GB1195980A - Hormone-Like Preparations Derived from Thymus Gland and Methods of Producing the Same. - Google Patents
Hormone-Like Preparations Derived from Thymus Gland and Methods of Producing the Same.Info
- Publication number
- GB1195980A GB1195980A GB37903/67A GB3790367A GB1195980A GB 1195980 A GB1195980 A GB 1195980A GB 37903/67 A GB37903/67 A GB 37903/67A GB 3790367 A GB3790367 A GB 3790367A GB 1195980 A GB1195980 A GB 1195980A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thymosin
- thymus gland
- hormone
- supernatant
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000001541 thymus gland Anatomy 0.000 title abstract 4
- 230000003054 hormonal effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 3
- 102000007501 Thymosin Human genes 0.000 abstract 3
- 108010046075 Thymosin Proteins 0.000 abstract 3
- 239000006228 supernatant Substances 0.000 abstract 3
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 239000000284 extract Substances 0.000 abstract 2
- 229920002401 polyacrylamide Polymers 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 210000003563 lymphoid tissue Anatomy 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Developmental Biology & Embryology (AREA)
- Physiology (AREA)
- Animal Husbandry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
1,195,980. Active thymus gland extracts. YESHIVA UNIVERSITY. 17 Aug., 1967 [24 Aug., 1966], No. 37903/67. Heading A5B. Hormone-like extracts of thymus gland called "Thymosin" and "anti-thymosin" are obtained by homogenising thymus glad tissue in saline, centrifuging and treating the supernatant with acetone after heating to 100‹C. for 15 minutes to produce a precipitate containing the thymosin and a supernatant containing the antithymosin. The precipitate may be worked up by passing its solution in 0.15M NaCl through a polyacrylamide gel column, lyophilization of the percolate and fractionation of a solution thereof in phosphate buffer on a DEAE-cellulose column. The supernatant may be worked up by passage of an aqueous solution of the lyophilizate thereof through a polyacrylamide gel column. "Thymosin" is stated to stimulate lymphoid tissue proliferation, "anti-hymosin" to have the opposite effect.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58055866A | 1966-08-24 | 1966-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1195980A true GB1195980A (en) | 1970-06-24 |
Family
ID=24321584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB37903/67A Expired GB1195980A (en) | 1966-08-24 | 1967-08-17 | Hormone-Like Preparations Derived from Thymus Gland and Methods of Producing the Same. |
Country Status (2)
| Country | Link |
|---|---|
| FR (2) | FR1605258A (en) |
| GB (1) | GB1195980A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2110436A1 (en) * | 1971-03-04 | 1972-09-14 | Lab Farmaco Biolog Ellem S P A | Anti-leukopenic partially-lysed thymus - extract |
| US4077949A (en) | 1973-12-28 | 1978-03-07 | Sloan-Kettering Institute For Cancer Research | Polypeptide hormones of the thymus |
| EP0259564A3 (en) * | 1986-07-10 | 1989-09-27 | ELLEM INDUSTRIA FARMACEUTICA S.p.A. | A thymus derivative active after oral administration, methods of preparation and pharmaceutical compositions |
| JP2006507349A (en) * | 2002-11-25 | 2006-03-02 | サイクローン・ファーマシューティカルズ・インコーポレイテッド | Methods for protecting radiation damage with alpha thymosin |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH633258A5 (en) * | 1976-10-28 | 1982-11-30 | Hoffmann La Roche | Process for preparing thymosin alpha 1 |
-
1967
- 1967-08-17 GB GB37903/67A patent/GB1195980A/en not_active Expired
- 1967-08-21 FR FR118423A patent/FR1605258A/en not_active Expired
- 1967-08-22 FR FR118576A patent/FR7373M/fr not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2110436A1 (en) * | 1971-03-04 | 1972-09-14 | Lab Farmaco Biolog Ellem S P A | Anti-leukopenic partially-lysed thymus - extract |
| US4077949A (en) | 1973-12-28 | 1978-03-07 | Sloan-Kettering Institute For Cancer Research | Polypeptide hormones of the thymus |
| EP0259564A3 (en) * | 1986-07-10 | 1989-09-27 | ELLEM INDUSTRIA FARMACEUTICA S.p.A. | A thymus derivative active after oral administration, methods of preparation and pharmaceutical compositions |
| JP2006507349A (en) * | 2002-11-25 | 2006-03-02 | サイクローン・ファーマシューティカルズ・インコーポレイテッド | Methods for protecting radiation damage with alpha thymosin |
| US7897567B2 (en) | 2002-11-25 | 2011-03-01 | Sciclone Pharmaceuticals, Inc. | Methods of protecting against radiation damage using alpha thymosin |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1605258A (en) | 1973-11-30 |
| FR7373M (en) | 1969-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |