GB1003474A - Tetracycline derivatives - Google Patents
Tetracycline derivativesInfo
- Publication number
- GB1003474A GB1003474A GB19034/62A GB1903462A GB1003474A GB 1003474 A GB1003474 A GB 1003474A GB 19034/62 A GB19034/62 A GB 19034/62A GB 1903462 A GB1903462 A GB 1903462A GB 1003474 A GB1003474 A GB 1003474A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tetracycline
- amino
- followed
- group
- reduction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004098 Tetracycline Substances 0.000 title abstract 11
- 229960002180 tetracycline Drugs 0.000 title abstract 11
- 229930101283 tetracycline Natural products 0.000 title abstract 10
- 235000019364 tetracycline Nutrition 0.000 title abstract 10
- 150000003522 tetracyclines Chemical class 0.000 title abstract 5
- 125000003277 amino group Chemical group 0.000 abstract 5
- -1 nitroso, diazonium halide Chemical class 0.000 abstract 5
- 230000009467 reduction Effects 0.000 abstract 4
- 238000006722 reduction reaction Methods 0.000 abstract 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- CIZVQWNPBGYCGK-UHFFFAOYSA-N benzenediazonium Chemical group N#[N+]C1=CC=CC=C1 CIZVQWNPBGYCGK-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- 238000006683 Mannich reaction Methods 0.000 abstract 1
- 239000007868 Raney catalyst Substances 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
- 241000191940 Staphylococcus Species 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- RHQKKJPJCHGKQO-UHFFFAOYSA-N [Cu+2].[O-][Cr]([O-])=O Chemical class [Cu+2].[O-][Cr]([O-])=O RHQKKJPJCHGKQO-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000010531 catalytic reduction reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006264 debenzylation reaction Methods 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- WREDNSAXDZCLCP-UHFFFAOYSA-N methanedithioic acid Chemical compound SC=S WREDNSAXDZCLCP-UHFFFAOYSA-N 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Substances [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 229910052718 tin Inorganic materials 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14713761A | 1961-10-24 | 1961-10-24 | |
| US161412A US3148212A (en) | 1961-12-22 | 1961-12-22 | Reductive alkylation process |
| US17159962A | 1962-02-07 | 1962-02-07 | |
| US53928266A | 1966-04-01 | 1966-04-01 | |
| US54436866A | 1966-04-22 | 1966-04-22 | |
| US58920666A | 1966-10-25 | 1966-10-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1003474A true GB1003474A (en) | 1965-09-02 |
Family
ID=56089740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB19034/62A Expired GB1003474A (en) | 1961-10-24 | 1962-05-17 | Tetracycline derivatives |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE618065A (es) |
| CH (2) | CH448070A (es) |
| DK (1) | DK126586B (es) |
| ES (3) | ES277406A1 (es) |
| GB (1) | GB1003474A (es) |
| LU (1) | LU41768A1 (es) |
| MC (1) | MC370A1 (es) |
| SE (1) | SE309416B (es) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2266590A2 (en) | 2002-02-22 | 2010-12-29 | Shire LLC | Active agent delivery sytems and methods for protecting and administering active agents |
| RU2789331C2 (ru) * | 2015-02-13 | 2023-02-01 | Ховионе Сциентиа Лимитед | Новые полиморфные формы миноциклинового основания и способы их получения |
-
1962
- 1962-05-16 MC MC389A patent/MC370A1/fr unknown
- 1962-05-17 GB GB19034/62A patent/GB1003474A/en not_active Expired
- 1962-05-17 ES ES277406A patent/ES277406A1/es not_active Expired
- 1962-05-22 CH CH1577466A patent/CH448070A/de unknown
- 1962-05-22 CH CH618162A patent/CH444848A/de unknown
- 1962-05-24 LU LU41768D patent/LU41768A1/xx unknown
- 1962-05-24 DK DK235062AA patent/DK126586B/da unknown
- 1962-05-24 BE BE618065A patent/BE618065A/fr unknown
-
1963
- 1963-11-22 SE SE12945/63A patent/SE309416B/xx unknown
-
1967
- 1967-03-31 ES ES338710A patent/ES338710A2/es not_active Expired
-
1970
- 1970-05-08 ES ES379444A patent/ES379444A2/es not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2266590A2 (en) | 2002-02-22 | 2010-12-29 | Shire LLC | Active agent delivery sytems and methods for protecting and administering active agents |
| EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
| EP2316469A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
| RU2789331C2 (ru) * | 2015-02-13 | 2023-02-01 | Ховионе Сциентиа Лимитед | Новые полиморфные формы миноциклинового основания и способы их получения |
| RU2789325C2 (ru) * | 2015-02-13 | 2023-02-01 | Ховионе Сциентиа Лимитед | Новые полиморфные формы миноциклинового основания и способы их получения |
Also Published As
| Publication number | Publication date |
|---|---|
| CH448070A (de) | 1967-12-15 |
| ES379444A2 (es) | 1972-11-01 |
| ES277406A1 (es) | 1962-12-01 |
| SE309416B (es) | 1969-03-24 |
| CH444848A (de) | 1967-10-15 |
| LU41768A1 (es) | 1962-07-24 |
| MC370A1 (fr) | 1963-03-28 |
| BE618065A (fr) | 1962-11-26 |
| ES338710A2 (es) | 1968-04-01 |
| DK126586B (da) | 1973-07-30 |
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