FR2385798A1 - Procede de production de maytansinol et de ses derives par voie microbiologique - Google Patents
Procede de production de maytansinol et de ses derives par voie microbiologiqueInfo
- Publication number
- FR2385798A1 FR2385798A1 FR7730340A FR7730340A FR2385798A1 FR 2385798 A1 FR2385798 A1 FR 2385798A1 FR 7730340 A FR7730340 A FR 7730340A FR 7730340 A FR7730340 A FR 7730340A FR 2385798 A1 FR2385798 A1 FR 2385798A1
- Authority
- FR
- France
- Prior art keywords
- maytansinol
- derivatives
- production
- propionate
- maytanacine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- QWPXBEHQFHACTK-RZKXNLMUSA-N CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 Chemical compound CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-RZKXNLMUSA-N 0.000 title 1
- 230000002906 microbiologic effect Effects 0.000 title 1
- QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 abstract 4
- MQYZCKOGTWYJAZ-UHFFFAOYSA-N ansamitocin P1 Natural products CN1C(=O)CC(OC(C)=O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 MQYZCKOGTWYJAZ-UHFFFAOYSA-N 0.000 abstract 3
- DGBBXVWXOHSLTG-UMDRASRXSA-N ansamitocin p 2 Chemical compound C([C@@H]([C@@]1(O[C@H]1[C@@H]1C)C)OC(=O)CC)C(=O)N(C)C(C(=C(OC)C=2)Cl)=CC=2C\C(C)=C\C=C\[C@@H](OC)[C@]2(O)NC(=O)O[C@H]1C2 DGBBXVWXOHSLTG-UMDRASRXSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241000187654 Nocardia Species 0.000 abstract 1
- 239000003080 antimitotic agent Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
La présente invention concerne un procédé de production de maytansinol et de ses dérivés. Le maytansinol, la maytanacine ou le propionate de maytansinol sont produits par culture d'un microorganisme appartenant au genre Nocardia capable de produire du maytansinol, de la maytanacine ou du propionate de maytansinol dans un milieu de culture contenant des sources de carbone assimilables et des sources digestibles jusqu'à ce que le maytansinol, la maytanacine ou le propionate de maytansinol soient accumulés de façon substantielle dans ce milieu et récupération de ces composés. Les composés obtenus selon l'invention sont utiles comme agents antimitotiques.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP52037167A JPS6010718B2 (ja) | 1977-03-31 | 1977-03-31 | メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2385798A1 true FR2385798A1 (fr) | 1978-10-27 |
| FR2385798B1 FR2385798B1 (fr) | 1980-04-25 |
Family
ID=12490032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7730340A Granted FR2385798A1 (fr) | 1977-03-31 | 1977-10-07 | Procede de production de maytansinol et de ses derives par voie microbiologique |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS6010718B2 (fr) |
| AT (1) | AT362058B (fr) |
| AU (1) | AU507869B2 (fr) |
| CA (1) | CA1092999A (fr) |
| CH (1) | CH631740A5 (fr) |
| CS (1) | CS214881B2 (fr) |
| DE (1) | DE2746253C2 (fr) |
| DK (1) | DK143570C (fr) |
| ES (1) | ES463206A1 (fr) |
| FR (1) | FR2385798A1 (fr) |
| GB (1) | GB1554395A (fr) |
| HU (1) | HU177391B (fr) |
| IE (1) | IE45888B1 (fr) |
| IT (1) | IT1094003B (fr) |
| NL (1) | NL7711273A (fr) |
| PL (1) | PL108863B1 (fr) |
| PT (1) | PT67853B (fr) |
| SE (1) | SE7711543L (fr) |
| SU (1) | SU938746A3 (fr) |
| YU (1) | YU243777A (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2409307A1 (fr) * | 1977-11-18 | 1979-06-15 | Takeda Chemical Industries Ltd | Procede de production de l'antibiotique c-15003 p-3 par culture d'un micro-organisme |
| FR2409306A1 (fr) * | 1977-11-18 | 1979-06-15 | Takeda Chemical Industries Ltd | Procede de production de l'antibiotique c-15003 p-4 par culture d'un micro-organisme du genre nocardia |
| EP0019934A1 (fr) * | 1979-06-05 | 1980-12-10 | Takeda Chemical Industries, Ltd. | Antibiotiques C-15003 PND et procédé pour leur préparation |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0028683A1 (fr) * | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotique C-15003 PHO et sa préparation |
| US6573074B2 (en) * | 2000-04-12 | 2003-06-03 | Smithkline Beecham Plc | Methods for ansamitocin production |
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| US7432088B2 (en) | 2003-05-08 | 2008-10-07 | Immunogen Inc. | Methods for the production of ansamitocins |
| CN116239607B (zh) * | 2023-01-04 | 2024-04-09 | 山东大学 | 一种美登素衍生物及其生物合成方法与应用 |
-
1977
- 1977-03-31 JP JP52037167A patent/JPS6010718B2/ja not_active Expired
- 1977-09-23 AU AU29073/77A patent/AU507869B2/en not_active Expired
- 1977-10-07 FR FR7730340A patent/FR2385798A1/fr active Granted
- 1977-10-07 SU SU772533351A patent/SU938746A3/ru active
- 1977-10-10 YU YU02437/77A patent/YU243777A/xx unknown
- 1977-10-13 HU HU77TA1458A patent/HU177391B/hu unknown
- 1977-10-13 NL NL7711273A patent/NL7711273A/xx not_active Application Discontinuation
- 1977-10-13 CS CS776677A patent/CS214881B2/cs unknown
- 1977-10-13 SE SE7711543A patent/SE7711543L/ not_active Application Discontinuation
- 1977-10-14 AT AT736377A patent/AT362058B/de not_active IP Right Cessation
- 1977-10-14 GB GB42821/77A patent/GB1554395A/en not_active Expired
- 1977-10-14 CA CA288,732A patent/CA1092999A/fr not_active Expired
- 1977-10-14 DK DK458977A patent/DK143570C/da not_active IP Right Cessation
- 1977-10-14 CH CH1260477A patent/CH631740A5/de not_active IP Right Cessation
- 1977-10-14 DE DE2746253A patent/DE2746253C2/de not_active Expired
- 1977-10-14 IE IE2100/77A patent/IE45888B1/en unknown
- 1977-10-14 ES ES463206A patent/ES463206A1/es not_active Expired
- 1977-10-15 PL PL1977201539A patent/PL108863B1/pl not_active IP Right Cessation
-
1978
- 1978-03-30 PT PT67853A patent/PT67853B/pt unknown
- 1978-03-30 IT IT21819/78A patent/IT1094003B/it active
Non-Patent Citations (1)
| Title |
|---|
| NV6013/75 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2409307A1 (fr) * | 1977-11-18 | 1979-06-15 | Takeda Chemical Industries Ltd | Procede de production de l'antibiotique c-15003 p-3 par culture d'un micro-organisme |
| FR2409306A1 (fr) * | 1977-11-18 | 1979-06-15 | Takeda Chemical Industries Ltd | Procede de production de l'antibiotique c-15003 p-4 par culture d'un micro-organisme du genre nocardia |
| EP0019934A1 (fr) * | 1979-06-05 | 1980-12-10 | Takeda Chemical Industries, Ltd. | Antibiotiques C-15003 PND et procédé pour leur préparation |
Also Published As
| Publication number | Publication date |
|---|---|
| GB1554395A (en) | 1979-10-17 |
| DE2746253A1 (de) | 1978-10-05 |
| AU2907377A (en) | 1979-03-29 |
| JPS6010718B2 (ja) | 1985-03-19 |
| DE2746253C2 (de) | 1986-08-21 |
| IE45888B1 (en) | 1982-12-29 |
| PL108863B1 (en) | 1980-05-31 |
| DK458977A (da) | 1978-10-01 |
| DK143570B (da) | 1981-09-07 |
| AT362058B (de) | 1981-04-27 |
| JPS53121998A (en) | 1978-10-24 |
| CH631740A5 (en) | 1982-08-31 |
| CA1092999A (fr) | 1981-01-06 |
| CS214881B2 (en) | 1982-06-25 |
| IT1094003B (it) | 1985-07-26 |
| PT67853A (en) | 1978-04-01 |
| ATA736377A (de) | 1980-09-15 |
| PT67853B (en) | 1980-05-05 |
| NL7711273A (nl) | 1978-10-03 |
| SU938746A3 (ru) | 1982-06-23 |
| DK143570C (da) | 1982-02-08 |
| YU243777A (en) | 1982-06-30 |
| SE7711543L (sv) | 1978-10-01 |
| IE45888L (en) | 1978-09-30 |
| FR2385798B1 (fr) | 1980-04-25 |
| HU177391B (en) | 1981-09-28 |
| PL201539A1 (pl) | 1978-09-25 |
| IT7821819A0 (it) | 1978-03-30 |
| ES463206A1 (es) | 1978-08-16 |
| AU507869B2 (en) | 1980-02-28 |
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