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GB1178958A - Production of Stable, High-Potency Human AHF - Google Patents

Production of Stable, High-Potency Human AHF

Info

Publication number
GB1178958A
GB1178958A GB20604/68A GB2060468A GB1178958A GB 1178958 A GB1178958 A GB 1178958A GB 20604/68 A GB20604/68 A GB 20604/68A GB 2060468 A GB2060468 A GB 2060468A GB 1178958 A GB1178958 A GB 1178958A
Authority
GB
United Kingdom
Prior art keywords
stable
production
precipitant
precipitate
cryoprecipitate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20604/68A
Inventor
Edward Shanbrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter Laboratories Inc
Baxter Travenol Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24545372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1178958(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Laboratories Inc, Baxter Travenol Laboratories Inc filed Critical Baxter Laboratories Inc
Publication of GB1178958A publication Critical patent/GB1178958A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1,178,958. Concentrating A.H.F. BAXTER LABORATORIES Inc. 1 May, 1968 [1 May, 1967], No. 20604/68. Heading A5B. Antihemophilic Factor (A.H.F.) is obtained in more concentrated form by precipitating a redissolved cryoprecipitate of A.H.F. with aqueous glycine and/or polyethylene solutions. The cryoprecipitate may be formed by cooling human blood plasma e.g. to -20‹C to -40‹C followed by slow thawing to about 4‹C. The precipitate is dissolved in glycine citrated saline and the precipitant is added. The precipitate is collected and may be redissolved and reprecipitated using the other precipitant and/or subjected to an additional purification step by adsorption on and ellution from a chromatographic column of "Eoteola" cellulose resin.
GB20604/68A 1967-05-01 1968-05-01 Production of Stable, High-Potency Human AHF Expired GB1178958A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63483967A 1967-05-01 1967-05-01

Publications (1)

Publication Number Publication Date
GB1178958A true GB1178958A (en) 1970-01-28

Family

ID=24545372

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20604/68A Expired GB1178958A (en) 1967-05-01 1968-05-01 Production of Stable, High-Potency Human AHF

Country Status (10)

Country Link
JP (1) JPS594402B1 (en)
BE (1) BE713764A (en)
DE (1) DE1767285C3 (en)
DK (1) DK119626B (en)
ES (1) ES353435A1 (en)
FR (1) FR1589414A (en)
GB (1) GB1178958A (en)
IT (1) IT1048951B (en)
NL (1) NL162838C (en)
SE (1) SE375008B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE29698E (en) 1972-05-17 1978-07-11 Baxter Travenol Laboratories, Inc. Stabilization of AHF using heparin
EP0022052A3 (en) * 1979-06-19 1981-11-11 David Amrani Process for the separation and isolation of the ahf fraction, the fibronectin fraction and the von willebrand's ristocetin cofactor fraction from blood plasma
EP0033582A3 (en) * 1980-01-18 1981-11-18 The Canadian Red Cross Society Method of obtaining factor viii
EP0221566A3 (en) * 1985-11-08 1987-10-07 Baxter Travenol Laboratories, Inc. Method for preparing antihemophilic factor (ahf) by cold precipitation and for improving solubility of recovered ahf product
EP0367840A1 (en) 1988-11-05 1990-05-16 Octapharma AG Process for producing by chromatography a non-infectious antihemophilic factor with high purity
EP0412466A3 (en) * 1989-08-07 1991-09-18 Behringwerke Aktiengesellschaft Preparation of a stable factor viii

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE348942B (en) * 1970-06-02 1972-09-18 Statens Bakteriologiska Labor
DE2550011C2 (en) * 1975-11-07 1982-11-25 Behringwerke Ag, 3550 Marburg Process for the preparation of an antihemophilic agent
DK144731C (en) 1976-07-30 1982-10-18 Nordisk Insulinlab PROCEDURE FOR INSULATING PROTEIN HORMONES DERIVED FROM HUMAN HYPPHYPHYSE TISSUE
FR2460305A2 (en) * 1979-06-29 1981-01-23 Merieux Inst PROCESS FOR PREPARING A FACTOR VIII CONCENTRATE
DE3318521A1 (en) * 1983-05-20 1984-11-22 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München METHOD FOR PRODUCING AN ANTIHAEMOPHILIE FACTOR CONCENTRATE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL286954A (en) * 1962-01-03

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE29698E (en) 1972-05-17 1978-07-11 Baxter Travenol Laboratories, Inc. Stabilization of AHF using heparin
EP0022052A3 (en) * 1979-06-19 1981-11-11 David Amrani Process for the separation and isolation of the ahf fraction, the fibronectin fraction and the von willebrand's ristocetin cofactor fraction from blood plasma
EP0033582A3 (en) * 1980-01-18 1981-11-18 The Canadian Red Cross Society Method of obtaining factor viii
EP0221566A3 (en) * 1985-11-08 1987-10-07 Baxter Travenol Laboratories, Inc. Method for preparing antihemophilic factor (ahf) by cold precipitation and for improving solubility of recovered ahf product
EP0367840A1 (en) 1988-11-05 1990-05-16 Octapharma AG Process for producing by chromatography a non-infectious antihemophilic factor with high purity
EP0412466A3 (en) * 1989-08-07 1991-09-18 Behringwerke Aktiengesellschaft Preparation of a stable factor viii

Also Published As

Publication number Publication date
NL162838C (en) 1980-07-15
DE1767285C3 (en) 1981-08-20
DK119626B (en) 1971-02-01
DE1767285A1 (en) 1971-08-19
NL162838B (en) 1980-02-15
JPS594402B1 (en) 1984-01-30
DE1767285B2 (en) 1980-12-04
BE713764A (en) 1968-09-16
ES353435A1 (en) 1969-09-16
FR1589414A (en) 1970-03-31
IT1048951B (en) 1980-12-20
NL6806162A (en) 1968-11-04
SE375008B (en) 1975-04-07

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