FI942161L - Menetelmä 5-metyyli-tetrahydrofoolihapon erottamiseksi - Google Patents

Menetelmä 5-metyyli-tetrahydrofoolihapon erottamiseksi Download PDF

Info

Publication number: FI942161L
Authority: FI; Finland
Prior art keywords: separation; methyltetrahydrofolic acid; methyltetrahydrofolic; acid
Prior art date: 1991-11-11

Application number

FI942161A

Other languages

English (en)

Swedish (sv)

Other versions

FI942161A0 (fi

FI105918B (fi

Inventor

Klaus Scheib

Peter Klein

Robert Carter

Original Assignee

Knoll Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-11

Filing date

1994-05-10

Publication date

1994-05-10

1994-05-10 Application filed by Knoll Ag filed Critical Knoll Ag

1994-05-10 Publication of FI942161A0 publication Critical patent/FI942161A0/fi

1994-05-10 Publication of FI942161L publication Critical patent/FI942161L/fi

2000-10-31 Application granted granted Critical

2000-10-31 Publication of FI105918B publication Critical patent/FI105918B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Hydrogenated Pyridines (AREA)

FI942161A 1991-11-11 1994-05-10 Menetelmä 5-metyyli-tetrahydrofoolihapon enantiomeerien erottamiseksi FI105918B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE4136921A DE4136921A1 (de)	1991-11-11	1991-11-11	Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
DE4136921		1991-11-11
EP9202515		1992-11-03
PCT/EP1992/002515 WO1993010118A1 (de)	1991-11-11	1992-11-03	Verfahren zur trennung von 5-methyl-tetrahydrofolsäure

Publications (3)

Publication Number	Publication Date
FI942161A0 FI942161A0 (fi)	1994-05-10
FI942161L true FI942161L (fi)	1994-05-10
FI105918B FI105918B (fi)	2000-10-31

Family

ID=6444446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI942161A FI105918B (fi)	1991-11-11	1994-05-10	Menetelmä 5-metyyli-tetrahydrofoolihapon enantiomeerien erottamiseksi

Country Status (16)

Country	Link
US (1)	US5457202A (fi)
EP (1)	EP0612322B1 (fi)
JP (1)	JP3162390B2 (fi)
KR (1)	KR100211915B1 (fi)
AT (1)	ATE177100T1 (fi)
AU (1)	AU664051B2 (fi)
CA (1)	CA2121351C (fi)
DE (2)	DE4136921A1 (fi)
DK (1)	DK0612322T3 (fi)
ES (1)	ES2127765T3 (fi)
FI (1)	FI105918B (fi)
GR (1)	GR3029552T3 (fi)
NO (1)	NO305175B1 (fi)
TW (1)	TW221293B (fi)
WO (1)	WO1993010118A1 (fi)
ZA (1)	ZA928643B (fi)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4136921A1 (de) *	1991-11-11	1993-05-13	Knoll Ag	Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
GB9222253D0 (en) *	1992-10-23	1992-12-09	Celltech Ltd	Chemical compounds
GB9304919D0 (en) *	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
GB9304920D0 (en) *	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
GB9326600D0 (en) *	1993-12-22	1994-03-02	Celltech Ltd	Chemical compounds
JP3806144B2 (ja) *	1993-12-22	2006-08-09	セルテックセラピューティックスリミテッド	三置換フェニル誘導体、その調製方法とホスホジエステラーゼ（ｉｖ型）阻害剤としてのその使用
IT1270185B (it) *	1994-06-08	1997-04-29	Bracco Spa	Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico
US6245774B1 (en)	1994-06-21	2001-06-12	Celltech Therapeutics Limited	Tri-substituted phenyl or pyridine derivatives
US5786354A (en) *	1994-06-21	1998-07-28	Celltech Therapeutics, Limited	Tri-substituted phenyl derivatives and processes for their preparation
GB9412571D0 (en)	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9412573D0 (en)	1994-06-22	1994-08-10	Celltech Ltd	Chemical compounds
GB9523675D0 (en)	1995-11-20	1996-01-24	Celltech Therapeutics Ltd	Chemical compounds
GB9526245D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9526246D0 (en) *	1995-12-21	1996-02-21	Celltech Therapeutics Ltd	Chemical compounds
GB9608435D0 (en) *	1996-04-24	1996-06-26	Celltech Therapeutics Ltd	Chemical compounds
GB9619284D0 (en) *	1996-09-16	1996-10-30	Celltech Therapeutics Ltd	Chemical compounds
GB9622363D0 (en) *	1996-10-28	1997-01-08	Celltech Therapeutics Ltd	Chemical compounds
GB9625184D0 (en) *	1996-12-04	1997-01-22	Celltech Therapeutics Ltd	Chemical compounds
AU5330698A (en)	1996-12-23	1998-07-17	Celltech Therapeutics Limited	Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
GB9705361D0 (en)	1997-03-14	1997-04-30	Celltech Therapeutics Ltd	Chemical compounds
GB9713087D0 (en) *	1997-06-20	1997-08-27	Celltech Therapeutics Ltd	Chemical compounds
CH693905A5 (de) *	1999-04-15	2004-04-15	Eprova Ag	Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
GB9914258D0 (en)	1999-06-18	1999-08-18	Celltech Therapeutics Ltd	Chemical compounds
GB9924862D0 (en)	1999-10-20	1999-12-22	Celltech Therapeutics Ltd	Chemical compounds
DE10022510A1 (de)	2000-05-10	2001-11-15	Basf Ag	Zusammensetzungen enthaltend Folsäure und reduziertes Folat
DE50213202D1 (de)	2001-05-29	2009-02-26	Bayer Schering Pharma Ag	Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel
CN101143863B (zh) *	2006-09-13	2010-08-11	南京莱因医药科技有限公司	5-甲基四氢叶酸的拆分及其成盐方法
CH698729B1 (de)	2007-05-30	2009-10-15	Cerbios Pharma Sa	Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN101407518A (zh) *	2007-10-11	2009-04-15	南京莱尔生物化工有限公司	(6r,s)-5-甲酰-四氢叶酸的拆分及其成盐的方法
ES2541314T3 (es) *	2008-02-20	2015-07-17	Gnosis S.P.A.	Procedimiento para la resolución diastereoisomérica de ácido 5-metiltetrahidrofólico
EP2837632B1 (en)	2012-04-13	2016-05-18	Lianyungang Jinkang Hexin Pharmaceutical Co. Ltd.	Derivatives of triazabicyclo[3.2.1]octane useful for the treatment of proliferative diseases
EP3609895B1 (en)	2017-03-31	2024-10-16	Merck Patent GmbH	Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid
CN108358928A (zh) *	2018-05-23	2018-08-03	浙江圣达生物药业股份有限公司	一种(6s)-5-甲基四氢叶酸钙的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8621268D0 (en) *	1986-09-03	1986-10-08	Univ Strathclyde	Separation of substances
CH673459A5 (fi) *	1987-05-15	1990-03-15	Eprova Ag
DE3821875C1 (fi) *	1988-06-29	1990-02-15	Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH676981A5 (fi) *	1988-11-11	1991-03-28	Eprova Ag
EP0432441B1 (en) *	1989-12-11	1996-06-26	American Cyanamid Company	Process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds
FR2659330B1 (fr) *	1990-03-09	1994-02-11	Sapec Sa	Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (fi) *	1990-04-12	1992-10-30	Sapec Fine Chemicals
CH681303A5 (fi) *	1991-01-16	1993-02-26	Eprova Ag
CH683261A5 (it) *	1991-10-10	1994-02-15	Applied Pharma Res	Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
DE4136921A1 (de) *	1991-11-11	1993-05-13	Knoll Ag	Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure

1991
- 1991-11-11 DE DE4136921A patent/DE4136921A1/de not_active Withdrawn
1992
- 1992-11-03 DE DE59209643T patent/DE59209643D1/de not_active Expired - Lifetime
- 1992-11-03 AU AU28983/92A patent/AU664051B2/en not_active Ceased
- 1992-11-03 EP EP92923141A patent/EP0612322B1/de not_active Expired - Lifetime
- 1992-11-03 AT AT92923141T patent/ATE177100T1/de not_active IP Right Cessation
- 1992-11-03 JP JP50892693A patent/JP3162390B2/ja not_active Expired - Fee Related
- 1992-11-03 ES ES92923141T patent/ES2127765T3/es not_active Expired - Lifetime
- 1992-11-03 US US08/232,267 patent/US5457202A/en not_active Expired - Lifetime
- 1992-11-03 KR KR1019940701569A patent/KR100211915B1/ko not_active Expired - Fee Related
- 1992-11-03 WO PCT/EP1992/002515 patent/WO1993010118A1/de not_active Ceased
- 1992-11-03 DK DK92923141T patent/DK0612322T3/da active
- 1992-11-03 CA CA002121351A patent/CA2121351C/en not_active Expired - Fee Related
- 1992-11-10 ZA ZA928643A patent/ZA928643B/xx unknown
- 1992-11-11 TW TW081109046A patent/TW221293B/zh active
1994
- 1994-05-10 FI FI942161A patent/FI105918B/fi not_active IP Right Cessation
- 1994-05-10 NO NO941756A patent/NO305175B1/no not_active IP Right Cessation
1999
- 1999-03-04 GR GR990400523T patent/GR3029552T3/el unknown

Also Published As

Publication number	Publication date
TW221293B (fi)	1994-02-21
JPH07500842A (ja)	1995-01-26
EP0612322A1 (de)	1994-08-31
NO941756D0 (no)	1994-05-10
NO941756L (no)	1994-05-10
WO1993010118A1 (de)	1993-05-27
NO305175B1 (no)	1999-04-12
FI942161A0 (fi)	1994-05-10
DE4136921A1 (de)	1993-05-13
FI105918B (fi)	2000-10-31
US5457202A (en)	1995-10-10
KR100211915B1 (ko)	1999-08-02
CA2121351A1 (en)	1993-05-27
GR3029552T3 (en)	1999-06-30
AU2898392A (en)	1993-06-15
CA2121351C (en)	2003-08-05
DE59209643D1 (de)	1999-04-08
EP0612322B1 (de)	1999-03-03
DK0612322T3 (da)	1999-09-27
ES2127765T3 (es)	1999-05-01
JP3162390B2 (ja)	2001-04-25
ATE177100T1 (de)	1999-03-15
ZA928643B (en)	1994-05-11
AU664051B2 (en)	1995-11-02

Publication	Publication Date	Title
FI942161L (fi)	1994-05-10	Menetelmä 5-metyyli-tetrahydrofoolihapon erottamiseksi
FI951596L (fi)	1995-04-04	Menetelmä 10-desasetyylibakkatiini-III:n saamiseksi
DE69130246D1 (de)	1998-10-29	System zur Bildung von Sätzen
FI20030932A7 (fi)	2003-06-24	Menetelmä cis-FTC:n enantiomeerien erottamiseksi
FI875655A0 (fi)	1987-12-22	Menetelmä kromatograafiseksi erottamiseksi
FI945441A7 (fi)	1994-11-18	Uusi menetelmä 7beta-substituoitu-4-atsa-5alfa-androstan-3-onien valmi stamiseksi
IS3809A (is)	1992-08-05	Hliðstæð aðferð við framleiðslu nýrra sykursteraestera
FI942612A7 (fi)	1994-06-03	Sivuttaiserotusliitin siirrännäisjärjestelmää varten
FI893100L (fi)	1989-06-26	Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi
FI940534L (fi)	1994-04-05	Menetelmä morfiini-6-glukuronidin tai substituoidun morfiini-6-glukuronidin valmistamiseksi
FI982790A0 (fi)	1998-12-23	Menetelmä klavulaanihapon valmistamiseksi
NO921218L (no)	1992-09-29	Reseptor-rensemetode
DK0441478T3 (da)	1993-11-24	Separeringsfremgangsmåde
FI941046A7 (fi)	1994-03-04	Farmaseuttinen menetelmä
FI921621L (fi)	1992-10-13	Sprutmetod foer braensle
FI884885A7 (fi)	1988-10-21	Menetelmä esineiden liittämiseksi
FI101530B1 (fi)	1998-07-15	Menetelmä sulfaatin erottamiseksi
ITMI931680A1 (it)	1995-01-28	Procedimento per la preparazione di alcansolfonammidi
FI933755A7 (fi)	1993-08-26	Menetelmä trans-piperidiini-2,5-dikarboksylaattien valmistamiseksi
FI915785L (fi)	1993-06-10	Menetelmä 3-asemassa substituoitujen tiofeenien valmistamiseksi
FI922125A7 (fi)	1992-12-22	Mikrobiologinen menetelmä 5-hydroksipyratsiinikarboksyylihapon valmistamiseksi
ITMI910193A0 (it)	1991-01-25	Processo per la preparazione di peraloolefine
FI940338L (fi)	1994-01-24	Menetelmä 13alfa-sinnamoyylibakkatiini III:n tai -10-desasetyylibakkatiini III:n valmistamiseksi
FI910662A7 (fi)	1991-08-14	Menetelmä 7-amino-3-metoksimetyyli-kef-3-emi-4-karboksyylihapon valmistamiseksi
FI911126L (fi)	1991-09-09	Organokupraattimenetelmä kefprotsilin valmistamiseksi

Legal Events

Date	Code	Title	Description
2011-07-08	MM	Patent lapsed