GB1069144A - Method for the treatment of malignant tumors - Google Patents
Method for the treatment of malignant tumorsInfo
- Publication number
- GB1069144A GB1069144A GB27185/64A GB2718564A GB1069144A GB 1069144 A GB1069144 A GB 1069144A GB 27185/64 A GB27185/64 A GB 27185/64A GB 2718564 A GB2718564 A GB 2718564A GB 1069144 A GB1069144 A GB 1069144A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ethyleneimino
- spores
- injection
- administered
- tumour
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N3/00—Spore forming or isolating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A method of treating malignant tumours in vertebrates other than human beings comprises parenterally administering to such vertebrates spores of a non-pathogenic, anaerobic strain of a microorganism of the genus Clostridium capable of localising in tumours and causing oncolysis thereof in conjunction with an anti-tumour chemotherapeutic agent selected from 5-fluoro-deoxyuridine or an alkylating agent of the ethyleneimino type, the latter being administered so as to be present in the animal body during the time of maximum oncolytic effect of the spores. Preferred alkylating agents of the ethyleneimino type are Mitomycin C, sec-1-ethyleneimino-2-hydroxy-butane, 2,5-bis (ethyleneimino)-3,6-bis-propoxy-1,4-benzoquinone, and 2,3,5-tris-ethyleneimino-1,4-benzoquinone. The anti-tumour agent may be administered 1-3 days after injection of spores, or 1-3 days prior to spore injection to build up a body level, followed by lower maintenance doses after injection of spores. The p anti-tumour agents may be administered dissolved or suspended in physiologically acceptable diluents or carriers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29418563A | 1963-07-10 | 1963-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1069144A true GB1069144A (en) | 1967-05-17 |
Family
ID=23132267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27185/64A Expired GB1069144A (en) | 1963-07-10 | 1964-07-01 | Method for the treatment of malignant tumors |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE650279A (en) |
| FR (1) | FR6631M (en) |
| GB (1) | GB1069144A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1716858A2 (en) | 1999-09-17 | 2006-11-02 | Wellstat Biologics Corporation | Oncolytic virus |
| US7470426B1 (en) | 1997-10-09 | 2008-12-30 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
| US7780962B2 (en) | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| US8043612B2 (en) | 1997-10-09 | 2011-10-25 | Wellstat Biologics Corporation | Infection and treatment of neoplasms with vesicular stomatitis virus |
| US8105578B2 (en) | 1997-10-09 | 2012-01-31 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
| US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
| CN103374538A (en) * | 2012-04-27 | 2013-10-30 | 格里菲斯大学 | Compositions comprising derived bacterial strains of Clostridium ghonii and methods of use thereof |
-
1964
- 1964-07-01 GB GB27185/64A patent/GB1069144A/en not_active Expired
- 1964-07-08 BE BE650279D patent/BE650279A/xx unknown
- 1964-10-08 FR FR990822A patent/FR6631M/fr not_active Expired
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7470426B1 (en) | 1997-10-09 | 2008-12-30 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
| US7780962B2 (en) | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| US8043612B2 (en) | 1997-10-09 | 2011-10-25 | Wellstat Biologics Corporation | Infection and treatment of neoplasms with vesicular stomatitis virus |
| US8105578B2 (en) | 1997-10-09 | 2012-01-31 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
| EP1716858A2 (en) | 1999-09-17 | 2006-11-02 | Wellstat Biologics Corporation | Oncolytic virus |
| US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
| CN103374538A (en) * | 2012-04-27 | 2013-10-30 | 格里菲斯大学 | Compositions comprising derived bacterial strains of Clostridium ghonii and methods of use thereof |
| EP2841558A4 (en) * | 2012-04-27 | 2015-11-04 | Univ Griffith | ONCOLYTIC GHONII CLOSTRIDIUM STRAINS AND METHODS OF MAKING AND USING THE SAME |
Also Published As
| Publication number | Publication date |
|---|---|
| FR6631M (en) | 1969-01-20 |
| BE650279A (en) | 1965-01-08 |
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