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FR2672595B1 - NOVEL NITROGEN BICYCLIC DERIVATIVES SUBSTITUTED BY A RADICAL BENZYL, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS. - Google Patents

NOVEL NITROGEN BICYCLIC DERIVATIVES SUBSTITUTED BY A RADICAL BENZYL, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS.

Info

Publication number
FR2672595B1
FR2672595B1 FR9101373A FR9101373A FR2672595B1 FR 2672595 B1 FR2672595 B1 FR 2672595B1 FR 9101373 A FR9101373 A FR 9101373A FR 9101373 A FR9101373 A FR 9101373A FR 2672595 B1 FR2672595 B1 FR 2672595B1
Authority
FR
France
Prior art keywords
medicaments
application
preparation process
derivatives substituted
new intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9101373A
Other languages
French (fr)
Other versions
FR2672595A1 (en
Inventor
Francois Clemence
Michel Fortin
Jean-Luc Haesslein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9101373A priority Critical patent/FR2672595B1/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to EP92400295A priority patent/EP0498722B1/en
Priority to ES92400295T priority patent/ES2104862T3/en
Priority to DK92400295.9T priority patent/DK0498722T3/en
Priority to DE69221175T priority patent/DE69221175T2/en
Priority to JP04774992A priority patent/JP3531944B2/en
Priority to AT92400295T priority patent/ATE156120T1/en
Priority to US07/832,003 priority patent/US5324839A/en
Priority to CA002060771A priority patent/CA2060771A1/en
Publication of FR2672595A1 publication Critical patent/FR2672595A1/en
Priority to US08/216,035 priority patent/US5478938A/en
Application granted granted Critical
Publication of FR2672595B1 publication Critical patent/FR2672595B1/en
Priority to GR970400155T priority patent/GR3024413T3/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/28—Cinnolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9101373A 1991-02-07 1991-02-07 NOVEL NITROGEN BICYCLIC DERIVATIVES SUBSTITUTED BY A RADICAL BENZYL, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS. Expired - Fee Related FR2672595B1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR9101373A FR2672595B1 (en) 1991-02-07 1991-02-07 NOVEL NITROGEN BICYCLIC DERIVATIVES SUBSTITUTED BY A RADICAL BENZYL, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS.
ES92400295T ES2104862T3 (en) 1991-02-07 1992-02-05 NITROGENATED BICYCLE DERIVATIVES, THEIR PREPARATION PROCEDURE, THEIR INTERMEDIATE PRODUCTS OBTAINED, THEIR APPLICATION AS DRUGS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
DK92400295.9T DK0498722T3 (en) 1991-02-07 1992-02-05 New bicyclic nitrogen compounds substituted with a benzyl group, process for their preparation, the novel intermediates obtained, their use as drugs and the pharmaceutical compositions contained in them.
DE69221175T DE69221175T2 (en) 1991-02-07 1992-02-05 Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as medicaments and pharmaceutical compositions containing them
JP04774992A JP3531944B2 (en) 1991-02-07 1992-02-05 Novel benzyl group-substituted nitrogen-based bicyclic derivative and method for producing the same
AT92400295T ATE156120T1 (en) 1991-02-07 1992-02-05 BIZYCLIC NITROGEN COMPOUNDS, THEIR PRODUCTION, INTERMEDIATE PRODUCTS OBTAINED, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP92400295A EP0498722B1 (en) 1991-02-07 1992-02-05 Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them
US07/832,003 US5324839A (en) 1991-02-07 1992-02-06 Nitrogenous bicyclic derivatives substituted with benzyl
CA002060771A CA2060771A1 (en) 1991-02-07 1992-02-06 Nitrogenated bicyclic derivatives substitutes by a benzyl radical, process for their preparation, novel intermediates thus obtaines, their applications as drugs, and pharmaceutical compositions containing them
US08/216,035 US5478938A (en) 1991-02-07 1994-03-22 Nitrogenous bicyclic derivatives substituted with benzyl
GR970400155T GR3024413T3 (en) 1991-02-07 1997-08-13 Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9101373A FR2672595B1 (en) 1991-02-07 1991-02-07 NOVEL NITROGEN BICYCLIC DERIVATIVES SUBSTITUTED BY A RADICAL BENZYL, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS.

Publications (2)

Publication Number Publication Date
FR2672595A1 FR2672595A1 (en) 1992-08-14
FR2672595B1 true FR2672595B1 (en) 1995-05-19

Family

ID=9409440

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9101373A Expired - Fee Related FR2672595B1 (en) 1991-02-07 1991-02-07 NOVEL NITROGEN BICYCLIC DERIVATIVES SUBSTITUTED BY A RADICAL BENZYL, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS.

Country Status (1)

Country Link
FR (1) FR2672595B1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419789A (en) * 1972-08-02 1975-12-31 Pfizer 2-trifluoromethyl-4-quinolinols
US3936461A (en) * 1973-09-24 1976-02-03 Warner-Lambert Company Substituted 4-benzylquinolines
FR2377400A2 (en) * 1977-01-18 1978-08-11 Roussel Uclaf Analgesic hydroxy:quinoline carboxamide cpds. - esp. N-(2-thiazolyl)-carboxamide cpds. with 8-tri:fluoro:methyl substit.
GB2143814A (en) * 1983-07-29 1985-02-20 Showa Denko Kk Quinazolines
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same

Also Published As

Publication number Publication date
FR2672595A1 (en) 1992-08-14

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TP Transmission of property
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