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FI963989L - Homogeneous assay methods based on luminescence energy transfer - Google Patents

Homogeneous assay methods based on luminescence energy transfer Download PDF

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Publication number
FI963989L
FI963989L FI963989A FI963989A FI963989L FI 963989 L FI963989 L FI 963989L FI 963989 A FI963989 A FI 963989A FI 963989 A FI963989 A FI 963989A FI 963989 L FI963989 L FI 963989L
Authority
FI
Finland
Prior art keywords
energy transfer
methods based
assay methods
homogeneous assay
luminescence energy
Prior art date
Application number
FI963989A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI963989A0 (en
FI963989A7 (en
Inventor
Ilkka Antero Hemmilae
Pertti Juhani Hurskainen
Kaj Runar Blomberg
Veli-Matti Mukkala
Harri Juhani Takalo
Satu Anneli Kovanen
Stuart Alan Webb
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Priority to FI963989A priority Critical patent/FI963989A7/en
Publication of FI963989A0 publication Critical patent/FI963989A0/en
Priority to EP97919087A priority patent/EP0929810A2/en
Priority to JP10517208A priority patent/JP2001502055A/en
Priority to PCT/FI1997/000560 priority patent/WO1998015830A2/en
Publication of FI963989L publication Critical patent/FI963989L/en
Publication of FI963989A7 publication Critical patent/FI963989A7/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6408Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G01N33/57555
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869Interleukin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743Steroid hormones
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/40Rare earth chelates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI963989A 1996-10-04 1996-10-04 Homogeneous determination methods based on luminescence energy transfer FI963989A7 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FI963989A FI963989A7 (en) 1996-10-04 1996-10-04 Homogeneous determination methods based on luminescence energy transfer
EP97919087A EP0929810A2 (en) 1996-10-04 1997-09-19 Homogenous luminescence energy transfer assays
JP10517208A JP2001502055A (en) 1996-10-04 1997-09-19 Homogeneous luminescence energy transfer assay
PCT/FI1997/000560 WO1998015830A2 (en) 1996-10-04 1997-09-19 Homogenous luminescence energy transfer assays

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI963989A FI963989A7 (en) 1996-10-04 1996-10-04 Homogeneous determination methods based on luminescence energy transfer

Publications (3)

Publication Number Publication Date
FI963989A0 FI963989A0 (en) 1996-10-04
FI963989L true FI963989L (en) 1998-04-05
FI963989A7 FI963989A7 (en) 1998-04-05

Family

ID=8546810

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963989A FI963989A7 (en) 1996-10-04 1996-10-04 Homogeneous determination methods based on luminescence energy transfer

Country Status (4)

Country Link
EP (1) EP0929810A2 (en)
JP (1) JP2001502055A (en)
FI (1) FI963989A7 (en)
WO (1) WO1998015830A2 (en)

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JP2001255326A (en) * 2000-01-31 2001-09-21 Pen State Res Found:The Inquiries about changes in the contents of sealed containers
FI20000333A0 (en) 2000-02-16 2000-02-16 Jussi Nurmi A homogeneous method for detecting a polynucleotide
US7160735B2 (en) 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US7537938B2 (en) 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US7771929B2 (en) 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
FR2809817B1 (en) 2000-06-02 2003-08-15 Cis Bio Int METHOD FOR DETECTING THE PRESENCE OF A LIQUID IN A MIXTURE
DE10058596A1 (en) 2000-11-25 2002-06-06 Aventis Pharma Gmbh Method of screening chemical compounds for modulating the interaction of an EVH1 domain or a protein with an EVH1 domain with an EVH1 binding domain or a protein with an EVH1 binding domain, and a method for detecting said interaction
ATE311596T1 (en) 2001-04-23 2005-12-15 Eiken Chemical ANALYSIS METHOD WITH INTERMOLECULAR INTERACTION OF A REPORTER (MARKER)
PL373962A1 (en) 2001-05-21 2005-09-19 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
HUP0501021A3 (en) 2001-05-21 2006-06-28 Aclara Biosciences Inc Mountai Methods and compositions for analyzing proteins
AU2002344221A1 (en) 2001-05-26 2002-12-09 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
US7211440B2 (en) * 2002-03-08 2007-05-01 Wallac Oy Dissociative fluorescence enhancement assay
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US7402397B2 (en) 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
EP1553408A4 (en) 2002-07-08 2005-08-17 Tetsuo Nagano FLUORESCENT PROBE
US7696245B2 (en) 2003-03-28 2010-04-13 Sekisui Medical Co., Ltd. Fluorescent probe for zinc
FI20030460A0 (en) 2003-03-28 2003-03-28 Tero Soukka Homogeneous method of determination based on transmission of luminescence energy
ATE370415T1 (en) * 2003-03-28 2007-09-15 Tero Soukka BIOASSAY WITH ENERGY TRANSFER WITH HOMOGENEOUS LUMINESCENCE
EP1673634B1 (en) * 2003-10-01 2008-08-06 Wallac Oy Improved homogeneous time-resolved energy transfer assay
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JP2005194244A (en) 2004-01-09 2005-07-21 Shigenobu Yano Zinc ion fluorescence sensor
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EP1994407A4 (en) 2005-12-30 2009-05-20 Turun Yliopisto METHOD FOR DETERMINING THE CONCENTRATION, THE LOAD OR THE UNIT SIZE OF A SUBSTANCE
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JP5732452B2 (en) * 2009-04-30 2015-06-10 セイエス ビオ アンテルナショナル Method for detecting compound that modulates dimer of VFT domain membrane protein
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US8673823B2 (en) 2010-03-18 2014-03-18 Sanofi Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia
JP5939994B2 (en) 2010-03-18 2016-06-29 サノフイ Methods and uses relating to identifying compounds related to pain and methods for diagnosing hyperalgesia
EP2547788A1 (en) 2010-03-18 2013-01-23 Sanofi Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia
EP2390348A1 (en) 2010-05-25 2011-11-30 Sanofi Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia
EP2390349A1 (en) 2010-05-25 2011-11-30 Sanofi Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia
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Also Published As

Publication number Publication date
WO1998015830A3 (en) 1998-06-18
FI963989A0 (en) 1996-10-04
WO1998015830A2 (en) 1998-04-16
EP0929810A2 (en) 1999-07-21
JP2001502055A (en) 2001-02-13
FI963989A7 (en) 1998-04-05

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