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FI954978A0 - Modifierade protein- och peptidläkemedel - Google Patents

Modifierade protein- och peptidläkemedel

Info

Publication number
FI954978A0
FI954978A0 FI954978A FI954978A FI954978A0 FI 954978 A0 FI954978 A0 FI 954978A0 FI 954978 A FI954978 A FI 954978A FI 954978 A FI954978 A FI 954978A FI 954978 A0 FI954978 A0 FI 954978A0
Authority
FI
Finland
Prior art keywords
amino acid
ctp units
partial
complete
modified protein
Prior art date
Application number
FI954978A
Other languages
English (en)
Finnish (fi)
Other versions
FI954978L (sv
FI954978A7 (sv
Inventor
Irving Boime
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of FI954978A0 publication Critical patent/FI954978A0/sv
Publication of FI954978L publication Critical patent/FI954978L/sv
Publication of FI954978A7 publication Critical patent/FI954978A7/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI954978A 1993-04-20 1994-04-13 Modifierade protein- och peptidläkemedel FI954978A7 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4986993A 1993-04-20 1993-04-20
PCT/US1994/004069 WO1994024148A1 (en) 1993-04-20 1994-04-13 Modified protein and peptide pharmaceuticals

Publications (3)

Publication Number Publication Date
FI954978A0 true FI954978A0 (sv) 1995-10-18
FI954978L FI954978L (sv) 1995-11-15
FI954978A7 FI954978A7 (sv) 1995-11-15

Family

ID=21962168

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954978A FI954978A7 (sv) 1993-04-20 1994-04-13 Modifierade protein- och peptidläkemedel

Country Status (14)

Country Link
EP (1) EP0695307B1 (sv)
JP (2) JP4156024B2 (sv)
AT (1) ATE187740T1 (sv)
AU (1) AU687053B2 (sv)
CA (1) CA2160800C (sv)
DE (1) DE69422169D1 (sv)
ES (1) ES2141229T3 (sv)
FI (1) FI954978A7 (sv)
GR (1) GR3032775T3 (sv)
NO (1) NO954188L (sv)
NZ (1) NZ265529A (sv)
PT (1) PT695307E (sv)
WO (1) WO1994024148A1 (sv)
ZA (1) ZA942729B (sv)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968513A (en) * 1996-06-24 1999-10-19 University Of Maryland Biotechnology Institute Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin
US6319504B1 (en) 1996-06-24 2001-11-20 University Of Maryland Biotechnology Institute Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
US5997871A (en) * 1996-06-24 1999-12-07 University Of Maryland Biotechnology Insitute Treatment and prevention of cancer by administration of derivatives of human chorionic gonadotropin
US6583109B1 (en) 1997-06-24 2003-06-24 Robert C. Gallo Therapeutic polypeptides from β-hCG and derivatives
US7994278B1 (en) * 1999-08-06 2011-08-09 Nobel Biosciences Llc Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA)
JP2001333772A (ja) 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
ATE320449T1 (de) * 2000-12-11 2006-04-15 Cheil Jedang Corp Fusionsprotein mit verbesserter in vivo erythropoietinwirkung
US6987172B2 (en) 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
KR100467751B1 (ko) * 2001-12-03 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US8476234B2 (en) 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US8304386B2 (en) 2006-02-03 2012-11-06 Prolor Biotech, Inc. Long-acting growth hormone and methods of producing same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US7553941B2 (en) * 2006-02-03 2009-06-30 Modigene Inc Long-acting polypeptides and methods of producing same
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
US12203113B2 (en) 2009-07-09 2025-01-21 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
AU2013250711A1 (en) 2012-04-19 2014-11-27 Opko Biologics Ltd. Long-acting oxyntomodulin variants and methods of producing same
KR102341581B1 (ko) 2012-11-20 2021-12-21 옵코 바이오로직스 리미티드 생식샘자극 호르몬 카복시 말단 펩타이드들과 부착하여 폴리펩타이드들의 유체역학적 부피를 증가시키는 방법
EP2968391A1 (en) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
PH12021552108A1 (en) 2014-12-10 2022-05-11 Opko Biologics Ltd Methods of producing long acting ctp-modified growth hormone polypeptides
CN113289009B (zh) 2015-06-19 2025-05-02 Opko生物科学有限公司 长效凝固因子及其产生方法
SG10202100189WA (en) 2016-07-11 2021-02-25 Opko Biologics Ltd Long-acting coagulation factor vii and methods of producing same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654324A (en) * 1981-08-27 1987-03-31 Eli Lilly And Company Human proinsulin pharmaceutical formulations
US4959455A (en) * 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
CA2053864C (en) * 1989-02-21 2001-11-20 Irving Boime Modified forms of reproductive hormones
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
JPH04156024A (ja) * 1990-10-19 1992-05-28 Fujitsu Ltd サブレート交換方式

Also Published As

Publication number Publication date
PT695307E (pt) 2000-05-31
NO954188L (no) 1995-12-19
CA2160800A1 (en) 1994-10-27
DE69422169D1 (de) 2000-01-20
ES2141229T3 (es) 2000-03-16
ATE187740T1 (de) 2000-01-15
JPH08509218A (ja) 1996-10-01
EP0695307B1 (en) 1999-12-15
CA2160800C (en) 2010-06-01
EP0695307A1 (en) 1996-02-07
GR3032775T3 (en) 2000-06-30
EP0695307A4 (en) 1996-08-21
FI954978L (sv) 1995-11-15
JP2008133295A (ja) 2008-06-12
WO1994024148A1 (en) 1994-10-27
NZ265529A (en) 1998-01-26
JP4156024B2 (ja) 2008-09-24
FI954978A7 (sv) 1995-11-15
AU687053B2 (en) 1998-02-19
ZA942729B (en) 1995-01-09
NO954188D0 (no) 1995-10-19
AU6633194A (en) 1994-11-08

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