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FR2359125B1 - Nouveaux derives de prostaglandine, leur procede de preparation et medicament les contenant - Google Patents

Nouveaux derives de prostaglandine, leur procede de preparation et medicament les contenant

Info

Publication number
FR2359125B1
FR2359125B1 FR7703076A FR7703076A FR2359125B1 FR 2359125 B1 FR2359125 B1 FR 2359125B1 FR 7703076 A FR7703076 A FR 7703076A FR 7703076 A FR7703076 A FR 7703076A FR 2359125 B1 FR2359125 B1 FR 2359125B1
Authority
FR
France
Prior art keywords
preparation
medicaments containing
prostaglandin derivatives
novel prostaglandin
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7703076A
Other languages
English (en)
Other versions
FR2359125A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2359125A1 publication Critical patent/FR2359125A1/fr
Application granted granted Critical
Publication of FR2359125B1 publication Critical patent/FR2359125B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
FR7703076A 1976-02-04 1977-02-03 Nouveaux derives de prostaglandine, leur procede de preparation et medicament les contenant Expired FR2359125B1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US65511076A 1976-02-04 1976-02-04
US71697276A 1976-08-23 1976-08-23
US71696076A 1976-08-23 1976-08-23
US71696976A 1976-08-23 1976-08-23
US71677176A 1976-08-23 1976-08-23
US71677076A 1976-08-23 1976-08-23
US72554876A 1976-09-22 1976-09-22

Publications (2)

Publication Number Publication Date
FR2359125A1 FR2359125A1 (fr) 1978-02-17
FR2359125B1 true FR2359125B1 (fr) 1985-11-15

Family

ID=27569874

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7703076A Expired FR2359125B1 (fr) 1976-02-04 1977-02-03 Nouveaux derives de prostaglandine, leur procede de preparation et medicament les contenant
FR7732283A Granted FR2362834A1 (fr) 1976-02-04 1977-10-26 Nouveaux derives 6-hemicetal ou 6-ceto de prostaglandine, leur procede de preparation et medicament les contenant
FR7732282A Granted FR2362833A1 (fr) 1976-02-04 1977-10-26 Nouveaux derives 5 de prostaglandine, leur procede de preparation et medicament les contenant

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR7732283A Granted FR2362834A1 (fr) 1976-02-04 1977-10-26 Nouveaux derives 6-hemicetal ou 6-ceto de prostaglandine, leur procede de preparation et medicament les contenant
FR7732282A Granted FR2362833A1 (fr) 1976-02-04 1977-10-26 Nouveaux derives 5 de prostaglandine, leur procede de preparation et medicament les contenant

Country Status (13)

Country Link
JP (1) JPS5936911B2 (fr)
BE (1) BE851122A (fr)
CA (3) CA1160627A (fr)
CH (2) CH632245A5 (fr)
DE (1) DE2702553C2 (fr)
FR (3) FR2359125B1 (fr)
GB (1) GB1554044A (fr)
HK (1) HK9385A (fr)
IL (1) IL51189A (fr)
MX (1) MX4811E (fr)
NL (2) NL185515C (fr)
NZ (1) NZ183050A (fr)
SE (1) SE435281B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1583961A (en) * 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
CH629493A5 (en) * 1976-05-11 1982-04-30 Wellcome Found Processes for preparing novel prostaglandin derivatives
GB1595056A (en) * 1976-10-12 1981-08-05 Wellcome Found Pharmaceutical combination
AU511711B2 (en) * 1976-12-30 1980-09-04 Upjohn Company, The 6-Oxo and 5, 6-Dihalo prostaglandin analogues
FI71138C (fi) * 1976-12-31 1986-11-24 Erba Farmitalia Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner
US4178367A (en) 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
AU524786B2 (en) * 1977-03-07 1982-10-07 The Upjohn Company Prostacyclins
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds
US4219647A (en) 1977-09-22 1980-08-26 Josef Fried Certain amides of prostacyclin and related compounds
JPS6022710B2 (ja) * 1977-09-16 1985-06-03 小野薬品工業株式会社 プロスタグランジン類似化合物
DE2743283A1 (de) * 1977-09-27 1979-04-05 Hoechst Ag Neue prostacyclin-analoga
IT1088036B (it) 1977-11-25 1985-06-04 Erba Carlo Spa 15-epi-prostaciclina e prostaciclina analoghi
US4705806A (en) * 1978-02-13 1987-11-10 Morton Jr Douglas R Prostacyclin analogs
DE2811950A1 (de) * 1978-03-18 1979-12-13 Hoechst Ag Neue analoga von prostacyclin
HU179001B (en) 1978-05-29 1982-08-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 5-halo-6,9alpha-oxido-prostaglandin derivatives
IT1099575B (it) * 1978-07-20 1985-09-18 Erba Carlo Spa 20-metil-13,14-deidro-pgi2' suoi sali e suoi 16s- e 16r-metil derivati
DE2834248A1 (de) * 1978-08-04 1980-02-28 Hoechst Ag Neue prostaglandinderivate in der delta 2-pgf tief 2 und delta 2-pge tief 2 -reihe
US4180657A (en) * 1978-08-14 1979-12-25 The Upjohn Company Acyl-substituted phenyl esters of prostacyclin-type compounds
JPS56122372A (en) * 1980-03-03 1981-09-25 Toray Ind Inc Prostaglandin i2 derivative
DE3029984C2 (de) * 1980-08-08 1983-12-15 Grünenthal GmbH, 5190 Stolberg 2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel
CH651033A5 (de) * 1981-03-11 1985-08-30 Hoffmann La Roche Fluorprostacycline.
AT381309B (de) * 1982-05-27 1986-09-25 Gruenenthal Gmbh Verfahren zur herstellung von 5z-formen von 2,3,4 -trinor-1,5-inter-m-phenylen-prostacyclinderiva en
JPS595155A (ja) * 1982-06-30 1984-01-12 Ono Pharmaceut Co Ltd プロスタグランジンｄ類似化合物
CA1324129C (fr) * 1987-04-30 1993-11-09 Ryuzo Ueno Prostaglandines de la serie f
US5221763A (en) * 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5591887A (en) * 1987-04-30 1997-01-07 R-Tech Ueno, Ltd. Prostaglandins of the F series
AU619543B2 (en) * 1988-05-11 1992-01-30 Sucampo Ag Use of 15-ketoprostaglandin e or f compounds for uterine contraction
US5185374A (en) * 1988-05-11 1993-02-09 K.K. Ueno Seiyaku Oyo Kenkyujo Use of 15-ketoprostaglandin E or F compounds for uterine contraction
KR101768235B1 (ko) 2009-07-28 2017-08-14 오노 야꾸힝 고교 가부시키가이샤 이환식 화합물 및 이의 의약 용도
EP2669279B1 (fr) 2011-01-27 2017-01-11 ONO Pharmaceutical Co., Ltd. Composé bicyclique et utilisation associée à des fins médicales
CN116143742B (zh) * 2023-02-27 2024-10-18 广州楷石生物科技有限公司 依前列醇一氧化氮供体药物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351112A1 (fr) * 1975-10-21 1977-12-09 Wellcome Found Derive de prostaglandine et medicament contenant ce derive
CH629493A5 (en) * 1976-05-11 1982-04-30 Wellcome Found Processes for preparing novel prostaglandin derivatives
MX4813E (es) * 1976-06-01 1982-10-19 Upjohn Co Procedimiento para preparar analogos de prostaglandinas
AU511711B2 (en) * 1976-12-30 1980-09-04 Upjohn Company, The 6-Oxo and 5, 6-Dihalo prostaglandin analogues

Also Published As

Publication number Publication date
FR2362834A1 (fr) 1978-03-24
FR2359125A1 (fr) 1978-02-17
SE7701045L (sv) 1977-08-05
MX4811E (es) 1982-10-19
NZ183050A (en) 1979-06-08
FR2362833B1 (fr) 1980-08-08
FR2362834B1 (fr) 1980-08-08
NL8300921A (nl) 1983-07-01
GB1554044A (en) 1979-10-17
JPS5936911B2 (ja) 1984-09-06
NL185515C (nl) 1990-05-01
NL7700896A (nl) 1977-08-08
DE2702553C2 (de) 1986-02-20
DE2702553A1 (de) 1977-08-18
FR2362833A1 (fr) 1978-03-24
IL51189A0 (en) 1977-02-28
IL51189A (en) 1985-08-30
SE435281B (sv) 1984-09-17
CH637949A5 (en) 1983-08-31
NL185515B (nl) 1989-12-01
CA1160627A (fr) 1984-01-17
JPS5295644A (en) 1977-08-11
BE851122A (fr) 1977-08-04
CH632245A5 (en) 1982-09-30
HK9385A (en) 1985-02-08
CA1179335A (fr) 1984-12-11
CA1160628A (fr) 1984-01-17

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Legal Events

Date Code Title Description
ST Notification of lapse