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GB1016079A - Oxazaphospholidines - Google Patents

Oxazaphospholidines

Info

Publication number
GB1016079A
GB1016079A GB539465A GB539465A GB1016079A GB 1016079 A GB1016079 A GB 1016079A GB 539465 A GB539465 A GB 539465A GB 539465 A GB539465 A GB 539465A GB 1016079 A GB1016079 A GB 1016079A
Authority
GB
United Kingdom
Prior art keywords
ephedrine
oxazaphospholidines
ccl4
intermediates
triethylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB539465A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Farmochimica Cutolo Calosi S P
Original Assignee
Farmochimica Cutolo Calosi S P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmochimica Cutolo Calosi S P filed Critical Farmochimica Cutolo Calosi S P
Publication of GB1016079A publication Critical patent/GB1016079A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65844—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a five-membered ring which may be condensed with another ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises L-, D-, and DL-2-chloro - 3,4 - dimethyl - 5 - phenyl - 2 - oxide - 1,3,2 - oxazaphospholidines. They may be obtained by treating the corresponding L-, D-, or DL-ephedrine dissolved in an inert solvent, e.g. benzene, ether or CCL4, with phosphorus oxychloride in the presence of a basic material, e.g. a tertiary organic base such as triethylamine. The products are useful as intermediates for the preparation of ephedrine phosphoric ester derivatives as disclosed in Specification 1,016,078 is referred to.
GB539465A 1961-10-26 1962-10-25 Oxazaphospholidines Expired GB1016079A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1963861 1961-10-26
IT1587962 1962-08-01

Publications (1)

Publication Number Publication Date
GB1016079A true GB1016079A (en) 1966-01-05

Family

ID=26326820

Family Applications (2)

Application Number Title Priority Date Filing Date
GB4042062A Expired GB1016078A (en) 1961-10-26 1962-10-25 Phosphorus-containing ephedrine derivatives
GB539465A Expired GB1016079A (en) 1961-10-26 1962-10-25 Oxazaphospholidines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB4042062A Expired GB1016078A (en) 1961-10-26 1962-10-25 Phosphorus-containing ephedrine derivatives

Country Status (1)

Country Link
GB (2) GB1016078A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229162A (en) * 1984-01-20 1993-07-20 Biocompatibles Ltd. Article having biocompatible surface
GB8401534D0 (en) * 1984-01-20 1984-02-22 Royal Free Hosp School Med Biocompatible surfaces
US5380904A (en) * 1984-01-20 1995-01-10 Biocompatibles Ltd. Process for rendering a surface biocompatible, and articles containing the same

Also Published As

Publication number Publication date
GB1016078A (en) 1966-01-05

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