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FI971486L - Alfa-interferonin stabiilit vesiliuosformulaatiot - Google Patents

Alfa-interferonin stabiilit vesiliuosformulaatiot Download PDF

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Publication number
FI971486L
FI971486L FI971486A FI971486A FI971486L FI 971486 L FI971486 L FI 971486L FI 971486 A FI971486 A FI 971486A FI 971486 A FI971486 A FI 971486A FI 971486 L FI971486 L FI 971486L
Authority
FI
Finland
Prior art keywords
interferon alpha
stable aqueous
aqueous formulations
formulations
stable
Prior art date
Application number
FI971486A
Other languages
English (en)
Swedish (sv)
Other versions
FI971486A0 (fi
FI116558B (fi
Inventor
Pui-Ho C Yuen
Douglas F Kline
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of FI971486A0 publication Critical patent/FI971486A0/fi
Publication of FI971486L publication Critical patent/FI971486L/fi
Application granted granted Critical
Publication of FI116558B publication Critical patent/FI116558B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
FI971486A 1994-10-11 1997-04-10 Alfa-interferonin stabiilit vesiliuosformulaatiot FI116558B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/329,813 US5766582A (en) 1994-10-11 1994-10-11 Stable, aqueous alfa interferon solution formulations
US32981394 1994-10-11
PCT/US1995/012362 WO1996011018A1 (en) 1994-10-11 1995-10-10 Stable, aqueous alfa interferon solution formulations
US9512362 1995-10-10

Publications (3)

Publication Number Publication Date
FI971486A0 FI971486A0 (fi) 1997-04-10
FI971486L true FI971486L (fi) 1997-04-10
FI116558B FI116558B (fi) 2005-12-30

Family

ID=23287133

Family Applications (2)

Application Number Title Priority Date Filing Date
FI971486A FI116558B (fi) 1994-10-11 1997-04-10 Alfa-interferonin stabiilit vesiliuosformulaatiot
FI20055562A FI117377B (fi) 1994-10-11 2005-10-19 Kelatointiaineen käyttö alfatyyppistä interferonia sisältävässä, stabiilissa vesiformulaatiossa

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20055562A FI117377B (fi) 1994-10-11 2005-10-19 Kelatointiaineen käyttö alfatyyppistä interferonia sisältävässä, stabiilissa vesiformulaatiossa

Country Status (24)

Country Link
US (2) US5766582A (fi)
EP (2) EP0777495B1 (fi)
JP (2) JP3978228B2 (fi)
KR (1) KR100401401B1 (fi)
CN (1) CN1102408C (fi)
AT (2) ATE245033T1 (fi)
AU (1) AU708337B2 (fi)
BR (1) BR9509313A (fi)
CA (1) CA2201749C (fi)
CZ (1) CZ296961B6 (fi)
DE (2) DE69531314T2 (fi)
DK (1) DK0777495T3 (fi)
ES (2) ES2148568T3 (fi)
FI (2) FI116558B (fi)
GR (1) GR3034619T3 (fi)
HU (1) HU225494B1 (fi)
NO (1) NO320604B1 (fi)
NZ (1) NZ294464A (fi)
PL (1) PL183797B1 (fi)
PT (1) PT777495E (fi)
RU (1) RU2157236C2 (fi)
SK (1) SK282949B6 (fi)
UA (1) UA42028C2 (fi)
WO (1) WO1996011018A1 (fi)

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ES2172288T3 (es) 1998-05-15 2002-09-16 Schering Corp Terapia de combinacion que comprende ribavirina e interferon alfa en pacientes que no han sido sometidos a tratamiento antiviral y que tienen infeccion cronica de hepatitis c.
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KR100922454B1 (ko) 1998-11-12 2009-10-21 쉐링 코포레이션 인터페론 알파의 피루베이트 부가 이소형을 인터페론 알파로 변환시켜 인터페론 알파 조성물의 수율을 증가시키는 방법
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KR100399156B1 (ko) * 1999-11-19 2003-09-26 주식회사 엘지생명과학 α-인터페론의 용액제형
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KR100771294B1 (ko) * 1999-12-14 2007-10-29 써모 바이오스타, 인크. 폴리펩티드 및 항원 안정화 희석제
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CN1245215C (zh) 2001-02-28 2006-03-15 四川省生物工程研究中心 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂
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TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
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KR200492470Y1 (ko) 2020-03-26 2020-10-21 사공탁 빌라 주택용 쓰레기 수거함
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Also Published As

Publication number Publication date
NO971633D0 (no) 1997-04-10
EP0970703A1 (en) 2000-01-12
WO1996011018A1 (en) 1996-04-18
ATE194774T1 (de) 2000-08-15
HK1008813A1 (en) 1999-05-21
PT777495E (pt) 2000-12-29
BR9509313A (pt) 1998-01-27
EP0970703B1 (en) 2003-07-16
KR100401401B1 (ko) 2004-02-18
EP0777495B1 (en) 2000-07-19
NO320604B1 (no) 2005-12-27
HUT77287A (hu) 1998-03-30
CZ110497A3 (en) 1997-09-17
ATE245033T1 (de) 2003-08-15
DE69518084T2 (de) 2001-03-22
SK282949B6 (sk) 2003-01-09
DE69531314D1 (de) 2003-08-21
CN1102408C (zh) 2003-03-05
CA2201749A1 (en) 1996-04-18
DE69531314T2 (de) 2004-05-13
CA2201749C (en) 1999-06-15
ES2148568T3 (es) 2000-10-16
FI971486A0 (fi) 1997-04-10
PL183797B1 (pl) 2002-07-31
JP3978228B2 (ja) 2007-09-19
DE69518084D1 (de) 2000-08-24
EP0777495A1 (en) 1997-06-11
GR3034619T3 (en) 2001-01-31
JP2006193536A (ja) 2006-07-27
DK0777495T3 (da) 2000-11-06
MX9702578A (es) 1997-07-31
PL319603A1 (en) 1997-08-18
US5766582A (en) 1998-06-16
NZ294464A (en) 1999-03-29
UA42028C2 (uk) 2001-10-15
RU2157236C2 (ru) 2000-10-10
SK43997A3 (en) 1997-10-08
CZ296961B6 (cs) 2006-08-16
ES2198830T3 (es) 2004-02-01
FI20055562L (fi) 2005-10-19
KR970706017A (ko) 1997-11-03
FI117377B (fi) 2006-09-29
FI116558B (fi) 2005-12-30
JPH10506912A (ja) 1998-07-07
NO971633L (no) 1997-04-10
HU225494B1 (en) 2007-01-29
CN1160355A (zh) 1997-09-24
US5935566A (en) 1999-08-10
AU708337B2 (en) 1999-08-05
AU3727995A (en) 1996-05-02

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