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GB0318107D0 - ›-Secretase enzyme compositions and methods - Google Patents

›-Secretase enzyme compositions and methods

Info

Publication number
GB0318107D0
GB0318107D0 GBGB0318107.0A GB0318107A GB0318107D0 GB 0318107 D0 GB0318107 D0 GB 0318107D0 GB 0318107 A GB0318107 A GB 0318107A GB 0318107 D0 GB0318107 D0 GB 0318107D0
Authority
GB
United Kingdom
Prior art keywords
methods
enzyme compositions
secretase enzyme
secretase
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GBGB0318107.0A
Other versions
GB2389113B (en
GB2389113A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Elan Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharmaceuticals LLC filed Critical Elan Pharmaceuticals LLC
Priority claimed from GB0121314A external-priority patent/GB2364059B/en
Publication of GB0318107D0 publication Critical patent/GB0318107D0/en
Publication of GB2389113A publication Critical patent/GB2389113A/en
Application granted granted Critical
Publication of GB2389113B publication Critical patent/GB2389113B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
GB0318107A 1999-02-10 2000-02-10 B-secretase inhibitor Expired - Fee Related GB2389113B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11957199P 1999-02-10 1999-02-10
US13917299P 1999-06-15 1999-06-15
GB0121314A GB2364059B (en) 1999-02-10 2000-02-10 Beta-Secretase enzyme compositions and methods

Publications (3)

Publication Number Publication Date
GB0318107D0 true GB0318107D0 (en) 2003-09-03
GB2389113A GB2389113A (en) 2003-12-03
GB2389113B GB2389113B (en) 2004-02-04

Family

ID=29407316

Family Applications (3)

Application Number Title Priority Date Filing Date
GB0318112A Expired - Fee Related GB2389114B (en) 1999-02-10 2000-02-10 Mouse b-secretase enzyme
GB0318113A Expired - Fee Related GB2389182B (en) 1999-02-10 2000-02-10 Method of purifying b-secretase
GB0318107A Expired - Fee Related GB2389113B (en) 1999-02-10 2000-02-10 B-secretase inhibitor

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB0318112A Expired - Fee Related GB2389114B (en) 1999-02-10 2000-02-10 Mouse b-secretase enzyme
GB0318113A Expired - Fee Related GB2389182B (en) 1999-02-10 2000-02-10 Method of purifying b-secretase

Country Status (1)

Country Link
GB (3) GB2389114B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115410B1 (en) 1999-02-10 2006-10-03 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
CA2359785A1 (en) 1999-02-10 2000-08-17 John P. Anderson .beta.-secretase enzyme compositions and methods
US7514408B1 (en) 1999-12-02 2009-04-07 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
ZA200603165B (en) 2003-11-03 2007-07-25 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
CN1918131B (en) 2004-02-05 2011-05-04 前体生物药物股份公司 Novel inhibitors of glutaminyl cyclase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863902A (en) * 1995-01-06 1999-01-26 Sibia Neurosciences, Inc. Methods of treating neurodegenerative disorders using protease inhibitors
JPH10155487A (en) * 1996-11-28 1998-06-16 Kagaku Gijutsu Shinko Jigyodan An amino acid sequence and a DNA sequence to which a protein having this amino acid sequence binds
WO1998026059A1 (en) * 1996-12-11 1998-06-18 Athena Neurosciences, Inc. Beta-secretase isolated from human 293 cells
GB9701684D0 (en) * 1997-01-28 1997-03-19 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
GB2389182B (en) 2004-02-04
GB2389113B (en) 2004-02-04
GB2389114A (en) 2003-12-03
GB0318112D0 (en) 2003-09-03
GB2389113A (en) 2003-12-03
GB2389182A (en) 2003-12-03
GB2389114B (en) 2004-02-04
GB0318113D0 (en) 2003-09-03

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