GB1033484A - Process for preparing tablets containing chloral betaine - Google Patents
Process for preparing tablets containing chloral betaineInfo
- Publication number
- GB1033484A GB1033484A GB1590464A GB1590464A GB1033484A GB 1033484 A GB1033484 A GB 1033484A GB 1590464 A GB1590464 A GB 1590464A GB 1590464 A GB1590464 A GB 1590464A GB 1033484 A GB1033484 A GB 1033484A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tablets
- tablets containing
- polyethylene glycols
- chloral betaine
- granules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ONAOIDNSINNZOA-UHFFFAOYSA-N chloral betaine Chemical compound OC(O)C(Cl)(Cl)Cl.C[N+](C)(C)CC([O-])=O ONAOIDNSINNZOA-UHFFFAOYSA-N 0.000 title abstract 2
- 229940118803 chloral betaine Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 235000010944 ethyl methyl cellulose Nutrition 0.000 abstract 2
- 239000008187 granular material Substances 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 229940068917 polyethylene glycols Drugs 0.000 abstract 2
- 241000220479 Acacia Species 0.000 abstract 1
- 229920000623 Cellulose acetate phthalate Chemical class 0.000 abstract 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- 239000004705 High-molecular-weight polyethylene Substances 0.000 abstract 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 abstract 1
- 229920001800 Shellac Chemical class 0.000 abstract 1
- 235000021355 Stearic acid Nutrition 0.000 abstract 1
- 239000000783 alginic acid Chemical class 0.000 abstract 1
- 235000010443 alginic acid Nutrition 0.000 abstract 1
- 229920000615 alginic acid Chemical class 0.000 abstract 1
- 229960001126 alginic acid Drugs 0.000 abstract 1
- 150000004781 alginic acids Chemical class 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 230000006835 compression Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 239000001761 ethyl methyl cellulose Substances 0.000 abstract 1
- -1 ethyl- Chemical class 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Chemical class 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Chemical class 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical class OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 229920003087 methylethyl cellulose Chemical class 0.000 abstract 1
- 235000010446 mineral oil Nutrition 0.000 abstract 1
- 239000002480 mineral oil Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract 1
- 239000010461 other edible oil Substances 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 239000004208 shellac Chemical class 0.000 abstract 1
- 235000013874 shellac Nutrition 0.000 abstract 1
- 229940113147 shellac Drugs 0.000 abstract 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical class OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 abstract 1
- 239000008117 stearic acid Substances 0.000 abstract 1
- 238000009495 sugar coating Methods 0.000 abstract 1
- 239000002278 tabletting lubricant Substances 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
Tablets containing at least 90% total dry weight of chloral betaine are prepared by mixing the said agent with acacia or polyvinylpyrrolidone as a binder, granulating this mixture with aqueous gelatine solution, adjusting the free moisture in the granules to a weight percent of 0. 6 to 1. 1%, and compressing into tablets while maintaining this moisture content. Tabletting lubricants such as stearic acid, talc, high molecular weight polyethylene glycols, fatty glycerides and other edible oils, magnesium stearate, or mineral oil may be added to the granules before compressing. The tablets may be coated, with film formers such as ethyl-, methyl-, or hydroxypropylmethyl-cellulose, cellulose acetate phthalate, polyethylene glycols, shellac or alginic acid derivatives, or with sugar coatings or compression coatings.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29130063A | 1963-06-28 | 1963-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1033484A true GB1033484A (en) | 1966-06-22 |
Family
ID=23119753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1590464A Expired GB1033484A (en) | 1963-06-28 | 1964-04-16 | Process for preparing tablets containing chloral betaine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1033484A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0235986A1 (en) * | 1986-02-13 | 1987-09-09 | Ethical Pharmaceuticals Limited | Slow release formulation |
| EP1279433A3 (en) * | 2001-06-26 | 2003-07-02 | Glatt Ingenieurtechnik GmbH | Process for coating of matrial in granular and powder form |
-
1964
- 1964-04-16 GB GB1590464A patent/GB1033484A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0235986A1 (en) * | 1986-02-13 | 1987-09-09 | Ethical Pharmaceuticals Limited | Slow release formulation |
| US4880830A (en) * | 1986-02-13 | 1989-11-14 | Ethical Pharmaceuticals Limited | Slow release formulation |
| EP1279433A3 (en) * | 2001-06-26 | 2003-07-02 | Glatt Ingenieurtechnik GmbH | Process for coating of matrial in granular and powder form |
| EP1987875A1 (en) * | 2001-06-26 | 2008-11-05 | Glatt Ingenieurtechnik GmbH | Method for coating granular and powder-form materials |
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