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GB1280551A - Quinazoline derivatives - Google Patents

Quinazoline derivatives

Info

Publication number
GB1280551A
GB1280551A GB3024669A GB3024669A GB1280551A GB 1280551 A GB1280551 A GB 1280551A GB 3024669 A GB3024669 A GB 3024669A GB 3024669 A GB3024669 A GB 3024669A GB 1280551 A GB1280551 A GB 1280551A
Authority
GB
United Kingdom
Prior art keywords
alkyl
substituted
clco
april
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3024669A
Inventor
Hans Ott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1280551A publication Critical patent/GB1280551A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C07D239/82—Oxygen atoms with an aryl radical attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/02—Viewing or reading apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1280551 1 - Substituted 4 - phenylquinazolin- 2-ones SANDOZ Ltd 13 June 1969 [1 July 1968 (2) 26 Dec 1968 (2) 15 April 1969 25 April 1969 (3)] 30246/69 Heading C2C Compounds of Formula Ia wherein R 2 is Ph (possibly substituted by CF 3 , or by 1 or 2 of F, Cl, Br, C 1-4 alkyl and C 1-4 alkoxy) and n is 0, 1 or 2, and (subject to limitations defined in the Specification with respect to the particular processes), R is F, Cl, Br, C 1-5 alkyl, C 1-4 alkoxy or alkylthio, NO 2 , CN or CF 3 , and R<SP>1</SP> 1 is C 1-5 alkyl, allyl or propargyl, are prepared by reacting a correspondingly substituted 2-aminobenzophenoneimine with a C 1-5 alkyl carbamate at above 140‹ C., or with ClCO 2 Me, ClCO 2 Et, COCl 2 or 1 ,1<SP>1</SP>-carboxyldiimidazole. The preparation of 2-nitro, 2-amino- and 2- isopropylamino-4-tolunitriles is also described. Therapeutic compositions for oral or parenteral administration comprise compounds of the above formula (subject to the limitations referred to), which have anti-inflammatory activity.
GB3024669A 1968-07-01 1969-06-13 Quinazoline derivatives Expired GB1280551A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74180668A 1968-07-01 1968-07-01
US74180768A 1968-07-01 1968-07-01
US78725268A 1968-12-26 1968-12-26

Publications (1)

Publication Number Publication Date
GB1280551A true GB1280551A (en) 1972-07-05

Family

ID=27419278

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3024669A Expired GB1280551A (en) 1968-07-01 1969-06-13 Quinazoline derivatives

Country Status (2)

Country Link
ES (10) ES368946A1 (en)
GB (1) GB1280551A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107398A1 (en) * 1982-09-30 1984-05-02 Ortho Pharmaceutical Corporation Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids
EP0713861A1 (en) * 1994-11-26 1996-05-29 Basf Aktiengesellschaft Process for the preparation of benzophenone imine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107398A1 (en) * 1982-09-30 1984-05-02 Ortho Pharmaceutical Corporation Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids
EP0713861A1 (en) * 1994-11-26 1996-05-29 Basf Aktiengesellschaft Process for the preparation of benzophenone imine
US5679855A (en) * 1994-11-26 1997-10-21 Basf Aktiengesellschaft Preparation of benzophenone imines

Also Published As

Publication number Publication date
ES379155A1 (en) 1973-02-01
ES379158A1 (en) 1973-02-01
ES379154A1 (en) 1973-02-01
ES381048A1 (en) 1973-04-01
ES381047A1 (en) 1973-03-16
ES379156A1 (en) 1973-02-01
ES379159A1 (en) 1973-02-01
ES379157A1 (en) 1973-02-01
ES379160A1 (en) 1973-02-01
ES368946A1 (en) 1971-07-16

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees