GB1026503A - Improvements in or relating to steroids and the manufacture thereof - Google Patents
Improvements in or relating to steroids and the manufacture thereofInfo
- Publication number
- GB1026503A GB1026503A GB49713/65A GB4971365A GB1026503A GB 1026503 A GB1026503 A GB 1026503A GB 49713/65 A GB49713/65 A GB 49713/65A GB 4971365 A GB4971365 A GB 4971365A GB 1026503 A GB1026503 A GB 1026503A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- hydrogen
- steroids
- relating
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006356 dehydrogenation reaction Methods 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- -1 hydrocarbon carboxylic acid Chemical class 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises a compound of the general formula <FORM:1026503/C2/1> wherein R is hydrogen or the acyl radical of a hydrocarbon carboxylic acid containing from 1-12 carbon atoms inclusive, Y is hydrogen, methyl or fluorine and the 1,2-carbon atom linkage represents a single- or double-bonded linkage and a process for the preparation thereof which comprises treating compounds having the formula <FORM:1026503/C2/2> <FORM:1026503/C2/3> with hydrogen chloride and then with acetic anhydride. If desired the D 4-compound so obtained may be converted into the corresponding D 1,4-compound by 1,2-dehydrogenation with selenium dioxide.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US144830A US3137712A (en) | 1961-10-13 | 1961-10-13 | 16alpha-chloro-1, 4-pregnadienes |
| US20240362A | 1962-06-14 | 1962-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1026503A true GB1026503A (en) | 1966-04-20 |
Family
ID=26842402
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB49713/65A Expired GB1026503A (en) | 1961-10-13 | 1962-10-12 | Improvements in or relating to steroids and the manufacture thereof |
| GB38760/62A Expired GB1026501A (en) | 1961-10-13 | 1962-10-12 | Improvements in or relating to steroids and the manufacture thereof |
| GB49712/65A Expired GB1026502A (en) | 1961-10-13 | 1962-10-12 | Improvements in or relating to steroids and the manufacture thereof |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB38760/62A Expired GB1026501A (en) | 1961-10-13 | 1962-10-12 | Improvements in or relating to steroids and the manufacture thereof |
| GB49712/65A Expired GB1026502A (en) | 1961-10-13 | 1962-10-12 | Improvements in or relating to steroids and the manufacture thereof |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR2260M (en) |
| GB (3) | GB1026503A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19715594A1 (en) | 1997-04-15 | 1998-10-22 | Bayer Ag | Analgesic combination |
-
1962
- 1962-10-12 GB GB49713/65A patent/GB1026503A/en not_active Expired
- 1962-10-12 GB GB38760/62A patent/GB1026501A/en not_active Expired
- 1962-10-12 GB GB49712/65A patent/GB1026502A/en not_active Expired
-
1963
- 1963-01-11 FR FR921196A patent/FR2260M/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| GB1026501A (en) | 1966-04-20 |
| GB1026502A (en) | 1966-04-20 |
| FR2260M (en) | 1964-01-06 |
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