GB1138969A - Improvements in or relating to indole derivative and method for its production - Google Patents
Improvements in or relating to indole derivative and method for its productionInfo
- Publication number
- GB1138969A GB1138969A GB36327/68A GB3632768A GB1138969A GB 1138969 A GB1138969 A GB 1138969A GB 36327/68 A GB36327/68 A GB 36327/68A GB 3632768 A GB3632768 A GB 3632768A GB 1138969 A GB1138969 A GB 1138969A
- Authority
- GB
- United Kingdom
- Prior art keywords
- relating
- production
- indole
- indole derivative
- isopropylbenzylamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,138,969. Indole derivatives. SANDOZ Ltd. 13 Jan., 1966 [1 Feb., 1965], No. 36327/68. Divided out of 1,138,968. Heading C2C. 4 - (2 - Hydroxy - 3 - isopropylaminopropoxy)- indole and its acid addition salts are prepared by reacting an alkali metal salt of 4-hydroxyindole with epichlorohydrin, heating the product with isopropylamine or N-isopropylbenzylamine in the presence of an acid binding agent (which may be an excess of the amine) and removing the benzyl group (if present) by hydrogenolysis, optionally followed by salt formation. The compounds of the invention are #-adrenergic blocking agents, and may be administered in the form of pharmaceutical preparations containing them together with a carrier.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH133865A CH453363A (en) | 1965-02-01 | 1965-02-01 | Process for the production of new indole derivatives |
| CH526465 | 1965-04-14 | ||
| CH1195465 | 1965-08-25 | ||
| CH1420665 | 1965-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1138969A true GB1138969A (en) | 1969-01-01 |
Family
ID=27428155
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB36327/68A Expired GB1138969A (en) | 1965-02-01 | 1966-01-13 | Improvements in or relating to indole derivative and method for its production |
| GB1700/66A Expired GB1138968A (en) | 1965-02-01 | 1966-01-13 | Improvements in or relating to indole derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1700/66A Expired GB1138968A (en) | 1965-02-01 | 1966-01-13 | Improvements in or relating to indole derivatives |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT256097B (en) |
| BE (1) | BE675847A (en) |
| BR (1) | BR6676829D0 (en) |
| CH (1) | CH453363A (en) |
| CY (1) | CY519A (en) |
| DE (1) | DE1620342A1 (en) |
| DK (1) | DK117705B (en) |
| FI (1) | FI46160C (en) |
| FR (2) | FR1466164A (en) |
| GB (2) | GB1138969A (en) |
| NL (2) | NL6601040A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH495983A (en) * | 1968-02-09 | 1970-09-15 | Sandoz Ag | Process for the preparation of levorotatory 4- (2-hydroxy-3-isopropylaminopropoxy) indole |
| SE375771B (en) * | 1970-09-30 | 1975-04-28 | Sandoz Ag | |
| DE2905053A1 (en) * | 1979-02-08 | 1980-08-14 | Schering Ag | 1-Methyl:indolyl:oxy-2,3-epoxy-propane prodn. - from 4-hydroxy-2-methyl:indole and epichlorohydrin in protic solvent |
-
0
- NL NL131726D patent/NL131726C/xx active
-
1965
- 1965-02-01 CH CH133865A patent/CH453363A/en unknown
-
1966
- 1966-01-13 GB GB36327/68A patent/GB1138969A/en not_active Expired
- 1966-01-13 GB GB1700/66A patent/GB1138968A/en not_active Expired
- 1966-01-27 NL NL6601040A patent/NL6601040A/xx unknown
- 1966-01-31 FI FI660235A patent/FI46160C/en active
- 1966-01-31 BR BR176829/66A patent/BR6676829D0/en unknown
- 1966-01-31 AT AT84666A patent/AT256097B/en active
- 1966-01-31 FR FR47796A patent/FR1466164A/en not_active Expired
- 1966-01-31 BE BE675847D patent/BE675847A/xx not_active IP Right Cessation
- 1966-01-31 DK DK49066AA patent/DK117705B/en unknown
- 1966-04-29 FR FR59690A patent/FR5673M/fr not_active Expired
-
1968
- 1968-09-04 DE DE19681620342 patent/DE1620342A1/en active Granted
-
1970
- 1970-01-29 CY CY51970A patent/CY519A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1620342B2 (en) | 1973-10-04 |
| FI46160B (en) | 1972-10-02 |
| FI46160C (en) | 1973-01-10 |
| NL6601040A (en) | 1966-08-02 |
| CY519A (en) | 1970-01-29 |
| FR5673M (en) | 1968-01-02 |
| NL131726C (en) | |
| GB1138968A (en) | 1969-01-01 |
| BE675847A (en) | 1966-08-01 |
| BR6676829D0 (en) | 1973-09-11 |
| DE1620342A1 (en) | 1970-04-30 |
| DK117705B (en) | 1970-05-25 |
| FR1466164A (en) | 1967-01-13 |
| AT256097B (en) | 1967-08-10 |
| DE1620342C3 (en) | 1974-05-16 |
| CH453363A (en) | 1968-06-14 |
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