agent Substances 0.000 abstract 1
- 230000001458 anti-acid effect Effects 0.000 abstract 1
- 230000001262 anti-secretory effect Effects 0.000 abstract 1
- 229940092732 belladonna alkaloid Drugs 0.000 abstract 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical class OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 abstract 1
- GERIGMSHTUAXSI-UHFFFAOYSA-N bis(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 4-phenyl-2,3-dihydro-1h-naphthalene-1,4-dicarboxylate Chemical compound CN1C(C2)CCC1CC2OC(=O)C(C1=CC=CC=C11)CCC1(C(=O)OC1CC2CCC(N2C)C1)C1=CC=CC=C1 GERIGMSHTUAXSI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001661 cadmium Chemical class 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 238000004040 coloring Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229960001543 isopropamide iodide Drugs 0.000 abstract 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- WRLGYAWRGXKSKG-UHFFFAOYSA-M phenobarbital sodium Chemical compound [Na+].C=1C=CC=CC=1C1(CC)C(=O)NC([O-])=NC1=O WRLGYAWRGXKSKG-UHFFFAOYSA-M 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 abstract 1
- TZUVXRIQLFTVFT-UHFFFAOYSA-M potassium 2,3-dichloro-4-iodobenzenesulfonate Chemical compound ClC1=C(C=CC(=C1Cl)I)S(=O)(=O)[O-].[K+] TZUVXRIQLFTVFT-UHFFFAOYSA-M 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 abstract 1
- 239000004299 sodium benzoate Substances 0.000 abstract 1
- 235000010234 sodium benzoate Nutrition 0.000 abstract 1
- QXCFFLGAAJDPTG-UHFFFAOYSA-M sodium;2,3-dichlorobenzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC(Cl)=C1Cl QXCFFLGAAJDPTG-UHFFFAOYSA-M 0.000 abstract 1
- WUJATLHOPBZDJE-UHFFFAOYSA-M sodium;3,4-dichlorobenzoate Chemical compound [Na+].[O-]C(=O)C1=CC=C(Cl)C(Cl)=C1 WUJATLHOPBZDJE-UHFFFAOYSA-M 0.000 abstract 1
- AQUJLVPFBDFODJ-UHFFFAOYSA-M sodium;3,5-dichlorobenzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC(Cl)=CC(Cl)=C1 AQUJLVPFBDFODJ-UHFFFAOYSA-M 0.000 abstract 1
- BNHGKKNINBGEQL-UHFFFAOYSA-M sodium;5-ethyl-5-(3-methylbutyl)pyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CC(C)CCC1(CC)C(=O)NC(=O)[N-]C1=O BNHGKKNINBGEQL-UHFFFAOYSA-M 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/39—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing halogen atoms bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
1283331 Antacid compositions SMITH KLINE & FRENCH LABORATORIES Ltd 11 Dec 1970 [3 Jan 1970] 336/70 Heading A5B [Also in Division C2] Pharmaceutical compositions each comprise (a) a pharmaceutically acceptable carrier (other than water or a common organic solvent) and (b) a compound of formula: in which A is a carboxylic, sulphonic, sulphinic, sulphamic, phosphonic, phosphinic or phosphoric acid group and R 1-5 are each hydrogen or halogen or R 2 together with R 1 or R 3 represent a second fused benzene ring or a pharmaceutically acceptable salt thereof, the following compounds being disclaimed:-benzoic acid and salts thereof, benzene phosphonic acid and salts thereof and cadmium salts of benzene sulphonic acid and substituted derivatives thereof. Compounds specified include 3, 4-dichlorobenzene sulphonic acid, sodium 2, 3- dichloro-4-iodobenzene sulphonate, sodium 2, 3-dichlorobenzene sulphonate, potassium 2, 3- dichloro-4-iodobenzene sulphonate, potassium 3, 4-dichloro-2-iodobenzene sulphonate, sodium 3, 5-dichlorobenzene sulphonate, sodium 3, 4- dichlorobenzoate and sodium alpha-naphthalene sulphonate. The compositions of the invention may also include sodium saccharin, sodium benzoate, an effervescent couple comprising sodium bicarbonate, tartaric acid and citric acid, antisecretory drugs (e.g. isopropamide iodide, atropine sulphate and Belladonna alkaloids), sedatives (e.g. sodium phenobarbitone and sodium amylobarbitone), dried aluminium hydroxide gel, sucrose, flavouring and colouring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB33670A GB1283331A (en) | 1970-01-03 | 1970-01-03 | Pharmaceutical compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB33670A GB1283331A (en) | 1970-01-03 | 1970-01-03 | Pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1283331A true GB1283331A (en) | 1972-07-26 |
Family
ID=9702605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB33670A Expired GB1283331A (en) | 1970-01-03 | 1970-01-03 | Pharmaceutical compositions |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1283331A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994027584A3 (en) * | 1993-05-21 | 1995-05-26 | Radopath Ltd | Arylating medicaments |
| WO1995024897A1 (en) * | 1994-03-17 | 1995-09-21 | Radopath Limited | Anti-viral and anti-cancer agents |
| WO1996029067A1 (en) * | 1995-03-17 | 1996-09-26 | Radopath Limited | Anti-viral and anti-cancer agents |
| GB2311221A (en) * | 1996-03-18 | 1997-09-24 | Radopath Ltd | Arylating agents for the treatment of viral infection |
| GB2312375A (en) * | 1993-05-21 | 1997-10-29 | Radopath Ltd | Therapeutic arylating agents |
-
1970
- 1970-01-03 GB GB33670A patent/GB1283331A/en not_active Expired
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994027584A3 (en) * | 1993-05-21 | 1995-05-26 | Radopath Ltd | Arylating medicaments |
| GB2312375A (en) * | 1993-05-21 | 1997-10-29 | Radopath Ltd | Therapeutic arylating agents |
| GB2284153B (en) * | 1993-05-21 | 1998-02-25 | Radopath Ltd | Substances for use in treatment of HIV-infection in HIV-infected patients |
| GB2312375B (en) * | 1993-05-21 | 1998-02-25 | Radopath Ltd | Agents for treatment of cancer |
| WO1995024897A1 (en) * | 1994-03-17 | 1995-09-21 | Radopath Limited | Anti-viral and anti-cancer agents |
| EP0677292A1 (en) * | 1994-03-17 | 1995-10-18 | Radopath Limited | Anti-viral and anti-cancer agents |
| AP575A (en) * | 1994-03-17 | 1997-01-31 | Radopath Ltd | Anti viral and anti cancer agents. |
| WO1996029067A1 (en) * | 1995-03-17 | 1996-09-26 | Radopath Limited | Anti-viral and anti-cancer agents |
| GB2311221A (en) * | 1996-03-18 | 1997-09-24 | Radopath Ltd | Arylating agents for the treatment of viral infection |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |