FI955709L - Indolokarbatsolijohdannaisten käyttö eturauhasen patologisten tilojen hoidossa - Google Patents

Indolokarbatsolijohdannaisten käyttö eturauhasen patologisten tilojen hoidossa Download PDF

Info

Publication number: FI955709L
Authority: FI; Finland
Prior art keywords: prostate; treatment; pathological conditions; indolocarbazole derivatives; indolocarbazole
Prior art date: 1993-05-28

Application number

FI955709A

Other languages

English (en)

Swedish (sv)

Other versions

FI955709A0 (fi

FI113537B (fi

Inventor

Craig A Dionne

Patricia C Contreras

Chikara Murakata

Original Assignee

Cephalon Inc

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-28

Filing date

1995-11-27

Publication date

1996-01-03

1995-11-27 Application filed by Cephalon Inc, Kyowa Hakko Kogyo Kk filed Critical Cephalon Inc

1995-11-27 Publication of FI955709A0 publication Critical patent/FI955709A0/fi

1996-01-03 Publication of FI955709L publication Critical patent/FI955709L/fi

2004-05-14 Application granted granted Critical

2004-05-14 Publication of FI113537B publication Critical patent/FI113537B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

FI955709A 1993-05-28 1995-11-27 Menetelmä terapeuttisesti käyttökelpoisten indolokarbatsolijohdannaisten valmistamiseksi FI113537B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US6917893A	1993-05-28	1993-05-28
US6917893		1993-05-28
US9662293A	1993-07-22	1993-07-22
US9662293		1993-07-22
PCT/US1994/006082 WO1994027982A1 (en)	1993-05-28	1994-05-27	Use of indolocarbazole derivatives to treat a pathological condition of the prostate
US9406082		1994-05-27

Publications (3)

Publication Number	Publication Date
FI955709A0 FI955709A0 (fi)	1995-11-27
FI955709L true FI955709L (fi)	1996-01-03
FI113537B FI113537B (fi)	2004-05-14

Family

ID=26749764

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FI955709A FI113537B (fi)	1993-05-28	1995-11-27	Menetelmä terapeuttisesti käyttökelpoisten indolokarbatsolijohdannaisten valmistamiseksi
FI20031516A FI114864B (fi)	1993-05-28	2003-10-16	Menetelmä terapeuttisesti käyttökelpoisten indolokarbatsolijohdannaisten valmistamiseksi

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
FI20031516A FI114864B (fi)	1993-05-28	2003-10-16	Menetelmä terapeuttisesti käyttökelpoisten indolokarbatsolijohdannaisten valmistamiseksi

Country Status (14)

Country	Link
US (2)	US5516771A (fi)
EP (2)	EP0699204B1 (fi)
JP (2)	JP3344586B2 (fi)
KR (1)	KR100201343B1 (fi)
AT (1)	ATE165097T1 (fi)
AU (1)	AU679752B2 (fi)
CA (1)	CA2163904C (fi)
DE (1)	DE69409641T2 (fi)
DK (1)	DK0699204T3 (fi)
ES (1)	ES2118414T3 (fi)
FI (2)	FI113537B (fi)
NO (1)	NO306902B1 (fi)
NZ (1)	NZ267337A (fi)
WO (1)	WO1994027982A1 (fi)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5756494A (en) *	1992-07-24	1998-05-26	Cephalon, Inc.	Protein kinase inhibitors for treatment of neurological disorders
DE4243321A1 (de) *	1992-12-21	1994-06-23	Goedecke Ag	Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
EP0695755B1 (en) *	1994-08-04	1998-10-21	F. Hoffmann-La Roche AG	Pyrrolocarbazole
US5686444A (en) *	1995-04-05	1997-11-11	Cephalon, Inc.	Selected soluble esters of hydroxyl-containing indolocarbazoles
US5650407A (en) *	1995-04-05	1997-07-22	Cephalon, Inc.	Selected soluble esters of hydroxyl-containing indolocarbazoles
US6197293B1 (en)	1997-03-03	2001-03-06	Calydon, Inc.	Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
US6676935B2 (en)	1995-06-27	2004-01-13	Cell Genesys, Inc.	Tissue specific adenoviral vectors
US5808060A (en) *	1995-12-11	1998-09-15	Cephalon, Inc.	Fused isoindolones
AU736333B2 (en) *	1996-05-01	2001-07-26	Eli Lilly And Company	Therapeutic treatment for VEGF related diseases
US6875865B1 (en)	1996-06-03	2005-04-05	Cephalon, Inc.	Selected derivatives of K-252a
UA67725C2 (en)	1996-06-03	2004-07-15	Cephalon Inc	K-252a derivatives and a method for improvement of functioning and cell survival enhancement
UA65542C2 (uk)	1996-06-25	2004-04-15	Сефалон, Інк.	Спосіб пригнічення надлишкового продукування фактора некрозу пухлин альфа , спосіб полегшення шкідливих ефектів надлишкового продукування фактора некрозу пухлин альфа та спосіб лікування запального стану або захворювання, пов'язаного з фактором некрозу пухлин.
DK1011648T4 (da) *	1997-08-15	2005-10-24	Cephalon Inc	Kombination af tyrosinkinase-inhibitor og kemisk kastration til behandling af prostatacancer
DE69812177T2 (de)	1997-12-31	2004-01-15	Cephalon Inc	3'-epi k-252a derivate
US6127401A (en) *	1998-06-05	2000-10-03	Cephalon, Inc.	Bridged indenopyrrolocarbazoles
US6013646A (en)	1998-07-02	2000-01-11	Bayer Corporation	Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US7795246B2 (en) *	1998-08-06	2010-09-14	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
US6200968B1 (en)	1998-08-06	2001-03-13	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
ES2288042T3 (es)	1998-09-25	2007-12-16	Cephalon, Inc.	Uso de pirrolocarbazoles condensados para prevenir/tratar daños de las celulas ciliadas sensoriales y neuronas cocleares.
CA2348835A1 (en) *	1998-10-28	2000-05-04	Cornell Research Foundation, Inc.	Methods for regulating angiogenesis and vascular integrity using trk receptor ligands
US6841567B1 (en) *	1999-02-12	2005-01-11	Cephalon, Inc.	Cyclic substituted fused pyrrolocarbazoles and isoindolones
US6472385B1 (en) *	1999-08-09	2002-10-29	Trustees Of Darmouth College	Compositions and methods to enhance cancer chemotherapy in p53 defective tumors
US6399780B1 (en)	1999-08-20	2002-06-04	Cephalon, Inc.	Isomeric fused pyrrolocarbazoles and isoindolones
US7129250B2 (en)	2000-05-19	2006-10-31	Aegera Therapeutics Inc.	Neuroprotective and anti-proliferative compounds
AR035971A1 (es) *	2001-05-16	2004-07-28	Cephalon Inc	Metodos para el tratamiento y la prevencion del dolor
IL144583A0 (en) *	2001-07-26	2002-05-23	Peptor Ltd	Chimeric protein kinase inhibitors
IL156429A0 (en) *	2003-06-12	2004-01-04	Peptor Ltd	Cell permeable conjugates of peptides for inhibition of protein kinases
CN101283275A (zh)	2005-10-11	2008-10-08	默克专利有限公司	趋化因子表达的依赖egfr的调控和对肿瘤的诊断和治疗的影响及其副作用
US20080021013A1 (en) *	2006-07-21	2008-01-24	Cephalon, Inc.	JAK inhibitors for treatment of myeloproliferative disorders
WO2009067221A2 (en) *	2007-11-20	2009-05-28	Cephalon, Inc.	Microemulsion containing indolocarbazole compound and dosage forms containing the same
CN104968680A (zh)	2012-12-21	2015-10-07	索兰徳特医院	神经障碍和疼痛的egfr靶向疗法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62155284A (ja) *	1985-12-27	1987-07-10	Kyowa Hakko Kogyo Co Ltd	生理活性物質ｋ−２５２の誘導体
JPS62155285A (ja) *	1985-12-27	1987-07-10	Kyowa Hakko Kogyo Co Ltd	生理活性物質ｋ−２５２の誘導体
JPS62240689A (ja) *	1986-04-07	1987-10-21	Meiji Seika Kaisha Ltd	Ｓｆ−２３７０物質誘導体及びその製法
JPH0826037B2 (ja) *	1987-01-22	1996-03-13	協和醗酵工業株式会社	生理活性物質ｋ−２５２の誘導体
JPH0826036B2 (ja) *	1987-01-22	1996-03-13	協和醗酵工業株式会社	生理活性物質ｋ−２５２の誘導体
DE3752123T2 (de) *	1987-03-09	1998-05-14	Kyowa Hakko Kogyo Kk	Derivate des physiologisch aktiven mittels k-252
JPH07113027B2 (ja) *	1987-12-24	1995-12-06	協和醗酵工業株式会社	Ｋ−２５２誘導体
DE3803620A1 (de) *	1988-02-06	1989-08-17	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
US5073633A (en) *	1989-03-23	1991-12-17	Bristol-Myers Company	BMY-41950 antitumor antibiotic
DE3924538A1 (de) *	1989-07-25	1991-01-31	Goedecke Ag	Indolocarbazol und dessen verwendung
JPH06509333A (ja) *	1991-07-03	1994-10-20	リジェネロン　ファーマシューティカルズ，インコーポレーテッド	ニューロトロフィン活性に対する方法およびアッセイ系
JPH07505124A (ja) *	1991-11-08	1995-06-08	ザユニバーシティオブサザンカリフォルニア	ニューロトロフィン活性増強のためのｋ−２５２化合物を含む組成物
US6271242B1 (en) *	1992-02-10	2001-08-07	Bristol-Myers Squibb Co.	Method for treating cancer using a tyrosine protein kinase inhibitor
US5461146A (en) *	1992-07-24	1995-10-24	Cephalon, Inc.	Selected protein kinase inhibitors for the treatment of neurological disorders

1994
- 1994-05-27 DK DK94918168T patent/DK0699204T3/da active
- 1994-05-27 ES ES94918168T patent/ES2118414T3/es not_active Expired - Lifetime
- 1994-05-27 JP JP50102695A patent/JP3344586B2/ja not_active Expired - Fee Related
- 1994-05-27 US US08/250,175 patent/US5516771A/en not_active Expired - Lifetime
- 1994-05-27 AT AT94918168T patent/ATE165097T1/de not_active IP Right Cessation
- 1994-05-27 CA CA002163904A patent/CA2163904C/en not_active Expired - Fee Related
- 1994-05-27 WO PCT/US1994/006082 patent/WO1994027982A1/en not_active Ceased
- 1994-05-27 NZ NZ267337A patent/NZ267337A/en not_active IP Right Cessation
- 1994-05-27 AU AU69607/94A patent/AU679752B2/en not_active Ceased
- 1994-05-27 EP EP94918168A patent/EP0699204B1/en not_active Expired - Lifetime
- 1994-05-27 DE DE69409641T patent/DE69409641T2/de not_active Expired - Lifetime
- 1994-05-27 EP EP98200023A patent/EP0839814A3/en not_active Withdrawn
- 1994-05-27 KR KR1019950705338A patent/KR100201343B1/ko not_active Expired - Fee Related
1995
- 1995-06-05 US US08/463,680 patent/US5654427A/en not_active Expired - Lifetime
- 1995-11-27 FI FI955709A patent/FI113537B/fi not_active IP Right Cessation
- 1995-11-27 NO NO954816A patent/NO306902B1/no not_active IP Right Cessation
2002
- 2002-05-27 JP JP2002153049A patent/JP3727613B2/ja not_active Expired - Fee Related
2003
- 2003-10-16 FI FI20031516A patent/FI114864B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3727613B2 (ja)	2005-12-14
FI955709A0 (fi)	1995-11-27
ATE165097T1 (de)	1998-05-15
DE69409641T2 (de)	1998-11-26
JP2002356487A (ja)	2002-12-13
EP0699204B1 (en)	1998-04-15
EP0699204A1 (en)	1996-03-06
KR100201343B1 (ko)	1999-06-15
ES2118414T3 (es)	1998-09-16
FI113537B (fi)	2004-05-14
FI114864B (fi)	2005-01-14
US5654427A (en)	1997-08-05
CA2163904A1 (en)	1994-12-08
NZ267337A (en)	2005-01-28
WO1994027982A1 (en)	1994-12-08
JP3344586B2 (ja)	2002-11-11
EP0699204A4 (en)	1996-01-10
AU679752B2 (en)	1997-07-10
FI20031516A7 (fi)	2003-10-16
AU6960794A (en)	1994-12-20
EP0839814A3 (en)	1998-09-16
CA2163904C (en)	2000-01-25
DK0699204T3 (da)	1999-02-22
NO954816L (no)	1996-01-26
US5516771A (en)	1996-05-14
NO306902B1 (no)	2000-01-10
KR960702838A (ko)	1996-05-23
DE69409641D1 (de)	1998-05-20
EP0839814A2 (en)	1998-05-06
JP2002504064A (ja)	2002-02-05
NO954816D0 (no)	1995-11-27

Publication	Publication Date	Title
FI955709L (fi)	1996-01-03	Indolokarbatsolijohdannaisten käyttö eturauhasen patologisten tilojen hoidossa
NO971015D0 (no)	1997-03-05	Forbindelser og metoder for behandling av cancer
DE69533177D1 (de)	2004-07-22	Wasserbehandlungsvorrichtung
FI962249A7 (fi)	1996-05-29	Substituoituja pyratsolyylibentseenisulfonamideja tulehduksen hoitoa varten
EE03512B1 (et)	2001-10-15	Epinastiin kasutamiseks valude ravis
NO983560D0 (no)	1998-08-03	Triazolderivater nyttige i terapi
EP0926955A4 (en)	2003-05-07	Conjugates useful in the treatment of prostate cancer
IS5025A (is)	1999-04-13	Samtengd efnasambönd nytsamleg við meðhöndlunina á krabbameini í blöðruhálskirtli
ID18679A (id)	1998-04-30	Penggunaan terapi lanjutan
IL133088A0 (en)	2001-03-19	Novel triptolide derivatives useful in the treatment of autoimmune diseases
FI960658L (fi)	1996-02-14	Uudet bis-naftalimidit syövän hoitamiseksi
ID16981A (id)	1997-11-27	Konsentrat-konsentrat mutiara yang encer
FI971527L (fi)	1997-04-11	Indolijohdannaisten käyttö erilaisten sairauksien hoitoon
IL133089A0 (en)	2001-03-19	Novel triptolide derivatives useful in the treatment of autoimmune diseases
FI971193A7 (fi)	1997-05-21	Hoidossa käyttökelpoisia kinoksaliinijohdannaisia
BR9709636A (pt)	1999-08-10	Uso de buckminsterfulereno no tratamento de ferimento neurotóxico
FI961339A7 (fi)	1996-03-22	Triaryylieteenijohdannaiset käytettäväksi hoidossa
GB9305467D0 (en)	1993-05-05	Substituted cephalosporin sulfones useful in the treatment of cancer
NO986053L (no)	1999-02-23	Anticonvulsivt virkende derivater for anvendelse ved behandling av psoriasis
KR940005082U (ko)	1994-03-16	전신 쑥뜸기
KR950005763U (ko)	1995-03-20	용수처리기
NO954115D0 (no)	1995-10-16	Anvendelse av ceruletid-dietylaminsalt ved behandling av psoriasis
KR950006374U (ko)	1995-03-20	용수처리기
SI1011649T1 (en)	2002-04-30	Use of endipalene in the treatment of psoriasis
LV10385B (en)	1995-04-20	Use of quinons in the treatment of cancer or aids

Legal Events

Date	Code	Title	Description
2012-12-20	MM	Patent lapsed