[go: up one dir, main page]

FR06C0010I1 - - Google Patents

Info

Publication number
FR06C0010I1
FR06C0010I1 FR06C0010C FR06C0010I1 FR 06C0010 I1 FR06C0010 I1 FR 06C0010I1 FR 06C0010 C FR06C0010 C FR 06C0010C FR 06C0010 I1 FR06C0010 I1 FR 06C0010I1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
Other languages
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23636708&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR06C0010(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of FR06C0010I1 publication Critical patent/FR06C0010I1/fr
Application granted granted Critical
Publication of FR06C0010I2 publication Critical patent/FR06C0010I2/fr
Active legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR06C0010C 1995-03-30 2006-03-15 Active FR06C0010I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41330095A 1995-03-30 1995-03-30
PCT/IB1995/000436 WO1996030347A1 (en) 1995-03-30 1995-06-06 Quinazoline derivatives

Publications (2)

Publication Number Publication Date
FR06C0010I1 true FR06C0010I1 (en) 2006-05-19
FR06C0010I2 FR06C0010I2 (en) 2006-12-29

Family

ID=23636708

Family Applications (1)

Application Number Title Priority Date Filing Date
FR06C0010C Active FR06C0010I2 (en) 1995-03-30 2006-03-15

Country Status (43)

Country Link
EP (5) EP0817775B1 (en)
JP (1) JP3088018B2 (en)
KR (1) KR100232335B1 (en)
CN (1) CN1066142C (en)
AP (1) AP735A (en)
AR (1) AR002723A1 (en)
AT (2) ATE205483T1 (en)
AU (2) AU703638B2 (en)
BR (1) BR9601200B1 (en)
CA (1) CA2216796C (en)
CO (1) CO4410333A1 (en)
CZ (2) CZ294967B6 (en)
DE (3) DE69522717T2 (en)
DK (1) DK0817775T3 (en)
EG (1) EG24229A (en)
ES (2) ES2332984T3 (en)
FI (1) FI120646B (en)
FR (1) FR06C0010I2 (en)
GR (1) GR3037070T3 (en)
HR (1) HRP960147B1 (en)
HU (2) HU229120B1 (en)
IL (7) IL129995A (en)
LU (1) LU91209I2 (en)
MA (1) MA23831A1 (en)
MX (1) MX9707453A (en)
MY (1) MY117896A (en)
NL (1) NL300214I2 (en)
NO (2) NO308740B1 (en)
NZ (1) NZ286263A (en)
OA (1) OA10277A (en)
PE (1) PE43897A1 (en)
PL (1) PL186843B1 (en)
PT (1) PT817775E (en)
RU (2) RU2694252C3 (en)
SA (1) SA96160707B1 (en)
SG (1) SG43262A1 (en)
SI (1) SI9600102A (en)
SK (2) SK283763B6 (en)
TR (1) TR199600265A1 (en)
TW (1) TW454000B (en)
UA (1) UA44254C2 (en)
WO (1) WO1996030347A1 (en)
ZA (1) ZA962522B (en)

Families Citing this family (559)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811779B2 (en) 1994-02-10 2004-11-02 Imclone Systems Incorporated Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy
TW321649B (en) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
WO1996033977A1 (en) * 1995-04-27 1996-10-31 Zeneca Limited Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (en) 1996-02-13 1999-07-27 Zeneca Ltd Quinazoline derivative process for the preparation of the same pharmaceutical composition and process for the production of an antiangiogenic effect and / or reduction of vascular permeability in a warm-blooded animal
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
AU719327B2 (en) 1996-03-05 2000-05-04 Astrazeneca Ab 4-anilinoquinazoline derivatives
NZ332119A (en) 1996-04-12 2001-08-31 Warner Lambert Co Quinazoline compounds which are irreversible inhibitors of tyrosine kinases
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
BR9709959A (en) * 1996-06-24 2000-05-09 Pfizer Tricyclic derivatives of substituted phenylamino for the treatment of hyperproliferative diseases
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
US6225318B1 (en) 1996-10-17 2001-05-01 Pfizer Inc 4-aminoquinazolone derivatives
EP0837063A1 (en) * 1996-10-17 1998-04-22 Pfizer Inc. 4-Aminoquinazoline derivatives
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6090096A (en) 1997-04-23 2000-07-18 Heartport, Inc. Antegrade cardioplegia catheter and method
DE19743435A1 (en) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidine derivatives
MEP42008A (en) * 1998-04-29 2011-02-10 Osi Farmaceuticals Inc N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
US6706721B1 (en) 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
US6384223B1 (en) 1998-07-30 2002-05-07 American Home Products Corporation Substituted quinazoline derivatives
EE200100097A (en) 1998-08-18 2002-06-17 The Regents Of The University Of California Inhibition of airway mucus production by administration of EGF-R antagonists
JP3270834B2 (en) 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク Heteroaromatic bicyclic derivatives useful as anticancer agents
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
RS49836B (en) * 1999-03-31 2008-08-07 Pfizer Products Inc., PROCEDURES AND INTERMEDIATES FOR OBTAINING ANTI-CANCIN UNITS
MXPA01012899A (en) 1999-06-21 2002-07-30 Boehringer Ingelheim Pharma Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof.
WO2001004111A1 (en) * 1999-07-09 2001-01-18 Glaxo Group Limited Anilinoquinazolines as protein tyrosine kinase inhibitors
US6933299B1 (en) 1999-07-09 2005-08-23 Smithkline Beecham Corporation Anilinoquinazolines as protein tyrosine kinase inhibitors
GB9922173D0 (en) 1999-09-21 1999-11-17 Zeneca Ltd Chemical compounds
CN1391561A (en) * 1999-09-21 2003-01-15 阿斯特拉曾尼卡有限公司 Quinazoline compounds and pharmaceutical compositions containing them
GB9925958D0 (en) 1999-11-02 1999-12-29 Bundred Nigel J Therapeutic use
PL203782B1 (en) 1999-11-05 2009-11-30 Astrazeneca Ab Quinazoline derivatives as vegf inhibitors
UA74803C2 (en) * 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. A stable polymorph of n-(3-ethynylphenyl)-6,7-bis(2-methoxyetoxy)-4-quinazolinamine hydrochloride, a method for producing thereof (variants) and pharmaceutical use
US7087613B2 (en) 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
CA2403365A1 (en) 2000-04-07 2001-10-18 Astrazeneca Ab Quinazoline compounds
UA73993C2 (en) 2000-06-06 2005-10-17 Астразенека Аб Quinazoline derivatives for the treatment of tumours and a pharmaceutical composition
EP1170011A1 (en) * 2000-07-06 2002-01-09 Boehringer Ingelheim International GmbH Novel use of inhibitors of the epidermal growth factor receptor
MXPA03001332A (en) 2000-08-21 2004-07-08 Astrazeneca Ab Quinazoline derivatives.
EP1415987B1 (en) 2000-10-20 2007-02-28 Eisai R&D Management Co., Ltd. Nitrogenous aromatic ring compounds as anti cancer agents
US7776315B2 (en) 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
DE60144284D1 (en) 2000-11-01 2011-05-05 Millennium Pharm Inc NITROGENIC HETEROCYCLIC COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
EP1363627A2 (en) 2001-02-19 2003-11-26 Novartis AG Treatment of solid tumours with rapamycin derivatives
JP2002293773A (en) * 2001-03-30 2002-10-09 Sumika Fine Chemicals Co Ltd Method for producing quinazoline derivative
RU2332415C2 (en) * 2001-04-27 2008-08-27 Вертекс Фармасьютикалз Инкорпорейтед Pyrazole derivatives, useful as inhibitors of protein kinase
WO2003000194A2 (en) 2001-06-21 2003-01-03 Pfizer Inc. Thienopyridine and thienopyrimidine anticancer agents
AU2002350105A1 (en) 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel quinazolines and uses thereof
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
WO2003074529A2 (en) 2002-03-01 2003-09-12 Pfizer Inc. iNDOLYL-UREA DERIVATIVES OF THIENOPYRIDINES USEFUL AS ANTI-ANGIOGENIC AGENTS
US7078409B2 (en) 2002-03-28 2006-07-18 Beta Pharma, Inc. Fused quinazoline derivatives useful as tyrosine kinase inhibitors
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
DE10221018A1 (en) 2002-05-11 2003-11-27 Boehringer Ingelheim Pharma Use of inhibitors of EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH) / prostatic hypertrophy
AU2003240655B2 (en) 2002-05-16 2007-09-06 Novartis Ag Use of EDG receptor binding agents in cancer
UA77303C2 (en) 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
ES2376165T3 (en) 2002-07-15 2012-03-09 F. Hoffmann-La Roche Ag TREATMENT OF THE C�? NCER WITH THE ANTIBODY DIRECTED AGAINST ERBB2 RHUMAB 2C4.
EP3321282A1 (en) 2002-09-27 2018-05-16 Xencor, Inc. Optimized fc variants and methods for their generation
US7488823B2 (en) 2003-11-10 2009-02-10 Array Biopharma, Inc. Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
WO2004046101A2 (en) 2002-11-20 2004-06-03 Array Biopharma, Inc. Cyanoguanidines and cyanoamidines as erbb2 and egfr inhibitors
US20060167026A1 (en) * 2003-01-06 2006-07-27 Hiroyuki Nawa Antipsychotic molecular-targeting epithelial growth factor receptor
GB0302882D0 (en) * 2003-02-07 2003-03-12 Univ Cardiff Improvements in or relating to agents for the treatment of cardiovascular dysfunction and weight loss
US7148231B2 (en) * 2003-02-17 2006-12-12 Hoffmann-La Roche Inc. [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
US7223749B2 (en) 2003-02-20 2007-05-29 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
PA8595001A1 (en) 2003-03-04 2004-09-28 Pfizer Prod Inc NEW CONDENSED HETEROAROMATIC COMPOUNDS THAT ARE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF)
ATE508747T1 (en) 2003-03-10 2011-05-15 Eisai R&D Man Co Ltd C-KIT KINASE INHIBITORS
CA2522522A1 (en) * 2003-04-16 2004-10-28 F. Hoffmann-La Roche Ag Quinazoline compounds
GB0309850D0 (en) 2003-04-30 2003-06-04 Astrazeneca Ab Quinazoline derivatives
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
EP2644195A1 (en) 2003-05-19 2013-10-02 Irm Llc Immunosuppressant Compounds and Compositions
JP4724657B2 (en) 2003-05-30 2011-07-13 アストラゼネカ ユーケー リミテッド process
WO2005001053A2 (en) 2003-06-09 2005-01-06 Samuel Waksal Method of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular antagonist
PL1680426T3 (en) 2003-06-10 2008-02-29 Hoffmann La Roche 1.3.4-triaza-phenalene and 1,3,4,6-tetraazaphenalene derivatives
CN1984660B (en) 2003-07-03 2010-12-15 美瑞德生物工程公司 4-Arylamino-quinazolines as caspase-specific activators and inducers of apoptosis
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
GB0317665D0 (en) 2003-07-29 2003-09-03 Astrazeneca Ab Qinazoline derivatives
WO2005016346A1 (en) * 2003-08-14 2005-02-24 Array Biopharma Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
SG135193A1 (en) * 2003-08-18 2007-09-28 Pfizer Prod Inc Dosing schedule for erbb2 anticancer agents
CA2536321A1 (en) 2003-08-29 2005-03-10 Pfizer Inc. Thienopyridine-phenylacet amides and their derivatives useful as new anti-angiogenic agents
ES2305844T3 (en) 2003-09-16 2008-11-01 Astrazeneca Ab DERIVATIVES OF QUINAZOLINE AS INHIBITORS OF THYROSINE KINASE.
GB0322409D0 (en) 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
DE10349113A1 (en) 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Process for the preparation of aminocrotonyl compounds
NZ547633A (en) 2003-11-06 2010-08-27 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
WO2005044788A1 (en) 2003-11-11 2005-05-19 Eisai Co., Ltd. Urea derivative and process for producing the same
GB0326459D0 (en) 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
BRPI0418102A (en) 2003-12-23 2007-04-27 Pfizer quinoline derivatives
ES2315834T3 (en) 2004-02-03 2009-04-01 Astrazeneca Ab DERIVATIVES OF QUINAZOLINA.
JP4934432B2 (en) 2004-02-19 2012-05-16 レクサン ファーマシューティカルズ インコーポレイテッド Quinazoline derivatives and therapeutic use of quinazoline derivatives
JP4734319B2 (en) 2004-03-19 2011-07-27 イムクローン・リミテッド・ライアビリティ・カンパニー Human anti-epidermal growth factor receptor antibody
ES2741546T3 (en) 2004-03-31 2020-02-11 Massachusetts Gen Hospital Method to determine the response of cancer to treatments directed at the epidermal growth factor receptor
BRPI0509721A (en) 2004-04-07 2007-09-25 Novartis Ag iap inhibitors
BRPI0510717B8 (en) 2004-05-06 2021-05-25 Bioresponse Llc use of 3,3'-diindolylmethane (dim) or 2-(indol-3-ylmethyl)-3,3'-diindolylmethane (ltr)
AU2005249490B2 (en) 2004-06-01 2010-07-29 Genentech, Inc. Antibody drug conjugates and methods
EP1765313A2 (en) 2004-06-24 2007-03-28 Novartis Vaccines and Diagnostics, Inc. Compounds for immunopotentiation
SI2471813T1 (en) 2004-07-15 2015-03-31 Xencor, Inc. Optimized Fc variants
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
AU2005283422C1 (en) 2004-09-17 2017-02-02 Eisai R & D Management Co., Ltd. Medicinal composition
KR101270829B1 (en) 2004-09-23 2013-06-07 제넨테크, 인크. Cystein engineered antibodies and conjugates
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
AU2005304624B2 (en) 2004-11-12 2010-10-07 Xencor, Inc. Fc variants with altered binding to FcRn
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
DE602005026865D1 (en) 2004-12-14 2011-04-21 Astrazeneca Ab PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUM-MEANS
PE20060777A1 (en) 2004-12-24 2006-10-06 Boehringer Ingelheim Int INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
ATE497762T1 (en) 2004-12-30 2011-02-15 Bioresponse Llc USE OF DIINDOLYLMETHANE-RELATED INDOLES FOR THE TREATMENT AND PREVENTION OF DISEASES RELATED TO THE RESPIRATORY SYNCYTIAL VIRUS
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US7625911B2 (en) 2005-01-12 2009-12-01 Mai De Ltd. Amorphous form of erlotinib hydrochloride and its solid amorphous dispersion
BRPI0518104B8 (en) 2005-01-21 2021-05-25 Genentech Inc industrialized article and use of her2 antibody
CN101146532B (en) 2005-01-21 2012-05-09 阿斯泰克斯治疗有限公司 Pharmaceutical compounds
GB0501999D0 (en) * 2005-02-01 2005-03-09 Sentinel Oncology Ltd Pharmaceutical compounds
RU2404806C2 (en) 2005-02-23 2010-11-27 Дженентек, Инк. Extension of time to progression of disease or lifetime of oncologic patients with application of her dimerisation inhibitors
KR100910333B1 (en) * 2005-02-23 2009-07-31 시오노기세이야쿠가부시키가이샤 Quinazoline derivative having tyrosine kinase inhibitory activity
JP5054544B2 (en) 2005-02-26 2012-10-24 アストラゼネカ アクチボラグ Quinazoline derivatives as tyrosine kinase inhibitors
CN101163468A (en) 2005-02-28 2008-04-16 卫材R&D管理有限公司 Novel combination of sulfonamide compounds
AU2006235487B2 (en) * 2005-04-12 2011-12-22 Elan Pharma International Limited Nanoparticulate quinazoline derivative formulations
CN1854130B (en) * 2005-04-15 2011-04-20 中国医学科学院药物研究所 Chinazoline derivative, its production, medicinal composition and use
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
CA2680945C (en) 2005-06-17 2014-03-18 Imclone Systems Incorporated Anti-pdgfralpha antibodies
EP2004695A2 (en) 2005-07-08 2008-12-24 Xencor, Inc. Optimized anti-ep-cam antibodies
EP2281901B1 (en) 2005-08-02 2013-11-27 Eisai R&D Management Co., Ltd. Anti-tumour pharmaceutical composition with angiogenesis inhibitors
US8129114B2 (en) 2005-08-24 2012-03-06 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
DE602006018331D1 (en) 2005-09-20 2010-12-30 Astrazeneca Ab 4- (1H-INDAZOL-5-YLAMINO) CHINAZOLINE COMPOUNDS AS INHIBITORS OF ERBB RECEPTORT ROSINKINASE FOR THE TREATMENT OF CANCER
WO2007041635A2 (en) 2005-10-03 2007-04-12 Xencor, Inc. Fc variants with optimized fc receptor binding properties
CA2627598C (en) 2005-11-07 2013-06-25 Eisai R & D Management Co., Ltd. Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
CA2833706C (en) 2005-11-11 2014-10-21 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
ES2481671T3 (en) 2005-11-21 2014-07-31 Novartis Ag MTOR inhibitors in the treatment of endocrine tumors
WO2007060691A2 (en) * 2005-11-23 2007-05-31 Natco Pharma Limited A novel process for the preparation of erlotinib
RU2384331C2 (en) * 2005-12-05 2010-03-20 Пфайзер Продактс Инк. Method of treating abnormal cell expansion
CN101003514A (en) 2006-01-20 2007-07-25 上海艾力斯医药科技有限公司 Derivative of quinazoline, preparation method and usage
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي PI-3 Kinase inhibitors and methods of their use
WO2007092453A2 (en) 2006-02-03 2007-08-16 Imclone Systems Incorporated Igf-ir antagonists as adjuvants for treatment of prostate cancer
GB0605120D0 (en) 2006-03-14 2006-04-26 Novartis Ag Organic Compounds
MX2008012715A (en) 2006-04-05 2008-10-14 Novartis Ag Combinations of therapeutic agents for treating cancer.
AU2007234382B2 (en) 2006-04-05 2011-06-09 Novartis Ag Combinations comprising BCR-ABL/C-KIT/PDGF-R TK inhibitors for treating cancer
AR060358A1 (en) 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic QUINAZOLINS FOR THE INHIBITION OF PDK 1
KR20080110912A (en) 2006-04-19 2008-12-19 노파르티스 아게 Inhibition method of indazole compound and CD7
MX2008014292A (en) 2006-05-09 2008-11-18 Novartis Ag Combination comprising an iron chelator and an anti-neoplastic agent and use thereof.
WO2007136103A1 (en) 2006-05-18 2007-11-29 Eisai R & D Management Co., Ltd. Antitumor agent for thyroid cancer
WO2007138613A2 (en) * 2006-05-25 2007-12-06 Vittal Mallya Scientific Research Foundation A process for synthesis of [6,7-bis-(2-methoxyethoxy)-quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride
WO2007138612A2 (en) * 2006-05-25 2007-12-06 Vittal Mallya Scientific Research Foundation A process for synthesis of [6,7-bis-(2-methoxyethoxy)-quinazolin-4- yl]-(3-ethynylphenyl)amine hydrochloride
CN101547910A (en) 2006-07-28 2009-09-30 合成纤维有限公司 Crystalline Erlotinib
US8524867B2 (en) 2006-08-14 2013-09-03 Xencor, Inc. Optimized antibodies that target CD19
WO2008026748A1 (en) 2006-08-28 2008-03-06 Eisai R & D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
ATE522625T1 (en) 2006-09-12 2011-09-15 Genentech Inc METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF LUNG CANCER USING PDGFRA, KIT OR KDG GENE AS GENETIC MARKERS
RU2492864C2 (en) 2006-09-18 2013-09-20 Бёрингер Ингельхайм Интернациональ Гмбх Method of treating cancer carrying egfr mutations
EP2081933B1 (en) 2006-09-29 2011-03-23 Novartis AG Pyrazolopyrimidines as pi3k lipid kinase inhibitors
KR101129868B1 (en) 2006-10-04 2012-04-12 화이자 프로덕츠 인코포레이티드 Pyrido[4,3-d]pyrimidin-43h-one derivatives as calcium receptor antagonists
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8372856B2 (en) * 2006-10-27 2013-02-12 Synthon Bv Hydrates of erlotinib hydrochloride
BRPI0717753B1 (en) 2006-10-27 2022-04-12 Bioresponse, Llc Use of a composition comprising 50-250 mg of one or more dim-related indoles and one or more anti-protozoal agents, and, composition
EP1921070A1 (en) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclic heterocycles, medicaments comprising them, their use and process for their preparation
US8343950B2 (en) * 2006-12-15 2013-01-01 Concert Pharmaceuticals, Inc. Quinazoline derivatives and methods of treatment
EP2116246A1 (en) 2007-01-19 2009-11-11 Eisai R&D Management Co., Ltd. Composition for treatment of pancreatic cancer
EP2119707B1 (en) 2007-01-29 2015-01-14 Eisai R&D Management Co., Ltd. Composition for treatment of undifferentiated-type of gastric cancer
US7998949B2 (en) 2007-02-06 2011-08-16 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
CN101245050A (en) 2007-02-14 2008-08-20 上海艾力斯医药科技有限公司 4-aniline quinazoline derivative salt
CA2677651A1 (en) 2007-02-15 2008-08-21 Novartis Ag Combinations of therapeutic agents for treating cancer
WO2008102369A1 (en) 2007-02-21 2008-08-28 Natco Pharma Limited Novel polymorphs of erlotinib hydrochloride and method of preparation
CA2677108A1 (en) 2007-03-02 2008-09-12 Genentech, Inc. Predicting response to a her inhibitor
KR20140069232A (en) 2007-04-04 2014-06-09 시플라 리미티드 Process for preparation of erlotinib and its pharmaceutically acceptable salts
DK2176298T3 (en) 2007-05-30 2018-02-12 Xencor Inc Methods and compositions for inhibiting CD32B-expressing cells
WO2008154249A2 (en) 2007-06-08 2008-12-18 Genentech, Inc. Gene expression markers of tumor resistance to her2 inhibitor treatment
MX2010000617A (en) 2007-07-17 2010-05-17 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor.
WO2009030224A2 (en) * 2007-09-07 2009-03-12 Schebo Biotech Ag Novel quinazoline compounds and the use thereof for treating cancerous diseases
CA2703767A1 (en) 2007-10-29 2009-05-07 Natco Pharma Limited Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents
CA2704000C (en) 2007-11-09 2016-12-13 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
CL2008003449A1 (en) 2007-11-21 2010-02-19 Imclone Llc Antibody or fragments thereof against the macrophage / rum stimulating protein receptor; pharmaceutical composition comprising it; use to inhibit angiogenesis, tumor growth, proliferation, migration and invasion of tumor cells, activation of rum or phosphorylation of mapk and / or akt; and use to treat cancer.
UY31545A1 (en) 2007-12-20 2009-08-03 NEW DERIVATIVES OF 2-CARBOXAMIDE CIANOAMINOUREA, ITS SALTS AND PHARMACEUTICALLY ACCEPTABLE PROFARMS, PREPARATION PROCESSES AND APPLICATIONS
DK2808343T3 (en) 2007-12-26 2019-08-19 Xencor Inc Fc variants with altered binding to FcRn
AU2008347940A1 (en) 2008-01-18 2009-07-23 Natco Pharma Limited 6,7-dialkoxy quinazoline derivatives useful for treatment of cancer related disorders
TWI472339B (en) 2008-01-30 2015-02-11 Genentech Inc Composition comprising antibody that binds to domain ii of her2 and acidic variants thereof
BRPI0907916A2 (en) 2008-02-07 2015-07-28 Boehringer Ingelheim Int Spirocycle heterocycles, medicaments containing such compounds, and processes for preparing them
US12492253B1 (en) 2008-02-25 2025-12-09 Xencor, Inc. Anti-human C5 antibodies
KR101673621B1 (en) 2008-03-24 2016-11-07 노파르티스 아게 Arylsulfonamide-based matrix metalloprotease inhibitors
CN101544609A (en) 2008-03-25 2009-09-30 上海艾力斯医药科技有限公司 Crystallization form of 4-anilinoquinazoline derivatives
ES2519474T3 (en) 2008-03-26 2014-11-07 Novartis Ag Hydroxamate-based deacetylase B inhibitors
US20090269354A1 (en) * 2008-03-28 2009-10-29 Concert Pharmaceuticals, Inc. Quinazoline derivatives and methods of treatment
WO2009138781A1 (en) 2008-05-13 2009-11-19 Astrazeneca Ab Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy}quinazoline
ES2430590T3 (en) 2008-05-14 2013-11-21 Genomic Health, Inc. Predictors of patient response to treatment with EGF receptor inhibitors
CN101584696A (en) 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 Composition containing quinazoline derivatives, preparation method and use
DE102008031039A1 (en) 2008-06-30 2009-12-31 Dömling, Alexander, Priv.-Doz. Dr. Use of N-phenylquinazolin-4-amine derivatives as receptor tyrosine kinase inhibitor for accompanying treatment of organ transplantations
US8648191B2 (en) 2008-08-08 2014-02-11 Boehringer Ingelheim International Gmbh Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
ES2704986T3 (en) 2008-10-16 2019-03-21 Celator Pharmaceuticals Inc Combinations of a water-soluble liposomal camptothecin with cetuximab or bevacizumab
MX2011004824A (en) 2008-11-07 2012-01-12 Triact Therapeutics Inc USE OF CATHOLIC BUTANE DERIVATIVES IN THERAPY AGAINST CANCER.
MX2011005002A (en) 2008-11-11 2011-05-25 Lilly Co Eli P70 s6 kinase inhibitor and egfr inhibitor combination therapy.
HRP20131106T1 (en) 2008-12-18 2013-12-20 Novartis Ag HEMIFUMARATE SALT OF 1- [4- [1- (4-CYCLOHEXYL-3-TRIFLUOROMETHYL-BENZYLOXYIMINO) -ETHYL] -2-ETHYL-BENZYL] -AZETIDINE-3-CARBOXYLIC ACIDS
CN102256941A (en) 2008-12-18 2011-11-23 诺瓦提斯公司 new salt
AU2009327405A1 (en) 2008-12-18 2011-06-30 Novartis Ag New polymorphic form of 1- (4- { l- [ (E) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzy l) -azetidine-3-carboxylic
WO2010083617A1 (en) 2009-01-21 2010-07-29 Oncalis Ag Pyrazolopyrimidines as protein kinase inhibitors
US20110281917A1 (en) 2009-01-29 2011-11-17 Darrin Stuart Substituted Benzimidazoles for the Treatment of Astrocytomas
EP2213281A1 (en) 2009-02-02 2010-08-04 Ratiopharm GmbH Pharmaceutical composition comprising N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
EP2400985A2 (en) 2009-02-25 2012-01-04 OSI Pharmaceuticals, LLC Combination of an either an anti-igf-1r antibody or an igf binding protein and a small molecule igf-1r kinase inhibitor
EP2400990A2 (en) 2009-02-26 2012-01-04 OSI Pharmaceuticals, LLC In situ methods for monitoring the emt status of tumor cells in vivo
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099363A1 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010107968A1 (en) 2009-03-18 2010-09-23 Osi Pharmaceuticals, Inc. Combination cancer therapy comprising administration of an egfr inhibitor and an igf-1r inhibitor
EP2411373B1 (en) * 2009-03-26 2015-10-21 Ranbaxy Laboratories Limited Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof
KR101360725B1 (en) 2009-06-26 2014-02-07 노파르티스 아게 1,3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp17
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
LT2451445T (en) 2009-07-06 2019-06-25 Boehringer Ingelheim International Gmbh Process for drying of bibw2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient
US9050341B2 (en) * 2009-07-14 2015-06-09 Natco Pharma Limited Methods of treating drug resistant and other tumors by administering 6,7-dialkoxy quinazoline derivatives
US9345661B2 (en) 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
EA201200260A1 (en) 2009-08-12 2012-09-28 Новартис Аг HETEROCYCLIC HYDRAZONES AND THEIR APPLICATION FOR THE TREATMENT OF CANCER AND INFLAMMATION
AU2010284254B2 (en) 2009-08-17 2015-09-17 Intellikine, Llc Heterocyclic compounds and uses thereof
ES2564797T3 (en) 2009-08-19 2016-03-29 Eisai R&D Management Co., Ltd. Pharmaceutical composition containing a quinoline derivative
EA201200318A1 (en) 2009-08-20 2012-09-28 Новартис Аг Heterocyclic oximes
JP2013503129A (en) 2009-08-26 2013-01-31 ノバルティス アーゲー Tetra-substituted heteroaryl compounds and their use as MDM2 and / or MDM4 modulators
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
US20120220594A1 (en) 2009-10-30 2012-08-30 Bristol-Meyers Squibb Company Methods for treating cancer in patients having igf-1r inhibitor resistance
EP2496575B1 (en) 2009-11-04 2014-04-30 Novartis AG Heterocyclic sulfonamide derivatives useful as mek inhibitors
WO2011058164A1 (en) 2009-11-13 2011-05-19 Pangaea Biotech, S.A. Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
WO2011069104A2 (en) 2009-12-04 2011-06-09 Genentech, Inc. Multispecific antibodies, antibody analogs, compositions, and methods
ES2484171T3 (en) 2009-12-08 2014-08-11 Novartis Ag Heterocyclic sulfonamide derivatives
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
CU24130B1 (en) 2009-12-22 2015-09-29 Novartis Ag ISOQUINOLINONES AND REPLACED QUINAZOLINONES
EP2348020A1 (en) 2009-12-23 2011-07-27 Esteve Química, S.A. Preparation process of erlotinib
WO2011086053A1 (en) 2010-01-12 2011-07-21 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof
AU2011222867B2 (en) 2010-03-04 2014-03-06 Annika Algars Method for selecting patients for treatment with an EGFR inhibitor
RU2012141536A (en) 2010-03-17 2014-04-27 Ф. Хоффманн-Ля Рош Аг IMIDAZOPYRIDINES, COMPOSITIONS AND METHODS OF APPLICATION
CA2794708C (en) 2010-03-29 2021-11-16 Zymeworks Inc. Antibodies with enhanced or suppressed effector function
CN103038643A (en) 2010-04-16 2013-04-10 基因泰克公司 FOXO3A as a predictive biomarker of PI3K/AKT kinase pathway inhibitor potency
DE202010006543U1 (en) 2010-05-07 2010-09-09 Ratiopharm Gmbh Erlotinibresinat
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
BR112012028964A2 (en) 2010-05-21 2016-07-26 Shanghai Inst Pharm Industry polycyclic quinazolines, their method of preparation and their uses
WO2011147102A1 (en) * 2010-05-28 2011-12-01 翔真生物科技股份有限公司 Synthetic method for 6,7-substituents-4-aniline quinazoline
RU2560683C2 (en) 2010-06-25 2015-08-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Anticancer agent involving combinations of kinase inhibitory compounds
UA112517C2 (en) 2010-07-06 2016-09-26 Новартіс Аг TETRAHYDROPYRIDOPYRIMIDINE DERIVATIVES
NZ606042A (en) * 2010-07-23 2015-05-29 Generics Uk Ltd Process for the preparation of erlotinib and salts thereof
AR082418A1 (en) 2010-08-02 2012-12-05 Novartis Ag CRYSTAL FORMS OF 1- (4-METHYL-5- [2- (2,2,2-TRIFLUORO-1,1-DIMETHYL-Ethyl) -PIRIDIN-4-IL] -TIAZOL-2-IL) -AMIDE OF 2 -AMIDA OF THE ACID (S) -PIRROLIDIN-1,2-DICARBOXILICO
BR112013006016A2 (en) 2010-09-15 2016-06-07 Hoffmann La Roche azabenzothiazole compounds, compositions and methods of use
US8946260B2 (en) 2010-09-16 2015-02-03 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
IT1402029B1 (en) 2010-10-14 2013-08-28 Italiana Sint Spa PROCEDURE FOR THE PREPARATION OF ERLOTINIB
EP2637692A4 (en) 2010-11-12 2014-09-10 Scott & White Healthcare ANTIBODIES AGAINST THE MARKER 8 TUMOR ENDOTHELIAL
BR112013011520A2 (en) 2010-11-19 2019-09-24 Hoffmann La Roche pyrazolo pyridines and pyrazolo pyridines and their use as tyk2 inhibitors
KR20130105675A (en) * 2010-11-25 2013-09-25 라티오팜 게엠베하 New Salts and Polymorphs of Afatinib
DE102010053124A1 (en) 2010-12-01 2012-06-06 Volkswagen Ag Clutch, particularly for transmission of motor vehicle, particularly dual clutch for automatic or automated dual clutch transmission, has friction clutch, which is connected with motor shaft on one side
MX2013007336A (en) 2010-12-21 2013-08-01 Novartis Ag Bi-heteroaryl compounds as vps34 inhibitors.
EP2468883A1 (en) 2010-12-22 2012-06-27 Pangaea Biotech S.L. Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
WO2012085176A1 (en) 2010-12-23 2012-06-28 F. Hoffmann-La Roche Ag Tricyclic pyrazinone compounds, compositions and methods of use thereof as janus kinase inhibitors
US9134297B2 (en) 2011-01-11 2015-09-15 Icahn School Of Medicine At Mount Sinai Method and compositions for treating cancer and related methods
PL2670753T3 (en) 2011-01-31 2017-05-31 Novartis Ag Novel heterocyclic derivatives
US20130324526A1 (en) 2011-02-10 2013-12-05 Novartis Ag [1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
EP2492688A1 (en) 2011-02-23 2012-08-29 Pangaea Biotech, S.A. Molecular biomarkers for predicting response to antitumor treatment in lung cancer
WO2012116237A2 (en) 2011-02-23 2012-08-30 Intellikine, Llc Heterocyclic compounds and uses thereof
WO2012122058A2 (en) 2011-03-04 2012-09-13 Newgen Therapeutics, Inc. Alkyne substituted quinazoline compound and methods of use
JP5832559B2 (en) 2011-03-10 2015-12-16 オメロス コーポレーション Generation of anti-FN14 monoclonal antibodies by accelerated antibody evolution ex vivo
WO2012129145A1 (en) 2011-03-18 2012-09-27 OSI Pharmaceuticals, LLC Nscle combination therapy
MX2013009931A (en) 2011-04-18 2013-10-01 Eisai R&D Man Co Ltd Therapeutic agent for tumor.
WO2012149014A1 (en) 2011-04-25 2012-11-01 OSI Pharmaceuticals, LLC Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
GB201106870D0 (en) 2011-04-26 2011-06-01 Univ Belfast Marker
WO2012149413A1 (en) 2011-04-28 2012-11-01 Novartis Ag 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
CN102918029B (en) * 2011-05-17 2015-06-17 江苏康缘药业股份有限公司 4-phenylamino-6-butenamide-7-alkyloxy quinazoline derivatives, preparative method and use thereof
ES2705950T3 (en) 2011-06-03 2019-03-27 Eisai R&D Man Co Ltd Biomarkers to predict and assess the responsiveness of subjects with thyroid and kidney cancer to lenvatinib compounds
KR20140034898A (en) 2011-06-09 2014-03-20 노파르티스 아게 Heterocyclic sulfonamide derivatives
US8859535B2 (en) 2011-06-20 2014-10-14 Novartis Ag Hydroxy substituted isoquinolinone derivatives
EP2721007B1 (en) 2011-06-20 2015-04-29 Novartis AG Cyclohexyl isoquinolinone compounds
CN102267952B (en) * 2011-06-21 2013-12-11 天津市汉康医药生物技术有限公司 Quinazoline compound and preparation method and application thereof
SG195067A1 (en) 2011-06-27 2013-12-30 Novartis Ag Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives
US8575339B2 (en) * 2011-07-05 2013-11-05 Xueheng Cheng Derivatives of erlotinib
WO2013007765A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases
WO2013007768A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
EP2742067A4 (en) 2011-08-12 2015-03-04 Omeros Corp ANTI-FZD10 MONOCLONAL ANTIBODIES AND METHODS OF USE
CA2843499A1 (en) 2011-08-12 2013-02-21 F. Hoffmann-La Roche Ag Indazole compounds, compositions and methods of use
US12194002B2 (en) 2011-08-17 2025-01-14 Dennis Brown Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dibromodulcitol
RU2614254C2 (en) 2011-08-31 2017-03-24 Дженентек, Инк. Diagnostic markers
EA026655B1 (en) 2011-09-15 2017-05-31 Новартис Аг 6-SUBSTITUTED 3-(QUINOLIN-6-YLTHIO)[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS c-Met TYROSINE KINASE INHIBITORS
WO2013041539A1 (en) 2011-09-20 2013-03-28 F. Hoffmann-La Roche Ag Imidazopyridine compounds, compositions and methods of use
MX2014003698A (en) 2011-09-30 2014-07-28 Genentech Inc Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells.
HU230483B1 (en) 2011-10-10 2016-07-28 Egis Gyógyszergyár Nyrt. Erlotinib salts
WO2013056069A1 (en) 2011-10-13 2013-04-18 Bristol-Myers Squibb Company Methods for selecting and treating cancer in patients with igf-1r/ir inhibitors
PT2771342T (en) 2011-10-28 2016-08-17 Novartis Ag Purine derivatives and their use in the treatment of disease
EP2785717B1 (en) 2011-11-29 2016-01-13 Novartis AG Pyrazolopyrrolidine compounds
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
LT2794600T (en) 2011-12-22 2018-02-26 Novartis Ag 2,3-dihydro-benzo[1,4]oxazine derivatives and related compounds as phosphoinositide-3 kinase (pi3k) inhibitors for the treatment of e.g. rheumatoid arthritis
WO2013093850A1 (en) 2011-12-22 2013-06-27 Novartis Ag Quinoline derivatives
KR20140104047A (en) 2011-12-23 2014-08-27 노파르티스 아게 Compounds for inhibiting the interaction of bcl2 with binding partners
EA201491268A1 (en) 2011-12-23 2014-11-28 Новартис Аг COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE INTERACTION OF BCL2 WITH PARTNERS ON THE LINKAGE
EA201491259A1 (en) 2011-12-23 2014-11-28 Новартис Аг COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE INTERACTION OF BCL2 WITH BOND PARTNERS
US20140357633A1 (en) 2011-12-23 2014-12-04 Novartis Ag Compounds for inhibiting the interaction of bcl2 with binding partners
EA201491265A1 (en) 2011-12-23 2014-11-28 Новартис Аг COMPOUNDS FOR INHIBITING THE INTERACTION OF BCL-2 WITH PARTNERS ON BINDING
UY34591A (en) 2012-01-26 2013-09-02 Novartis Ag IMIDAZOPIRROLIDINONA COMPOUNDS
CA2866612C (en) 2012-03-08 2018-01-16 Halozyme, Inc. Conditionally active ph-dependent cetuximab variant anti-epidermal growth factor receptor antibodies and method of use thereof
CN104220457A (en) 2012-03-27 2014-12-17 霍夫曼-拉罗奇有限公司 Diagnosis and treatment involving HER3 inhibitors
US20150297604A1 (en) 2012-04-03 2015-10-22 Novartis Ag Combination Products with Tyrosine Kinase Inhibitors and their Use
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
US10213432B2 (en) 2012-05-16 2019-02-26 Novartis Ag Dosage regimen for a PI-3 kinase inhibitor
WO2013175417A1 (en) 2012-05-24 2013-11-28 Novartis Ag Pyrrolopyrrolidinone compounds
US9789193B2 (en) 2012-06-15 2017-10-17 The Brigham And Women's Hospital, Inc. Compositions for treating cancer and methods for making the same
WO2013190089A1 (en) 2012-06-21 2013-12-27 Pangaea Biotech, S.L. Molecular biomarkers for predicting outcome in lung cancer
WO2014037961A1 (en) 2012-09-04 2014-03-13 Shilpa Medicare Limited Crystalline erlotinib hydrochloride process
TW201422625A (en) 2012-11-26 2014-06-16 Novartis Ag Solid form of dihydro-pyrido-oxazine derivative
WO2014098176A1 (en) 2012-12-21 2014-06-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 Amorphous form of quinoline derivative, and method for producing same
WO2014115080A1 (en) 2013-01-22 2014-07-31 Novartis Ag Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction
US9403827B2 (en) 2013-01-22 2016-08-02 Novartis Ag Substituted purinone compounds
WO2014118112A1 (en) 2013-01-29 2014-08-07 Synthon B.V. Pharmaceutical composition comprising erlotinib hydrochloride
WO2014128612A1 (en) 2013-02-20 2014-08-28 Novartis Ag Quinazolin-4-one derivatives
WO2014134202A1 (en) 2013-02-26 2014-09-04 Triact Therapeutics, Inc. Cancer therapy
BR112015022545A2 (en) 2013-03-13 2017-07-18 Constellation Pharmaceuticals Inc pyrazole compounds and the uses thereof
CN105246482A (en) 2013-03-15 2016-01-13 因特利凯有限责任公司 Combinations of kinase inhibitors and uses thereof
US20160051556A1 (en) 2013-03-21 2016-02-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Method and Pharmaceutical Composition for use in the Treatment of Chronic Liver Diseases Associated with a Low Hepcidin Expression
WO2014155268A2 (en) 2013-03-25 2014-10-02 Novartis Ag Fgf-r tyrosine kinase activity inhibitors - use in diseases associated with lack of or reduced snf5 activity
RU2658601C2 (en) 2013-05-14 2018-06-21 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
US20150018376A1 (en) 2013-05-17 2015-01-15 Novartis Ag Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof
UY35675A (en) 2013-07-24 2015-02-27 Novartis Ag SUBSTITUTED DERIVATIVES OF QUINAZOLIN-4-ONA
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
WO2015022664A1 (en) 2013-08-14 2015-02-19 Novartis Ag Compounds and compositions as inhibitors of mek
WO2015022663A1 (en) 2013-08-14 2015-02-19 Novartis Ag Compounds and compositions as inhibitors of mek
MX2016002794A (en) 2013-09-05 2016-09-13 Genentech Inc Antiproliferative compounds.
CA2923667A1 (en) 2013-09-09 2015-03-12 Triact Therapeutics, Inc. Cancer therapy
CA2922562A1 (en) 2013-09-12 2015-03-19 Halozyme, Inc. Modified anti-epidermal growth factor receptor antibodies and methods of use thereof
AR097661A1 (en) 2013-09-17 2016-04-06 Obi Pharma Inc COMPOSITIONS OF A CARBOHYDRATE VACCINE TO INDUCE IMMUNE RESPONSES AND THEIR USES IN CANCER TREATMENT
AU2014321419B2 (en) 2013-09-22 2017-06-15 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine compounds and methods of use
TW201605857A (en) 2013-10-03 2016-02-16 赫孚孟拉羅股份公司 Therapeutic inhibitors of CDK8 and uses thereof
TW201605450A (en) 2013-12-03 2016-02-16 諾華公司 Combination of Mdm2 inhibitor and BRAF inhibitor and their use
MX378409B (en) 2013-12-06 2025-03-10 Novartis Ag DOSAGE REGIMEN FOR AN ALPHA-ISOMORPHIC SELECTIVE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR.
EP3527587A1 (en) 2013-12-17 2019-08-21 F. Hoffmann-La Roche AG Combination therapy comprising ox40 binding agonists and pd-l1 binding antagonists
CA2933883A1 (en) 2013-12-17 2015-06-25 Genentech, Inc. Methods of treating her2-positive cancers using pd-1 axis binding antagonists and anti-her2 antibodies
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
WO2015145388A2 (en) 2014-03-27 2015-10-01 Novartis Ag Methods of treating colorectal cancers harboring upstream wnt pathway mutations
EP3122729A4 (en) 2014-03-28 2017-11-15 Calitor Sciences, LLC Substituted heteroaryl compounds and methods of use
CN106103486B (en) 2014-03-31 2020-04-21 豪夫迈·罗氏有限公司 Anti-OX40 antibodies and methods of use
AU2015241038A1 (en) 2014-03-31 2016-10-13 Genentech, Inc. Combination therapy comprising anti-angiogenesis agents and OX40 binding agonists
RU2016140160A (en) 2014-04-03 2018-05-07 Инвиктус Онколоджи Пвт. Лтд. SUPRAMOLECULAR COMBINATOR MEDICINES
US20170027940A1 (en) 2014-04-10 2017-02-02 Stichting Het Nederlands Kanker Instituut Method for treating cancer
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
JP6526789B2 (en) 2014-07-31 2019-06-05 ノバルティス アーゲー Combination therapy
ES2926687T3 (en) 2014-08-28 2022-10-27 Eisai R&D Man Co Ltd Highly pure quinoline derivative and method for its production
CN107074823B (en) 2014-09-05 2021-05-04 基因泰克公司 Therapeutic compounds and their uses
JP2017529358A (en) 2014-09-19 2017-10-05 ジェネンテック, インコーポレイテッド Use of CBP / EP300 inhibitors and BET inhibitors for the treatment of cancer
EP3204379B1 (en) 2014-10-10 2019-03-06 Genentech, Inc. Pyrrolidine amide compounds as histone demethylase inhibitors
EP3206717B1 (en) 2014-10-17 2020-11-25 Novartis AG Combination of ceritinib with an egfr inhibitor
CA2908441A1 (en) 2014-10-28 2016-04-28 Cerbios-Pharma Sa Process for the preparation of erlotinib
CN106796235B (en) 2014-11-03 2021-01-29 豪夫迈·罗氏有限公司 Assays for detecting T cell immune subsets and methods of use thereof
MX2017005751A (en) 2014-11-03 2018-04-10 Genentech Inc Method and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment.
BR112017008628A2 (en) 2014-11-06 2018-01-30 Genentech Inc combination therapy comprising ox40 binding agonists and tigit inhibitors
MA40940A (en) 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc SUBSTITUTED PYRROLOPYRIDINES USED AS BROMODOMA INHIBITORS
MA40943A (en) 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc SUBSTITUTED PYRROLOPYRIDINES USED AS BROMODOMA INHIBITORS
EP3218376B1 (en) 2014-11-10 2019-12-25 Genentech, Inc. Bromodomain inhibitors and uses thereof
CA2967368A1 (en) 2014-11-17 2016-05-26 Genentech, Inc. Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
CN107531690B (en) 2014-11-27 2020-11-06 基因泰克公司 4,5,6,7-Tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-amine compounds useful as CBP and/or EP300 inhibitors
WO2016082879A1 (en) * 2014-11-27 2016-06-02 Synthon B.V. Pharmaceutical composition comprising erlotinib hydrochloride
WO2016106340A2 (en) 2014-12-23 2016-06-30 Genentech, Inc. Compositions and methods for treating and diagnosing chemotherapy-resistant cancers
CN107223163A (en) 2014-12-24 2017-09-29 豪夫迈·罗氏有限公司 Methods for treatment, diagnosis and prognosis of bladder cancer
EP3240908A2 (en) 2014-12-30 2017-11-08 F. Hoffmann-La Roche AG Methods and compositions for prognosis and treatment of cancers
WO2016112284A1 (en) 2015-01-09 2016-07-14 Genentech, Inc. (piperidin-3-yl)(naphthalen-2-yl)methanone derivatives and related compounds as inhibitors of the histone demethylase kdm2b for the treatment of cancer
WO2016112251A1 (en) 2015-01-09 2016-07-14 Genentech, Inc. 4,5-dihydroimidazole derivatives and their use as histone demethylase (kdm2b) inhibitors
JP6659703B2 (en) 2015-01-09 2020-03-04 ジェネンテック, インコーポレイテッド Pyridazinone derivatives and their use in the treatment of cancer
EP3250571B1 (en) 2015-01-29 2022-11-30 Genentech, Inc. Therapeutic compounds and uses thereof
EP3250552B1 (en) 2015-01-30 2019-03-27 Genentech, Inc. Therapeutic compounds and uses thereof
RS65049B1 (en) 2015-02-25 2024-02-29 Eisai R&D Man Co Ltd Method for suppressing bitterness of quinoline derivative
MA41598A (en) 2015-02-25 2018-01-02 Constellation Pharmaceuticals Inc PYRIDAZINE THERAPEUTIC COMPOUNDS AND THEIR USES
CN104725327B (en) * 2015-03-03 2017-08-25 山东大学 A kind of environment-friendly preparation method of erlotinib Hydrochloride
AU2015384801B2 (en) 2015-03-04 2022-01-06 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
MX2017012805A (en) 2015-04-07 2018-04-11 Genentech Inc Antigen binding complex having agonistic activity and methods of use.
AU2016262074A1 (en) 2015-05-12 2017-11-09 Genentech, Inc. Therapeutic and diagnostic methods for cancer
MX392671B (en) 2015-05-29 2025-03-24 Genentech Inc PD-L1-BINDING ANTAGONISTS AND THEIR USES FOR CANCER TREATMENT
AU2016274585A1 (en) 2015-06-08 2017-12-14 Genentech, Inc. Methods of treating cancer using anti-OX40 antibodies
KR20180025888A (en) 2015-06-08 2018-03-09 제넨테크, 인크. Methods for treating cancer using anti-OX40 antibodies and PD-1 axis-binding antagonists
CA2988707C (en) 2015-06-16 2023-10-10 Eisai R&D Management Co., Ltd. Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
KR102689256B1 (en) 2015-06-17 2024-07-30 제넨테크, 인크. Methods for treating locally advanced or metastatic breast cancer using PD-1 axis binding antagonists and taxanes
CN105017162B (en) * 2015-06-26 2017-10-27 陕西师范大学 4 pairs of propenylbenzene amido quinazoline derivatives and its application in antineoplastic is prepared
ES2887426T3 (en) 2015-08-20 2021-12-22 Eisai R&D Man Co Ltd Lenvatinib combined with etoposide and ifosfamide for use in treating a tumor
ES2862727T3 (en) 2015-08-26 2021-10-07 Fundacion Del Sector Publico Estatal Centro Nac De Investigaciones Oncologicas Carlos Iii F S P Cnio Fused tricyclic compounds as protein kinase inhibitors
ES2761885T3 (en) 2015-08-28 2020-05-21 Novartis Ag Pharmaceutical combinations comprising (a) cyclin-dependent kinase inhibitor 4/6 (CDK4 / 6) LEE011 (= ribociclib) and (b) epidermal growth factor receptor (EGFR) inhibitor erlotinib, for the treatment or cancer prevention
HK1256912A1 (en) 2015-09-04 2019-10-04 台湾浩鼎生技股份有限公司 Glycan arrays and method of use
EP3347097B1 (en) 2015-09-11 2021-02-24 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora
NZ739750A (en) 2015-09-25 2019-11-29 Genentech Inc Anti-tigit antibodies and methods of use
JP2018532750A (en) 2015-11-02 2018-11-08 ノバルティス アーゲー Dosage regimen of phosphatidylinositol 3-kinase inhibitor
AU2016369528B2 (en) 2015-12-16 2021-04-22 Genentech, Inc. Process for the preparation of tricyclic PI3K inhibitor compounds and methods for using the same for the treatment of cancer
WO2017118675A1 (en) 2016-01-08 2017-07-13 F. Hoffmann-La Roche Ag Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies
EP4155415A1 (en) 2016-02-29 2023-03-29 Genentech, Inc. Therapeutic and diagnostic methods for cancer
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
TWI780045B (en) 2016-03-29 2022-10-11 台灣浩鼎生技股份有限公司 Antibodies, pharmaceutical compositions and methods
KR20180134347A (en) 2016-04-15 2018-12-18 제넨테크, 인크. Diagnosis and Treatment of Cancer
PL3443350T3 (en) 2016-04-15 2021-05-31 F. Hoffmann-La Roche Ag Methods of monitoring and treating cancer
EP3443120A2 (en) 2016-04-15 2019-02-20 H. Hoffnabb-La Roche Ag Methods for monitoring and treating cancer
RU2018140976A (en) 2016-04-22 2020-05-22 Оби Фарма, Инк. CANCER IMMUNOTHERAPY BY IMMUNE ACTIVATION OR IMMUNE MODULATION THROUGH GLOBO SERIES ANTIGENS
US20190151346A1 (en) 2016-05-10 2019-05-23 INSERM (Institute National de la Santé et de la Recherche Médicale) Combinations therapies for the treatment of cancer
MA45146A (en) 2016-05-24 2021-03-24 Constellation Pharmaceuticals Inc PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER
WO2017205536A2 (en) 2016-05-24 2017-11-30 Genentech, Inc. Therapeutic compounds and uses thereof
US20200129519A1 (en) 2016-06-08 2020-04-30 Genentech, Inc. Diagnostic and therapeutic methods for cancer
EP4371570A3 (en) 2016-06-08 2024-07-17 Xencor, Inc. Treatment of igg4-related diseases with anti-cd19 antibodies crossbinding to cd32b
US11642400B2 (en) 2016-07-27 2023-05-09 Obi Pharma, Inc. Immunogenic/therapeutic glycan compositions and uses thereof
KR102528998B1 (en) 2016-07-29 2023-05-03 오비아이 파머 인코퍼레이티드 Human Antibodies, Pharmaceutical Compositions and Methods
JP2019530434A (en) 2016-08-05 2019-10-24 ジェネンテック, インコーポレイテッド Multivalent and multi-epitope antibodies with agonist activity and methods of use
CN109476748B (en) 2016-08-08 2023-05-23 豪夫迈·罗氏有限公司 Methods for the treatment and diagnosis of cancer
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
CN110418851A (en) 2016-10-06 2019-11-05 基因泰克公司 The treatment of cancer and diagnostic method
WO2018078143A1 (en) 2016-10-28 2018-05-03 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Means and methods for determining efficacy of anti-egfr inhibitors in colorectal cancer (crc) therapy
CN110267678A (en) 2016-10-29 2019-09-20 霍夫曼-拉罗奇有限公司 Anti-MIC antibodies and methods of use
KR20190077103A (en) 2016-11-21 2019-07-02 오비아이 파머 인코퍼레이티드 Conjugated biological molecules, pharmaceutical compositions and methods
KR20230150408A (en) 2016-12-22 2023-10-30 암젠 인크 Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
JP6581320B2 (en) 2017-02-08 2019-09-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 Pharmaceutical composition for tumor treatment
AU2018228873A1 (en) 2017-03-01 2019-08-29 Genentech, Inc. Diagnostic and therapeutic methods for cancer
CN106928069B (en) * 2017-03-21 2019-03-19 上海玉函化工有限公司 A kind of preparation method of 4,5- bis- (2- methoxy ethoxy) -2- ethyl nitrobenzoate
BR112019021411A2 (en) 2017-04-13 2020-05-05 Hoffmann La Roche methods to treat or slow the progression of cancer and to improve function, uses of an immunoconjugate, an agonist, an antagonist, compositions, kit and invention
RU2019134940A (en) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. TREATMENT OF HEPATOCELLULAR CARCINOMA
JOP20190272A1 (en) 2017-05-22 2019-11-21 Amgen Inc Kras g12c inhibitors and methods of using the same
CN107200715B (en) * 2017-06-22 2020-05-29 陕西师范大学 Quinazoline derivatives and their application in the preparation of antitumor drugs
IL271888B2 (en) 2017-07-21 2024-09-01 Genentech Inc Therapeutic and diagnostic methods for cancer
AU2018316343B2 (en) 2017-08-11 2025-06-12 Genentech, Inc. Anti-CD8 antibodies and uses thereof
JP7530829B2 (en) 2017-09-08 2024-08-08 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Cancer diagnosis and treatment methods
AU2018329920B2 (en) 2017-09-08 2022-12-01 Amgen Inc. Inhibitors of KRAS G12C and methods of using the same
US20200290978A1 (en) * 2017-09-26 2020-09-17 The Regents Of The University Of California Compositions and methods for treating cancer
WO2019084395A1 (en) 2017-10-27 2019-05-02 University Of Virginia Patent Foundation Compounds and methods for regulating, limiting, or inhibiting avil expression
KR20200075860A (en) 2017-11-06 2020-06-26 제넨테크, 인크. How to diagnose and treat cancer
US10683297B2 (en) 2017-11-19 2020-06-16 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
SG11202006441SA (en) 2018-01-15 2020-08-28 Epiaxis Therapeutics Pty Ltd Agents and methods for predicting response to therapy
US10751339B2 (en) 2018-01-20 2020-08-25 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine compounds and methods of use
US11673897B2 (en) 2018-01-26 2023-06-13 Exelixis, Inc. Compounds for the treatment of kinase-dependent disorders
CR20200355A (en) 2018-01-26 2021-02-22 Exelixis Inc COMPOUNDS FOR THE TREATMENT OF KINE-DEPENDENT DISORDERS
SMT202500395T1 (en) 2018-01-26 2025-11-10 Exelixis Inc Compounds for the treatment of kinase-dependent disorders
TWI660728B (en) * 2018-02-09 2019-06-01 國立交通大學 Quinazolinamine derivatives and pharmaceutical compositions and uses thereof
JP7391027B2 (en) 2018-02-26 2023-12-04 ジェネンテック, インコーポレイテッド Medication for treatment with anti-TIGIT and anti-PD-L1 antagonist antibodies
AU2019262599B2 (en) 2018-05-04 2023-10-12 Amgen Inc. KRAS G12C inhibitors and methods of using the same
MA52501A (en) 2018-05-04 2021-03-10 Amgen Inc KRAS G12C INHIBITORS AND THEIR PROCEDURES FOR USE
MA52564A (en) 2018-05-10 2021-03-17 Amgen Inc KRAS G12C INHIBITORS FOR CANCER TREATMENT
AU2019275404A1 (en) 2018-05-21 2020-12-03 Bruker Spatial Biology, Inc. Molecular gene signatures and methods of using same
EP3802535B1 (en) 2018-06-01 2022-12-14 Amgen, Inc Kras g12c inhibitors and methods of using the same
AU2019284472B2 (en) 2018-06-11 2024-05-30 Amgen Inc. KRAS G12C inhibitors for treating cancer
US11285156B2 (en) 2018-06-12 2022-03-29 Amgen Inc. Substituted piperazines as KRAS G12C inhibitors
JP7399895B2 (en) 2018-06-23 2023-12-18 ジェネンテック, インコーポレイテッド Method of treating lung cancer with PD-1 axis binding antagonists, platinum agents, and topoisomerase II inhibitors
CN110642796B (en) * 2018-06-27 2023-03-17 烟台药物研究所 Quinazoline derivative and application thereof
TW202504930A (en) 2018-06-27 2025-02-01 台灣浩鼎生技股份有限公司 Glycosynthase variants for glycoprotein engineering and methods of use
BR112021000673A2 (en) 2018-07-18 2021-04-20 Genentech, Inc. methods for treating an individual with lung cancer, kits, anti-pd-l1 antibody and compositions
CN112805267B (en) 2018-09-03 2024-03-08 豪夫迈·罗氏有限公司 Formamide and sulfonamide derivatives used as TEAD modulators
CN112955747A (en) 2018-09-19 2021-06-11 豪夫迈·罗氏有限公司 Methods for treatment and diagnosis of bladder cancer
JP7475336B2 (en) 2018-09-21 2024-04-26 ジェネンテック, インコーポレイテッド Diagnostic methods for triple-negative breast cancer
MX2021003517A (en) 2018-09-25 2021-08-16 Black Diamond Therapeutics Inc Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use.
JP2022512584A (en) 2018-10-04 2022-02-07 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル EGFR inhibitor for treating keratoderma
AU2019362972A1 (en) 2018-10-17 2021-05-20 The University Of Queensland Epigenetic biomarker and uses therefor
AU2019361983A1 (en) 2018-10-18 2021-05-20 Genentech, Inc. Diagnostic and therapeutic methods for sarcomatoid kidney cancer
JP7516029B2 (en) 2018-11-16 2024-07-16 アムジエン・インコーポレーテツド Improved synthesis of key intermediates for KRAS G12C inhibitor compounds
MX2021005700A (en) 2018-11-19 2021-07-07 Amgen Inc Kras g12c inhibitors and methods of using the same.
JP7377679B2 (en) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド Combination therapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer
MX419368B (en) 2018-12-20 2025-01-14 Amgen Inc Heteroaryl amides useful as kif18a inhibitors
EP3898592B1 (en) 2018-12-20 2024-10-09 Amgen Inc. Heteroaryl amides useful as kif18a inhibitors
KR102875569B1 (en) 2018-12-20 2025-10-23 암젠 인크 KIF18A inhibitor
CA3123042A1 (en) 2018-12-20 2020-06-25 Amgen Inc. Kif18a inhibitors
EP3903828A4 (en) 2018-12-21 2022-10-05 Daiichi Sankyo Company, Limited COMBINATION OF AN ANTIBODY-DRUG CONJUGATE AND A KINASE INHIBITOR
CN113396230A (en) 2019-02-08 2021-09-14 豪夫迈·罗氏有限公司 Methods of diagnosis and treatment of cancer
JP7520389B2 (en) 2019-02-27 2024-07-23 エピアクシス セラピューティクス プロプライエタリー リミテッド Methods and agents for assessing T cell function and predicting response to therapy - Patents.com
BR112021016923A2 (en) 2019-02-27 2021-11-03 Genentech Inc Methods for treating a patient with hematologic cancer, methods for treating a patient with relapsed or refractory mm, methods for treating a patient having a relapsed or refractory lnh, and kits
CN113727758A (en) 2019-03-01 2021-11-30 锐新医药公司 Bicyclic heterocyclic compounds and use thereof
AU2020232242A1 (en) 2019-03-01 2021-09-09 Revolution Medicines, Inc. Bicyclic heteroaryl compounds and uses thereof
WO2020223233A1 (en) 2019-04-30 2020-11-05 Genentech, Inc. Prognostic and therapeutic methods for colorectal cancer
MX2021013222A (en) 2019-05-03 2022-01-06 Genentech Inc Methods of treating cancer with an anti-pd-l1 antibody.
EP3738593A1 (en) 2019-05-14 2020-11-18 Amgen, Inc Dosing of kras inhibitor for treatment of cancers
CA3140392A1 (en) 2019-05-21 2020-11-26 Amgen Inc. Solid state forms
CN112300279A (en) 2019-07-26 2021-02-02 上海复宏汉霖生物技术股份有限公司 Methods and compositions directed to anti-CD 73 antibodies and variants
AU2020324406A1 (en) 2019-08-02 2022-03-17 Amgen Inc. KIF18A inhibitors
ES3051917T3 (en) 2019-08-02 2025-12-30 Amgen Inc Kif18a inhibitors
CA3147276A1 (en) 2019-08-02 2021-02-11 Amgen Inc. Kif18a inhibitors
US20220281843A1 (en) 2019-08-02 2022-09-08 Amgen Inc. Kif18a inhibitors
CA3150701A1 (en) 2019-08-15 2021-02-18 Black Diamond Therapeutics, Inc. Alkynyl quinazoline compounds
TWI873176B (en) 2019-09-04 2025-02-21 美商建南德克公司 Cd8 binding agents and uses thereof
JP2022551422A (en) 2019-09-26 2022-12-09 エグゼリクシス, インコーポレイテッド Pyridone compounds and methods of use in modulating protein kinases
WO2021062085A1 (en) 2019-09-27 2021-04-01 Genentech, Inc. Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
AU2020369569A1 (en) 2019-10-24 2022-04-14 Amgen Inc. Pyridopyrimidine derivatives useful as KRAS G12C and KRAS G12D inhibitors in the treatment of cancer
EP4051674A1 (en) 2019-10-29 2022-09-07 F. Hoffmann-La Roche AG Bifunctional compounds for the treatment of cancer
BR112022008535A2 (en) 2019-11-04 2022-08-09 Revolution Medicines Inc COMPOUND, PHARMACEUTICAL COMPOSITION, METHODS TO TREAT CANCER AND A RAS PROTEIN DISORDER
WO2021091982A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
CN120699039A (en) 2019-11-04 2025-09-26 锐新医药公司 RAS inhibitors
JP2022553803A (en) 2019-11-06 2022-12-26 ジェネンテック, インコーポレイテッド Diagnostic and therapeutic methods for the treatment of blood cancers
US20210139517A1 (en) 2019-11-08 2021-05-13 Revolution Medicines, Inc. Bicyclic heteroaryl compounds and uses thereof
WO2021094379A1 (en) 2019-11-12 2021-05-20 Astrazeneca Ab Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
KR20220101138A (en) 2019-11-13 2022-07-19 제넨테크, 인크. Therapeutic compounds and methods of use
TW202532412A (en) 2019-11-14 2025-08-16 美商安進公司 Improved synthesis of kras g12c inhibitor compound
AU2020383535A1 (en) 2019-11-14 2022-05-05 Amgen Inc. Improved synthesis of KRAS G12C inhibitor compound
JP2023505100A (en) 2019-11-27 2023-02-08 レボリューション メディシンズ インコーポレイテッド Covalent RAS inhibitors and uses thereof
PE20221511A1 (en) 2019-12-13 2022-10-04 Genentech Inc ANTI-LY6G6D ANTIBODIES AND METHODS OF USE
WO2021127404A1 (en) 2019-12-20 2021-06-24 Erasca, Inc. Tricyclic pyridones and pyrimidones
JP2023509701A (en) 2020-01-07 2023-03-09 レヴォリューション・メディスンズ,インコーポレイテッド SHP2 inhibitor dosing and methods of treating cancer
KR20220130190A (en) 2020-01-20 2022-09-26 아스트라제네카 아베 Epidermal growth factor receptor tyrosine kinase inhibitor for cancer treatment
WO2022050954A1 (en) 2020-09-04 2022-03-10 Genentech, Inc. Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
WO2021194481A1 (en) 2020-03-24 2021-09-30 Genentech, Inc. Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
IL294800A (en) 2020-01-27 2022-09-01 Genentech Inc Methods of treating cancer with an antibody to an anti-ti antagonist
WO2021177980A1 (en) 2020-03-06 2021-09-10 Genentech, Inc. Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist
JP2023520515A (en) 2020-04-03 2023-05-17 ジェネンテック, インコーポレイテッド Therapeutic and diagnostic methods for cancer
CN115885050A (en) 2020-04-28 2023-03-31 基因泰克公司 Methods and compositions for non-small cell lung cancer immunotherapy
AU2021293038A1 (en) 2020-06-16 2023-02-02 F. Hoffmann-La Roche Ag Methods and compositions for treating triple-negative breast cancer
KR20230042600A (en) 2020-06-18 2023-03-28 레볼루션 메디슨즈, 인크. Methods of Delaying, Preventing, and Treating Acquired Resistance to RAS Inhibitors
MX2022015881A (en) 2020-06-18 2023-01-24 Genentech Inc Treatment with anti-tigit antibodies and pd-1 axis binding antagonists.
EP4172628A1 (en) 2020-06-30 2023-05-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery
JP2023531305A (en) 2020-06-30 2023-07-21 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル A method for predicting the risk of recurrence and/or death in patients with solid tumors after neoadjuvant therapy.
US11787775B2 (en) 2020-07-24 2023-10-17 Genentech, Inc. Therapeutic compounds and methods of use
EP4189121A1 (en) 2020-08-03 2023-06-07 Genentech, Inc. Diagnostic and therapeutic methods for lymphoma
EP4196612A1 (en) 2020-08-12 2023-06-21 Genentech, Inc. Diagnostic and therapeutic methods for cancer
WO2022047243A1 (en) 2020-08-27 2022-03-03 Enosi Life Sciences Corp. Methods and compositions to treat autoimmune diseases and cancer
CA3187757A1 (en) 2020-09-03 2022-03-24 Ethan AHLER Use of sos1 inhibitors to treat malignancies with shp2 mutations
MX2023003060A (en) 2020-09-15 2023-04-05 Revolution Medicines Inc Indole derivatives as ras inhibitors in the treatment of cancer.
MX2023003338A (en) 2020-09-23 2023-06-14 Erasca Inc Tricyclic pyridones and pyrimidones.
CA3193952A1 (en) 2020-10-05 2022-04-14 Bernard Martin Fine Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
US20230107642A1 (en) 2020-12-18 2023-04-06 Erasca, Inc. Tricyclic pyridones and pyrimidones
JP2024501280A (en) 2020-12-22 2024-01-11 キル・レガー・セラピューティクス・インコーポレーテッド SOS1 inhibitors and their uses
KR20230146052A (en) 2021-02-12 2023-10-18 에프. 호프만-라 로슈 아게 Bicyclic tetrahydroazepine derivatives for cancer treatment
CA3211063A1 (en) 2021-02-19 2022-08-25 Exelixis, Inc. Pyridone compounds and methods of use
CN118561952A (en) 2021-05-05 2024-08-30 锐新医药公司 RAS inhibitors
CN117500811A (en) 2021-05-05 2024-02-02 锐新医药公司 Covalent RAS inhibitors and their uses
CR20230558A (en) 2021-05-05 2024-01-24 Revolution Medicines Inc RAS INHIBITORS FOR CANCER TREATMENT
EP4347603A1 (en) 2021-05-25 2024-04-10 Erasca, Inc. Sulfur-containing heteroaromatic tricyclic kras inhibitors
WO2022266206A1 (en) 2021-06-16 2022-12-22 Erasca, Inc. Kras inhibitor conjugates
AU2022315530A1 (en) 2021-07-20 2024-01-18 Ags Therapeutics Sas Extracellular vesicles from microalgae, their preparation, and uses
TW202321261A (en) 2021-08-10 2023-06-01 美商伊瑞斯卡公司 Selective kras inhibitors
AR127308A1 (en) 2021-10-08 2024-01-10 Revolution Medicines Inc RAS INHIBITORS
WO2023097195A1 (en) 2021-11-24 2023-06-01 Genentech, Inc. Therapeutic indazole compounds and methods of use in the treatment of cancer
JP2024543912A (en) 2021-11-24 2024-11-26 ジェネンテック, インコーポレイテッド Bicyclic therapeutic compounds and methods of use in the treatment of cancer - Patents.com
EP4448526A1 (en) 2021-12-17 2024-10-23 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
WO2023144127A1 (en) 2022-01-31 2023-08-03 Ags Therapeutics Sas Extracellular vesicles from microalgae, their biodistribution upon administration, and uses
EP4227307A1 (en) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
CN118829629A (en) 2022-03-07 2024-10-22 美国安进公司 Process for the preparation of 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile
JP2025510572A (en) 2022-03-08 2025-04-15 レボリューション メディシンズ インコーポレイテッド Methods for treating immunorefractory lung cancer
US20250205233A1 (en) 2022-03-31 2025-06-26 Astrazeneca Ab Epidermal growth factor receptor (egfr) tyrosine kinase inhibitors in combination with an akt inhibitor for the treatment of cancer
CA3246312A1 (en) 2022-04-01 2023-10-05 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
AU2022458320A1 (en) 2022-05-11 2024-11-28 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
CA3257760A1 (en) 2022-06-07 2023-12-14 Genentech, Inc. Prognostic and therapeutic methods for cancer
CN119998298A (en) 2022-06-10 2025-05-13 锐新医药公司 Macrocyclic RAS inhibitors
MA71241A (en) 2022-06-27 2025-04-30 Astrazeneca Ab COMBINATIONS INVOLVING EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER
EP4554978A1 (en) 2022-07-13 2025-05-21 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
CN119604530A (en) 2022-07-19 2025-03-11 基因泰克公司 Administration of Therapeutic Antibodies Using Anti-FCRH5/Anti-CD3 Bispecific Antibodies
JP2025526726A (en) 2022-08-11 2025-08-15 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Bicyclic Tetrahydroazepine Derivatives
PE20250876A1 (en) 2022-08-11 2025-03-28 Hoffmann La Roche Bicyclic derivatives of tetrahydrothiazepine
WO2024033457A1 (en) 2022-08-11 2024-02-15 F. Hoffmann-La Roche Ag Bicyclic tetrahydrothiazepine derivatives
KR20250038674A (en) 2022-08-11 2025-03-19 에프. 호프만-라 로슈 아게 Bicyclic tetrahydrothiazepine derivatives
EP4601644A1 (en) 2022-10-14 2025-08-20 Black Diamond Therapeutics, Inc. Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
JP2025538859A (en) 2022-10-21 2025-12-02 公益財団法人川崎市産業振興財団 Non-adsorbing or super stealth vesicles
CN121038801A (en) 2022-10-24 2025-11-28 Ags治疗简易股份公司 Extracellular vesicles from microalgae, their biodistribution during intranasal administration, and their uses
TW202426505A (en) 2022-10-25 2024-07-01 美商建南德克公司 Therapeutic and diagnostic methods for cancer
TW202434206A (en) 2023-02-17 2024-09-01 美商伊瑞斯卡公司 Kras inhibitors
AU2024241633A1 (en) 2023-03-30 2025-11-06 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
AR132338A1 (en) 2023-04-07 2025-06-18 Revolution Medicines Inc RAS INHIBITORS
WO2024211712A1 (en) 2023-04-07 2024-10-10 Revolution Medicines, Inc. Condensed macrocyclic compounds as ras inhibitors
TW202448897A (en) 2023-04-14 2024-12-16 美商銳新醫藥公司 Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
CN121100123A (en) 2023-04-14 2025-12-09 锐新医药公司 Crystalline form of Ras inhibitors
WO2024229406A1 (en) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
AU2024270495A1 (en) 2023-05-05 2025-10-09 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
TW202504641A (en) 2023-06-08 2025-02-01 美商建南德克公司 Macrophage signatures for diagnostic and therapeutic methods for lymphoma
WO2025024257A1 (en) 2023-07-21 2025-01-30 Genentech, Inc. Diagnostic and therapeutic methods for cancer
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
WO2025049277A1 (en) 2023-08-25 2025-03-06 Genentech, Inc. Methods and compositions for treating non-small cell lung cancer comprising an anti-tigit antagonist antibody and a pd-1 axis binding antagonist
TW202530228A (en) 2023-10-12 2025-08-01 美商銳新醫藥公司 Ras inhibitors
WO2025137507A1 (en) 2023-12-22 2025-06-26 Regor Pharmaceuticals, Inc. Sos1 inhibitors and uses thereof
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025176843A1 (en) 2024-02-21 2025-08-28 Ags Therapeutics Sas Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU400048A1 (en) * 1970-12-14 1973-10-03
SU466233A1 (en) * 1973-06-08 1975-04-05 Всесоюзный научно-исследовательский химико-фармацевтический институт им. С.Орджоникидзе Method for producing 2-methyl-4-dialkylaminoalkylaminoquinazoline derivatives
DE69222637T2 (en) 1991-05-10 1998-02-26 Rhone Poulenc Rorer Int UP TO MONO AND BICYCLIC ARYL AND HETEROARYL DERIVATIVES WITH INHIBITING EFFECT ON EGF AND / OR PDGF RECEPTOR TYROSINKINASE
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
US5258518A (en) * 1992-04-01 1993-11-02 G. D. Searle & Co. 2-substituted tertiary carbinol derivatives of deoxynojirimycin
GB9323290D0 (en) 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
GB9314884D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Tricyclic derivatives
GB9314893D0 (en) * 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives

Also Published As

Publication number Publication date
NZ286263A (en) 1997-11-24
JP3088018B2 (en) 2000-09-18
GR3037070T3 (en) 2002-01-31
BR9601200A (en) 1998-01-06
RU2694252C3 (en) 2019-08-20
SK283763B6 (en) 2004-01-08
RU2174977C2 (en) 2001-10-20
MX9707453A (en) 1997-12-31
HK1038740A1 (en) 2002-03-28
TR199600265A1 (en) 1997-03-21
LU91209I2 (en) 2006-10-05
WO1996030347A1 (en) 1996-10-03
MY117896A (en) 2004-08-30
JPH10506633A (en) 1998-06-30
KR100232335B1 (en) 1999-12-01
IL129994A (en) 2008-04-13
ZA962522B (en) 1997-09-29
IL129996A0 (en) 2000-02-29
ES2332984T3 (en) 2010-02-16
UA44254C2 (en) 2002-02-15
IL189037A0 (en) 2008-06-05
EP2295415A1 (en) 2011-03-16
MA23831A1 (en) 1996-10-01
EP3103799B1 (en) 2018-06-06
CA2216796C (en) 2003-09-02
SI9600102A (en) 1997-02-28
EP0817775B1 (en) 2001-09-12
SA96160707B1 (en) 2006-03-25
PL313541A1 (en) 1996-10-14
DE69522717T2 (en) 2002-02-14
ES2161290T3 (en) 2001-12-01
OA10277A (en) 1997-10-07
NO2006004I1 (en) 2006-03-20
BR9601200B1 (en) 2010-12-14
SK283762B6 (en) 2004-01-08
NO2006004I2 (en) 2011-07-25
NO308740B1 (en) 2000-10-23
HUP9600834A1 (en) 1997-05-28
ATE446955T1 (en) 2009-11-15
NL300214I1 (en) 2006-03-01
IL117598A0 (en) 1996-07-23
PE43897A1 (en) 1997-10-10
SK38796A3 (en) 1997-08-06
AP9600788A0 (en) 1996-04-30
HUP9600834A3 (en) 1997-08-28
DE122005000053I2 (en) 2008-01-17
NO961299D0 (en) 1996-03-29
FI973832A0 (en) 1997-09-29
DE122005000053I1 (en) 2006-03-16
IL129995A0 (en) 2000-02-29
NL300214I2 (en) 2006-07-03
EP1110953A1 (en) 2001-06-27
HRP960147B1 (en) 2002-04-30
EP0817775A1 (en) 1998-01-14
HU229120B1 (en) 2013-08-28
IL129994A0 (en) 2000-02-29
CA2216796A1 (en) 1996-10-03
TW454000B (en) 2001-09-11
PL186843B1 (en) 2004-03-31
AU703638B2 (en) 1999-03-25
HU9600834D0 (en) 1996-05-28
CZ295145B6 (en) 2005-06-15
EG24229A (en) 2008-11-10
AR002723A1 (en) 1998-04-29
IL129995A (en) 2005-11-20
AU3585499A (en) 1999-08-19
CO4410333A1 (en) 1997-01-09
DE69522717D1 (en) 2001-10-18
PT817775E (en) 2002-01-30
SG43262A1 (en) 1997-10-17
RU2694252C2 (en) 2019-07-10
FI120646B (en) 2010-01-15
HRP960147A2 (en) 1997-08-31
DE69536015D1 (en) 2009-12-10
ATE205483T1 (en) 2001-09-15
EP3103799A1 (en) 2016-12-14
CN1137037A (en) 1996-12-04
DK0817775T3 (en) 2001-11-19
FR06C0010I2 (en) 2006-12-29
IL189037A (en) 2011-03-31
FI973832L (en) 1997-09-29
EP2163546A1 (en) 2010-03-17
CN1066142C (en) 2001-05-23
NO961299L (en) 1996-10-01
AP735A (en) 1999-02-25
CZ93196A3 (en) 1997-02-12
HUS1400001I1 (en) 2016-02-29
KR960034184A (en) 1996-10-22
IL117598A (en) 2005-11-20
EP1110953B1 (en) 2009-10-28
AU5040696A (en) 1996-10-10
CZ294967B6 (en) 2005-04-13
EP2163546B1 (en) 2016-06-01

Similar Documents

Publication Publication Date Title
BR122012014331A2 (en)
BRPI9612258B1 (en)
BRPI9612138B1 (en)
CH0741373H1 (en)
AU1627395A (en)
BR7501503U (en)
BR7502120U (en)
CN3031926S (en)
CN3032568S (en)
CN3029801S (en)
CN3029928S (en)
CN3030154S (en)
CN3030197S (en)
CN3030225S (en)
CN3030296S (en)
CN3030415S (en)
CN3030489S (en)
CN3030542S (en)
CN3030543S (en)
CN3030760S (en)
CN3031001S (en)
CN3031350S (en)
CN3031655S (en)
CN3031742S (en)
CN3037433S (en)