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FR2190425A1 - N-methylaspartic acid salts - with aminoalcohols useful as CNS stimulants - Google Patents

N-methylaspartic acid salts - with aminoalcohols useful as CNS stimulants

Info

Publication number
FR2190425A1
FR2190425A1 FR7222969A FR7222969A FR2190425A1 FR 2190425 A1 FR2190425 A1 FR 2190425A1 FR 7222969 A FR7222969 A FR 7222969A FR 7222969 A FR7222969 A FR 7222969A FR 2190425 A1 FR2190425 A1 FR 2190425A1
Authority
FR
France
Prior art keywords
acid salts
cns stimulants
methylaspartic acid
useful
aminoalcohols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7222969A
Other languages
French (fr)
Other versions
FR2190425B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHARMAC BIOLOG SOC
Original Assignee
PHARMAC BIOLOG SOC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PHARMAC BIOLOG SOC filed Critical PHARMAC BIOLOG SOC
Priority to FR7222969A priority Critical patent/FR2190425A1/en
Publication of FR2190425A1 publication Critical patent/FR2190425A1/en
Application granted granted Critical
Publication of FR2190425B1 publication Critical patent/FR2190425B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Title cpds are of formula (I) -OOC.CH2.CH(NHMe).COO- - R1+R2+ (I) (R1 and R2 = R4 and R5 = H, alkyl, aryl or hydroxyalkyl, R3 = (CH2)n, n=0-5; or one of R1 and R2 may also be H). (I) are powerful CNS stimulants useful in treatment of fatigue, depression and astheniaard are prepd by conventional salt formation. Suitably R4=A2-(N,N-dimethylamino)ethanol ation and R2 = R1 or H.
FR7222969A 1972-06-26 1972-06-26 N-methylaspartic acid salts - with aminoalcohols useful as CNS stimulants Granted FR2190425A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7222969A FR2190425A1 (en) 1972-06-26 1972-06-26 N-methylaspartic acid salts - with aminoalcohols useful as CNS stimulants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7222969A FR2190425A1 (en) 1972-06-26 1972-06-26 N-methylaspartic acid salts - with aminoalcohols useful as CNS stimulants

Publications (2)

Publication Number Publication Date
FR2190425A1 true FR2190425A1 (en) 1974-02-01
FR2190425B1 FR2190425B1 (en) 1975-08-08

Family

ID=9100794

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7222969A Granted FR2190425A1 (en) 1972-06-26 1972-06-26 N-methylaspartic acid salts - with aminoalcohols useful as CNS stimulants

Country Status (1)

Country Link
FR (1) FR2190425A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0094412A4 (en) * 1981-11-23 1984-04-24 Frederick Bertram Johnston MEDICAL PREPARATION AND PROCESSES.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3571M (en) * 1963-12-31 1965-09-27 Pharmaco Biolog Soc Medicines based on n-methyl-amino-butanedioic acid.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3571M (en) * 1963-12-31 1965-09-27 Pharmaco Biolog Soc Medicines based on n-methyl-amino-butanedioic acid.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0094412A4 (en) * 1981-11-23 1984-04-24 Frederick Bertram Johnston MEDICAL PREPARATION AND PROCESSES.

Also Published As

Publication number Publication date
FR2190425B1 (en) 1975-08-08

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Legal Events

Date Code Title Description
ST Notification of lapse