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FR2035774A2 - Active protein product - with polymeric carrier - Google Patents

Active protein product - with polymeric carrier

Info

Publication number
FR2035774A2
FR2035774A2 FR6907897A FR6907897A FR2035774A2 FR 2035774 A2 FR2035774 A2 FR 2035774A2 FR 6907897 A FR6907897 A FR 6907897A FR 6907897 A FR6907897 A FR 6907897A FR 2035774 A2 FR2035774 A2 FR 2035774A2
Authority
FR
France
Prior art keywords
protein
active protein
carrier
protein product
polymeric carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6907897A
Other languages
French (fr)
Other versions
FR2035774B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR6907897A priority Critical patent/FR2035774A2/en
Priority to CH613172A priority patent/CH564031A5/xx
Priority to CH453269A priority patent/CH538003A/en
Priority to CH453269D priority patent/CH453269A4/xx
Priority to DE1915970A priority patent/DE1915970C3/en
Priority to GB1257263D priority patent/GB1257263A/en
Priority to JP44023729A priority patent/JPS5112712B1/ja
Publication of FR2035774A2 publication Critical patent/FR2035774A2/en
Application granted granted Critical
Publication of FR2035774B2 publication Critical patent/FR2035774B2/fr
Priority to US05/541,257 priority patent/US4004979A/en
Priority to US06/369,253 priority patent/US4464468A/en
Priority to US06/775,956 priority patent/US4970156A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6955—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a plaster, a bandage, a dressing or a patch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

Carrier is contacted with soln. of active protein substance in presence of bridging agent, then isolated. Yield of fixed protein is high, fixing is stable and protein is not denatured during fixing. In medicine, e.g. for oral use, injection, plastic surgery, artificial valves and bones, and in cosmetics. Suitable components include: active proteins: enzymes, antibodies, antigens, allergens, hormones, microbes or viruses; carrier may be film, membrane, fabric, porous or solid granulate, pellets or tablets of natural or synthetic macromol. substances.
FR6907897A 1968-03-29 1969-03-19 Active protein product - with polymeric carrier Granted FR2035774A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR6907897A FR2035774A2 (en) 1969-03-19 1969-03-19 Active protein product - with polymeric carrier
CH453269A CH538003A (en) 1968-03-29 1969-03-25 Process for obtaining textile articles carrying enzymes
CH453269D CH453269A4 (en) 1968-03-29 1969-03-25
CH613172A CH564031A5 (en) 1968-03-29 1969-03-25
DE1915970A DE1915970C3 (en) 1968-03-29 1969-03-28 Process for the production of active protein substances bound to inactive proteins by dialdehydes by crosslinking
GB1257263D GB1257263A (en) 1968-03-29 1969-03-28
JP44023729A JPS5112712B1 (en) 1968-03-29 1969-03-29
US05/541,257 US4004979A (en) 1968-03-29 1975-01-15 Preparation of active proteins cross-linked to inactive proteins
US06/369,253 US4464468A (en) 1968-03-29 1982-04-16 Immobilization of active protein by cross-linking to inactive protein
US06/775,956 US4970156A (en) 1968-03-29 1985-09-13 Immobilization of active protein by cross-linking to inactive protein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6907897A FR2035774A2 (en) 1969-03-19 1969-03-19 Active protein product - with polymeric carrier

Publications (2)

Publication Number Publication Date
FR2035774A2 true FR2035774A2 (en) 1970-12-24
FR2035774B2 FR2035774B2 (en) 1974-08-30

Family

ID=9030896

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6907897A Granted FR2035774A2 (en) 1968-03-29 1969-03-19 Active protein product - with polymeric carrier

Country Status (1)

Country Link
FR (1) FR2035774A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2423497A1 (en) * 1978-04-19 1979-11-16 Novo Industri As IMMOBILIZED ENZYMES, THEIR PREPARATION AND THEIR USE
FR2437837A1 (en) * 1978-10-04 1980-04-30 Univ Johns Hopkins PROCESS FOR THE PREPARATION OF AN ALLERGEN TREATED WITH AN ALDEHYDE, PRODUCT OBTAINED AND ITS THERAPEUTIC APPLICATION
FR2446317A1 (en) * 1979-01-12 1980-08-08 Solvay COMPLEX GRANULES CONTAINING ACTIVE PROTEIN SUBSTANCES AND METHODS FOR THEIR MANUFACTURE, USE, AND REGENERATION
US4261969A (en) * 1979-05-03 1981-04-14 World Health Organization Controlled drug release composition
FR2543972A1 (en) * 1983-04-06 1984-10-12 Immunotech Sa METHOD FOR FIXING BIOLOGICAL MACROMOLECULES ON SUPPORTS

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1293278A (en) * 1961-05-27 1962-05-11 Improvements to Compositions Containing Enzymes, and to Processes for the Preparation and Use of Such Compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1293278A (en) * 1961-05-27 1962-05-11 Improvements to Compositions Containing Enzymes, and to Processes for the Preparation and Use of Such Compositions

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2423497A1 (en) * 1978-04-19 1979-11-16 Novo Industri As IMMOBILIZED ENZYMES, THEIR PREPARATION AND THEIR USE
FR2437837A1 (en) * 1978-10-04 1980-04-30 Univ Johns Hopkins PROCESS FOR THE PREPARATION OF AN ALLERGEN TREATED WITH AN ALDEHYDE, PRODUCT OBTAINED AND ITS THERAPEUTIC APPLICATION
FR2446317A1 (en) * 1979-01-12 1980-08-08 Solvay COMPLEX GRANULES CONTAINING ACTIVE PROTEIN SUBSTANCES AND METHODS FOR THEIR MANUFACTURE, USE, AND REGENERATION
EP0014003A3 (en) * 1979-01-12 1980-08-20 Solvay & Cie (Societe Anonyme) Complex particles containing active protein substances and processes for their production, application and regeneration
US4261969A (en) * 1979-05-03 1981-04-14 World Health Organization Controlled drug release composition
FR2543972A1 (en) * 1983-04-06 1984-10-12 Immunotech Sa METHOD FOR FIXING BIOLOGICAL MACROMOLECULES ON SUPPORTS
EP0122209A1 (en) * 1983-04-06 1984-10-17 Société Anonyme dite: IMMUNOTECH Process for binding biological macromolecules to carriers

Also Published As

Publication number Publication date
FR2035774B2 (en) 1974-08-30

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