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GB1065889A - Improvements in or relating to the production of isoxazole compounds and the products thereof - Google Patents

Improvements in or relating to the production of isoxazole compounds and the products thereof

Info

Publication number
GB1065889A
GB1065889A GB4706563A GB4706563A GB1065889A GB 1065889 A GB1065889 A GB 1065889A GB 4706563 A GB4706563 A GB 4706563A GB 4706563 A GB4706563 A GB 4706563A GB 1065889 A GB1065889 A GB 1065889A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
groups
defined above
relating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4706563A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB1065889A publication Critical patent/GB1065889A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises isoxazole compounds of the general Formula (I) <FORM:1065889/C2/1> wherein R is a substituted or unsubstituted isocyclic or heterocyclic ring, each of R1 and R11 is a hydrogen atom or an aliphatic hydrocarbon residue, or wherein R1 and R11 together with the nitrogen atom represent a heterocyclic group, A is an alkylene group of 1 to 5 carbon atoms, and wherein one of the groups R and AN< is present at the 3-position and the other at the 5-position, and salts thereof. These compounds may be prepared by reacting a halogenoalkylisoxazole of the Formula (II) <FORM:1065889/C2/2> wherein R and A are as defined above and X is a halogen atom and one of the groups R and AX is in the 3-position and the other in the 5-position, with an amine of the Formula (III) <FORM:1065889/C2/3> wherein R1 and R11 are as defined above, if necessary in the presence of a basic substance. The compounds of Formula (I) or nontoxic salts thereof may be employed in admixture with inert diluents or carriers as antipyretic, analgesic, antitussive, and/or anti-inflammatory agents.
GB4706563A 1962-12-22 1963-11-28 Improvements in or relating to the production of isoxazole compounds and the products thereof Expired GB1065889A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5851962 1962-12-22

Publications (1)

Publication Number Publication Date
GB1065889A true GB1065889A (en) 1967-04-19

Family

ID=13086662

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4706563A Expired GB1065889A (en) 1962-12-22 1963-11-28 Improvements in or relating to the production of isoxazole compounds and the products thereof

Country Status (7)

Country Link
BR (1) BR6355171D0 (en)
CH (1) CH441358A (en)
DE (2) DE1795490B1 (en)
FR (1) FR3192M (en)
GB (1) GB1065889A (en)
NL (2) NL141877B (en)
SE (1) SE317077B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189771A3 (en) * 1985-01-22 1986-10-08 Hoechst-Roussel Pharmaceuticals Incorporated (isoxazol-3-yl)arylmethanones, a process for their preparation and their use as medicaments
US8828992B2 (en) 2009-02-25 2014-09-09 Sk Biopharmaceuticals Co., Ltd. Substituted azole derivatives, pharmaceutical composition containing the derivatives, and method for treating Parkinson's disease using the same

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU180567B (en) * 1980-03-19 1983-03-28 Egyt Gyogyszervegyeszeti Gyar Method for producing derivatives of isooxazole

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189771A3 (en) * 1985-01-22 1986-10-08 Hoechst-Roussel Pharmaceuticals Incorporated (isoxazol-3-yl)arylmethanones, a process for their preparation and their use as medicaments
US8828992B2 (en) 2009-02-25 2014-09-09 Sk Biopharmaceuticals Co., Ltd. Substituted azole derivatives, pharmaceutical composition containing the derivatives, and method for treating Parkinson's disease using the same

Also Published As

Publication number Publication date
SE317077B (en) 1969-11-10
DE1795490B1 (en) 1972-01-13
DE1470258A1 (en) 1969-06-12
BR6355171D0 (en) 1973-07-19
NL141877B (en) 1974-04-16
FR3192M (en) 1965-04-16
CH441358A (en) 1967-08-15
NL302496A (en)

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