GB1199330A - New Aminoalcohols and Process for Preparing Same - Google Patents
New Aminoalcohols and Process for Preparing SameInfo
- Publication number
- GB1199330A GB1199330A GB41645/67A GB4164567A GB1199330A GB 1199330 A GB1199330 A GB 1199330A GB 41645/67 A GB41645/67 A GB 41645/67A GB 4164567 A GB4164567 A GB 4164567A GB 1199330 A GB1199330 A GB 1199330A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- optically active
- alkyl
- aminoalcohols
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001414 amino alcohols Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,199,330. Aminoalcohols. RICHTER GEDEON VEGYESZETI GYAR RT. 12 Sept., 1967 [24 Sept., 1966], No. 41645/67. Heading C2C. Racemic and optically active compounds of the general Formula (I): (R 1 = H, halogen, C 1-5 alkyl or alkoxy; R 2 =H, C 1-5 alkyl; R 3 =H, branched alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl; R 4 = cycloalkyl, alkenyl or (when R 3 is not H) branched alkyl; or NR 3 R 4 = heterocyclic ring provided that when the ring contains a further heteroatom it is not N) and their acid addition salts, are prepared by (a) reacting a compound of the Formula (II): (X=halogen) and/or a compound of the Formula (III): with R 3 R 4 NH and reducing the resulting nitrophenylalkanolamine, (b) hydrolysing or alcoholysing a compound of the Formula (IV): (R 5 = alkanoyl, aroyl, alkylsulphonyl, arylsulphonyl), (c) hydrogenolysing a compound of the Formula (IV) but in which R 5 = alkylsulphonyl, arylsulphonyl, benzyl, or (d) reducing a compound of the formula in one or two steps, optionally followed by salt formation. If an optically active product is required an optically active starting material may be used or resolution effected at any desired stage. The above compounds are antidepressants and hypotensive agents, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUGO000995 | 1966-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1199330A true GB1199330A (en) | 1970-07-22 |
Family
ID=10996659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB41645/67A Expired GB1199330A (en) | 1966-09-24 | 1967-09-12 | New Aminoalcohols and Process for Preparing Same |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT277213B (en) |
| CH (1) | CH487112A (en) |
| DE (1) | DE1643498A1 (en) |
| DK (1) | DK136814B (en) |
| FR (1) | FR7206M (en) |
| GB (1) | GB1199330A (en) |
| NL (1) | NL157891B (en) |
| SE (1) | SE350026B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2124157A1 (en) * | 1971-02-10 | 1972-09-22 | Ugine Kuhlmann | |
| WO1999037293A3 (en) * | 1998-01-27 | 2000-04-20 | Thomas N Thomas | Use of an mao-a or mao-b inhibitor for the treatment of vascular disorders |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BG33347A1 (en) * | 1981-06-10 | 1983-02-15 | Zabunova Cvetanova | Method for obtaining of n- (2- aminobenzyl)- 1- phenyl- 2- methylaminoethanol |
-
1967
- 1967-09-12 GB GB41645/67A patent/GB1199330A/en not_active Expired
- 1967-09-21 AT AT860867A patent/AT277213B/en not_active IP Right Cessation
- 1967-09-22 DK DK474967A patent/DK136814B/en unknown
- 1967-09-22 CH CH1327267A patent/CH487112A/en not_active IP Right Cessation
- 1967-09-22 FR FR121853A patent/FR7206M/fr not_active Expired
- 1967-09-22 SE SE1309067A patent/SE350026B/xx unknown
- 1967-09-22 NL NL6712997A patent/NL157891B/en not_active IP Right Cessation
- 1967-11-21 DE DE19671643498 patent/DE1643498A1/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2124157A1 (en) * | 1971-02-10 | 1972-09-22 | Ugine Kuhlmann | |
| WO1999037293A3 (en) * | 1998-01-27 | 2000-04-20 | Thomas N Thomas | Use of an mao-a or mao-b inhibitor for the treatment of vascular disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1643498B2 (en) | 1973-11-15 |
| NL157891B (en) | 1978-09-15 |
| DE1643498A1 (en) | 1972-06-15 |
| DK136814C (en) | 1978-05-08 |
| NL6712997A (en) | 1968-03-25 |
| CH487112A (en) | 1970-03-15 |
| DK136814B (en) | 1977-11-28 |
| DE1643498C3 (en) | 1974-06-12 |
| FR7206M (en) | 1969-08-25 |
| SE350026B (en) | 1972-10-16 |
| AT277213B (en) | 1969-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1496769A (en) | 5-substituted ethyl-8-hydroxycarbostyril derivatives and production thereof | |
| GB1333471A (en) | Imidazoline derivatives and process for preparing the same | |
| GB1106040A (en) | Novel benzdiaz[1,4]epine derivatives and a process for the manufacture thereof | |
| GB1433701A (en) | 5-6-benzene ring substituted benzimidazole-2-carbamate derivative having anthelmintic activity apparatus | |
| GB1198317A (en) | Benzophenone Derivatives | |
| GB1456627A (en) | Pyridobenzodiazepinones | |
| GB1142066A (en) | New diphenyl-ureas and process for preparing them | |
| GB1188846A (en) | Thiazole Derivatives | |
| GB1342558A (en) | Substituted 3-benzylpyridines | |
| GB1199330A (en) | New Aminoalcohols and Process for Preparing Same | |
| GB1475314A (en) | Phenyl-propylamine derivatives | |
| GB1421006A (en) | Imidazolidine derivatives | |
| ES334756A1 (en) | PROCEDURE FOR THE PRODUCTION OF DERIVATIVES OF BENZO-TIACEPIN - 4 - ONA. | |
| GB1261989A (en) | 5-thiazolecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing the same | |
| GB1138315A (en) | 2-amino-benzylamines | |
| GB1233268A (en) | ||
| GB1210156A (en) | Novel dibenzocycloheptenone amines and a process for the manufacture thereof | |
| GB1050633A (en) | ||
| GB1441872A (en) | Nitrobenzophenones | |
| GB1208231A (en) | beta-PHENETHYLAMINE DERIVATIVES AND A PROCESS FOR THE MANUFACTURE THEREOF | |
| GB1160448A (en) | Alkanolamine Derivatives | |
| GB1195319A (en) | Alkyl Sulfate Salts of 1-(p-Chlorobenzhydryl)-4-Methylhomopiperazines | |
| GB1132397A (en) | Improvements in or relating to fluorene derivatives and the manufacture thereof | |
| GB1221407A (en) | 0,2,3,4-tetrahydro-7-substituted-6-sulfamyl-4-quinazolinones, process for preparing the same and pharmaceutical compositions comprising the same | |
| GB1348259A (en) | Process for the preparation of 10-oxo-7,10-dihydro-1h-dioxino- 5,4-f-quinolyl-9-carboxylic acids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |