GB1066466A - Dentifrice composition and method of making same - Google Patents
Dentifrice composition and method of making sameInfo
- Publication number
- GB1066466A GB1066466A GB2350664A GB2350664A GB1066466A GB 1066466 A GB1066466 A GB 1066466A GB 2350664 A GB2350664 A GB 2350664A GB 2350664 A GB2350664 A GB 2350664A GB 1066466 A GB1066466 A GB 1066466A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salts
- acid
- dentifrice
- phosphate buffer
- ammonium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000551 dentifrice Substances 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 5
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 3
- -1 alkali metal salts Chemical class 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 239000008363 phosphate buffer Substances 0.000 abstract 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 2
- ROBFUDYVXSDBQM-UHFFFAOYSA-N hydroxymalonic acid Chemical compound OC(=O)C(O)C(O)=O ROBFUDYVXSDBQM-UHFFFAOYSA-N 0.000 abstract 2
- 229910052700 potassium Inorganic materials 0.000 abstract 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- 239000005995 Aluminium silicate Substances 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 239000004135 Bone phosphate Substances 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004677 Nylon Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003082 abrasive agent Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- PZZYQPZGQPZBDN-UHFFFAOYSA-N aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 abstract 1
- 229910000323 aluminium silicate Inorganic materials 0.000 abstract 1
- 235000012211 aluminium silicate Nutrition 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 239000012050 conventional carrier Substances 0.000 abstract 1
- 229910052593 corundum Inorganic materials 0.000 abstract 1
- 208000002925 dental caries Diseases 0.000 abstract 1
- WPUMTJGUQUYPIV-JIZZDEOASA-L disodium (S)-malate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](O)CC([O-])=O WPUMTJGUQUYPIV-JIZZDEOASA-L 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 abstract 1
- 239000008108 microcrystalline cellulose Substances 0.000 abstract 1
- 229940016286 microcrystalline cellulose Drugs 0.000 abstract 1
- 229920001778 nylon Polymers 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000011007 phosphoric acid Nutrition 0.000 abstract 1
- 239000008262 pumice Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 230000000979 retarding effect Effects 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
- 235000019265 sodium DL-malate Nutrition 0.000 abstract 1
- 239000001394 sodium malate Substances 0.000 abstract 1
- 235000019983 sodium metaphosphate Nutrition 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 229910052718 tin Inorganic materials 0.000 abstract 1
- 239000000606 toothpaste Substances 0.000 abstract 1
- 229940034610 toothpaste Drugs 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
- 229910001845 yogo sapphire Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
A dentifrice comprises an inorganic water-soluble fluoride capable of retarding caries, an insoluble alkali-metal metaphosphate abrasive, and a sacrificial metal ion-free dentifrice vehicle, the dentifrice being buffered at an acid pH which can be tolerated by oral tissues with either a phosphate buffer capable of adjusting pH to the acid side or an hydroxy carboxylate buffer, the latter being used when the water-soluble fluoride tends to form insoluble salts with the phosphate buffer. The water-soluble fluoride component may comprise HF in aqueous solution, or an alkali metal (e.g. Na, K or Li), ammonium, or transition metal (e.g. Mn or Sn) salt thereof. Insoluble Na, K or ammonium metaphosphates e.g. Maddrell's salts may be used as the abrasive, optionally with other non-calcium-containing abrasives e.g. Al2O3, TiO2, ground pumice, powered nylon, ground melamine-aldehyde resins, calcined aluminium silicate, and micro-crystalline cellulose. The phosphate buffer may be H3PO4, or one of its alkali metal salts, ammonium salts, or salts of an organic base e.g. ethanolamine. The salts may be in the mono-, di- or tri-basic forms. Either aliphatic or aromatic mono- or poly-hydroxy carboxylic acids or salts thereof may be used. Specified hydroxy carboxylates are sodium malate, malic acid, citric acid, tartaric acid, tartronic acid, and salicylic acid. The dentifrice may also contain one or more surface active agents, flavouring agents, and sweeteners. The dentifrice may be formulated as a toothpaste or toothpowder with conventional carriers, softeners, binders, and/or humectants.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30421163A | 1963-08-23 | 1963-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1066466A true GB1066466A (en) | 1967-04-26 |
Family
ID=23175547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2350664A Expired GB1066466A (en) | 1963-08-23 | 1964-06-05 | Dentifrice composition and method of making same |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1066466A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2216005A (en) * | 1988-03-01 | 1989-10-04 | Procter & Gamble | Dental compositions containing stannous ions |
| US5004597A (en) * | 1987-09-14 | 1991-04-02 | The Procter & Gamble Company | Oral compositions comprising stannous flouride and stannous gluconate |
| US5281411A (en) * | 1992-07-31 | 1994-01-25 | The Procter & Gamble Company | Oral compositions |
| WO2002007694A1 (en) * | 2000-07-24 | 2002-01-31 | Kao Corporation | Oral preparation |
| ES2178953A1 (en) * | 2000-12-20 | 2003-01-01 | Limitadfa Para El Dearrollo Ci | Dentifrice product |
| US9072658B2 (en) | 2003-02-05 | 2015-07-07 | Fmc Corporation | Toothpaste compositions with reduced abrasivity |
| WO2021226154A1 (en) * | 2020-05-05 | 2021-11-11 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2021226155A1 (en) * | 2020-05-05 | 2021-11-11 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| AU2024227094B2 (en) * | 2020-05-05 | 2026-01-22 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
-
1964
- 1964-06-05 GB GB2350664A patent/GB1066466A/en not_active Expired
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004597A (en) * | 1987-09-14 | 1991-04-02 | The Procter & Gamble Company | Oral compositions comprising stannous flouride and stannous gluconate |
| GB2216005A (en) * | 1988-03-01 | 1989-10-04 | Procter & Gamble | Dental compositions containing stannous ions |
| US5281411A (en) * | 1992-07-31 | 1994-01-25 | The Procter & Gamble Company | Oral compositions |
| WO2002007694A1 (en) * | 2000-07-24 | 2002-01-31 | Kao Corporation | Oral preparation |
| ES2178953A1 (en) * | 2000-12-20 | 2003-01-01 | Limitadfa Para El Dearrollo Ci | Dentifrice product |
| US9072658B2 (en) | 2003-02-05 | 2015-07-07 | Fmc Corporation | Toothpaste compositions with reduced abrasivity |
| WO2021226154A1 (en) * | 2020-05-05 | 2021-11-11 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2021226155A1 (en) * | 2020-05-05 | 2021-11-11 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| CN115515552A (en) * | 2020-05-05 | 2022-12-23 | 宝洁公司 | Oral care compositions comprising dicarboxylic acids |
| CN115551468A (en) * | 2020-05-05 | 2022-12-30 | 宝洁公司 | Oral care compositions comprising dicarboxylic acids |
| AU2024227092B2 (en) * | 2020-05-05 | 2026-01-22 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| AU2024227094B2 (en) * | 2020-05-05 | 2026-01-22 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3282792A (en) | Stabilized stannous fluoride dentifrice compositions | |
| GB1066466A (en) | Dentifrice composition and method of making same | |
| DE3206711C2 (en) | In the dental care field usable Remineralisierungslösung | |
| GB1429746A (en) | Dentifrices | |
| GB1110987A (en) | Oral compositions for calculus retardation | |
| EP0422803A3 (en) | Dentifrice comprising cationic antibacterial agent | |
| IT1229075B (en) | Topical compsn. contg. hyaluronic acid deriv. as vehicle | |
| IE33630L (en) | Stabilised toothpaste composition | |
| GB1319396A (en) | Inhibiting dental plaque | |
| GB1066192A (en) | Improvements in or relating to silicate grout | |
| GB1090340A (en) | Dentrifice composition | |
| ES335791A1 (en) | Tooth-paste | |
| GB953636A (en) | Process for preparing a polishing compound | |
| JPH03145417A (en) | Dentifrice agent composition | |
| GB1407787A (en) | Dentifrices | |
| GB1425056A (en) | Cleaning composition and preparation and use thereof | |
| ES377526A1 (en) | Dental creams | |
| NL6916151A (en) | Antibacterial cephalosporin compsns | |
| GB1309026A (en) | Dentifrice gel compositions | |
| GB1442396A (en) | Dentifrice | |
| FR2068419A1 (en) | Antibacterial cephalosporin compsns | |
| GB1261493A (en) | A dentifrice | |
| GB999857A (en) | Toothpastes | |
| GB1348492A (en) | Gel dentifrices | |
| GB1349373A (en) | Dentifrices |