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FI954088L - Pyrrolopyridiinijohdannaisia - Google Patents

Pyrrolopyridiinijohdannaisia Download PDF

Info

Publication number
FI954088L
FI954088L FI954088A FI954088A FI954088L FI 954088 L FI954088 L FI 954088L FI 954088 A FI954088 A FI 954088A FI 954088 A FI954088 A FI 954088A FI 954088 L FI954088 L FI 954088L
Authority
FI
Finland
Prior art keywords
pyrrolopyridine derivatives
pyrrolopyridine
derivatives
Prior art date
Application number
FI954088A
Other languages
English (en)
Swedish (sv)
Other versions
FI954088A7 (fi
FI954088A0 (fi
Inventor
Raymond Baker
Neil Roy Curtis
Janusz Jozef Kulagowski
Paul David Leeson
Mark Peter Ridgill
Adrian Leonard Smith
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939304111A external-priority patent/GB9304111D0/en
Priority claimed from GB939316275A external-priority patent/GB9316275D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of FI954088A7 publication Critical patent/FI954088A7/fi
Publication of FI954088L publication Critical patent/FI954088L/fi
Publication of FI954088A0 publication Critical patent/FI954088A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI954088A 1993-03-01 1994-02-21 Pyrrolopyridiinijohdannaisia FI954088A0 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939304111A GB9304111D0 (en) 1993-03-01 1993-03-01 Therapeutic agents
GB939316275A GB9316275D0 (en) 1993-08-05 1993-08-05 Therapeutic agents
PCT/GB1994/000337 WO1994020497A1 (en) 1993-03-01 1994-02-21 Pyrrolo-pyridine derivatives

Publications (3)

Publication Number Publication Date
FI954088A7 FI954088A7 (fi) 1995-08-31
FI954088L true FI954088L (fi) 1995-08-31
FI954088A0 FI954088A0 (fi) 1995-08-31

Family

ID=26302519

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954088A FI954088A0 (fi) 1993-03-01 1994-02-21 Pyrrolopyridiinijohdannaisia

Country Status (20)

Country Link
US (1) US5432177A (fi)
EP (1) EP0623618A3 (fi)
JP (1) JP2710751B2 (fi)
KR (1) KR960701052A (fi)
CN (1) CN1118598A (fi)
AU (1) AU674373B2 (fi)
BG (1) BG99885A (fi)
BR (1) BR9406128A (fi)
CA (1) CA2116213A1 (fi)
CZ (1) CZ224195A3 (fi)
FI (1) FI954088A0 (fi)
HU (1) HUT71799A (fi)
IL (1) IL108729A0 (fi)
NO (1) NO953406L (fi)
NZ (1) NZ261593A (fi)
PL (1) PL310443A1 (fi)
SI (1) SI9400091A (fi)
SK (1) SK106395A3 (fi)
WO (1) WO1994020497A1 (fi)
YU (1) YU9194A (fi)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622950A (en) * 1993-03-01 1997-04-22 Merck, Sharp & Dohme Ltd. Pyrrolo-pyridine derivatives
US5700809A (en) * 1993-03-01 1997-12-23 Merck Sharp & Dohme, Ltd. Pyrrolo-pyridine derivatives
GB9305641D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
US6060473A (en) * 1993-04-01 2000-05-09 Ucb S.A. - Dtb 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
US5817679A (en) 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US5814644A (en) * 1993-04-15 1998-09-29 Merck Sharp & Dohme, Ltd. Indole derivatives as dopamine D4 antagonists
WO1995007078A1 (en) 1993-09-10 1995-03-16 Cytomed, Inc. Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
EP0759918A1 (en) * 1994-05-19 1997-03-05 MERCK SHARP & DOHME LTD. Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists
NZ290936A (en) * 1994-09-30 1998-01-26 Pfizer 2,7-substituted octahydro-1h-pyrido[1,2-a]pyrazine derivatives
GB9423460D0 (en) * 1994-11-21 1995-01-11 Merck Sharp & Dohme Therapeutic agents
WO1996025414A1 (en) * 1995-02-15 1996-08-22 Pharmacia & Upjohn Company Imidazo[1,2-a]pyridines for the treatment of cns and cardiac diseases
GB2298199A (en) * 1995-02-21 1996-08-28 Merck Sharp & Dohme Synthesis of azaindoles
GB9507291D0 (en) * 1995-04-07 1995-05-31 Merck Sharp & Dohme Therapeutic agents
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
US5725838A (en) * 1996-05-31 1998-03-10 Resolution Pharmaceuticals, Inc. Radiolabeled D4 receptor ligands
DE19637237A1 (de) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
AU8096798A (en) * 1997-06-27 1999-01-19 Resolution Pharmaceuticals Inc. Dopamine d4 receptor ligands
US5976497A (en) * 1997-08-04 1999-11-02 Resolution Pharmaceuticals, Inc. Dopamine D4 receptor ligands
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
MXPA02001473A (es) * 1999-08-12 2003-07-21 Nps Allelix Corp Azaindoles que tienen afinidad con el receptor de serotonina.
US6686374B1 (en) 1999-08-12 2004-02-03 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
AR028945A1 (es) * 2000-06-19 2003-05-28 Lundbeck & Co As H Derivados de indol
JP2004501912A (ja) * 2000-06-29 2004-01-22 ハー・ルンドベック・アクチエゼルスカベット Ｃｎｓ障害の治療に有用なインドール誘導体
EP1325008B1 (en) * 2000-07-31 2005-10-05 F. Hoffmann-La Roche Ag Piperazine derivatives
US7432304B2 (en) 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
EP1406631A4 (en) * 2001-06-13 2005-03-23 Univ Michigan DOPAMIN RECEPTOR LIGANDS AND THERAPEUTIC METHODS BASED THEREFOR
US7354928B2 (en) 2001-11-01 2008-04-08 The Regents Of The University Of Michigan Small molecule inhibitors targeted at Bcl-2
CN100347171C (zh) * 2002-02-08 2007-11-07 中国科学院上海原子核研究所 一种吡啶类化合物及其制备方法和作为多巴胺d4受体拮抗剂的应用
CN1305873C (zh) * 2002-07-12 2007-03-21 中国科学院上海原子核研究所 [18f]氟标记的吡啶类化合物及其制备方法和作为多巴胺d4受体显像剂的应用
JP2004123562A (ja) * 2002-09-30 2004-04-22 Japan Science & Technology Corp 神経細胞死抑制作用を有する化合物を用いた医薬
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
PL1696920T3 (pl) 2003-12-19 2015-03-31 Plexxikon Inc Związki i sposoby opracowywania modulatorów Ret
CA2561303C (en) 2004-03-25 2011-01-18 The Regents Of The University Of Michigan Gossypol co-crystals and the use thereof
US20060058339A1 (en) * 2004-06-17 2006-03-16 Ibrahim Prabha N Compounds modulating c-kit activity and uses therefor
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
DE102004054634A1 (de) * 2004-11-12 2006-05-18 Schwarz Pharma Ag Azaindolcarboxamide
US7846941B2 (en) * 2005-05-17 2010-12-07 Plexxikon, Inc. Compounds modulating c-kit and c-fms activity and uses therefor
MX2007016463A (es) * 2005-06-22 2008-03-04 Plexxikon Inc Derivados de pirrolo [2,3-b] piridina como inhibidores de proteina cinasa.
US7544685B2 (en) 2005-08-17 2009-06-09 H. Lundbeck A/S 2,3-dihydroindole compounds
MX2008010481A (es) 2006-02-17 2008-12-19 Memory Pharm Corp Compuestos que tienen afinado para el receptor f-ht6.
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
US7872018B2 (en) 2006-12-21 2011-01-18 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
AU2008276063B2 (en) 2007-07-17 2013-11-28 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
BRPI1008709B8 (pt) 2009-04-03 2021-05-25 Hoffmann La Roche dispersão sólida, formulação, composição e comprimido compreendendo {3-[5-(4-cloro-fenil)-1h-pirrol[2,3-b]piridina-3-carbonil]-2,4-diflúor-fenil}-amida do ácido propano-1-sulfônico
US8546377B2 (en) * 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8518933B2 (en) * 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
US20110112127A1 (en) 2009-11-06 2011-05-12 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
EP2646437B1 (en) * 2010-12-02 2014-09-03 Eli Lilly and Company 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds
MY162950A (en) 2011-02-07 2017-07-31 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
KR20150065191A (ko) * 2012-11-08 2015-06-12 화이자 인코포레이티드 헤테로방향족 화합물 및 도파민 d1 리간드로서 이의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
US3511841A (en) * 1967-05-29 1970-05-12 Sterling Drug Inc 1-((4-,5-,6-,and 7-azaindolyl)-lower-alkyl)- 4-substituted-piperazines
US5422265A (en) * 1990-12-07 1995-06-06 State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The Oregon Health Sciences University DNA sequence for the human dopamine receptor D4 and expression thereof in mammalian cells

Also Published As

Publication number Publication date
FI954088A7 (fi) 1995-08-31
BR9406128A (pt) 1996-02-27
CZ224195A3 (en) 1996-03-13
SI9400091A (en) 1994-12-31
NO953406L (no) 1995-10-31
WO1994020497A1 (en) 1994-09-15
US5432177A (en) 1995-07-11
NZ261593A (en) 1996-09-25
AU5647094A (en) 1994-09-08
HUT71799A (en) 1996-02-28
NO953406D0 (no) 1995-08-30
AU674373B2 (en) 1996-12-19
EP0623618A2 (en) 1994-11-09
HU9501871D0 (en) 1995-08-28
CN1118598A (zh) 1996-03-13
KR960701052A (ko) 1996-02-24
JP2710751B2 (ja) 1998-02-10
SK106395A3 (en) 1995-12-06
JPH06279442A (ja) 1994-10-04
BG99885A (en) 1996-02-29
CA2116213A1 (en) 1994-09-02
IL108729A0 (en) 1994-05-30
YU9194A (sh) 1997-08-22
PL310443A1 (en) 1995-12-11
EP0623618A3 (en) 1997-04-02
FI954088A0 (fi) 1995-08-31

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Legal Events

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