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GB1051382A - - Google Patents

Info

Publication number
GB1051382A
GB1051382A GB1051382DA GB1051382A GB 1051382 A GB1051382 A GB 1051382A GB 1051382D A GB1051382D A GB 1051382DA GB 1051382 A GB1051382 A GB 1051382A
Authority
GB
United Kingdom
Prior art keywords
red blood
cells
aldehyde
surface active
blood cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Publication date
Publication of GB1051382A publication Critical patent/GB1051382A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • G01N33/555—Red blood cell
    • G01N33/556—Fixed or stabilised red blood cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2496/00—Reference solutions for assays of biological material
    • G01N2496/05—Reference solutions for assays of biological material containing blood cells or plasma
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2496/00—Reference solutions for assays of biological material
    • G01N2496/25—Reference solutions for assays of biological material containing added polymers to stabilise biological material against degradation or maintain viscosity or density, e.g. gelatin, polyacrylamides or polyvinyl alcohol
    • G01N2496/35—Polyvinylpyrrolidone, e.g. PVP

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1,051,382. Stabilized red blood cell suspension. WARNER-LAMBERT PHARMACEUTICAL CO. Feb. 11, 1965 [March 10, 1964], No. 6075/65. Heading B1X. A stabilized red blood cell suspension comprises aldehyde-treated red blood cells in a buffered iso-tonic aqueous medium containing a macromolecular compound compatible with said cells, and a surface active agent. The cells may be derived from warm-blooded animals including chicken, sheep, bovine species, and monkeys, and from human beings; the aldehyde employed may be formaldehyde, pyruvaldehyde or paraldehyde; the buffer may be phosphate buffer; the macromolecular compound may be polyvinyl pyrrolidone, dextran, gum acacia, gum tragacanth or gelatin; and the surface active agent may be polyoxyethylene sorbitan monooleate. The invention also comprises a method of producing stabilized red blood cell suspensions comprising mixing in a phosphate buffer of pH7, a suspension of said cells in isotonic saline solution with an aldehyde, allowing to stand at 4-10‹C., washing with isotonic saline to free from aldehyde and resuspending in an aqueous medium comprising a macromolecular compound. In the Example, pyruvaldehyde, adjusted to pH7 with Na 2 CO 3 , is used, and sodium azide is added as a preservative with the surface active compound, to the final suspension.
GB1051382D Expired GB1051382A (en)

Publications (1)

Publication Number Publication Date
GB1051382A true GB1051382A (en) 1900-01-01

Family

ID=1756358

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1051382D Expired GB1051382A (en)

Country Status (1)

Country Link
GB (1) GB1051382A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2408838A1 (en) * 1977-11-22 1979-06-08 Louderback Allan BLOOD CONTROL STANDARD AND PROCESS FOR ITS PREPARATION
FR2884717A1 (en) * 2005-04-25 2006-10-27 Erytech Pharma Soc Par Actions ERYTHROCYTES CONTAINING ARGININE DEIMINASE
US9364504B2 (en) 2007-08-08 2016-06-14 Erytech Pharma Compostition and therapeutic anti-tumour vaccine
US11613759B2 (en) 2015-09-04 2023-03-28 Sqz Biotechnologies Company Intracellular delivery of biomolecules to cells comprising a cell wall
US12201652B2 (en) 2016-05-03 2025-01-21 Stemcell Technologies Canada Inc. Intracellular delivery of biomolecules to induce tolerance

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2408838A1 (en) * 1977-11-22 1979-06-08 Louderback Allan BLOOD CONTROL STANDARD AND PROCESS FOR ITS PREPARATION
FR2884717A1 (en) * 2005-04-25 2006-10-27 Erytech Pharma Soc Par Actions ERYTHROCYTES CONTAINING ARGININE DEIMINASE
US9125876B2 (en) 2005-04-25 2015-09-08 Erytech Pharma Erythrocytes containing arginine deiminase
US9364504B2 (en) 2007-08-08 2016-06-14 Erytech Pharma Compostition and therapeutic anti-tumour vaccine
US9950049B2 (en) 2007-08-08 2018-04-24 Erytech Pharma Composition and therapeutic anti-tumour vaccine
US10780151B2 (en) 2007-08-08 2020-09-22 Erytech Pharma Composition and therapeutic anti-tumour vaccine
US11613759B2 (en) 2015-09-04 2023-03-28 Sqz Biotechnologies Company Intracellular delivery of biomolecules to cells comprising a cell wall
US12201652B2 (en) 2016-05-03 2025-01-21 Stemcell Technologies Canada Inc. Intracellular delivery of biomolecules to induce tolerance

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