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GB1043484A - Thiaza heterocyclics and a process for the manufacture thereof - Google Patents

Thiaza heterocyclics and a process for the manufacture thereof

Info

Publication number
GB1043484A
GB1043484A GB4914865A GB4914865A GB1043484A GB 1043484 A GB1043484 A GB 1043484A GB 4914865 A GB4914865 A GB 4914865A GB 4914865 A GB4914865 A GB 4914865A GB 1043484 A GB1043484 A GB 1043484A
Authority
GB
United Kingdom
Prior art keywords
group
general formula
compound
carbon atoms
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4914865A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority claimed from GB11161/64A external-priority patent/GB1043481A/en
Priority claimed from US445248A external-priority patent/US3346638A/en
Publication of GB1043484A publication Critical patent/GB1043484A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/18—Eight-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compounds of the general formula <FORM:1043484/C2/1> wherein Z represents either an orthophenylene group or a methylene group which may carry one or two lower-alkyl groups or an ethylene group which may carry one or two lower-alkyl groups on one of its carbon atoms, and wherein the bonds shown as broken lines indicate that the atoms or groups attached thereby are optional and "lower" denotes groups containing up to 4 carbon atoms, and acid addition salts thereof, are prepared by reduction of the carbonyl group of a compound of the general formula <FORM:1043484/C2/2> in accordance with methods known per se, oxidizing any thio group present to a sulphinyl or sulphonyl group if desired, alkylating any unsubstituted N-atom if desired, and converting any resulting base into an acid addition salt if desired. Pharmaceutical compositions in conventional forms for enteral or parenteral administration comprise a compound of the first general formula above and a carrier therefor.
GB4914865A 1963-03-18 1964-03-17 Thiaza heterocyclics and a process for the manufacture thereof Expired GB1043484A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26603063A 1963-03-18 1963-03-18
GB11161/64A GB1043481A (en) 1963-03-18 1964-03-17 Thiaza heterocyclics and the manufacture thereof
US44526465A 1965-04-02 1965-04-02
US445248A US3346638A (en) 1965-04-02 1965-04-02 Alpha-phenyl-2-amino-benzylmercaptanes
US535722A US3400119A (en) 1963-03-18 1966-03-21 Novel 4, 1-benzothiazepin-2(1h)-ones and 4, 1-benzothiazepines

Publications (1)

Publication Number Publication Date
GB1043484A true GB1043484A (en) 1966-09-21

Family

ID=27516077

Family Applications (3)

Application Number Title Priority Date Filing Date
GB4914765A Expired GB1043483A (en) 1963-03-18 1964-03-17 Novel benzylsulphonyl acids and a process for the preparation thereof
GB4914665A Expired GB1043482A (en) 1963-03-18 1964-03-17 Novel nitro-benzyl mercaptoacids and a process for the preparation thereof
GB4914865A Expired GB1043484A (en) 1963-03-18 1964-03-17 Thiaza heterocyclics and a process for the manufacture thereof

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB4914765A Expired GB1043483A (en) 1963-03-18 1964-03-17 Novel benzylsulphonyl acids and a process for the preparation thereof
GB4914665A Expired GB1043482A (en) 1963-03-18 1964-03-17 Novel nitro-benzyl mercaptoacids and a process for the preparation thereof

Country Status (1)

Country Link
GB (3) GB1043483A (en)

Also Published As

Publication number Publication date
GB1043483A (en) 1966-09-21
GB1043482A (en) 1966-09-21

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