[go: up one dir, main page]

FI953717L - 4-Hydroxybenzopyran-2-ones and 4-hydroxycycloalkyl(b)pyran-2-ones, which can be used to treat retroviral infections - Google Patents

4-Hydroxybenzopyran-2-ones and 4-hydroxycycloalkyl(b)pyran-2-ones, which can be used to treat retroviral infections Download PDF

Info

Publication number
FI953717L
FI953717L FI953717A FI953717A FI953717L FI 953717 L FI953717 L FI 953717L FI 953717 A FI953717 A FI 953717A FI 953717 A FI953717 A FI 953717A FI 953717 L FI953717 L FI 953717L
Authority
FI
Finland
Prior art keywords
ones
hydroxybenzopyran
hydroxycycloalkyl
pyran
retroviral infections
Prior art date
Application number
FI953717A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI953717A0 (en
FI953717A7 (en
Inventor
David John Anderson
Lee S Banitt
Paul Kosta Tomich
Michael John Bohanon
Steven Ronald Turner
Joseph Walter Strohbach
Suvit Thaisrivongs
Chih-Ping Yang
Richard C Thomas
Karen Rene Romines
Paul Adrian Aristoff
Harvey Irving Skulnick
Paul D Johnson
Ronald B Gammill
Qingwei Zhang
Gordon L Bundy
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FI953717A0 publication Critical patent/FI953717A0/en
Publication of FI953717L publication Critical patent/FI953717L/en
Publication of FI953717A7 publication Critical patent/FI953717A7/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI953717A 1993-02-05 1994-02-03 4-Hydroxybenzopyran-2-ones and 4-hydroxycycloalkyl(b)pyran-2-ones, which can be used to treat retroviral infections FI953717A7 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1445993A 1993-02-05 1993-02-05
US6871593A 1993-05-27 1993-05-27
US16930293A 1993-12-17 1993-12-17
PCT/US1994/000938 WO1994018188A1 (en) 1993-02-05 1994-02-03 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl[b]pyran-2-ones useful to treat retroviral infections

Publications (3)

Publication Number Publication Date
FI953717A0 FI953717A0 (en) 1995-08-04
FI953717L true FI953717L (en) 1995-08-04
FI953717A7 FI953717A7 (en) 1995-08-04

Family

ID=27360109

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953717A FI953717A7 (en) 1993-02-05 1994-02-03 4-Hydroxybenzopyran-2-ones and 4-hydroxycycloalkyl(b)pyran-2-ones, which can be used to treat retroviral infections

Country Status (22)

Country Link
US (1) US5686486A (en)
EP (1) EP0682663B1 (en)
JP (2) JPH08505641A (en)
CN (1) CN1117291A (en)
AT (1) ATE200669T1 (en)
AU (1) AU6166194A (en)
CA (1) CA2153237A1 (en)
CZ (1) CZ9502002A3 (en)
DE (1) DE69427120T2 (en)
DK (1) DK0682663T3 (en)
FI (1) FI953717A7 (en)
GR (1) GR3036189T3 (en)
HU (1) HUT72755A (en)
IL (1) IL108459A0 (en)
LV (1) LV12863B (en)
NO (1) NO953070L (en)
NZ (1) NZ262255A (en)
PL (1) PL310111A1 (en)
PT (1) PT682663E (en)
RU (1) RU2125999C1 (en)
SK (1) SK95695A3 (en)
WO (1) WO1994018188A1 (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637589A (en) * 1993-10-29 1997-06-10 University Of North Carolina At Chapel Hill Suksdorfin, analogs, compositions thereof, and methods for making and using thereof
MD1560G2 (en) * 1993-11-19 2001-07-31 Parke, Davis & Company Cyclic compounds, pharmaceutical compositions based on them and methods for treating infections or diseases caused by retroviruses
US6005103A (en) * 1993-11-19 1999-12-21 Warner-Lambert Company Pyrone derivatives as protease inhibitors and antiviral agents
US5510375A (en) * 1993-11-19 1996-04-23 Warner-Lambert Company Coumarin derivatives as protease inhibitors and antiviral agents
US5789440A (en) * 1993-11-19 1998-08-04 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US5504104A (en) * 1993-11-19 1996-04-02 Warner-Lambert Company Tricyclic pyrone derivatives as protease inhibitors and antiviral agents
US6319929B1 (en) 1994-04-29 2001-11-20 The University Of North Carolina At Chapel Hill Suksdorfin analogs, compositions thereof, and methods for making and using thereof
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
US6060600A (en) * 1995-03-20 2000-05-09 Pharmacia & Upjohn Company Substituted tetronic acids useful for treating HIV and other retroviruses
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
CN1215835C (en) * 1996-03-27 2005-08-24 东丽株式会社 Ketone Derivatives and Their Applications in Medicine
EP0980861A4 (en) * 1997-04-04 2001-05-23 Teijin Ltd Salicylic ester derivatives and process for producing the same
DE69833952T2 (en) * 1997-09-26 2006-12-07 Toray Industries, Inc. Cyclic ketone derivatives and their pharmaceutical use
US7145020B2 (en) * 2001-04-24 2006-12-05 Aryx Therapeutics Materials and methods for treating coagulation disorders
CA2445160A1 (en) * 2001-04-24 2002-10-31 Aryx Therapeutics Coumarin derivatives to be used as anticoagulants
CN100350036C (en) * 2001-04-27 2007-11-21 宝洁公司 Apparatus and method for controlling biofilms
US7202928B2 (en) * 2003-10-16 2007-04-10 Lg. Philips Lcd Co., Ltd Array substrate for in-plane switching mode liquid crystal display device and method of fabricating the same
JP5036532B2 (en) * 2004-04-08 2012-09-26 アルメテオン、インコーポレイテッド Substances and methods for treating blood coagulation diseases
DK2161261T3 (en) * 2004-04-08 2013-11-04 Armetheon Inc Materials and methods for treating coagulation disorders
US7253208B2 (en) 2004-04-08 2007-08-07 Aryx Therapeutics Materials and methods for treating coagulation disorders
AR059339A1 (en) 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd CUMARINE DERIVATIVES FOR PROLIFERATIVE DISORDERS OF CELLS, PHARMACEUTICAL COMPOSITION AND THERAPEUTIC AGENT CONTAINING THEM
US7939545B2 (en) * 2006-05-16 2011-05-10 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
TWI295288B (en) * 2006-08-17 2008-04-01 Univ Nat Chunghsing New route for the synthesis of benzoxazine
WO2009014100A1 (en) * 2007-07-20 2009-01-29 Chugai Seiyaku Kabushiki Kaisha p27 PROTEIN INDUCER
WO2009062289A1 (en) * 2007-11-15 2009-05-22 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
US8354429B2 (en) 2007-11-16 2013-01-15 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
ES2322121B1 (en) * 2007-12-10 2010-04-19 Consejo Superior De Investigaciones Cientificas NEW DERIVATIVES OF DICARBOXYL AMINO ACIDS AND ITS APPLICATION IN THE TREATMENT OF NEURODEGENERATIVE DISEASES.
JP2012513471A (en) * 2008-12-22 2012-06-14 スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ Coumarin compounds for the treatment of Alzheimer's disease and cancer
CN102040592B (en) * 2009-10-10 2015-07-15 西南大学 Coumarin azole compound with antimicrobial activity, and preparation method and medicinal application thereof
WO2014089296A2 (en) * 2012-12-06 2014-06-12 Institute For Hepatitis And Virus Research Functionalized benzamide derivatives as antiviral agents against hbv infection
EP2963019B1 (en) 2013-02-28 2020-08-12 Takeda Pharmaceutical Company Limited Method for producing pyridine-3-sulfonyl chloride
WO2014151100A1 (en) 2013-03-15 2014-09-25 Micromidas, Inc. Methods for preparing alkylfurans
BR112016015449A8 (en) * 2013-12-30 2020-06-09 Lifesci Pharmaceuticals Inc therapeutic inhibitory compounds, pharmaceutical composition comprising them and use thereof
WO2016040527A1 (en) * 2014-09-09 2016-03-17 Vanderbilt University Metabolism probes for therapy and diagnosis
CN104374858B (en) * 2014-11-21 2016-06-29 宜昌人福药业有限责任公司 A kind of detection method of sufentanil citrate synthesis material and impurity
CN105218530B (en) * 2015-10-20 2019-07-02 青岛农业大学 3-(1-Aryl-2-(2-azaarene)ethyl)-4-hydroxycoumarin and preparation method thereof
CN109608421A (en) * 2019-01-22 2019-04-12 河北科技大学 A kind of synthetic method of 5-aminolevulinic acid hydrochloride
RU2707103C1 (en) * 2019-06-15 2019-11-22 Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр "КОМИ научный центр Уральского отделения Российской академии наук" Coumarins with bicyclic monoterpene substitutes
WO2021158575A1 (en) * 2020-02-03 2021-08-12 Natural Extraction Systems, LLC Compositions related to bioactive agents that convert from anions to molecules
WO2022182523A1 (en) * 2021-02-26 2022-09-01 Natural Extraction Systems, LLC Compositions related to bioactive agents that convert from anions to molecules
CN117326942A (en) * 2023-09-28 2024-01-02 江苏集萃光敏电子材料研究所有限公司 Extraction-free process for preparing p-acetoxystyrene

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL80964C (en) * 1952-03-08
NL82169C (en) * 1952-05-16
US2723277A (en) * 1952-08-26 1955-11-08 Hoffmann La Roche Malonic acid derivatives and process for the manufacture thereof
FR1463767A (en) * 1963-04-03 1966-07-22 Clin Byla Ets Coumarin derivatives and their preparation
BE674997A (en) * 1965-01-13 1966-07-12
US3489774A (en) * 1967-04-24 1970-01-13 Dow Chemical Co 3-(beta-aryl-beta-(arylthio) (or arylseleno) propionyl)-coumarin products
US3493586A (en) * 1969-01-23 1970-02-03 Dow Chemical Co 3-(beta-aryl-beta-(arylthio) (or arylseleno)-propionyl)pyrone products
US3764693A (en) * 1969-11-21 1973-10-09 Lipha A rodenticidal compositions containing 4-hydroxy coumarins
US3835161A (en) * 1972-10-24 1974-09-10 Realisations Scient S E Res C 3-substituted-4-hydroxy-coumarins
CH648030A5 (en) * 1980-12-15 1985-02-28 Sandoz Ag BENZOPYRANE ALLYLAMINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE.
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4701456A (en) * 1984-09-19 1987-10-20 Warner-Lambert Company Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents
WO1988004652A1 (en) * 1986-12-17 1988-06-30 Nippon Soda Co., Ltd. Heterocyclic compounds having triketo skeleton
JPH03503635A (en) * 1988-03-01 1991-08-15 ジ・アップジョン・カンパニー Coumarins inhibit reverse transcriptase in humans
JPH05503073A (en) * 1989-09-26 1993-05-27 オクタマー，インコーポレイテッド 6-Amino-1,2-benzopyrone useful in the treatment of viral diseases
WO1991006561A1 (en) * 1989-10-27 1991-05-16 The Upjohn Company Method for treating hiv and other retroviruses and compounds useful therefor
JPH03227923A (en) * 1990-01-30 1991-10-08 Sawai Seiyaku Kk Agent for treating human immunoinsufficiency virus disease
SE9000624D0 (en) * 1990-02-22 1990-02-22 Pharmacia Ab NEW USE
EP0549729B1 (en) * 1990-09-07 1997-12-17 Schering Corporation Antiviral compounds and antihypertensive compounds
JPH06501465A (en) * 1990-09-07 1994-02-17 シェリング・コーポレーション antiviral compounds
WO1992004328A1 (en) * 1990-09-07 1992-03-19 Schering Corporation Antiviral compounds and antihypertensive compounds
WO1992017490A1 (en) * 1991-04-04 1992-10-15 The Upjohn Company Phosphorus containing compounds as inhibitors of retroviruses

Also Published As

Publication number Publication date
PT682663E (en) 2001-10-30
CZ9502002A3 (en) 1995-12-13
CN1117291A (en) 1996-02-21
HUT72755A (en) 1996-05-28
WO1994018188A1 (en) 1994-08-18
NO953070L (en) 1995-10-04
GR3036189T3 (en) 2001-10-31
NO953070D0 (en) 1995-08-04
LV12863B (en) 2002-11-20
DK0682663T3 (en) 2001-06-18
AU6166194A (en) 1994-08-29
CA2153237A1 (en) 1994-08-18
DE69427120T2 (en) 2001-08-23
IL108459A0 (en) 1994-04-12
SK95695A3 (en) 1995-12-06
JP2005002133A (en) 2005-01-06
ATE200669T1 (en) 2001-05-15
HU9501968D0 (en) 1995-09-28
JPH08505641A (en) 1996-06-18
EP0682663A1 (en) 1995-11-22
NZ262255A (en) 1997-05-26
PL310111A1 (en) 1995-11-27
DE69427120D1 (en) 2001-05-23
FI953717A0 (en) 1995-08-04
US5686486A (en) 1997-11-11
RU2125999C1 (en) 1999-02-10
FI953717A7 (en) 1995-08-04
EP0682663B1 (en) 2001-04-18

Similar Documents

Publication Publication Date Title
FI953717L (en) 4-Hydroxybenzopyran-2-ones and 4-hydroxycycloalkyl(b)pyran-2-ones, which can be used to treat retroviral infections
FI961030L (en) Epoxidation catalyst and process
FI941378L (en) Benzimidazole compounds, their use and preparation
FI952302L (en) Pyran-2-ones and 5,6-dihydropyranones useful in the treatment of HIV and other retroviruses
DE59408821D1 (en) Exhaust treatment device
IT1240078B (en) INORGANIC DUST TREATMENT PROCEDURE.
BR8900962A (en) BACTERICIDE COMPOSITION AND TREATMENT PROCESS
DE68910799D1 (en) Fiber treatment composition.
DK73891D0 (en) ENZYME TREATMENT
BR9202294A (en) CATALYST, PROCESS OF PREPARATION OF THE SAME AND PROCESS OF TREATMENT OF GASES CONTAINING SULFURED COMPOUNDS
BR9105095A (en) SUBSTITUABLE SLIDING, PROCESSING AND REFRACTORY VALVE
NO940810D0 (en) Treatment of viral infections
FI874939A7 (en) ANTIBIOTICAL TREATMENTS.
FI940425A7 (en) Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
FI934680A7 (en) Arylmorpholine, preparation and use
DE68913088D1 (en) Fiber treatment composition.
TR28651A (en) Glass composition and use.
BR9302297A (en) CONVERSIBLE BOWLING HAND, AND USA-LA PROCESS
DE58900806D1 (en) MULTIPACK.
DE3875192D1 (en) EXHAUST TREATMENT.
FI951655L (en) Treatment of H. pylori infections
FI944563L (en) Microorganisms, preparation method and use
BR8901342A (en) POLIDIORGANOSILOXAN AND THE SAME PREPARATION PROCESS
DE59702263D1 (en) Purification of p.p-bisphenolate solutions
FI954213L (en) Antitumor compositions and treatment methods

Legal Events

Date Code Title Description
HC Name/ company changed in application

Owner name: PHARMACIA & UPJOHN COMPANY