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GB1063512A - Aerosols - Google Patents

Aerosols

Info

Publication number
GB1063512A
GB1063512A GB45282/62A GB4528262A GB1063512A GB 1063512 A GB1063512 A GB 1063512A GB 45282/62 A GB45282/62 A GB 45282/62A GB 4528262 A GB4528262 A GB 4528262A GB 1063512 A GB1063512 A GB 1063512A
Authority
GB
United Kingdom
Prior art keywords
surface active
sulphate
solid
carbon atoms
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB45282/62A
Inventor
Philip Saxton Hartley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BENGER LAB Ltd
Original Assignee
BENGER LAB Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BENGER LAB Ltd filed Critical BENGER LAB Ltd
Priority to GB45282/62A priority Critical patent/GB1063512A/en
Priority to DEB74324A priority patent/DE1208036B/en
Priority to FR955430A priority patent/FR3384M/en
Priority to BE654599A priority patent/BE654599A/xx
Priority to NL646412459A priority patent/NL144832B/en
Publication of GB1063512A publication Critical patent/GB1063512A/en
Priority to US742521A priority patent/US3560607A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/141—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant specially adapted for specific contents or propellants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

A pressurized aerosol composition comprises a finely divided solid medicament having a particle size less than 100 microns, a substantially anhydrous propellant and a solid anionic surface active agent selected from alkali metal, ammonium and amine salts of dialkyl sulphosuccinates where the alkyl groups have 4 to 12 carbon atoms, and alkylbenzene sulphonic acids where the alkyl group has 8 to 14 carbon atoms. Suitable propellants include fluorinated and fluorochlorinated alkanes. The preferred surface active agent is sodium dioctylsulphosuccinate. The medicament may be isoprenaline sulphate, atropine methonitrate, adrenaline acid tartrate, ephedrine hydrochloride, ergotamine tartrate, diphenhydramine hydrochloride, hydrocortisone acetate, penicillin, streptomycin or tetracycline. An inert auxiliary solid such as sodium chloride or sulphate may be included to increase the average density of the solid phase. In examples, there are described mixtures of isoprenaline sulphate and atropine methonitrate; and ephedrine hydrochloride, naphazoline nitrate, cineole and sodium chloride together with the surface active agents and propellants.ALSO:A pressurised aerosol composition comprises a finely divided solid medicament having a particle size less than 100 microns, a substantially anhydrous propellant and a solid anionic surface active agent selected from alkali metal, ammonium and amine salts of dialkyl suphosuccinates where the alkyl groups have 4 to 12 carbon atoms, and alkylbenzene sulphonic acids where the alkyl group has 8 to 14 carbon atoms. Suitable propellants include fluorinated and fluorochlorinated alkanes. The preferred surface active agent is sodium dioctylsulphosuccinate. The medicament may be isoprenaline sulphate, atropine methonitrate, adrenaline acid tartrate, ephedrine hydrochloride, ergotamine tartrate, diphenhydramine hydrochloride, hydrocortisone acetate, penicillin, streptomycin or tetracycline. An inert auxiliary solid such as sodium chloride or sulphate may be included to increase the average density of the solid phase. In examples, there are described mixtures of isoprenaline sulphate and atropine methonitrate; and ephedrine hydrochloride, naphazoline nitrate, cineole and sodium chloride together with the surface active agents and propellants.
GB45282/62A 1962-11-30 1962-11-30 Aerosols Expired GB1063512A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB45282/62A GB1063512A (en) 1962-11-30 1962-11-30 Aerosols
DEB74324A DE1208036B (en) 1962-11-30 1963-11-19 Manufacture of drug aerosols
FR955430A FR3384M (en) 1962-11-30 1963-11-29 New composition for pharmaceutical aerosols.
BE654599A BE654599A (en) 1962-11-30 1964-10-20
NL646412459A NL144832B (en) 1962-11-30 1964-10-26 METHOD FOR PRODUCING AN AEROSOL PREPARATION WHICH ONE IN ALMOST ANHYDROUS propellant a finely divided solid, IN propellant insoluble drug particle sizes of less than 100 microns and an anionic surfactant PICKING AND THEN THIS MIXTURE IN AN AEROSOL PREPARATIONS USUAL HOLDER HAS .
US742521A US3560607A (en) 1962-11-30 1968-07-05 Aerosol formulations of finely divided solid medicaments with anionic surface-active agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB45282/62A GB1063512A (en) 1962-11-30 1962-11-30 Aerosols

Publications (1)

Publication Number Publication Date
GB1063512A true GB1063512A (en) 1967-03-30

Family

ID=10436603

Family Applications (1)

Application Number Title Priority Date Filing Date
GB45282/62A Expired GB1063512A (en) 1962-11-30 1962-11-30 Aerosols

Country Status (6)

Country Link
US (1) US3560607A (en)
BE (1) BE654599A (en)
DE (1) DE1208036B (en)
FR (1) FR3384M (en)
GB (1) GB1063512A (en)
NL (1) NL144832B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2703119A1 (en) * 1976-01-30 1977-08-04 Fisons Ltd SODIUMCROMOGLYCAT WITH LESS THAN 5% WATER AND THIS COMPREHENSIVE PHARMACEUTICAL PREPARATIONS
GB2125426A (en) * 1980-03-17 1984-03-07 Riker Laboratories Inc Powder aerosol composition
US5348730A (en) * 1989-09-20 1994-09-20 Minnesota Mining And Manufacturing Company Method for preparing medicinal aerosol formulation containing coated medicament

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405598A (en) * 1976-01-30 1983-09-20 Fisons, Limited Composition for treating asthma
DE2750090A1 (en) * 1976-11-19 1978-06-01 Sandoz Ag NEW FORMS OF ADMINISTRATION FOR ORGANIC COMPOUNDS
US4897256A (en) * 1986-11-25 1990-01-30 Abbott Laboratories LHRH analog formulations
GB9200148D0 (en) * 1992-01-06 1992-02-26 Minnesota Mining & Mfg Aerosol valves
ATE236617T1 (en) 1994-12-22 2003-04-15 Astrazeneca Ab AEROSOL MEDICINAL FORMULATIONS
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US6737042B2 (en) 2001-05-24 2004-05-18 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
CA2447519C (en) * 2001-05-24 2008-09-16 Alexza Molecular Delivery Corporation Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
WO2002094239A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of diphenhydramine through an inhalation route
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US6759029B2 (en) * 2001-05-24 2004-07-06 Alexza Molecular Delivery Corporation Delivery of rizatriptan and zolmitriptan through an inhalation route
WO2002094216A2 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of stimulants through an inhalation route
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US6805853B2 (en) * 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
EP1446102A1 (en) 2001-11-21 2004-08-18 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
CA2483687A1 (en) 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Delivery of drug amines through an inhalation route
US20060193788A1 (en) * 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
CN1717237A (en) * 2002-11-26 2006-01-04 艾利斯达分子传输公司 Application of loxapine and amoxapine in preparation of medicine for treating pain
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US20040105818A1 (en) * 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
MXPA05005609A (en) * 2002-11-26 2005-07-26 Alexza Pharmaceuticals Inc Treatment of headache with antipsychotics delivered by inhalation.
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
JP2007516149A (en) 2003-05-21 2007-06-21 アレックザ ファーマシューティカルズ， インコーポレイテッド Method for controlling uniformity of substrate temperature, built-in heating unit and chemical supply unit using the same
US7540286B2 (en) * 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US20100006092A1 (en) * 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
EP2246086A3 (en) * 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heating unit
ES2594867T3 (en) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
KR102852740B1 (en) 2018-02-02 2025-08-29 알렉스자 파마스티칼즈, 인크. Electrical Condensation Aerosol Device
EP3941450A4 (en) 2019-03-22 2022-12-21 Dbbh, Llc Intranasally administered antihistamines and uses thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2703119A1 (en) * 1976-01-30 1977-08-04 Fisons Ltd SODIUMCROMOGLYCAT WITH LESS THAN 5% WATER AND THIS COMPREHENSIVE PHARMACEUTICAL PREPARATIONS
GB2125426A (en) * 1980-03-17 1984-03-07 Riker Laboratories Inc Powder aerosol composition
US5348730A (en) * 1989-09-20 1994-09-20 Minnesota Mining And Manufacturing Company Method for preparing medicinal aerosol formulation containing coated medicament

Also Published As

Publication number Publication date
FR3384M (en) 1965-06-21
BE654599A (en) 1965-04-20
US3560607A (en) 1971-02-02
DE1208036B (en) 1965-12-30
NL144832B (en) 1975-02-17
NL6412459A (en) 1966-04-27

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