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FR2732971B1 - OLIGONUCLEOTIDE SENSE INHIBITOR OF HERPES SIMPLEX VIRUS (HSV) WITH HALTERED STRUCTURE - Google Patents

OLIGONUCLEOTIDE SENSE INHIBITOR OF HERPES SIMPLEX VIRUS (HSV) WITH HALTERED STRUCTURE

Info

Publication number
FR2732971B1
FR2732971B1 FR9504463A FR9504463A FR2732971B1 FR 2732971 B1 FR2732971 B1 FR 2732971B1 FR 9504463 A FR9504463 A FR 9504463A FR 9504463 A FR9504463 A FR 9504463A FR 2732971 B1 FR2732971 B1 FR 2732971B1
Authority
FR
France
Prior art keywords
haltered
hsv
herpes simplex
simplex virus
oligonucleotide sense
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9504463A
Other languages
French (fr)
Other versions
FR2732971A1 (en
Inventor
Marta Blumenfeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Biodevelopment SAS
Original Assignee
Genset SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genset SA filed Critical Genset SA
Priority to FR9504463A priority Critical patent/FR2732971B1/en
Priority to EP96913570A priority patent/EP0820508A1/en
Priority to PCT/FR1996/000548 priority patent/WO1996032473A1/en
Publication of FR2732971A1 publication Critical patent/FR2732971A1/en
Application granted granted Critical
Publication of FR2732971B1 publication Critical patent/FR2732971B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1133—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against herpetoviridae, e.g. HSV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR9504463A 1995-04-13 1995-04-13 OLIGONUCLEOTIDE SENSE INHIBITOR OF HERPES SIMPLEX VIRUS (HSV) WITH HALTERED STRUCTURE Expired - Fee Related FR2732971B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR9504463A FR2732971B1 (en) 1995-04-13 1995-04-13 OLIGONUCLEOTIDE SENSE INHIBITOR OF HERPES SIMPLEX VIRUS (HSV) WITH HALTERED STRUCTURE
EP96913570A EP0820508A1 (en) 1995-04-13 1996-04-11 Dumbbell sense oligonucleotide for inhibiting herpes simplex virus (hsv)
PCT/FR1996/000548 WO1996032473A1 (en) 1995-04-13 1996-04-11 Dumbbell sense oligonucleotide for inhibiting herpes simplex virus (hsv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9504463A FR2732971B1 (en) 1995-04-13 1995-04-13 OLIGONUCLEOTIDE SENSE INHIBITOR OF HERPES SIMPLEX VIRUS (HSV) WITH HALTERED STRUCTURE

Publications (2)

Publication Number Publication Date
FR2732971A1 FR2732971A1 (en) 1996-10-18
FR2732971B1 true FR2732971B1 (en) 1997-07-04

Family

ID=9478094

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9504463A Expired - Fee Related FR2732971B1 (en) 1995-04-13 1995-04-13 OLIGONUCLEOTIDE SENSE INHIBITOR OF HERPES SIMPLEX VIRUS (HSV) WITH HALTERED STRUCTURE

Country Status (3)

Country Link
EP (1) EP0820508A1 (en)
FR (1) FR2732971B1 (en)
WO (1) WO1996032473A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19648625A1 (en) 1996-11-13 1998-05-14 Soft Gene Gmbh Microprojectile for the introduction of substances into cells by ballistic transfer
DE19935756A1 (en) 1999-07-27 2001-02-08 Mologen Forschungs Entwicklung Covalently closed nucleic acid molecule for immune stimulation
GB0901593D0 (en) 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
GB201013153D0 (en) 2010-08-04 2010-09-22 Touchlight Genetics Ltd Primer for production of closed linear DNA
LU92821B1 (en) 2015-09-09 2017-03-20 Mologen Ag Combination comprising immunostimulatory oligonucleotides
GB2542425A (en) 2015-09-21 2017-03-22 Mologen Ag Means for the treatment of HIV
EP3878971B1 (en) * 2020-03-10 2024-12-04 Commissariat à l'Energie Atomique et aux Energies Alternatives Method for detecting and possibly quantifying an analyte with an oligonucleotide with double stem-loop structure

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2675803B1 (en) * 1991-04-25 1996-09-06 Genset Sa CLOSED, ANTISENSE AND SENSE OLIGONUCLEOTIDES AND THEIR APPLICATIONS.
FR2703053B1 (en) * 1993-03-26 1995-06-16 Genset Sa STAPLE AND SEMI-STAPLE OLIGONUCLEOTIDES, PREPARATION METHOD AND APPLICATIONS.
FR2708270B1 (en) * 1993-07-28 1995-10-20 Genset Sa Antisense oligonucleotides directed against Herpes Simplex virus types 1 & 2.

Also Published As

Publication number Publication date
FR2732971A1 (en) 1996-10-18
WO1996032473A1 (en) 1996-10-17
EP0820508A1 (en) 1998-01-28

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Legal Events

Date Code Title Description
ST Notification of lapse