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GB1188197A - Lysergic Acid Derivatives - Google Patents

Lysergic Acid Derivatives

Info

Publication number
GB1188197A
GB1188197A GB4648767A GB4648767A GB1188197A GB 1188197 A GB1188197 A GB 1188197A GB 4648767 A GB4648767 A GB 4648767A GB 4648767 A GB4648767 A GB 4648767A GB 1188197 A GB1188197 A GB 1188197A
Authority
GB
United Kingdom
Prior art keywords
acid
general formula
acid derivatives
carbon atoms
aryl radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4648767A
Inventor
Franz Troxler
Albert Hofmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Priority to GB4648767A priority Critical patent/GB1188197A/en
Publication of GB1188197A publication Critical patent/GB1188197A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,188,197. d-Lysergic acid derivatives. SANDOZ Ltd. 11 Oct., 1967, No. 46487/67. Heading C2C. The invention comprises compounds of general Formula I in which R 1 signifies an aralkyl radical having from 7 to 9 carbon atoms or an aryl radical, whereby the aryl radical may be substituted by one or more of the following radicals: methyl alkoxy having 1-4 carbon atoms, chlorine or bromine, and their acid addition salts. They are obtained by reacting a functional derivative of an acid of general Formula II with a compound of general Formula III in which R 1 has the above significance, and when an acid addition salt is required, the resulting compound of Formula I is reacted with an organic or inorganic acid. The acid chloride hydrochloride, the acid azide or the mixed anhydride with sulphuric acid may be used as the functional acid derivatives. Pharmaceutical compositions containing as active ingredients one of the compounds claimed and having anti-depressant activity are administered orally, parenterally or rectally.
GB4648767A 1967-10-11 1967-10-11 Lysergic Acid Derivatives Expired GB1188197A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4648767A GB1188197A (en) 1967-10-11 1967-10-11 Lysergic Acid Derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4648767A GB1188197A (en) 1967-10-11 1967-10-11 Lysergic Acid Derivatives

Publications (1)

Publication Number Publication Date
GB1188197A true GB1188197A (en) 1970-04-15

Family

ID=10441467

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4648767A Expired GB1188197A (en) 1967-10-11 1967-10-11 Lysergic Acid Derivatives

Country Status (1)

Country Link
GB (1) GB1188197A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221870B1 (en) 1997-05-29 2001-04-24 Novartis Ag Ergoline derivatives and their use as somatostatin receptor antagonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221870B1 (en) 1997-05-29 2001-04-24 Novartis Ag Ergoline derivatives and their use as somatostatin receptor antagonists

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Legal Events

Date Code Title Description
PS Patent sealed
429A Application made for amendment of specification (sect. 29/1949)
429H Application (made) for amendment of specification now open to opposition (sect. 29/1949)
429D Case decided by the comptroller ** specification amended (sect. 29/1949)
426 Order made revoking patent and granting patent of addition in lieu thereof (sect. 26(2)/1949)
PLNP Patent lapsed through nonpayment of renewal fees