FR2770779A1 - Solutions of plasma electrolytes having a lower osmolarity than plasma - Google Patents
Solutions of plasma electrolytes having a lower osmolarity than plasma Download PDFInfo
- Publication number
- FR2770779A1 FR2770779A1 FR9714073A FR9714073A FR2770779A1 FR 2770779 A1 FR2770779 A1 FR 2770779A1 FR 9714073 A FR9714073 A FR 9714073A FR 9714073 A FR9714073 A FR 9714073A FR 2770779 A1 FR2770779 A1 FR 2770779A1
- Authority
- FR
- France
- Prior art keywords
- plasma
- electrolytes
- osmolarity
- injection
- hypo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003792 electrolyte Substances 0.000 title claims abstract description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000008215 water for injection Substances 0.000 claims abstract description 6
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 5
- 239000011780 sodium chloride Substances 0.000 claims abstract description 5
- 239000007924 injection Substances 0.000 claims abstract description 4
- 238000002347 injection Methods 0.000 claims abstract description 4
- 239000002504 physiological saline solution Substances 0.000 claims abstract description 4
- 239000008223 sterile water Substances 0.000 claims abstract 2
- 238000011282 treatment Methods 0.000 claims description 6
- 206010016654 Fibrosis Diseases 0.000 claims description 5
- 239000012895 dilution Substances 0.000 claims description 5
- 238000010790 dilution Methods 0.000 claims description 5
- 230000004761 fibrosis Effects 0.000 claims description 5
- 238000007920 subcutaneous administration Methods 0.000 claims description 3
- 208000035484 Cellulite Diseases 0.000 claims description 2
- 206010020112 Hirsutism Diseases 0.000 claims description 2
- 206010049752 Peau d'orange Diseases 0.000 claims description 2
- 230000036232 cellulite Effects 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 abstract description 4
- 238000007865 diluting Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 description 4
- 230000008034 disappearance Effects 0.000 description 2
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000007379 Muscle Hypotonia Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000000694 mesotherapy Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
La présente invention consiste en un soluté ayant pour propriété de faire disparaître l'aspect cellulitique, les petits amas graisseux, les défauts de la surface cutanée, les fibroses sous-cutanées et la pilosité de manière définitive.The present invention consists of a solute having the property of eliminating the cellulitic appearance, small fatty deposits, skin surface defects, subcutaneous fibrosis and hair growth permanently.
Jusqu'à aujourd'hui le traitement de l'aspect cellulitique ou des amas graisseux était réalisé soit médicalement, soit chirurgicalement.Until today, the treatment of cellulite or fatty deposits was carried out either medically or surgically.
Les procédés médicaux : crèmes, passage de courant électrique et mésothérapie se révèlent ou inefficaces ou apportent des résultats éphémères (quelques mois).Medical procedures: creams, passage of electric current and mesotherapy prove to be either ineffective or bring ephemeral results (a few months).
Les procédés chirurgicaux représentent un risque chirurgical, une rançon cicatricielle et des résultats parfois désastreux.Surgical procedures represent a surgical risk, a ransom scar and sometimes disastrous results.
En ce qui concerne le traitement des amas graisseux, le soluté faisant l'objet de la présente description est efficace à 100%, d'une manière reproductible et définitive sans les inconvénients ou les risques chirurgicaux.ll est différent des solutions injectées avant les lipo-aspirations car beaucoup plus hypotonique et se suffisant à lui-même.With regard to the treatment of fatty deposits, the solute which is the subject of the present description is 100% effective, in a reproducible and definitive manner without the disadvantages or the surgical risks. It is different from the solutions injected before the lipos -aspirations because much more hypotonic and self-sufficient.
Aucun traitement des fibroses n'existe en dehors de ce procédé.No treatment for fibrosis exists outside of this process.
Les traitements définitifs de la pilosité soit demandent un temps trop long (épilation électrique), soient ne sont pas encore des procédés éprouvés (épilation LASER).The final hair treatments either take too long (electric hair removal) or are not yet proven procedures (LASER hair removal).
Le soluté est hypotonique et hypo-osmolaire par rapport au plasma
L'hypo-osmolarité ou hypotonicité du soluté est comprise entre 30 et 50% de l'osmolarité ou de la tonicité du plasma
Ces propriétés sont obtenues de plusieurs manières, soit par un procédé de dilution, soit par un procédé d'ajout d'électrolytes: - dilution de sérum physiologique à 0,9% en chlorure de sodium dans de l'eau stérile et déminéralisée, connue sous le nom d"'eau pour préparation injectable".The solute is hypotonic and hypo-osmolar compared to plasma
The hypo-osmolarity or hypotonicity of the solute is between 30 and 50% of the osmolarity or the tone of the plasma
These properties are obtained in several ways, either by a dilution process or by a process of adding electrolytes: - dilution of physiological saline to 0.9% in sodium chloride in sterile and demineralized water, known under the name of "water for injection".
- dilution de sérum physiologique à 0,9% en chlorure de sodium associé en partie avec du bicarbonate de sodium dans de l'eau pour préparation injectable, quelle que soit la part de bicarbonate de sodium.- 0.9% physiological saline dilution in sodium chloride associated in part with sodium bicarbonate in water for injection, whatever the proportion of sodium bicarbonate.
- dilution de bicarbonate de sodium dans de l'eau pour préparation injectable.- dilution of sodium bicarbonate in water for injection.
- dilution d'un ensemble d'électrolytes dans de l'eau pour préparation injectable, de manière à obtenir quels que soient ces électrolytes, une hypo-30 osmolarité ou hypotonie comprise entre 30 et 50% de l'osmolarité ou de la tonicité du plasma.dilution of a set of electrolytes in water for injection, so as to obtain, whatever these electrolytes, a hypo-osmolarity or hypotonia of between 30 and 50% of the osmolarity or the tone of the plasma.
Le soluté est injecté en sous-cutané de manière à obtenir un durcissement de la peau au toucher.The solute is injected subcutaneously so as to harden the skin to the touch.
L'injection sera réalisée plus superficiellement dans les indications de traitement de la pilosité, de manière à obtenir un aspect boursouflé de la peau.The injection will be made more superficially in the indications for hair treatment, so as to obtain a puffy appearance of the skin.
Le rythme des injections est d'une tous les 10 à 15 jours sans limite de nombre.The injection rate is one every 10 to 15 days with no limit on the number.
Les résultats sont observables et quantifiables: - amas graisseux: diminution de 1 1 mm de l'épaisseur en 4 séances - pilosité: disparition définitive dès la lère séance - fibrose sous cutanée : disparition progressive, le nombre de séances nécessaire est fonction de l'importance de la fibrose.The results are observable and quantifiable: - fatty deposits: reduction of 1 1 mm in thickness in 4 sessions - hairiness: permanent disappearance from the 1st session - subcutaneous fibrosis: progressive disappearance, the number of sessions required depends on the importance of fibrosis.
Les réactions observées correspondent à celles d'une nécrose tissulaire de faible importance : fièvre de 24 heures et inflammation. The reactions observed correspond to those of a minor tissue necrosis: 24-hour fever and inflammation.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9714073A FR2770779B1 (en) | 1997-11-10 | 1997-11-10 | HYPOTONIC OR HYPOOSMOLAR PLASMA SOLUTE FOR THE TREATMENT OF CELLULITE, FIBROSIS, AND HIRSUTISM |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9714073A FR2770779B1 (en) | 1997-11-10 | 1997-11-10 | HYPOTONIC OR HYPOOSMOLAR PLASMA SOLUTE FOR THE TREATMENT OF CELLULITE, FIBROSIS, AND HIRSUTISM |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2770779A1 true FR2770779A1 (en) | 1999-05-14 |
| FR2770779B1 FR2770779B1 (en) | 2000-07-21 |
Family
ID=9513197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9714073A Expired - Fee Related FR2770779B1 (en) | 1997-11-10 | 1997-11-10 | HYPOTONIC OR HYPOOSMOLAR PLASMA SOLUTE FOR THE TREATMENT OF CELLULITE, FIBROSIS, AND HIRSUTISM |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2770779B1 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2795320A1 (en) * | 1999-06-23 | 2000-12-29 | Veronique Bernstein | Hypotonic injectable solutions for esthetic treatment and for use in cancer treatment |
| WO2002030432A1 (en) * | 2000-06-23 | 2002-04-18 | Cambridgemed, Inc | Agent for reduction of scar formation by using wound alkalinization |
| EP1655057A1 (en) | 2004-10-27 | 2006-05-10 | Serge Bernstein | Water based solutions for the treatment of cellulite |
| US7323184B2 (en) | 2005-08-22 | 2008-01-29 | Healagenics, Inc. | Compositions and methods for the treatment of wounds and the reduction of scar formation |
| US9808539B2 (en) | 2013-03-11 | 2017-11-07 | Endomagnetics Ltd. | Hypoosmotic solutions for lymph node detection |
| US10595957B2 (en) | 2015-06-04 | 2020-03-24 | Endomagnetics Ltd | Marker materials and forms for magnetic marker localization (MML) |
| US10634741B2 (en) | 2009-12-04 | 2020-04-28 | Endomagnetics Ltd. | Magnetic probe apparatus |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100518152B1 (en) | 2002-05-09 | 2005-09-29 | 메디제네스(주) | A Pharmaceutical Composition for Treatment of Wounds Containing Blood Plasma or Serum |
| US9427186B2 (en) | 2009-12-04 | 2016-08-30 | Endomagnetics Ltd. | Magnetic probe apparatus |
| US9239314B2 (en) | 2013-03-13 | 2016-01-19 | Endomagnetics Ltd. | Magnetic detector |
| US9234877B2 (en) | 2013-03-13 | 2016-01-12 | Endomagnetics Ltd. | Magnetic detector |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4371522A (en) * | 1979-04-25 | 1983-02-01 | Gilbard Jeffrey P | Keratoconjunctivitis sicca therapy |
-
1997
- 1997-11-10 FR FR9714073A patent/FR2770779B1/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4371522A (en) * | 1979-04-25 | 1983-02-01 | Gilbard Jeffrey P | Keratoconjunctivitis sicca therapy |
Non-Patent Citations (1)
| Title |
|---|
| BUSSIEN R. ET AL: "The tumescent technique revisited", EUROPEAN JOURNAL OF PLASTIC SURGERY, 1996, 19/3 (124-131), GERMANY, XP002059321 * |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2795320A1 (en) * | 1999-06-23 | 2000-12-29 | Veronique Bernstein | Hypotonic injectable solutions for esthetic treatment and for use in cancer treatment |
| WO2002030432A1 (en) * | 2000-06-23 | 2002-04-18 | Cambridgemed, Inc | Agent for reduction of scar formation by using wound alkalinization |
| US7255883B2 (en) | 2000-06-23 | 2007-08-14 | Healagenics, Inc. | Agent for reduction of scar formation by using wound alkalinization |
| EP1655057A1 (en) | 2004-10-27 | 2006-05-10 | Serge Bernstein | Water based solutions for the treatment of cellulite |
| US7323184B2 (en) | 2005-08-22 | 2008-01-29 | Healagenics, Inc. | Compositions and methods for the treatment of wounds and the reduction of scar formation |
| US10634741B2 (en) | 2009-12-04 | 2020-04-28 | Endomagnetics Ltd. | Magnetic probe apparatus |
| US11592501B2 (en) | 2009-12-04 | 2023-02-28 | Endomagnetics Ltd. | Magnetic probe apparatus |
| US12092708B2 (en) | 2009-12-04 | 2024-09-17 | Endomagnetics Ltd. | Magnetic probe apparatus |
| US9808539B2 (en) | 2013-03-11 | 2017-11-07 | Endomagnetics Ltd. | Hypoosmotic solutions for lymph node detection |
| US10595957B2 (en) | 2015-06-04 | 2020-03-24 | Endomagnetics Ltd | Marker materials and forms for magnetic marker localization (MML) |
| US11504207B2 (en) | 2015-06-04 | 2022-11-22 | Endomagnetics Ltd | Marker materials and forms for magnetic marker localization (MML) |
| US12161513B2 (en) | 2015-06-04 | 2024-12-10 | Endomagnetics Ltd | Marker materials and forms for magnetic marker localization (MML) |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2770779B1 (en) | 2000-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |
Effective date: 20130731 |