FR2935141B1 - Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate - Google Patents
Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarateInfo
- Publication number
- FR2935141B1 FR2935141B1 FR0804665A FR0804665A FR2935141B1 FR 2935141 B1 FR2935141 B1 FR 2935141B1 FR 0804665 A FR0804665 A FR 0804665A FR 0804665 A FR0804665 A FR 0804665A FR 2935141 B1 FR2935141 B1 FR 2935141B1
- Authority
- FR
- France
- Prior art keywords
- hemifumarate
- phenylmethyl
- cyclohexyl
- trans
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- BKGUSKMTBRFLKO-UAPYVXQJSA-N C1=CC(C(=O)O)=CC=C1[C@@H]1CC[C@@H](NCC=2C=CC=CC=2)CC1 Chemical compound C1=CC(C(=O)O)=CC=C1[C@@H]1CC[C@@H](NCC=2C=CC=CC=2)CC1 BKGUSKMTBRFLKO-UAPYVXQJSA-N 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical class CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0804665A FR2935141B1 (fr) | 2008-08-21 | 2008-08-21 | Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate |
| EP09737019A EP2331492A1 (fr) | 2008-08-21 | 2009-08-18 | Procede de preparation de l'ester ethylique de l'acide 4- [trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoïque et de son sel hemifumarate |
| PCT/FR2009/001013 WO2010020719A1 (fr) | 2008-08-21 | 2009-08-18 | Procede de preparation de l'ester ethylique de l'acide 4- [trans-4-[(phenylmethyl)-amino]cyclohexyl] benzoïque et de son sel hemifumarate |
| US13/059,871 US20110190529A1 (en) | 2008-08-21 | 2009-08-18 | Method for preparing the ethyl ester of 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoic acid and the hemifumarate salt thereof |
| JP2011523435A JP2012500251A (ja) | 2008-08-21 | 2009-08-18 | ４−［トランス−４−［（フェニルメチル）アミノ］シクロヘキシル］安息香酸のエチルエステルおよびこのヘミフマル酸塩の調製方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0804665A FR2935141B1 (fr) | 2008-08-21 | 2008-08-21 | Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2935141A1 FR2935141A1 (fr) | 2010-02-26 |
| FR2935141B1 true FR2935141B1 (fr) | 2010-10-08 |
Family
ID=40465096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0804665A Expired - Fee Related FR2935141B1 (fr) | 2008-08-21 | 2008-08-21 | Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110190529A1 (fr) |
| EP (1) | EP2331492A1 (fr) |
| JP (1) | JP2012500251A (fr) |
| FR (1) | FR2935141B1 (fr) |
| WO (1) | WO2010020719A1 (fr) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0096006A3 (fr) * | 1982-05-28 | 1984-12-19 | Ciba-Geigy Ag | Dérivés de 3-(ureidocyclohexylamino)-propane-1,2-diol, procédé pour leur préparation, préparations pharmaceutiques contenant ces composés ainsi que leur utilisation thérapeutique |
| FR2817257B1 (fr) * | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
| FR2840301B1 (fr) * | 2002-05-29 | 2007-03-23 | Sanofi Synthelabo | Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique |
| FR2840304B1 (fr) * | 2002-05-29 | 2007-05-18 | Sanofi Synthelabo | Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique |
| JP4079727B2 (ja) * | 2002-09-06 | 2008-04-23 | セントラル硝子株式会社 | 光学活性１−（フルオロ、トリフルオロメチルまたはトリフルオロメトキシ置換フェニル）アルキルアミンｎ−モノアルキル誘導体とその製造方法 |
| CA2517205C (fr) * | 2003-02-28 | 2010-08-24 | Lupin Limited | Procede de preparation de perindopril et de sels de celui-ci |
-
2008
- 2008-08-21 FR FR0804665A patent/FR2935141B1/fr not_active Expired - Fee Related
-
2009
- 2009-08-18 WO PCT/FR2009/001013 patent/WO2010020719A1/fr not_active Ceased
- 2009-08-18 EP EP09737019A patent/EP2331492A1/fr not_active Withdrawn
- 2009-08-18 US US13/059,871 patent/US20110190529A1/en not_active Abandoned
- 2009-08-18 JP JP2011523435A patent/JP2012500251A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012500251A (ja) | 2012-01-05 |
| FR2935141A1 (fr) | 2010-02-26 |
| US20110190529A1 (en) | 2011-08-04 |
| WO2010020719A1 (fr) | 2010-02-25 |
| EP2331492A1 (fr) | 2011-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI1012744A2 (pt) | "processo contínuo para preparação de ésteres de ácidos carboxílicos alifáticos" | |
| EP2445890A4 (fr) | Procédé de préparation d'ester (r)-1-aryl-2-tétrazolyl-éthylique de l'acide carbamique | |
| FR2934261B1 (fr) | Procede de synthese d'esters de l'acide acrylique | |
| BRPI0822106A2 (pt) | "processo para preparação de ácido metacrílico de alta pureza." | |
| EP2511271A4 (fr) | Dérivé d'ester d'acide hétéroarylcarboxylique | |
| ZA201100631B (en) | "production method of isoxazoline-substituted benzoic acid amide compound" | |
| FI20055568A0 (fi) | Menetelmä karboksyylihappoesteriseoksien valmistamiseksi ja niiden käyttö | |
| BRPI0823162A2 (pt) | Processo destinado à produção de ácido forsfórico de alta pureza | |
| EP2049692A4 (fr) | Acide polysialique hautement pur et procédé d'élaboration | |
| FR2909999B1 (fr) | Procede de preparation d'acide acrylique a partir de glycerol | |
| BRPI0909369A2 (pt) | processo contínuo para preparação de amidas de ácidos carboxílicos alifáticos inferiores | |
| IL212597A0 (en) | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester hcl | |
| EP2426103A4 (fr) | Procede de production d'amide n,n-disubstituee d'acide carboxylique, alpha, beta-insature et procede de production d'amide -n,n-disubstituee d'acide 3-alcoxycarboxylique | |
| FR2928919B1 (fr) | Procede de preparation de l'acide difluoroacetique et de ses sels | |
| EP1893756A4 (fr) | Elimination d'acide n-glycolylneuraminique de produits mammaliens pour usage humain | |
| EP2471943A4 (fr) | Procédé de fabrication d'un l-amino acide | |
| EP2657261A4 (fr) | Solution aqueuse (de sel) d'acide poly(méth)acrylique et son procédé de préparation | |
| EP2405005A4 (fr) | Micro-organisme produisant un acide aminé l et procédé de production d'acide aminé l à l'aide de ce micro-organisme | |
| FR2939795B1 (fr) | Procede de preparation d'esters actives | |
| EP2548872A4 (fr) | Dérivé d'acide cyclopropanecarboxylique | |
| EG25838A (en) | Process for the preparation of amino acid methyl esters | |
| EP2164483A4 (fr) | Inhibiteur de transglutaminase comprenant de l'acide chlorogénique et son procédé de production | |
| EP2431349A4 (fr) | Procede de production d'acide (meth)acrylique | |
| FR2948659B1 (fr) | Procede de preparation des esters de l'acide difluoroacetique | |
| FR2966360B1 (fr) | Composition cosmetique comprenant des esters d'acide behenique |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |
Effective date: 20130430 |