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FI951630L - Infraröd-färgmedel-märkade nukleotide och deras användning i nukleinsyra-detektering - Google Patents

Infraröd-färgmedel-märkade nukleotide och deras användning i nukleinsyra-detektering Download PDF

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Publication number
FI951630L
FI951630L FI951630A FI951630A FI951630L FI 951630 L FI951630 L FI 951630L FI 951630 A FI951630 A FI 951630A FI 951630 A FI951630 A FI 951630A FI 951630 L FI951630 L FI 951630L
Authority
FI
Finland
Prior art keywords
nucleic acids
labeled nucleotides
detecting nucleic
infrared dye
dye
Prior art date
Application number
FI951630A
Other languages
English (en)
Finnish (fi)
Other versions
FI105555B (sv
FI951630A0 (sv
Inventor
Klaus Muehlegger
Hans-Joachim Hoeltke
Christian Birkner
Der Eltz Herbert Von
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6494618&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI951630(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of FI951630L publication Critical patent/FI951630L/sv
Publication of FI951630A0 publication Critical patent/FI951630A0/sv
Application granted granted Critical
Publication of FI105555B publication Critical patent/FI105555B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
FI951630A 1993-08-06 1995-04-05 Infraröd-färgmedel-märkade nukleotider och deras användning i nukleinsyra-detektering FI105555B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4326466 1993-08-06
DE4326466A DE4326466A1 (de) 1993-08-06 1993-08-06 Infrarot-Farbstoff-markierte Nucleotide und ihre Verwendung in der Nucleinsäure-Detektion
PCT/EP1994/002541 WO1995004747A1 (de) 1993-08-06 1994-07-30 Infrarot-farbstoff-markierte nucleotide und ihre verwendung in der nucleinsäure-detektion
EP9402541 1994-07-30

Publications (3)

Publication Number Publication Date
FI951630L true FI951630L (sv) 1995-04-05
FI951630A0 FI951630A0 (sv) 1995-04-05
FI105555B FI105555B (sv) 2000-09-15

Family

ID=6494618

Family Applications (1)

Application Number Title Priority Date Filing Date
FI951630A FI105555B (sv) 1993-08-06 1995-04-05 Infraröd-färgmedel-märkade nukleotider och deras användning i nukleinsyra-detektering

Country Status (14)

Country Link
US (1) US6573374B1 (sv)
EP (1) EP0663922B1 (sv)
JP (2) JP2966524B2 (sv)
KR (2) KR0156095B1 (sv)
AT (1) ATE186304T1 (sv)
AU (2) AU671928B2 (sv)
CA (1) CA2145405C (sv)
DE (2) DE4326466A1 (sv)
DK (1) DK0663922T3 (sv)
ES (1) ES2140551T3 (sv)
FI (1) FI105555B (sv)
NO (1) NO303543B1 (sv)
NZ (1) NZ271092A (sv)
WO (1) WO1995004747A1 (sv)

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US5360523A (en) * 1984-03-29 1994-11-01 Li-Cor, Inc. DNA sequencing
US4729947A (en) * 1984-03-29 1988-03-08 The Board Of Regents Of The University Of Nebraska DNA sequencing
US5571388A (en) * 1984-03-29 1996-11-05 Li-Cor, Inc. Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof
US6207421B1 (en) 1984-03-29 2001-03-27 Li-Cor, Inc. DNA sequencing and DNA terminators
US6004446A (en) * 1984-03-29 1999-12-21 Li-Cor, Inc. DNA Sequencing
US6048982A (en) * 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US6956032B1 (en) 1986-04-18 2005-10-18 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US6225050B1 (en) 1986-04-18 2001-05-01 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5808044A (en) * 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US6593148B1 (en) 1994-03-01 2003-07-15 Li-Cor, Inc. Cyanine dye compounds and labeling methods
DE4438918A1 (de) * 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
US6338943B1 (en) * 1996-10-08 2002-01-15 Kreatech Biotechnology B.V. Methods for labeling nucleotides, labeled nucleotides and useful intermediates
US6027709A (en) * 1997-01-10 2000-02-22 Li-Cor Inc. Fluorescent cyanine dyes
US5986086A (en) * 1997-06-20 1999-11-16 Amersham Pharmacia Biotech Inc. Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
WO2000056933A1 (en) * 1999-03-24 2000-09-28 Princeton Separations Chemically reactive plane-rigidized cyanine dyes and their derivatives
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
ATE315066T1 (de) 2000-09-19 2006-02-15 Li Cor Inc Cyaninfarbstoffe
US7597878B2 (en) 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
CA2425663C (en) * 2000-10-11 2009-12-29 Applera Corporation Fluorescent nucleobase conjugates having anionic linkers
US6331632B1 (en) * 2000-11-09 2001-12-18 Beckman Coulter, Inc. Cyanine dye phosphoramidites
EP1221465A1 (en) * 2001-01-03 2002-07-10 Innosense S.r.l. Symmetric, monofunctionalised polymethine dyes labelling reagents
WO2002072892A1 (en) * 2001-03-12 2002-09-19 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
WO2003064626A2 (en) 2002-02-01 2003-08-07 Sequitur, Inc. Double-stranded oligonucleotides
EP1572902B1 (en) * 2002-02-01 2014-06-11 Life Technologies Corporation HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
JP2007516695A (ja) * 2003-06-12 2007-06-28 アプレラ コーポレイション ユニバーサル塩基アナログを含む組合せ核酸塩基オリゴマーならびにこれらを作製する方法および使用する方法
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
DE602005020421D1 (de) 2004-02-19 2010-05-20 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
US7312326B2 (en) * 2004-04-09 2007-12-25 Beckman Coulter, Inc. Fluorescent labeled nucleotide derivatives
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
ATE507305T1 (de) 2004-05-25 2011-05-15 Helicos Biosciences Corp Verfahren zur nukleinsäureimmobilisierung
US7910753B2 (en) * 2004-09-10 2011-03-22 Anaspec Incorporated Cyanine dyes and their applications as luminescence quenching compounds
US7445902B2 (en) * 2004-09-30 2008-11-04 Ge Healthcare Uk Limited Fluorescent nucleotide analogues
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
AR059193A1 (es) 2006-01-31 2008-03-12 Bayer Schering Pharma Ag Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
EP2005970A1 (de) 2007-06-22 2008-12-24 Berlin Science Partners GmbH i.V. Bildgebende Diagnostik durch Kombination von Kontrastmitteln
WO2011027219A1 (en) 2009-09-04 2011-03-10 Progenika Biopharma, S.A. High throughput detection of small genomic deletions and insertions
US20120215459A1 (en) 2009-09-04 2012-08-23 Marianne Stef High throughput detection of genomic copy number variations
US10017551B2 (en) 2013-03-15 2018-07-10 The Regents Of The University Of California Peptides having reduced toxicity that stimulate cholesterol efflux
CN119662792A (zh) 2019-02-19 2025-03-21 阿尔缇玛基因组学公司 用于光学检测和测序的接头和方法
US11807851B1 (en) 2020-02-18 2023-11-07 Ultima Genomics, Inc. Modified polynucleotides and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US5151507A (en) 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US4997928A (en) * 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
IL91673A0 (en) * 1988-09-20 1990-04-29 Us Health Method for tagging an oligodeoxynucleotide
ATE147400T1 (de) * 1991-08-13 1997-01-15 Bayer Ag Fluoreszierendes etikett

Also Published As

Publication number Publication date
WO1995004747A1 (de) 1995-02-16
US6573374B1 (en) 2003-06-03
JP3266865B2 (ja) 2002-03-18
FI105555B (sv) 2000-09-15
EP0663922B1 (de) 1999-11-03
DK0663922T3 (da) 2000-04-10
AU671928B2 (en) 1996-09-12
AU7461194A (en) 1995-02-28
KR0156042B1 (ko) 1998-10-15
AU5942496A (en) 1996-09-19
KR0156095B1 (ko) 1998-10-15
AU682290B2 (en) 1997-09-25
JPH11286498A (ja) 1999-10-19
ES2140551T3 (es) 2000-03-01
CA2145405A1 (en) 1995-02-16
NO951319D0 (no) 1995-04-05
ATE186304T1 (de) 1999-11-15
NZ271092A (en) 1996-11-26
DE59408887D1 (de) 1999-12-09
JP2966524B2 (ja) 1999-10-25
CA2145405C (en) 2002-09-17
FI951630A0 (sv) 1995-04-05
NO951319L (no) 1995-04-05
DE4326466A1 (de) 1995-02-09
JPH07507576A (ja) 1995-08-24
EP0663922A1 (de) 1995-07-26
KR950703571A (ko) 1995-09-20
NO303543B1 (no) 1998-07-27

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Owner name: ROCHE DIAGNOSTICS GMBH

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