FR13C0034I2 - Derives de styrylpyridine et leurs applications a la liaison et a l'imagerie de plaques amyloides - Google Patents

Derives de styrylpyridine et leurs applications a la liaison et a l'imagerie de plaques amyloides

Info

Publication number: FR13C0034I2
Authority: FR; France
Prior art keywords: imaging; applications; amyloid plaque; styrylpyridine; plaque binding
Prior art date: 2006-03-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

FR13C0034C

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Pennsylvania Penn

Original Assignee

University of Pennsylvania Penn

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-30

Filing date

2013-06-26

Publication date

2014-03-07

2013-06-26 Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn

2013-08-09 Publication of FR13C0034I1 publication Critical patent/FR13C0034I1/fr

2014-03-07 Application granted granted Critical

2014-03-07 Publication of FR13C0034I2 publication Critical patent/FR13C0034I2/fr

Status Active legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Optics & Photonics (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurology (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FR13C0034C 2006-03-30 2013-06-26 Derives de styrylpyridine et leurs applications a la liaison et a l'imagerie de plaques amyloides Active FR13C0034I2 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78715606P	2006-03-30	2006-03-30
PCT/US2007/007400 WO2007126733A2 (en)	2006-03-30	2007-03-26	Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

Publications (2)

Publication Number	Publication Date
FR13C0034I1 FR13C0034I1 (uk)	2013-08-09
FR13C0034I2 true FR13C0034I2 (fr)	2014-03-07

Family

ID=38326579

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR13C0034C Active FR13C0034I2 (fr)	2006-03-30	2013-06-26	Derives de styrylpyridine et leurs applications a la liaison et a l'imagerie de plaques amyloides

Country Status (34)

Country	Link
US (3)	US7687052B2 (uk)
EP (3)	EP2363391A1 (uk)
JP (1)	JP5290954B2 (uk)
KR (1)	KR101376807B1 (uk)
CN (1)	CN101522624B (uk)
AT (1)	ATE539060T1 (uk)
AU (1)	AU2007243712B2 (uk)
BR (1)	BRPI0710225B1 (uk)
CA (1)	CA2644530C (uk)
CR (1)	CR10329A (uk)
CY (3)	CY1113048T1 (uk)
DK (2)	DK2363392T3 (uk)
EA (1)	EA017898B1 (uk)
EC (1)	ECSP088783A (uk)
ES (2)	ES2628882T3 (uk)
FR (1)	FR13C0034I2 (uk)
GT (1)	GT200800201A (uk)
HR (2)	HRP20120135T1 (uk)
HU (2)	HUE032660T2 (uk)
IL (1)	IL193567A (uk)
LT (1)	LT2363392T (uk)
LU (1)	LU92232I2 (uk)
MX (1)	MX2008012527A (uk)
NO (2)	NO342090B1 (uk)
NZ (1)	NZ570887A (uk)
PL (2)	PL1999109T3 (uk)
PT (2)	PT1999109E (uk)
RS (2)	RS52222B (uk)
SG (1)	SG173338A1 (uk)
SI (2)	SI2363392T1 (uk)
TW (1)	TWI399366B (uk)
UA (1)	UA97802C2 (uk)
WO (1)	WO2007126733A2 (uk)
ZA (1)	ZA200807955B (uk)

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JP5322180B2 (ja) *	2007-07-04	2013-10-23	国立大学法人東北大学	フッ素およびヒドロキシ基で置換されたアルコキシ基を有するｐｅｔプローブ
JP5603855B2 (ja)	2008-04-04	2014-10-08	アビッドレディオファーマシューティカルズ、インク．	神経変成疾患の放射性薬剤による画像化
MX2011007063A (es) *	2008-12-31	2011-12-16	Avid Radiopharmaceuticals Inc	Sintesis de estirilpiridinas radiomarcadas con 18f a partir de precursores de tosilato y composiciones farmaceuticas estables de los mismos.
CA2767475A1 (en) *	2009-07-10	2011-01-13	Bayer Pharma Aktiengesellschaft	Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
EP2501696B1 (en)	2009-10-15	2016-12-28	Guerbet	Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
JP5774023B2 (ja) *	2009-12-23	2015-09-02	ピラマルイメージングソシエテアノニム	疎水性ｐｅｔ剤を用いたｐｅｔイメージングのために適した配合物
WO2011141515A1 (en)	2010-05-14	2011-11-17	Bayer Pharma Aktiengesellschaft	Diagnostic agents for amyloid beta imaging
PT2579902T (pt)	2010-06-04	2017-08-17	Piramal Imaging Sa	Processo para a produção de ligandos de betaamilóides marcados com f-18
MX2012014115A (es)	2010-06-04	2013-07-03	Piramal Imaging Sa	Metodo para la produccion de ligandos beta amiloide marcados con 18f.
TWI504414B (zh)	2010-06-04	2015-10-21	Bayer Schering Pharma Ag	生產Ｆ－１８標記之Ａβ配位體之方法
BR112012030944A2 (pt) *	2010-06-04	2016-11-01	Piramal Imaging Sa	método para a produção de ligantes para beta amiloide marcados com f-18
CN101891674B (zh) *	2010-06-24	2012-11-14	山东大学	4-苯乙烯基吡啶类化合物及其制备方法与应用
EP2627361B1 (en) *	2010-10-12	2017-09-20	Mayo Foundation For Medical Education And Research	Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
US20140079635A1 (en) *	2011-03-30	2014-03-20	Case Western Reserve University	Molecular probes for detecting lipid composition
CN103491870B (zh) *	2011-04-21	2016-12-28	加利福尼亚大学董事会	官能化磁性纳米颗粒及在淀粉样沉积物和神经原纤维缠结成像中用途
US20140243533A1 (en)	2011-10-19	2014-08-28	Piramal Imaging Sa	Method for production of f-18 labeled a-beta ligands
SG10201608370TA (en)	2012-04-10	2016-11-29	Lantheus Medical Imaging Inc	Radiopharmaceutical synthesis methods
JP6099045B2 (ja) *	2013-04-30	2017-03-22	国立大学法人京都大学	トリアゾロピリミジン誘導体化合物
JP2014218454A (ja) *	2013-05-07	2014-11-20	日本メジフィジックス株式会社	スチリルピリジン誘導体化合物
JP6041751B2 (ja) *	2013-05-07	2016-12-14	日本メジフィジックス株式会社	スチリルピリジン誘導体化合物
CN103645254B (zh) *	2013-11-28	2015-01-07	江苏省原子医学研究所	一种Aβ斑块显像剂前体AV45的含量分析方法
KR102530129B1 (ko)	2014-05-13	2023-05-10	에프. 호프만-라 로슈 아게	중수소화된 헤테로사이클릭 화합물 및 이의 조영제로서의 용도
WO2017031239A1 (en)	2015-08-18	2017-02-23	The Regents Of The University Of California	Nitroxide containing amyloid binding agents for imaging and therapeutic uses
US10300155B2 (en)	2015-12-31	2019-05-28	Washington University	Alpha-synuclein ligands
CN109400615B (zh) *	2017-08-18	2021-07-16	上海交通大学医学院附属新华医院	一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) *	2018-01-02	2018-07-20	北京师范大学	与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
CN114805190A (zh) *	2022-06-08	2022-07-29	吉林大学第一医院	一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法
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JPH0545875A (ja) *	1991-08-08	1993-02-26	Konica Corp	感光性組成物
US6020436A (en)	1993-03-09	2000-02-01	The Chromaline Corporation	Photosensitive resin composition
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US8007954B2 (en)	2000-11-09	2011-08-30	The Trustees Of The University Of Pennsylvania	Use of sulfur-containing fuels for direct oxidation fuel cells
JP2002182254A (ja)	2000-12-18	2002-06-26	Fuji Photo Film Co Ltd	非線形光学材料とその製造方法
EP1432453B1 (en) *	2001-08-27	2013-08-14	The Trustees of The University of Pennsylvania	Stilbene derivatives and their use for binding and imaging amyloid plaques
EP1530814A4 (en)	2002-06-06	2009-05-27	Univ Pennsylvania	CERAMIC ANODES AND PROCESS FOR PRODUCING THESE ANODES
AU2003258612A1 (en) *	2002-08-14	2004-03-03	4Sc Ag	Pyrimidones as antiviral agents
JP4482352B2 (ja)	2004-03-11	2010-06-16	本田技研工業株式会社	固体高分子型燃料電池
WO2006078384A2 (en) *	2004-12-17	2006-07-27	The Trustees Of The University Of Pennsylvania	Stilbene derivatives and their use
SG194363A1 (en) *	2004-12-17	2013-11-29	Univ Pennsylvania	Stilbene derivatives and their use for binding and imaging amyloid plaques
CA2617319A1 (en) *	2005-06-24	2007-01-04	The Trustees Of The University Of Pennsylvania	Radiolabeled-pegylation of ligands for use as imaging agents
MX2008012527A (es)	2006-03-30	2008-10-14	Univ Pennsylvania	Derivados de estirilpiridina y sus usos para union a placas amiloides y obtencion de imagenes de las mismas.
US20080253967A1 (en)	2007-04-13	2008-10-16	Kung Hank F	Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques

2007
- 2007-03-26 MX MX2008012527A patent/MX2008012527A/es active IP Right Grant
- 2007-03-26 RS RS20120077A patent/RS52222B/sr unknown
- 2007-03-26 EP EP11152115A patent/EP2363391A1/en not_active Withdrawn
- 2007-03-26 SI SI200731938T patent/SI2363392T1/sl unknown
- 2007-03-26 SG SG2011048477A patent/SG173338A1/en unknown
- 2007-03-26 PL PL07753982T patent/PL1999109T3/pl unknown
- 2007-03-26 PL PL11152124T patent/PL2363392T3/pl unknown
- 2007-03-26 LT LTEP11152124.1T patent/LT2363392T/lt unknown
- 2007-03-26 DK DK11152124.1T patent/DK2363392T3/en active
- 2007-03-26 EA EA200870389A patent/EA017898B1/ru not_active IP Right Cessation
- 2007-03-26 SI SI200730865T patent/SI1999109T1/sl unknown
- 2007-03-26 PT PT07753982T patent/PT1999109E/pt unknown
- 2007-03-26 AT AT07753982T patent/ATE539060T1/de active
- 2007-03-26 CA CA2644530A patent/CA2644530C/en active Active
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- 2007-03-26 ES ES11152124.1T patent/ES2628882T3/es active Active
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- 2007-03-26 UA UAA200812698A patent/UA97802C2/uk unknown
- 2007-03-26 HR HR20120135T patent/HRP20120135T1/hr unknown
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- 2007-03-26 WO PCT/US2007/007400 patent/WO2007126733A2/en not_active Ceased
- 2007-04-26 TW TW096114833A patent/TWI399366B/zh active
2008
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- 2008-09-16 ZA ZA2008/07955A patent/ZA200807955B/en unknown
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- 2008-09-30 EC EC2008008783A patent/ECSP088783A/es unknown
- 2008-09-30 CR CR10329A patent/CR10329A/es unknown
- 2008-09-30 GT GT200800201A patent/GT200800201A/es unknown
- 2008-10-29 NO NO20084590A patent/NO342090B1/no active Protection Beyond IP Right Term
2012
- 2012-03-07 CY CY20121100225T patent/CY1113048T1/el unknown
2013
- 2013-01-07 US US13/735,609 patent/US8840866B2/en active Active
- 2013-06-26 FR FR13C0034C patent/FR13C0034I2/fr active Active
- 2013-06-26 LU LU92232C patent/LU92232I2/fr unknown
- 2013-06-27 HU HUS1300028C patent/HUS1300028I1/hu unknown
- 2013-06-27 CY CY2013024C patent/CY2013024I1/el unknown
2017
- 2017-06-06 HR HRP20170857TT patent/HRP20170857T1/hr unknown
- 2017-06-22 CY CY20171100664T patent/CY1119048T1/el unknown
2018
- 2018-09-11 NO NO2018030C patent/NO2018030I1/no unknown

Also Published As

Publication number	Publication date
EA200870389A1 (ru)	2009-04-28
FR13C0034I1 (uk)	2013-08-09
WO2007126733A3 (en)	2008-03-06
ES2628882T3 (es)	2017-08-04
WO2007126733A2 (en)	2007-11-08
UA97802C2 (uk)	2012-03-26
SI1999109T1 (sl)	2012-04-30
CN101522624A (zh)	2009-09-02
HUS1300028I1 (hu)	2017-08-28
JP5290954B2 (ja)	2013-09-18
EP2363392A1 (en)	2011-09-07
US8840866B2 (en)	2014-09-23
EP1999109A2 (en)	2008-12-10
PL2363392T3 (pl)	2017-10-31
CY2013024I2 (el)	2015-11-04
US7687052B2 (en)	2010-03-30
PT1999109E (pt)	2012-03-16
CA2644530C (en)	2015-05-19
CY2013024I1 (el)	2015-11-04
IL193567A0 (en)	2009-05-04
SG173338A1 (en)	2011-08-29
AU2007243712A1 (en)	2007-11-08
RS52222B (sr)	2012-10-31
BRPI0710225A2 (pt)	2011-08-02
PL1999109T3 (pl)	2012-05-31
PT2363392T (pt)	2017-06-15
NO342090B1 (no)	2018-03-19
NO20084590L (no)	2008-12-29
CY1119048T1 (el)	2018-01-10
HUE032660T2 (en)	2017-10-30
EP2363391A1 (en)	2011-09-07
CY1113048T1 (el)	2015-11-04
CA2644530A1 (en)	2007-11-08
ATE539060T1 (de)	2012-01-15
CN101522624B (zh)	2013-11-06
DK2363392T3 (en)	2017-07-03
CR10329A (es)	2008-10-29
TW200838852A (en)	2008-10-01
RS56171B1 (sr)	2017-11-30
SI2363392T1 (sl)	2017-09-29
ZA200807955B (en)	2012-11-28
LT2363392T (lt)	2017-07-25
KR20080106564A (ko)	2008-12-08
BRPI0710225B1 (pt)	2021-07-13
HRP20170857T1 (hr)	2017-12-01
TWI399366B (zh)	2013-06-21
LU92232I2 (fr)	2013-08-26
GT200800201A (es)	2009-08-20
US20130129624A1 (en)	2013-05-23
NZ570887A (en)	2011-05-27
ECSP088783A (es)	2008-10-31
DK1999109T3 (da)	2012-04-02
JP2009532349A (ja)	2009-09-10
ES2378785T3 (es)	2012-04-17
KR101376807B1 (ko)	2014-03-20
EP1999109B1 (en)	2011-12-28
NO2018030I1 (no)	2018-09-11
LU92232I9 (uk)	2019-01-15
EP2363392B1 (en)	2017-05-03
HRP20120135T1 (hr)	2012-03-31
US20090123369A1 (en)	2009-05-14
US8506929B2 (en)	2013-08-13
AU2007243712B2 (en)	2013-01-10
IL193567A (en)	2014-03-31
MX2008012527A (es)	2008-10-14
EA017898B1 (ru)	2013-04-30
US20080038195A1 (en)	2008-02-14

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