GB1057940A - Improvements in and relating to the preparation of pharmacentical compositions comprising orally active mineral medicaments - Google Patents
Improvements in and relating to the preparation of pharmacentical compositions comprising orally active mineral medicamentsInfo
- Publication number
- GB1057940A GB1057940A GB4113564A GB4113564A GB1057940A GB 1057940 A GB1057940 A GB 1057940A GB 4113564 A GB4113564 A GB 4113564A GB 4113564 A GB4113564 A GB 4113564A GB 1057940 A GB1057940 A GB 1057940A
- Authority
- GB
- United Kingdom
- Prior art keywords
- water
- hydroxide
- product
- colloidal
- medicaments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229910052500 inorganic mineral Inorganic materials 0.000 title abstract 4
- 239000011707 mineral Substances 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 4
- PPQREHKVAOVYBT-UHFFFAOYSA-H aluminium carbonate Inorganic materials [Al+3].[Al+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O PPQREHKVAOVYBT-UHFFFAOYSA-H 0.000 abstract 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 abstract 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 abstract 2
- 229920001817 Agar Polymers 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 240000008886 Ceratonia siliqua Species 0.000 abstract 2
- 235000013912 Ceratonia siliqua Nutrition 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 244000046052 Phaseolus vulgaris Species 0.000 abstract 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 abstract 2
- 239000004372 Polyvinyl alcohol Substances 0.000 abstract 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract 2
- 229920002472 Starch Polymers 0.000 abstract 2
- 229920001938 Vegetable gum Polymers 0.000 abstract 2
- 239000008272 agar Substances 0.000 abstract 2
- 235000010419 agar Nutrition 0.000 abstract 2
- 229940072056 alginate Drugs 0.000 abstract 2
- 235000010443 alginic acid Nutrition 0.000 abstract 2
- 229920000615 alginic acid Polymers 0.000 abstract 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 abstract 2
- 229910021502 aluminium hydroxide Inorganic materials 0.000 abstract 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 abstract 2
- 229940001007 aluminium phosphate Drugs 0.000 abstract 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 229940049676 bismuth hydroxide Drugs 0.000 abstract 2
- 229910000416 bismuth oxide Inorganic materials 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 238000001246 colloidal dispersion Methods 0.000 abstract 2
- TYIXMATWDRGMPF-UHFFFAOYSA-N dibismuth;oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Bi+3].[Bi+3] TYIXMATWDRGMPF-UHFFFAOYSA-N 0.000 abstract 2
- 235000013312 flour Nutrition 0.000 abstract 2
- 239000000499 gel Substances 0.000 abstract 2
- 239000003349 gelling agent Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- 229920000609 methyl cellulose Polymers 0.000 abstract 2
- 239000001923 methylcellulose Substances 0.000 abstract 2
- 235000010981 methylcellulose Nutrition 0.000 abstract 2
- 229960002900 methylcellulose Drugs 0.000 abstract 2
- 239000001814 pectin Substances 0.000 abstract 2
- 235000010987 pectin Nutrition 0.000 abstract 2
- 229920001277 pectin Polymers 0.000 abstract 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 abstract 2
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract 2
- 229940068984 polyvinyl alcohol Drugs 0.000 abstract 2
- 239000000377 silicon dioxide Substances 0.000 abstract 2
- 229910052709 silver Inorganic materials 0.000 abstract 2
- 239000004332 silver Substances 0.000 abstract 2
- 239000008107 starch Substances 0.000 abstract 2
- 229940032147 starch Drugs 0.000 abstract 2
- 235000019698 starch Nutrition 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- XQJMXPAEFMWDOZ-UHFFFAOYSA-N 3exo-benzoyloxy-tropane Natural products CN1C(C2)CCC1CC2OC(=O)C1=CC=CC=C1 XQJMXPAEFMWDOZ-UHFFFAOYSA-N 0.000 abstract 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 235000017945 Matricaria Nutrition 0.000 abstract 1
- 244000042664 Matricaria chamomilla Species 0.000 abstract 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 abstract 1
- QQXLDOJGLXJCSE-UHFFFAOYSA-N N-methylnortropinone Natural products C1C(=O)CC2CCC1N2C QQXLDOJGLXJCSE-UHFFFAOYSA-N 0.000 abstract 1
- QIZDQFOVGFDBKW-DHBOJHSNSA-N Pseudotropine Natural products OC1C[C@@H]2[N+](C)[C@H](C1)CC2 QIZDQFOVGFDBKW-DHBOJHSNSA-N 0.000 abstract 1
- 229960000458 allantoin Drugs 0.000 abstract 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- CXYOBRKOFHQONJ-UHFFFAOYSA-N betoxycaine Chemical compound CCCCOC1=CC=C(C(=O)OCCOCCN(CC)CC)C=C1N CXYOBRKOFHQONJ-UHFFFAOYSA-N 0.000 abstract 1
- 229950005028 betoxycaine Drugs 0.000 abstract 1
- TZSXPYWRDWEXHG-UHFFFAOYSA-K bismuth;trihydroxide Chemical compound [OH-].[OH-].[OH-].[Bi+3] TZSXPYWRDWEXHG-UHFFFAOYSA-K 0.000 abstract 1
- 229940110716 cicatrizants Drugs 0.000 abstract 1
- -1 gaiazulene Chemical compound 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 abstract 1
- 229960004919 procaine Drugs 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- CYHOMWAPJJPNMW-JIGDXULJSA-N tropine Chemical compound C1[C@@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-JIGDXULJSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Abstract
A product which forms a gel on mixing with water is prepared by lyophilizing a colloidal dispersion of a water-insoluble mineral substance in an aqueous medium comprising an organic gelling agent, e.g. agar, pectin, carob bean flour, vegetable gum, water-soluble alginate, methyl-cellulose, starch or polyvinyl alcohol. Specified minerals are colloidal aluminium phosphate, hydroxide and carbonate, bismuth oxide and hydroxide silica, carbon and silver.ALSO:A product which forms a gel on mixing with water is prepared by lyophilizing a colloidal dispersion of a water-insoluble, orally active mineral medicament in an aqueous medium comprising an organic gelling agent e.g. agar, pectin, carob bean flour, vegetable gum, water-soluble alginate, methyl-cellulose, water-soluble polyvinyl alcohol or a starch. Specified medicaments are colloidal aluminium phosphate, aluminium hydroxide, aluminium carbonate, bismuth oxide, bismuth hydroxide, silica carbon or silver. Local anaesthetic, cicatrizants, deangestants and spasmolytics e.g. procaine, betoxycaine, allantoin, matricaria, glycine, gaiazulene, sorbitol and tropine may also be present. The product may be made up into pills or tablets.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR949883A FR1386266A (en) | 1963-10-08 | 1963-10-08 | Process for the treatment of aqueous dispersions of mineral substances in colloidal state |
| FR959309A FR3133M (en) | 1963-10-08 | 1964-01-03 | Medicinal product based on mineral colloid. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1057940A true GB1057940A (en) | 1967-02-08 |
Family
ID=26203775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4113564A Expired GB1057940A (en) | 1963-10-08 | 1964-10-08 | Improvements in and relating to the preparation of pharmacentical compositions comprising orally active mineral medicaments |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1057940A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3692898A (en) * | 1970-11-05 | 1972-09-19 | Sterling Drug Inc | Aqueous magnesium hydroxide suspensions |
| EP0003589A3 (en) * | 1978-02-06 | 1979-09-05 | The Wellcome Foundation Limited | Antacid tablet formulation |
-
1964
- 1964-10-08 GB GB4113564A patent/GB1057940A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3692898A (en) * | 1970-11-05 | 1972-09-19 | Sterling Drug Inc | Aqueous magnesium hydroxide suspensions |
| EP0003589A3 (en) * | 1978-02-06 | 1979-09-05 | The Wellcome Foundation Limited | Antacid tablet formulation |
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