[go: up one dir, main page]

FR08C0052I2 - 6-MERCAPTO-CYCLODEXTRIN DERIVATIVES: AGENTS FOR REVERSING NEUROMUSCULAR BLOCKAGE CAUSED BY DRUG SUBSTANCES - Google Patents

6-MERCAPTO-CYCLODEXTRIN DERIVATIVES: AGENTS FOR REVERSING NEUROMUSCULAR BLOCKAGE CAUSED BY DRUG SUBSTANCES

Info

Publication number
FR08C0052I2
FR08C0052I2 FR08C0052C FR08C0052C FR08C0052I2 FR 08C0052 I2 FR08C0052 I2 FR 08C0052I2 FR 08C0052 C FR08C0052 C FR 08C0052C FR 08C0052 C FR08C0052 C FR 08C0052C FR 08C0052 I2 FR08C0052 I2 FR 08C0052I2
Authority
FR
France
Prior art keywords
mercapto
agents
drug substances
cyclodextrin derivatives
blockage caused
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR08C0052C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8241767&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR08C0052(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organon NV filed Critical Organon NV
Publication of FR08C0052I1 publication Critical patent/FR08C0052I1/fr
Application granted granted Critical
Publication of FR08C0052I2 publication Critical patent/FR08C0052I2/en
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/724Cyclodextrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FR08C0052C 1999-11-29 2008-12-30 6-MERCAPTO-CYCLODEXTRIN DERIVATIVES: AGENTS FOR REVERSING NEUROMUSCULAR BLOCKAGE CAUSED BY DRUG SUBSTANCES Active FR08C0052I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99309558 1999-11-29
PCT/EP2000/011789 WO2001040316A1 (en) 1999-11-29 2000-11-23 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
EP00993261A EP1259550B1 (en) 1999-11-29 2000-11-23 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block

Publications (2)

Publication Number Publication Date
FR08C0052I1 FR08C0052I1 (en) 2009-02-27
FR08C0052I2 true FR08C0052I2 (en) 2009-12-18

Family

ID=8241767

Family Applications (1)

Application Number Title Priority Date Filing Date
FR08C0052C Active FR08C0052I2 (en) 1999-11-29 2008-12-30 6-MERCAPTO-CYCLODEXTRIN DERIVATIVES: AGENTS FOR REVERSING NEUROMUSCULAR BLOCKAGE CAUSED BY DRUG SUBSTANCES

Country Status (33)

Country Link
US (3) US6670340B1 (en)
EP (1) EP1259550B1 (en)
JP (2) JP3880041B2 (en)
KR (1) KR100716524B1 (en)
CN (1) CN1188428C (en)
AR (1) AR026605A1 (en)
AT (1) ATE288450T1 (en)
AU (1) AU776536B2 (en)
BE (1) BE2008C047I2 (en)
BR (1) BRPI0015947B8 (en)
CA (1) CA2390463C (en)
CO (1) CO5251450A1 (en)
CY (1) CY2008018I1 (en)
CZ (1) CZ298206B6 (en)
DE (2) DE60017947T2 (en)
DK (1) DK1259550T3 (en)
ES (1) ES2237496T3 (en)
FR (1) FR08C0052I2 (en)
HU (1) HU227451B1 (en)
IL (1) IL149423A0 (en)
LU (1) LU91501I2 (en)
MX (1) MXPA02004940A (en)
NL (1) NL300356I2 (en)
NO (2) NO328790B1 (en)
NZ (1) NZ518752A (en)
PE (1) PE20010902A1 (en)
PL (1) PL203012B1 (en)
PT (1) PT1259550E (en)
RU (1) RU2260013C2 (en)
SK (1) SK286282B6 (en)
TW (1) TWI242015B (en)
WO (1) WO2001040316A1 (en)
ZA (1) ZA200203538B (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6744471B1 (en) * 1997-12-05 2004-06-01 Olympus Optical Co., Ltd Electronic camera that synthesizes two images taken under different exposures
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
DE60122764T2 (en) * 2000-11-02 2007-10-11 N.V. Organon USE OF CORTISOL SEQUESTRIAL AGENTS FOR THE TREATMENT OF HYPERCORTISOLAEMY-RELATED DISEASES
AU2004285032A1 (en) 2003-10-31 2005-05-12 The University Of Kansas Sulfoalkyl ether-alkyl ether cyclodextrin derivatives
JP2007538112A (en) 2004-01-29 2007-12-27 ピナクル ファーマシューティカルズ β-cyclodextrin derivatives and their use against anthrax lethal toxin
KR101725225B1 (en) 2004-04-23 2017-04-12 사이덱스 파마슈티칼스, 인크. DPI formulation containing sulfoalkyl ether cyclodextrin
WO2006083678A2 (en) 2005-01-28 2006-08-10 Pinnacle Pharmaceuticals, Inc. β-CYCLODEXTRIN DERIVATIVES AS ANTIBACTERIAL AGENTS
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
HUE035181T2 (en) 2005-10-26 2018-05-02 Cydex Pharmaceuticals Inc Sulphoalkyl ether cyclodextrin compositions and methods for their preparation
US20090069412A1 (en) * 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched sugammadex
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
US7938283B2 (en) * 2008-06-20 2011-05-10 Grainpro, Inc. System and method for hermetic storage of agricultural commodities during shipping
WO2010053487A1 (en) 2008-11-07 2010-05-14 Cydex Pharmaceuticals, Inc. Composition containing sulfoalkyl ether cyclodextrin and latanoprost
CN101591402B (en) * 2009-05-05 2011-11-30 杭州奥默医药技术有限公司 6-deoxy-sulfones cyclodextrin derivatives and preparation method thereof
US8492538B1 (en) 2009-06-04 2013-07-23 Jose R. Matos Cyclodextrin derivative salts
DE102010012281A1 (en) 2010-03-22 2011-09-22 Fresenius Medical Care Deutschland Gmbh Pharmaceutical compositions containing substituted 6-deoxy-6-sulfanylcyclodextrin
CN101864003B (en) * 2010-06-11 2012-05-02 漆又毛 A kind of synthetic method of 6-deoxythioether amino acid cyclodextrin derivative
ES2551585T3 (en) 2010-08-25 2015-11-20 Davuluri, Ramamohan Rao Improved procedure for the preparation of Sugammadex
CN102060941B (en) 2010-11-26 2012-12-26 漆又毛 6-deoxy alpha-amino acid derivative cyclodextrin, preparation and application thereof
PT3702374T (en) 2012-02-15 2022-06-23 Cydex Pharmaceuticals Inc Manufacturing process for cyclodextrin derivatives
MX390762B (en) 2012-02-28 2025-03-19 Cydex Pharmaceuticals Inc Compositions of alkylated cyclodextrin and processes for preparing and using the same
JP5892847B2 (en) * 2012-04-27 2016-03-23 Dowaホールディングス株式会社 Composite material of cyclodextrin and silica-containing substance, method for producing the same, and gas adsorbent
GB201211153D0 (en) * 2012-06-22 2012-08-08 Farmhispania Pharmaceutical compositions
SG11201503089WA (en) 2012-10-22 2015-05-28 Cydex Pharmaceuticals Inc Alkylated cyclodextrin compositions and processes for preparing and using the same
EP2956486B1 (en) 2013-02-14 2020-09-30 Neuland Laboratories Ltd An improved process for preparation of sugammadex sodium
WO2015179963A1 (en) 2014-05-29 2015-12-03 Uti Limited Partnership Cyclodextrin-based polyanionic and non-ionic dendrimers
US10869876B2 (en) 2014-06-26 2020-12-22 Maruishi Pharmaceutical Co., Ltd. Rocuronium preparation with improved stability
EP3183295B1 (en) 2014-08-22 2023-08-02 CyDex Pharmaceuticals, Inc. Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same
CN105348412B (en) * 2014-08-22 2018-06-05 江苏恩华药业股份有限公司 A kind of purification process for the more glucose sodium that relaxes
JP6971963B2 (en) 2015-03-19 2021-11-24 サイデックス・ファーマシューティカルズ・インコーポレイテッド Compositions containing silymarin and sulfoalkyl ether cyclodextrins and methods of using them
CN104844732B (en) * 2015-03-27 2017-05-03 山东滨州智源生物科技有限公司 Preparation method for sugammadex sodium
US20180296679A1 (en) * 2015-04-08 2018-10-18 Chang-Chun Ling Pharmaceutical compositions of polyanionic and non-ionic cyclodextrin-based dendrimers and uses thereof
JP6946275B2 (en) * 2015-05-29 2021-10-06 ラクシュミ・プラサド・アラパルティLakshmi Prasad ALAPARTHI Manufacturing method of Sugamadex and its intermediates
CN104922693A (en) * 2015-06-19 2015-09-23 南开大学 Anionic-type cyclodextrin and anti-cancer drug clathrate compound and preparation method
WO2017059547A1 (en) * 2015-10-07 2017-04-13 Uti Limited Partnership Multifunctional polyanionic cyclodextrin dendrimers
US10414830B2 (en) 2015-11-25 2019-09-17 Fresenius Kabi Ipsum S.R.L. Crystalline forms of per-chloro-γ-cyclodextrines
US10414829B2 (en) 2015-11-25 2019-09-17 Fresenius Kabi Ipsum S.R.L. Process for the preparation of sugammadex and its intermediates
ES2810980T3 (en) 2016-03-22 2021-03-10 Fresenius Kabi Ipsum S R L An improved process for the preparation of sugammadex
EP3448395B1 (en) * 2016-04-29 2020-04-22 Alveron Pharma B.V. Cyclodextrins as procoagulants
EP3474865B1 (en) 2016-06-23 2022-03-02 Synthon BV Process for making sugammadex
EP3421503B1 (en) * 2016-06-29 2020-05-20 Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. Sugammadex preparation and purification method
US10526422B2 (en) 2016-06-29 2020-01-07 Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. Process for preparation and purification of Sugammades sodium
CN107778383B (en) 2016-08-24 2020-03-10 王炳永 Refining method of sugammadex sodium
US10385142B2 (en) 2017-01-23 2019-08-20 Scinopharm Taiwan, Ltd. Method for preparing sugammadex sodium
AU2018263924B2 (en) 2017-05-03 2024-07-04 Cydex Pharmaceuticals, Inc. Composition containing cyclodextrin and busulfan
CN109021148B (en) * 2017-06-08 2020-11-10 天津科伦药物研究有限公司 Method for preparing sugammadex sodium
US10442871B2 (en) * 2017-06-22 2019-10-15 Lawrence Livermore National Security, Llc Modified cyclodextrins for the selective sequestration of fentanyl related compounds and uses thereof
EP3421504B1 (en) 2017-06-30 2019-09-18 Synthon B.V. Process for making sugammadex
TWI703163B (en) * 2017-08-23 2020-09-01 台耀化學股份有限公司 Method for preparing sugammadex sodium and crystalline form thereof
US10233263B1 (en) * 2017-08-23 2019-03-19 Formosa Laboratories, Inc. Method for preparation of sugammadex sodium
EP3717521B1 (en) 2017-11-27 2023-04-05 Medichem, S.A. Process for the synthesis of a cyclodextrin derivative
CN107892727B (en) * 2017-11-27 2019-12-24 合肥博思科创医药科技有限公司 Method for purifying sugammadex sodium
EP4047047A1 (en) 2018-04-06 2022-08-24 Synthon B.V. Purification of sugammadex
KR102054228B1 (en) 2018-05-28 2019-12-10 연성정밀화학(주) Process for Preparing Sugammadex Sodium
AU2019281969B2 (en) 2018-06-07 2024-03-07 Merck Sharp & Dohme Llc Processes for the preparation of sugammadex
CN110615860A (en) * 2018-06-20 2019-12-27 江苏恒瑞医药股份有限公司 Method for purifying sugammadex sodium
EP3830184B1 (en) * 2018-08-02 2025-04-30 TAPI Croatia Industries Ltd Solid state forms of sugammadex sodium
US11845811B2 (en) 2018-09-20 2023-12-19 Natco Pharma Limited Process for the preparation of Sugammadex sodium and its novel polymorphic form
EP3856791A1 (en) * 2018-09-27 2021-08-04 Werthenstein Biopharma GmbH Novel crystalline forms of sugammadex
JP6950966B2 (en) * 2018-11-01 2021-10-13 丸石製薬株式会社 Sugamadex or its pharmacologically acceptable salt-containing liquid and its production method
CN109824800A (en) * 2018-12-29 2019-05-31 鼎元(天津)生物医药科技有限公司 A kind of preparation method of the easypro more glucose sodium of selectivity flesh pine antagonistic
CN109438591B (en) * 2018-12-29 2021-02-09 博瑞生物医药(苏州)股份有限公司 Preparation process of sugammadex sodium
WO2020201930A1 (en) 2019-03-29 2020-10-08 Hospira, Inc. An improved process for preparation of sugammadex acid and sugammadex sodium
CN111978435B (en) 2019-05-22 2021-05-25 合肥博思科创医药科技有限公司 Preparation method of high-purity sugammadex sodium
US11324692B2 (en) 2019-07-03 2022-05-10 Galenicum Health S.L.U. Method to prepare pharmaceutical compositions of suggamadex
EP4023292A4 (en) 2019-08-30 2023-09-06 TERUMO Kabushiki Kaisha INJECTION FORMULATION
RU2724900C1 (en) * 2019-10-24 2020-06-26 Маруиси Фармасьютикал Ко., Лтд. Rocuronium preparation with improved stability
CN111019016B (en) * 2019-12-27 2022-02-18 武汉嘉诺康医药技术有限公司 Synthesis method of sugammadex impurity
EP4110832A1 (en) 2020-02-28 2023-01-04 Medichem, S.A. Method for drying sugammadex
CN111714459B (en) * 2020-06-18 2022-06-14 广州瑞尔医药科技有限公司 Shugeng sodium gluconate powder injection and preparation method thereof
US11097023B1 (en) 2020-07-02 2021-08-24 Par Pharmaceutical, Inc. Pre-filled syringe containing sugammadex
EP3932391A1 (en) 2020-07-03 2022-01-05 Galenicum Health S.L.U. Method to prepare pharmaceutical compositions
US11446325B2 (en) * 2020-09-30 2022-09-20 Cyclolab Cyclodextrin Research And Development Laboratory Ltd. Cyclodextrin derivatives in the treatment or prevention of lysosomal neurodegenerative diseases
US11945788B2 (en) 2021-06-07 2024-04-02 Nuray Chemicals Private Limited Process for preparing pitolisant hydrochloride and solid-state forms thereof
CN113637097A (en) * 2021-08-10 2021-11-12 北京恒创星远医药科技有限公司 6-full-deoxidation-6-full-iodo-gamma-cyclodextrin crystal and preparation method and application thereof
CN115708777A (en) * 2021-08-19 2023-02-24 北京费森尤斯卡比医药有限公司 Packaged pharmaceutical product comprising mercaptocyclodextrin derivative or pharmaceutically acceptable salt thereof and method of preservation
CN119679816A (en) * 2023-09-15 2025-03-25 杭州奥默医药股份有限公司 A muscle relaxant antagonist for reversing benzylisoquinoline muscle relaxants
EP4656660A1 (en) * 2024-05-31 2025-12-03 Universidad de Almeria Alfa-, beta-, and gamma- cyclodextrin derivatives decorated with (2-mercaptoethyl)phosphonic acid branches, synthesis and applications

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929813A (en) * 1973-12-26 1975-12-30 Interx Research Corp Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and process for preparing same
JPS52108027A (en) 1976-03-09 1977-09-10 Rikagaku Kenkyusho Anticarcinogen
US4816462A (en) 1982-05-18 1989-03-28 Nowicky Wassili Method for diagnosing and for the therapeutic treatment of tumors and/or infectious diseases of different types with alkaloid-compounds
HU194858B (en) 1982-12-03 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
IT1196033B (en) 1984-02-22 1988-11-10 Chiesi Farma Spa COMPOUND WITH ANTI-INFLAMMATORY ACTIVITY OBTAINED BY COMPLEXATION WITH BETA-CYCLODEXTRINE AND RELATED PHARMACEUTICAL FORMULATIONS
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
GB8613688D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPH0819004B2 (en) 1986-12-26 1996-02-28 日清製粉株式会社 Sustained-release pharmaceutical preparation
HU201783B (en) 1987-10-13 1990-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing partially methylized carboxy-acyl-beta-cyclodextrines and salts
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5017566A (en) 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
KR0163440B1 (en) 1989-04-03 1998-11-16 디르크 반테 Regioselective substitutions in cyclodextrins
US5173481A (en) 1989-04-03 1992-12-22 The United States Of America As Represented By The Department Of Health And Human Services Preparation of specifically substituted cyclodextrins
SU1703657A1 (en) * 1990-01-23 1992-01-07 Пятигорский фармацевтический институт Compound of nicotinic acid diethylamide and @-cyclodextrin association, showing prolonging analeptic action
DK0447171T3 (en) 1990-03-15 1994-12-12 Tanabe Seiyaku Co Polysulfate of cyclodextrin derivative and process for its preparation
US5180716A (en) * 1990-08-01 1993-01-19 The Regents Of The University Of California Cyclodextrin complexes for neuraxial administration of drugs
US5180176A (en) * 1991-08-08 1993-01-19 Far Great Plastics Industrial Co., Ltd. Elastic truck for roller skates
JP2556236B2 (en) 1991-08-29 1996-11-20 田辺製薬株式会社 Polysulfate of β-cyclodextrin derivative and process for producing the same
US5840881A (en) 1992-11-27 1998-11-24 Takeda Chemical Industries, Ltd. Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility
US5767112A (en) 1994-10-21 1998-06-16 Poli Industria Chimica, S.P.A. Muscle relaxant pharmaceutical compositions
AU708107B2 (en) 1994-11-04 1999-07-29 Commonwealth Scientific And Industrial Research Organisation Method for treating animals
GB2307176A (en) * 1995-11-15 1997-05-21 Todd Selwyn Everest Anti-inflammatory clathrating agents for topical use
US5935941A (en) 1997-10-24 1999-08-10 Pitha; Josef Alkylations of cyclodextrins leading to derivatives which have a ridgidly extended cavity
US5834446A (en) * 1996-06-21 1998-11-10 Queen's University At Kingston Nerve process growth modulators
JP4249282B2 (en) 1998-02-27 2009-04-02 日本食品化工株式会社 Novel cyclodextrin derivative and process for producing the same
CA2330681C (en) 1998-05-29 2008-08-26 Andrea Giuffrida Control of pain with endogenous cannabinoids
US7265099B1 (en) * 1999-08-13 2007-09-04 Organon N.V. Use of chemical chelators as reversal agents for drug-induced neuromuscular block
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
US20020111377A1 (en) 2000-12-22 2002-08-15 Albany College Of Pharmacy Transdermal delivery of cannabinoids
US7026304B2 (en) 2001-02-14 2006-04-11 Akzo Nobel N.V. 2-alkylated-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
TW200402417A (en) 2002-06-21 2004-02-16 Akzo Nobel Nv 1-[(Indol-3-yl)carbonyl]piperazine derivatives

Also Published As

Publication number Publication date
DE60017947T2 (en) 2005-06-23
PT1259550E (en) 2005-05-31
PL356097A1 (en) 2004-06-14
CA2390463C (en) 2009-02-03
FR08C0052I1 (en) 2009-02-27
BRPI0015947B1 (en) 2012-02-07
SK7262002A3 (en) 2002-11-06
PL203012B1 (en) 2009-08-31
CA2390463A1 (en) 2001-06-07
BRPI0015947A (en) 2002-08-20
SK286282B6 (en) 2008-06-06
NZ518752A (en) 2003-03-28
CY2008018I2 (en) 2009-11-04
USRE44733E1 (en) 2014-01-28
NO328790B1 (en) 2010-05-18
US20040029833A1 (en) 2004-02-12
HK1049489A1 (en) 2003-05-16
JP2003515623A (en) 2003-05-07
DK1259550T3 (en) 2005-04-25
LU91501I2 (en) 2009-01-26
DE60017947D1 (en) 2005-03-10
KR20020063900A (en) 2002-08-05
NL300356I1 (en) 2008-10-01
WO2001040316A1 (en) 2001-06-07
NO2010019I1 (en) 2010-11-22
EP1259550A1 (en) 2002-11-27
NO20022522L (en) 2002-05-28
ES2237496T3 (en) 2005-08-01
RU2260013C2 (en) 2005-09-10
US6949527B2 (en) 2005-09-27
NL300356I2 (en) 2009-04-01
DE122008000068I1 (en) 2009-04-23
JP2006348301A (en) 2006-12-28
BE2008C047I2 (en) 2019-12-11
KR100716524B1 (en) 2007-05-10
MXPA02004940A (en) 2003-05-23
AU776536B2 (en) 2004-09-16
AU5438001A (en) 2001-06-12
CZ20021814A3 (en) 2002-08-14
BRPI0015947B8 (en) 2021-07-06
CZ298206B6 (en) 2007-07-18
NO2010019I2 (en) 2012-08-27
DE122008000068I2 (en) 2011-06-16
ATE288450T1 (en) 2005-02-15
NO20022522D0 (en) 2002-05-28
IL149423A0 (en) 2002-11-10
JP3880041B2 (en) 2007-02-14
CO5251450A1 (en) 2003-02-28
CN1402737A (en) 2003-03-12
HUP0203755A3 (en) 2003-10-28
EP1259550B1 (en) 2005-02-02
US6670340B1 (en) 2003-12-30
CN1188428C (en) 2005-02-09
TWI242015B (en) 2005-10-21
LU91501I9 (en) 2019-01-02
ZA200203538B (en) 2003-08-04
HU227451B1 (en) 2011-06-28
HUP0203755A2 (en) 2003-04-28
PE20010902A1 (en) 2001-09-06
JP4563972B2 (en) 2010-10-20
AR026605A1 (en) 2003-02-19
CY2008018I1 (en) 2009-11-04

Similar Documents

Publication Publication Date Title
FR08C0052I2 (en) 6-MERCAPTO-CYCLODEXTRIN DERIVATIVES: AGENTS FOR REVERSING NEUROMUSCULAR BLOCKAGE CAUSED BY DRUG SUBSTANCES
FR15C0086I2 (en) HYDROXAMATE DERIVATIVES AS DESACETYLASE INHIBITORS
FR15C0096I2 (en) N-SUBSTITUTED CARBAMOYLOXYALKYL-AZOLIUM DERIVATIVES
MA26816A1 (en) AMINO-TRIAZOLOPYRIDINE DERIVATIVES
NO20004392L (en) Product for personal hygiene with improved scent
MA25433A1 (en) ARYLMETHYL-CARBONYLAMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS
NL300385I1 (en) Synergistic combinations including a renin inhibitor for cardiovascular diseases.
PT1163237E (en) AMIDA DERIVATIVES
EE200000574A (en) Pharmaceutical compounds for displaying angiogenic disorders
MA26548A1 (en) TOPICAL PHARMACEUTICAL COMPOSITIONS CONTAINING RESORCINOL DERIVATIVES.
NL1014545A1 (en) Oxim derivatives and their use as latent acids.
ATE293618T1 (en) 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTI-TUMOR AGENTS
MA26831A1 (en) BENZODIAZEPINE DERIVATIVES. "
MA26848A1 (en) NEW HETEROCYCLO-ALKYLSUFONYLPYRAZOLE DERIVATIVES AS ANTI-INFLAMMATORY / ANALGESIC AGENTS.
DK1226131T3 (en) Isoxazole carboxamide derivatives
CY1109334T1 (en) N-alkoxyalkyl, N-dialkylamine derivatives or salts thereof and drugs for neuro-depressant diseases. Contents thereof
EP1167375A4 (en) ERYTHROMYCIN DERIVATIVES
PT1153014E (en) BETA-ALANINE DERIVATIVES
EE200100445A (en) Smoked product
FR2792529B1 (en) NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING 2-ISOXAZOLE-8-AMINOTETRALINE DERIVATIVES
GB0026578D0 (en) Heterocyclic derivatives useful as pharmaceutical agents
FR2802207B1 (en) ISOSORBIDE DERIVATIVES FOR USE IN DETERGENT COMPOSITIONS FOR PETROL-TYPE FUELS
ITMI20001848A0 (en) DRUGS FOR INCONTINENCE.
MA25653A1 (en) DERIVATIVES OF HETEROCYCLIC AMIDES.
FR2800360B1 (en) EXTEMPORANE MIXTURE DISPENSER