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FR2530625B1 - Derives d'indole, procedes pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives d'indole, procedes pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
FR2530625B1
FR2530625B1 FR8309429A FR8309429A FR2530625B1 FR 2530625 B1 FR2530625 B1 FR 2530625B1 FR 8309429 A FR8309429 A FR 8309429A FR 8309429 A FR8309429 A FR 8309429A FR 2530625 B1 FR2530625 B1 FR 2530625B1
Authority
FR
France
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
indole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8309429A
Other languages
English (en)
Other versions
FR2530625A1 (fr
Inventor
Michael Dennis Dowle
Ian Harold Coates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10530876&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2530625(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2530625A1 publication Critical patent/FR2530625A1/fr
Application granted granted Critical
Publication of FR2530625B1 publication Critical patent/FR2530625B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
FR8309429A 1982-06-07 1983-06-07 Derives d'indole, procedes pour leur preparation et compositions pharmaceutiques les contenant Expired FR2530625B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8216526 1982-06-07

Publications (2)

Publication Number Publication Date
FR2530625A1 FR2530625A1 (fr) 1984-01-27
FR2530625B1 true FR2530625B1 (fr) 1986-04-18

Family

ID=10530876

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8309429A Expired FR2530625B1 (fr) 1982-06-07 1983-06-07 Derives d'indole, procedes pour leur preparation et compositions pharmaceutiques les contenant

Country Status (33)

Country Link
US (1) US4816470A (fr)
JP (1) JPS5942366A (fr)
KR (1) KR900006681B1 (fr)
AT (1) AT381933B (fr)
AU (1) AU566149B2 (fr)
BE (1) BE896986A (fr)
CA (1) CA1199643A (fr)
CH (1) CH657359A5 (fr)
CY (1) CY1458A (fr)
CZ (1) CZ280529B6 (fr)
DE (2) DE3320521A1 (fr)
DK (1) DK260183D0 (fr)
DO (1) DOP1989476000A (fr)
ES (3) ES523039A0 (fr)
FI (1) FI79530C (fr)
FR (1) FR2530625B1 (fr)
GB (1) GB2124210B (fr)
GR (1) GR79215B (fr)
HK (1) HK14789A (fr)
IE (1) IE55358B1 (fr)
IL (1) IL68913A (fr)
IT (1) IT1170387B (fr)
KE (1) KE3833A (fr)
LU (1) LU84852A1 (fr)
MX (1) MX9202623A (fr)
MY (1) MY8700179A (fr)
NL (1) NL193694C (fr)
NZ (1) NZ204482A (fr)
PH (1) PH19908A (fr)
PT (1) PT76830B (fr)
SE (1) SE452459B (fr)
SK (1) SK404091A3 (fr)
ZA (1) ZA834110B (fr)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
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GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332434D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Production of chemical compounds
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
AU611469B2 (en) * 1987-08-13 1991-06-13 Glaxo Group Limited Indole derivatives
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
HUT57185A (en) * 1990-03-21 1991-11-28 Merrell Dow Pharma Process for producing 8-sulfamil-methylen-2-amino-tetraline derivatives and pharmaceutical compositions containing them
US5935925A (en) * 1990-05-08 1999-08-10 Synaptic Pharmaceutical Corporation Methods of treating migraine and compounds useful for such methods
US5155218A (en) 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
UA37178C2 (uk) * 1990-06-07 2001-05-15 Астразенека Аб Терапевтичні гетероциклічні сполуки, спосіб їх одержання, спосіб профілактики та лікування, лікарський засіб та спосіб його одержання
GB9013845D0 (en) * 1990-06-21 1990-08-15 Glaxo Group Ltd Process
CA2043709C (fr) * 1990-06-29 2002-01-22 David W. Smith Derives pour combattre la migraine d'alcoxypirimidine
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
GB9022250D0 (en) * 1990-10-12 1990-11-28 Glaxo Group Ltd Medicaments
GB9103770D0 (en) * 1991-02-22 1991-04-10 Glaxo Group Ltd Chemical compounds
GB9104890D0 (en) 1991-03-08 1991-04-24 Glaxo Group Ltd Compositions
CA2084531A1 (fr) * 1991-12-19 1993-06-20 David W. Smith Derives antimigraines 4-pyrimidinyle et pyridinyle d'indol-3yl-alkylpiperazines
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
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ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
ES2056025B1 (es) * 1992-10-08 1995-05-01 Almirall Lab Nuevos derivados de indol.
RU2108326C1 (ru) * 1993-02-26 1998-04-10 Вита-Инвест С.А. Способ получения 2-карбокси-3-[2-(диметиламино)этил]-n-метил-1h-индол-5-метансульфонамида или его сложных эфиров
US5382592A (en) * 1993-09-16 1995-01-17 Bristol-Myers Squibb Company Antimigraine cyclobutenedione derivatives of tryptamines
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US6416472B1 (en) 1997-11-06 2002-07-09 Edus Inc. Method and device for measuring cognitive efficiency
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
WO2002015899A1 (fr) * 2000-08-23 2002-02-28 Bristol-Myers Squibb Company Polythérapie traitant la migraine
US6951654B2 (en) * 2001-03-27 2005-10-04 Galen (Chemicals) Limited Intravaginal drug delivery devices for the administration of an antimicrobial agent
EP1435945B1 (fr) * 2001-06-05 2008-08-13 Aung-din, Ronald Therapie antimigraineuse par voie topique
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
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AU2003299227A1 (en) * 2002-12-20 2004-07-14 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof
PT1575566E (pt) 2002-12-26 2012-03-29 Pozen Inc Formas de dosagem em multicamada contendo naproxeno e triptanos
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WO2004076403A1 (fr) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Formes cristallines du sumatriptan, compositions pharmaceutiques et procedes
BRPI0410807A (pt) * 2003-06-06 2006-06-27 Glaxo Group Ltd composição farmacêutica, e, método pata tratar um mamìfero sofrendo de ou susceptìvel a condições associadas com dor cefálica
EP1644004A4 (fr) 2003-06-20 2010-10-06 Ronald Aung-Din Therapie locale pour le traitement des migraines, des claquages musculaires, des spasmes musculaires, de la spasticite et d'etats apparentes
CA2540059C (fr) * 2003-09-26 2013-08-06 Alza Corporation Formulations a liberation commandee presentant un taux croisssant de liberation
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US8541026B2 (en) * 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
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CA2705833A1 (fr) * 2007-11-16 2009-05-22 Subhash C. Annedi Composes d'indole 3,5-substitues ayant une activite d'inhibition de la reabsorption de la nos et de la noradrenaline
EP2219449A4 (fr) * 2007-11-16 2010-10-27 Univ Arizona State Procédés de traitement de la douleur viscérale
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US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US10537554B2 (en) 2015-08-05 2020-01-21 Upsher-Smith Laboratories, Llc Pharmaceutical composition for treating migraine
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US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
EP3766483A1 (fr) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Composition de poudre orodispersible comprenant un triptane

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ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
CH652394A5 (fr) * 1980-08-12 1985-11-15 Glaxo Group Ltd Derives indoliques, leur preparation et medicaments les renfermant.
NL8103769A (nl) * 1980-08-12 1982-03-01 Glaxo Group Ltd Heterocyclische verbindingen, werkwijze ter bereiding daarvan alsmede farmaceutische preparaten die deze verbindingen als actieve component bevatten.
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
GB2082175B (en) * 1980-08-12 1984-05-02 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
PH19908A (en) 1986-08-13
FR2530625A1 (fr) 1984-01-27
JPH0329069B2 (fr) 1991-04-23
US4816470A (en) 1989-03-28
FI79530B (fi) 1989-09-29
CY1458A (en) 1989-07-21
FI832035A0 (fi) 1983-06-07
IE831335L (en) 1983-12-07
GR79215B (fr) 1984-10-22
AT381933B (de) 1986-12-10
SE8303208D0 (sv) 1983-06-07
CA1199643A (fr) 1986-01-21
PT76830A (en) 1983-07-01
ES529802A0 (es) 1985-11-16
DE3320521C2 (fr) 1992-06-25
ES8407473A1 (es) 1984-10-01
GB8315564D0 (en) 1983-07-13
MX9202623A (es) 1992-06-30
GB2124210A (en) 1984-02-15
HK14789A (en) 1989-02-24
ES544281A0 (es) 1986-07-16
CH657359A5 (fr) 1986-08-29
KR840005095A (ko) 1984-11-03
SE8303208L (sv) 1983-12-08
SK277877B6 (en) 1995-06-07
SK404091A3 (en) 1995-06-07
NL193694C (nl) 2000-07-04
AU1544183A (en) 1983-12-15
JPS5942366A (ja) 1984-03-08
IL68913A (en) 1987-08-31
DK260183D0 (da) 1983-06-06
ES8601880A1 (es) 1985-11-16
NZ204482A (en) 1986-09-10
IT1170387B (it) 1987-06-03
LU84852A1 (fr) 1985-03-29
SE452459B (sv) 1987-11-30
ES8609247A1 (es) 1986-07-16
ZA834110B (en) 1985-01-30
AU566149B2 (en) 1987-10-08
IT8348422A0 (it) 1983-06-03
IL68913A0 (en) 1983-10-31
NL8302031A (nl) 1984-01-02
KR900006681B1 (ko) 1990-09-17
DE3320521A1 (de) 1983-12-08
MY8700179A (en) 1987-12-31
DOP1989476000A (es) 1996-02-03
KE3833A (en) 1988-11-18
CZ280529B6 (cs) 1996-02-14
FI832035L (fi) 1983-12-08
FI79530C (fi) 1990-01-10
ES523039A0 (es) 1984-10-01
DE19375045I2 (de) 2002-09-05
GB2124210B (en) 1985-11-13
BE896986A (fr) 1983-12-07
ATA208483A (de) 1986-05-15
NL193694B (nl) 2000-03-01
IE55358B1 (en) 1990-08-29
PT76830B (en) 1986-04-21
CZ404091A3 (en) 1993-04-14

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