GB1279547A - N-arylidene derivatives of erythromycylamine - Google Patents
N-arylidene derivatives of erythromycylamineInfo
- Publication number
- GB1279547A GB1279547A GB5535770A GB5535770A GB1279547A GB 1279547 A GB1279547 A GB 1279547A GB 5535770 A GB5535770 A GB 5535770A GB 5535770 A GB5535770 A GB 5535770A GB 1279547 A GB1279547 A GB 1279547A
- Authority
- GB
- United Kingdom
- Prior art keywords
- erythromycylamine
- formula
- derivatives
- arylidene
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1279547 N-arylidene erythromycylamine derivatives ELI LILLY & CO 20 Nov 1970 [21 Nov 1969 30 Sept 1970] 55357/70 Heading C2A The invention comprises N-arylidene derivatives of erythromycylamine of Formula I: or of Formula II: wherein R is H or OH and R<SP>1</SP> is phenyl, naphthyl, pyridyl, substituted (phenyl, naphthyl or pyridyl) in which the substituents may be one or more members of the group consisting of C 1 to C 3 alkyl, halo, C 1 to C 3 alkyloxy, lower alkanoyl, hydroxy, carboxy, phenyl, nitro or trifluoromethyl. Formula I represents normal erythromycylamine or erythromycyl B amine derivatives and Formula II the corresponding epi derivatives. The compounds of the invention are effective in curing infections in mammals caused by Gram-positive organisms and may be administered by oral or parenteral methods, at doses such as 25 mg./kg. Pharmaceutical compositions containing the compounds of the invention may be prepared by mixing these with suitable carriers. The compounds of the invention may also be used as washes to control Gram-positive and Gram-negative organisms on equipment, furnishings, walls and floors in dental and medical offices and in hospitals. Usually the N-arylidene erythromycylamine is dissolved in water and a surface-active agent added.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87893569A | 1969-11-21 | 1969-11-21 | |
| US7704970A | 1970-09-30 | 1970-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1279547A true GB1279547A (en) | 1972-06-28 |
Family
ID=26758829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5535770A Expired GB1279547A (en) | 1969-11-21 | 1970-11-20 | N-arylidene derivatives of erythromycylamine |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT301029B (en) |
| AU (1) | AU2238370A (en) |
| BE (1) | BE759251A (en) |
| DE (1) | DE2057190A1 (en) |
| DK (1) | DK126039B (en) |
| ES (1) | ES385679A1 (en) |
| FR (1) | FR2073401B1 (en) |
| GB (1) | GB1279547A (en) |
| NL (1) | NL7016982A (en) |
| SU (1) | SU373939A3 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP960497B1 (en) * | 1996-10-28 | 2003-08-31 | Pliva Pharm & Chem Works | 9-n-ethenyl derivatives of 9(s)-erythromycylamine |
-
0
- BE BE759251D patent/BE759251A/en unknown
-
1970
- 1970-11-18 ES ES385679A patent/ES385679A1/en not_active Expired
- 1970-11-18 AU AU22383/70A patent/AU2238370A/en not_active Expired
- 1970-11-18 SU SU1493530A patent/SU373939A3/ru active
- 1970-11-19 NL NL7016982A patent/NL7016982A/xx unknown
- 1970-11-19 AT AT1044370A patent/AT301029B/en not_active IP Right Cessation
- 1970-11-20 DE DE19702057190 patent/DE2057190A1/en active Pending
- 1970-11-20 GB GB5535770A patent/GB1279547A/en not_active Expired
- 1970-11-20 DK DK590470A patent/DK126039B/en unknown
- 1970-11-20 FR FR7041735A patent/FR2073401B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES385679A1 (en) | 1973-08-16 |
| BE759251A (en) | 1971-05-21 |
| NL7016982A (en) | 1971-05-25 |
| DK126039B (en) | 1973-06-04 |
| SU373939A3 (en) | 1973-03-12 |
| FR2073401A1 (en) | 1971-10-01 |
| DE2057190A1 (en) | 1971-06-03 |
| FR2073401B1 (en) | 1974-06-21 |
| AU2238370A (en) | 1972-05-25 |
| AT301029B (en) | 1972-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 429A | Application made for amendment of specification (sect. 29/1949) | ||
| 429Q | Case decided by the comptroller ** application withdrawn (sect. 29/1949) | ||
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |