GB1073309A - 18-nor-steroids - Google Patents
18-nor-steroidsInfo
- Publication number
- GB1073309A GB1073309A GB1426565A GB1426565A GB1073309A GB 1073309 A GB1073309 A GB 1073309A GB 1426565 A GB1426565 A GB 1426565A GB 1426565 A GB1426565 A GB 1426565A GB 1073309 A GB1073309 A GB 1073309A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen atom
- group
- hydroxy
- formyloxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 formyloxy group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000468 ketone group Chemical group 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 abstract 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001792 virilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises compounds of formula <F\1> wherein X is a C1- 6 alkenyl, or alkynyl group, Y is a hydrogen atom or a hydroxy or formyloxy group, Y1 is a hydrogen atom or a hydroxy, formyloxy or keto group and Z when present is a hydrogen atom or a methyl group, wherein rings A and B may contain one or more double bonds and/or additional substituents, and their preparation by heating a compound of formula <F\2> wherein Y1 is a hydrogen atom or a hydroxy group and Y11 is a hydrogen atom or a hydroxy or keto group, with formic acid, followed, if desired, by hydrolysis of any formyloxy groups. The compounds of the invention may be used in fertility control, treatment of carcinomas of the prostate or treatment of virilizing tumours of the suprarenals, as pharmaceutical composi sions in combination with a carrier, for example in forms suitable for oral, parenteral or rectal administration, including implants.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1426565A GB1073309A (en) | 1965-04-05 | 1965-04-05 | 18-nor-steroids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1426565A GB1073309A (en) | 1965-04-05 | 1965-04-05 | 18-nor-steroids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1073309A true GB1073309A (en) | 1967-06-21 |
Family
ID=10038029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1426565A Expired GB1073309A (en) | 1965-04-05 | 1965-04-05 | 18-nor-steroids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1073309A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2068404A1 (en) * | 1969-10-13 | 1971-08-27 | Labo Prodotti Braglia | |
| WO1986006078A1 (en) * | 1985-04-17 | 1986-10-23 | Schering Aktiengesellschaft | Skin treatment agents |
-
1965
- 1965-04-05 GB GB1426565A patent/GB1073309A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2068404A1 (en) * | 1969-10-13 | 1971-08-27 | Labo Prodotti Braglia | |
| WO1986006078A1 (en) * | 1985-04-17 | 1986-10-23 | Schering Aktiengesellschaft | Skin treatment agents |
| US4859659A (en) * | 1985-04-17 | 1989-08-22 | Schering Aktiengesellschaft | Dermatics utilizing 17βmethyl-18 nor steroids and methods for their use |
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