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FI943164L - 2-(1-(1,3-tiatsolin-2-yyli)atsetidin-3-yyli)tiokarbapeneemijohdannaisia - Google Patents

2-(1-(1,3-tiatsolin-2-yyli)atsetidin-3-yyli)tiokarbapeneemijohdannaisia Download PDF

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Publication number
FI943164L
FI943164L FI943164A FI943164A FI943164L FI 943164 L FI943164 L FI 943164L FI 943164 A FI943164 A FI 943164A FI 943164 A FI943164 A FI 943164A FI 943164 L FI943164 L FI 943164L
Authority
FI
Finland
Prior art keywords
thiocarbapenem
thiazolin
azetidin
derivatives
thiocarbapenem derivatives
Prior art date
Application number
FI943164A
Other languages
English (en)
Swedish (sv)
Other versions
FI106962B (fi
FI943164A0 (fi
Inventor
Takao Abe
Takeshi Isoda
Chisato Sato
Ado Mihira
Satoshi Tamai
Toshio Kumagai
Original Assignee
Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lederle Japan Ltd filed Critical Lederle Japan Ltd
Publication of FI943164A0 publication Critical patent/FI943164A0/fi
Publication of FI943164L publication Critical patent/FI943164L/fi
Application granted granted Critical
Publication of FI106962B publication Critical patent/FI106962B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
FI943164A 1993-07-01 1994-07-01 Menetelmä (1R, 5S, 6S)-2-[1-(1,3-tiatsolin-2-yyli)atsetidin-3-yyli]-tio-6-[(R)-1-hydroksietyyli]-1-metyylikarbapen-2-eemi-3-karboksyylihappojohdannaisten valmistamiseksi FI106962B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP21330693 1993-07-01
JP21330693 1993-07-01
JP7932094 1994-03-28
JP7932094 1994-03-28
JP12204694 1994-05-12
JP12204694 1994-05-12

Publications (3)

Publication Number Publication Date
FI943164A0 FI943164A0 (fi) 1994-07-01
FI943164L true FI943164L (fi) 1995-01-02
FI106962B FI106962B (fi) 2001-05-15

Family

ID=27302982

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943164A FI106962B (fi) 1993-07-01 1994-07-01 Menetelmä (1R, 5S, 6S)-2-[1-(1,3-tiatsolin-2-yyli)atsetidin-3-yyli]-tio-6-[(R)-1-hydroksietyyli]-1-metyylikarbapen-2-eemi-3-karboksyylihappojohdannaisten valmistamiseksi

Country Status (16)

Country Link
US (2) US5534510A (fi)
EP (2) EP0632039B1 (fi)
JP (1) JP2666118B2 (fi)
KR (1) KR100331293B1 (fi)
AT (2) ATE212636T1 (fi)
AU (1) AU682510B2 (fi)
CA (1) CA2127193C (fi)
DE (2) DE69429742T2 (fi)
DK (2) DK0924210T3 (fi)
ES (2) ES2222630T3 (fi)
FI (1) FI106962B (fi)
HU (1) HU220609B1 (fi)
IL (1) IL110161A (fi)
NO (2) NO306780B1 (fi)
PT (2) PT924210E (fi)
TW (1) TW254943B (fi)

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US5783703A (en) * 1993-07-01 1998-07-21 Lederle (Japan), Ltd. Sulfur-containing compounds method for their use and prodction
TW432061B (en) * 1994-08-09 2001-05-01 Pfizer Res & Dev Lactams
DK0717042T3 (da) * 1994-12-12 2001-08-06 Wyeth Lederle Japan Ltd Fremgangsmåde til fremstilling af 1-(4,5-dihydro-2-thiazolyl)-3-azetidin-thiol-derivater
TW420681B (en) * 1995-12-08 2001-02-01 Lederle Japan Ltd Carbapenem-3-carboxylic acid ester derivatives
CA2253860A1 (en) 1996-05-09 1997-11-13 Sankyo Company, Limited Anti-helicobacter pylori compositions containing 1-methylcarbapenem derivatives as the active ingredient
KR20010079713A (ko) 1998-09-10 2001-08-22 마쓰자와 도로, 하야시 지로 카르바페넴 화합물
KR100325375B1 (ko) * 2000-01-31 2002-03-06 박호군 이미다졸린 고리가 치환된 카바페넴 유도체
PL362132A1 (en) * 2000-11-16 2004-10-18 Sankyo Company, Limited 1-methylcarbapenem derivatives
KR100441406B1 (ko) * 2001-09-05 2004-07-23 한국과학기술연구원 티아졸리딘 고리 치환체를 갖는 1-β-메틸 카바페넴유도체 및 그 제조 방법
KR100451670B1 (ko) * 2001-09-14 2004-10-08 한국화학연구원 내성균에 대해 항생작용을 갖는 카바페넴 유도체 및 이의제조방법
EP1443047A4 (en) * 2001-11-05 2005-04-27 Sumitomo Pharma NEW CARBAPENE COMPOUNDS
TW200403244A (en) * 2002-05-14 2004-03-01 Sankyo Co 1β-Methylcarbapenem derivatives for oral use
JP4694370B2 (ja) 2002-10-18 2011-06-08 明治製菓株式会社 マロン酸モノエステルおよびその製造方法
WO2004035539A1 (ja) * 2002-10-18 2004-04-29 Meiji Seika Kaisha, Ltd. カルバペネム類の製造方法およびその製造に用いられる中間体
US7524952B2 (en) 2002-11-13 2009-04-28 Kaneka Corporation Process for producing carbapenem compound for oral administration
CA2519794A1 (en) * 2003-04-08 2004-10-21 Sumitomo Pharmaceuticals Co., Ltd. Novel carbapenem compounds
AU2004311459B2 (en) * 2003-12-30 2011-07-14 Medicis Technologies Corporation Ultrasound therapy head with movement control
EP1627891A1 (en) * 2004-08-11 2006-02-22 Covion Organic Semiconductors GmbH Polymers for use in organic electroluminescent devices
KR100599876B1 (ko) 2004-08-31 2006-07-13 한국화학연구원 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
US20070265242A1 (en) * 2004-09-03 2007-11-15 Makoto Sunagawa Novel Carbapenem Compound
JP2006176418A (ja) * 2004-12-21 2006-07-06 Kaneka Corp 経口投与用カルバペネム化合物の製造方法と新規β−ラクタム化合物
JPWO2006103999A1 (ja) * 2005-03-25 2008-09-04 大日本住友製薬株式会社 新規なカルバペネム化合物
KR100723889B1 (ko) 2006-06-30 2007-05-31 주식회사 하이닉스반도체 직렬 입/출력 인터페이스를 가진 멀티 포트 메모리 소자
JP5013795B2 (ja) * 2006-09-25 2012-08-29 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 経口投与用カルバペネム
JP2010540433A (ja) * 2007-09-20 2010-12-24 クジェ ファーマシューティカル インダストリアル カンパニー リミテッド カルバペネム系抗生物質の合成中間体の酸付加塩及びその製造方法
EP2212325A4 (en) * 2007-11-23 2011-03-02 Kukje Pharm Ind Co Ltd 2-ARYLMETHYLAZETIDINE-CARBAPENEM-3-CARBOXYLIC ACID ESTER DERIVATIVE OR SALTS THEREOF, PREPARATION PROCESS OF THE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
CN102558181B (zh) * 2010-12-15 2015-04-22 石药集团中奇制药技术（石家庄）有限公司 一种碳青霉烯抗生素的制备方法
CN102731507B (zh) * 2011-04-13 2015-04-01 石药集团中奇制药技术（石家庄）有限公司 泰比培南晶型、其制备方法及其在制备药物中的应用
CN103059026A (zh) * 2011-10-20 2013-04-24 北京康健源科技有限公司 一种替比培南匹夫酯的制备方法
CN102584812B (zh) * 2011-11-18 2014-03-12 深圳万乐药业有限公司 一种泰比培南酯杂质的制备方法
CN102503940B (zh) * 2011-11-22 2013-12-25 深圳万乐药业有限公司 制备泰比培南酯开环杂质的方法
CN103059027A (zh) * 2012-12-20 2013-04-24 安徽悦康凯悦制药有限公司 替比培南匹伏酯的制备方法
US12226403B2 (en) * 2016-12-15 2025-02-18 Spero Therapeutics, Inc. Tebipenem pivoxil immediate and modified release oral dosage forms
NZ753781A (en) 2017-02-06 2022-10-28 Spero Therapeutics Inc Tebipenem pivoxil crystalline forms, compositions including the same, methods of manufacture, and methods of use
CN110698469A (zh) * 2019-10-28 2020-01-17 南京红杉生物科技有限公司 泰比培南酯中间体及其合成方法、应用
EP4243783A1 (en) 2020-11-11 2023-09-20 Spero Therapeutics, Inc. High dosage tebipenem pivoxil tablet formulation

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US3665001A (en) * 1970-06-11 1972-05-23 Exxon Research Engineering Co Azinyl organophosphorus compounds
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
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GB9210096D0 (en) * 1992-05-11 1992-06-24 Fujisawa Pharmaceutical Co 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives and their preparation

Also Published As

Publication number Publication date
DE69429742T2 (de) 2002-06-06
DE69433955D1 (de) 2004-09-23
HU220609B1 (hu) 2002-03-28
FI106962B (fi) 2001-05-15
EP0924210A1 (en) 1999-06-23
KR100331293B1 (ko) 2002-10-25
AU6598794A (en) 1995-01-12
JPH0853453A (ja) 1996-02-27
NO942483D0 (no) 1994-06-30
NO307379B1 (no) 2000-03-27
EP0632039B1 (en) 2002-01-30
PT632039E (pt) 2002-06-28
ES2170080T3 (es) 2002-08-01
US5679790A (en) 1997-10-21
NO306780B1 (no) 1999-12-20
EP0924210B1 (en) 2004-08-18
DK0924210T3 (da) 2004-12-13
NO942483L (no) 1995-01-02
US5534510A (en) 1996-07-09
HU9401957D0 (en) 1994-09-28
DK0632039T3 (da) 2002-05-13
CA2127193C (en) 2005-04-12
FI943164A0 (fi) 1994-07-01
AU682510B2 (en) 1997-10-09
CA2127193A1 (en) 1995-01-02
TW254943B (fi) 1995-08-21
NO991019L (no) 1995-01-02
HUT68057A (en) 1995-05-29
ATE212636T1 (de) 2002-02-15
DE69433955T2 (de) 2005-09-08
NO991019D0 (no) 1999-03-02
JP2666118B2 (ja) 1997-10-22
IL110161A0 (en) 1994-10-07
ATE273975T1 (de) 2004-09-15
ES2222630T3 (es) 2005-02-01
PT924210E (pt) 2004-12-31
EP0632039A1 (en) 1995-01-04
IL110161A (en) 1998-09-24
KR950003292A (ko) 1995-02-16
DE69429742D1 (de) 2002-03-14

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