GB1041787A - Novel medicament having as a base thiazolidine carboxylic acid for treatment of illnesses caused by disturbances of the liver - Google Patents
Novel medicament having as a base thiazolidine carboxylic acid for treatment of illnesses caused by disturbances of the liverInfo
- Publication number
- GB1041787A GB1041787A GB3345/64A GB334564A GB1041787A GB 1041787 A GB1041787 A GB 1041787A GB 3345/64 A GB3345/64 A GB 3345/64A GB 334564 A GB334564 A GB 334564A GB 1041787 A GB1041787 A GB 1041787A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carboxylic acid
- thiazolidine carboxylic
- disturbances
- liver
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- DZLNHFMRPBPULJ-VKHMYHEASA-N L-thioproline Chemical compound OC(=O)[C@@H]1CSCN1 DZLNHFMRPBPULJ-VKHMYHEASA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 210000004185 liver Anatomy 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 230000001553 hepatotropic effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000005995 Aluminium silicate Substances 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 235000012211 aluminium silicate Nutrition 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 239000000644 isotonic solution Substances 0.000 abstract 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 239000007935 oral tablet Substances 0.000 abstract 1
- 229940096978 oral tablet Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- 235000012222 talc Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Thiazolidine carboxylic acid <FORM:1041787/C2/1> is prepared by reacting cysteine with formaldehyde in oxygen-free distilled water; crystallization is encouraged by addition of ethanol and the crude product is recrystallized from boiling water and dried, to give a product melting at 198 DEG to 199 DEG C. with decomposition. The acid is useful in hepatotropic pharmaceutical compositions (see Division A5).ALSO:Hepatotropic compositions for internal administration, comprise a suitable pharmaceutical carrier with thiazolidine carboxylic acid: <FORM:1041787/A5-A6/1> The composition suitably takes the form of an oral tablet, with starch, kaolin, gelatin and talc, or may be employed in sterile isotonic solution.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR923562A FR3184M (en) | 1963-02-04 | 1963-02-04 | New drug based on thiazolidine carboxylic acid. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1041787A true GB1041787A (en) | 1966-09-07 |
Family
ID=8796176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3345/64A Expired GB1041787A (en) | 1963-02-04 | 1964-01-27 | Novel medicament having as a base thiazolidine carboxylic acid for treatment of illnesses caused by disturbances of the liver |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR3184M (en) |
| GB (1) | GB1041787A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007077276A1 (en) * | 2006-01-02 | 2007-07-12 | Universidad De Cádiz | Use of thioproline in body weight reduction treatments |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE53332B1 (en) * | 1980-03-14 | 1988-10-26 | Efamol Ltd | Pharmaceutical compositions |
| FR2547729B1 (en) * | 1983-06-24 | 1986-05-02 | Riker Laboratories Inc | DL THIAZOLIDINE CARBOXYLIC ACID MEDICINAL PRODUCT |
| FR2547728B1 (en) * | 1983-06-24 | 1986-05-02 | Riker Laboratories Inc | THIAZOLIDINE CARBOXYLIC ACID MEDICINAL PRODUCT |
| CA2355117A1 (en) * | 1998-02-19 | 1999-08-26 | Gabe Soto | .beta.-lactam-like chaperone inhibitors |
-
1963
- 1963-02-04 FR FR923562A patent/FR3184M/en not_active Expired
-
1964
- 1964-01-27 GB GB3345/64A patent/GB1041787A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007077276A1 (en) * | 2006-01-02 | 2007-07-12 | Universidad De Cádiz | Use of thioproline in body weight reduction treatments |
| ES2277787A1 (en) * | 2006-01-02 | 2007-07-16 | Universidad De Cadiz (Diego Sales Marquez) | EMPLOYMENT OF THIOPROLINE IN BODY REDUCTION TREATMENTS. |
| ES2277787B1 (en) * | 2006-01-02 | 2008-06-16 | Universidad De Cadiz | EMPLOYMENT OF THIOPROLINE IN BODY REDUCTION TREATMENTS. |
Also Published As
| Publication number | Publication date |
|---|---|
| FR3184M (en) | 1965-03-15 |
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