[go: up one dir, main page]

FI971479L - Fuusioituja pyrrolokarbatsoleja - Google Patents

Fuusioituja pyrrolokarbatsoleja Download PDF

Info

Publication number
FI971479L
FI971479L FI971479A FI971479A FI971479L FI 971479 L FI971479 L FI 971479L FI 971479 A FI971479 A FI 971479A FI 971479 A FI971479 A FI 971479A FI 971479 L FI971479 L FI 971479L
Authority
FI
Finland
Prior art keywords
fused pyrrolocarbazoles
pyrrolocarbazoles
fused
Prior art date
Application number
FI971479A
Other languages
English (en)
Swedish (sv)
Other versions
FI115911B (fi
FI971479A0 (fi
Inventor
Robert L Hudkins
Ernest Knight Jr
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27502273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI971479(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/323,755 external-priority patent/US5475110A/en
Priority claimed from US08/427,160 external-priority patent/US5591855A/en
Priority claimed from US08/452,335 external-priority patent/US5594009A/en
Application filed by Cephalon Inc filed Critical Cephalon Inc
Publication of FI971479A0 publication Critical patent/FI971479A0/fi
Publication of FI971479L publication Critical patent/FI971479L/fi
Application granted granted Critical
Publication of FI115911B publication Critical patent/FI115911B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI971479A 1994-10-14 1997-04-09 Fuusioidut pyrrolokarbatsolit, menetelmä niiden valmistamiseksi ja niiden käyttö FI115911B (fi)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US08/323,755 US5475110A (en) 1994-10-14 1994-10-14 Fused Pyrrolocarbazoles
US32375594 1994-10-14
US42716095 1995-04-24
US08/427,160 US5591855A (en) 1994-10-14 1995-04-24 Fused pyrrolocarbazoles
US08/452,335 US5594009A (en) 1994-10-14 1995-05-26 Fused pyrrolocarbazoles
US45233595 1995-05-26
US08/526,798 US5705511A (en) 1994-10-14 1995-09-11 Fused pyrrolocarbazoles
US52679895 1995-09-11
US9512761 1995-10-03
PCT/US1995/012761 WO1996011933A1 (en) 1994-10-14 1995-10-03 Fused pyrrolocarbazoles

Publications (3)

Publication Number Publication Date
FI971479A0 FI971479A0 (fi) 1997-04-09
FI971479L true FI971479L (fi) 1997-06-11
FI115911B FI115911B (fi) 2005-08-15

Family

ID=27502273

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971479A FI115911B (fi) 1994-10-14 1997-04-09 Fuusioidut pyrrolokarbatsolit, menetelmä niiden valmistamiseksi ja niiden käyttö

Country Status (16)

Country Link
US (1) US5705511A (fi)
EP (2) EP1088823B1 (fi)
JP (1) JP2001509775A (fi)
AT (2) ATE286055T1 (fi)
AU (1) AU705306B2 (fi)
BR (1) BR9509348A (fi)
CA (1) CA2202487C (fi)
DE (2) DE69533899T2 (fi)
DK (2) DK0785938T3 (fi)
ES (2) ES2235769T3 (fi)
FI (1) FI115911B (fi)
MX (1) MX9702682A (fi)
NO (1) NO308996B1 (fi)
NZ (1) NZ296244A (fi)
PT (2) PT1088823E (fi)
WO (1) WO1996011933A1 (fi)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808060A (en) * 1995-12-11 1998-09-15 Cephalon, Inc. Fused isoindolones
SE9603283D0 (sv) * 1996-09-10 1996-09-10 Astra Ab New compounds
DK1011648T4 (da) * 1997-08-15 2005-10-24 Cephalon Inc Kombination af tyrosinkinase-inhibitor og kemisk kastration til behandling af prostatacancer
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
WO1999047522A1 (en) * 1998-03-13 1999-09-23 The University Of British Columbia Granulatimide derivatives for use in cancer treatment
US6811992B1 (en) * 1998-05-14 2004-11-02 Ya Fang Liu Method for identifying MLK inhibitors for the treatment of neurological conditions
US6127401A (en) 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
US7795246B2 (en) * 1998-08-06 2010-09-14 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
US6200968B1 (en) 1998-08-06 2001-03-13 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
DK1105728T3 (da) * 1998-08-26 2005-08-08 Cephalon Inc Modulering af multiple lineage kinase-proteiner
ES2288042T3 (es) * 1998-09-25 2007-12-16 Cephalon, Inc. Uso de pirrolocarbazoles condensados para prevenir/tratar daños de las celulas ciliadas sensoriales y neuronas cocleares.
US6841567B1 (en) * 1999-02-12 2005-01-11 Cephalon, Inc. Cyclic substituted fused pyrrolocarbazoles and isoindolones
US6399780B1 (en) * 1999-08-20 2002-06-04 Cephalon, Inc. Isomeric fused pyrrolocarbazoles and isoindolones
GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
US7122679B2 (en) * 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
US20060276497A1 (en) 2000-05-09 2006-12-07 Cephalon, Inc. Novel multicyclic compounds and the use thereof
IL154311A0 (en) * 2000-08-11 2003-09-17 Cephalon Inc Modulating multiple lineage kinase proteins
US6630500B2 (en) * 2000-08-25 2003-10-07 Cephalon, Inc. Selected fused pyrrolocarbazoles
AU2001285205B2 (en) * 2000-08-25 2007-03-01 Cephalon, Inc. Fused pyrrolocarbazoles against inflammation
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6855698B2 (en) 2001-03-22 2005-02-15 Bristol-Myers Squibb Company Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
AR035971A1 (es) * 2001-05-16 2004-07-28 Cephalon Inc Metodos para el tratamiento y la prevencion del dolor
FR2826653B1 (fr) * 2001-06-29 2005-10-14 Servier Lab Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IL144583A0 (en) 2001-07-26 2002-05-23 Peptor Ltd Chimeric protein kinase inhibitors
US20050054555A1 (en) * 2001-10-19 2005-03-10 Jose Jimeno Kahalalide compounds for use in cancer therapy
WO2003104482A1 (en) * 2002-06-05 2003-12-18 Metabolic Engineering Laboratories Co., Ltd. Signals and molecular species involved in senescence
FR2845997B1 (fr) * 2002-10-18 2004-12-24 Servier Lab Nouveaux derives de[1,4]benzodioxino[2,3-e]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0304367D0 (en) * 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) * 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
AU2003250150A1 (en) * 2003-07-23 2005-02-25 Creabilis Therapeutics S.R.L. Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excessive cell proliferation
GB0321066D0 (en) * 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
US7169802B2 (en) * 2003-12-23 2007-01-30 Cephalon, Inc. Fused pyrrolocarbazoles
US7241779B2 (en) * 2003-12-23 2007-07-10 Cephalon, Inc. Fused pyrrolocarbazoles
MX2007001155A (es) * 2004-07-29 2007-08-14 Creabilis Therapeutics Spa Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1.
US20060058250A1 (en) * 2004-09-10 2006-03-16 Cephalon, Inc. Methods of treating proliferative skin diseases using carbazole derivatives
KR100734429B1 (ko) * 2004-12-06 2007-07-03 재단법인서울대학교산학협력재단 노화에 관여하는 신호 및 분자종
US20060134174A1 (en) * 2004-12-22 2006-06-22 Bausch & Lomb Incorporated Pharmaceutical delivery system and method of use
US20060134175A1 (en) * 2004-12-22 2006-06-22 Stephen Bartels Drug eluting pharmaceutical delivery system for treatment of ocular disease and method of use
US20060134176A1 (en) * 2004-12-22 2006-06-22 Bausch & Lomb Incorporated Pharmaceutical delivery system and method of use
WO2007002670A2 (en) * 2005-06-28 2007-01-04 Bausch & Lomb Incorporated Method of lowering intraocular pressure
CN101283275A (zh) 2005-10-11 2008-10-08 默克专利有限公司 趋化因子表达的依赖egfr的调控和对肿瘤的诊断和治疗的影响及其副作用
US20070249590A1 (en) * 2005-10-28 2007-10-25 Wilson Lawrence J Substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds useful in treating kinase disorders
US20080021013A1 (en) * 2006-07-21 2008-01-24 Cephalon, Inc. JAK inhibitors for treatment of myeloproliferative disorders
KR100831367B1 (ko) 2007-02-16 2008-05-22 재단법인서울대학교산학협력재단 아데닐일 시클라아제의 억제제를 노화 세포에 처리하는 단계를 포함하는 세포의 노화 조절방법 및 아데닐일 시클라아제의 억제제를 포함하는 세포 노화 조절용 조성물
EP2207561A2 (en) * 2007-10-19 2010-07-21 Pharma Mar, S.A. Improved antitumoral treatments
WO2009067221A2 (en) * 2007-11-20 2009-05-28 Cephalon, Inc. Microemulsion containing indolocarbazole compound and dosage forms containing the same
CA2932121A1 (en) 2007-11-30 2009-06-11 Newlink Genetics Corporation Ido inhibitors
JP2012509282A (ja) * 2008-11-19 2012-04-19 セファロン、インク． インダゾロ［５，４−ａ］ピロロ［３，４−ｃ］カルバゾール化合物の新しい形態
EP2192121A1 (en) 2008-11-27 2010-06-02 Cephalon France Regioselective reduction of fused pyrrolocarbazoles-5,7-diones
EP2415773B1 (en) * 2009-03-30 2016-02-17 Duk San Neolux Co., Ltd. Organic electronic device, compounds for same, and terminal
KR101182438B1 (ko) * 2009-08-14 2012-09-12 삼성디스플레이 주식회사 유기 발광 소자
CN104968680A (zh) 2012-12-21 2015-10-07 索兰徳特医院 神经障碍和疼痛的egfr靶向疗法
CN110191709A (zh) 2017-01-17 2019-08-30 德州大学系统董事会 可用作吲哚胺2,3-双加氧酶和/或色氨酸双加氧酶抑制剂的化合物
DE102017117328A1 (de) * 2017-07-31 2019-01-31 Mitsubishi Polyester Film Gmbh Peelfähige Polyesterfolie, Verfahren zu ihrer Herstellung und ihre Verwendung
EP3823604A4 (en) 2018-07-17 2022-03-16 Board of Regents, The University of Texas System COMPOUNDS AS INHIBITORS OF INDOLAMINE-2,3-DIOXYGENASE AND/OR TRYPTOPHANE DIOXYGENASE

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552842A (en) * 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
DE3752123T2 (de) * 1987-03-09 1998-05-14 Kyowa Hakko Kogyo Kk Derivate des physiologisch aktiven mittels k-252
DE3835842A1 (de) * 1988-10-21 1990-04-26 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
DE3833008A1 (de) * 1988-09-29 1990-04-05 Goedecke Ag Pyrrolocarbozol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
US5185260A (en) * 1991-08-29 1993-02-09 The United States Of America As Represented By The United States Department Of Energy Method for distinguishing normal and transformed cells using G1 kinase inhibitors
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US6271242B1 (en) * 1992-02-10 2001-08-07 Bristol-Myers Squibb Co. Method for treating cancer using a tyrosine protein kinase inhibitor
US5405864A (en) * 1993-10-15 1995-04-11 Syntex (U.S.A.) Inc. Chemotherapeutic maleimides
DE4337521A1 (de) * 1993-11-03 1995-05-04 Teves Gmbh Alfred Verfahren zur Funktionsprüfung eines hydraulischen Aggregats

Also Published As

Publication number Publication date
BR9509348A (pt) 1997-11-04
JP2001509775A (ja) 2001-07-24
EP0785938B1 (en) 2002-01-02
NO308996B1 (no) 2000-11-27
CA2202487C (en) 2008-06-17
PT785938E (pt) 2002-06-28
FI115911B (fi) 2005-08-15
NO971677D0 (no) 1997-04-11
WO1996011933A1 (en) 1996-04-25
DK1088823T3 (da) 2005-04-25
AU3998695A (en) 1996-05-06
EP0785938A1 (en) 1997-07-30
US5705511A (en) 1998-01-06
HK1036622A1 (en) 2002-01-11
PT1088823E (pt) 2005-03-31
EP1088823B1 (en) 2004-12-29
NZ296244A (en) 1998-11-25
ES2170812T3 (es) 2002-08-16
ATE211472T1 (de) 2002-01-15
DE69533899T2 (de) 2005-12-08
EP1088823A1 (en) 2001-04-04
CA2202487A1 (en) 1996-04-25
AU705306B2 (en) 1999-05-20
DE69524882T2 (de) 2002-09-12
DE69524882D1 (de) 2002-02-07
FI971479A0 (fi) 1997-04-09
MX9702682A (es) 1998-02-28
NO971677L (no) 1997-06-11
DK0785938T3 (da) 2002-04-22
DE69533899D1 (de) 2005-02-03
ATE286055T1 (de) 2005-01-15
ES2235769T3 (es) 2005-07-16

Similar Documents

Publication Publication Date Title
FI971479L (fi) Fuusioituja pyrrolokarbatsoleja
FI954008A7 (fi) Substituoituja bifenyyli-isoksatsolisulfoniamideja
FI951908A7 (fi) Substituoituja pyridyylipyratsoleja
FI955927A0 (fi) Substituoidut 1H-imidatsolit
DE69524185D1 (de) Zwei-walzen-giessverfahren
DE69534718D1 (de) Substituierte 9-alkyladenine
BR9509559A (pt) Azolilulsolfonilfeniluracilas substituídas
DE59510274D1 (de) Substituierte biphenyloxazoline
BR7400683U (pt) Odontoportátil
ATE197372T1 (de) Vorteig
FI1359U1 (fi) Luftningsanordning foer vaetskor
FI1381U1 (fi) Baerrem foer dryckskorger
FI1696U1 (fi) Reklamsockel
FIU940362U0 (fi) Skylt- och blomsterstaell
BR7401146U (pt) Translixo
BR9401008A (pt) Helistato
BR9401864A (pt) Pescoço-giratório
BR9403310A (pt) Regulex
BR9400290A (pt) Selo-contrato
BR9400287A (pt) Bi-vaso sanitário
BR9401966A (pt) Intervalômetro-foto ARJ-07
BR9400154A (pt) Telaprotege
BR9400078A (pt) Emergensos
BR7402342U (pt) Hidro-potenciômetro
SE9403067D0 (sv) Unikey

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 115911

Country of ref document: FI

MA Patent expired