[go: up one dir, main page]

FI941085L - O-heteroaryyli-, O-alkyyliheteroaryyli-, O-alkenyyliheteroaryyli- ja O-alkynyyliheteroaryylimakrolideja - Google Patents

O-heteroaryyli-, O-alkyyliheteroaryyli-, O-alkenyyliheteroaryyli- ja O-alkynyyliheteroaryylimakrolideja Download PDF

Info

Publication number
FI941085L
FI941085L FI941085A FI941085A FI941085L FI 941085 L FI941085 L FI 941085L FI 941085 A FI941085 A FI 941085A FI 941085 A FI941085 A FI 941085A FI 941085 L FI941085 L FI 941085L
Authority
FI
Finland
Prior art keywords
alkenylheteroaryl
alkylheteroaryl
heteroaryl
alkynylheteroaryl macrolides
alkynylheteroaryl
Prior art date
Application number
FI941085A
Other languages
English (en)
Swedish (sv)
Other versions
FI941085A0 (fi
FI941085A7 (fi
Inventor
Peter J Sinclair
Frederick Wong
Joung Goulet
Mark Goulet
William H Parsons
Matthew J Wyvratt
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI941085A0 publication Critical patent/FI941085A0/fi
Publication of FI941085A7 publication Critical patent/FI941085A7/fi
Publication of FI941085L publication Critical patent/FI941085L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Measurement Of Force In General (AREA)
FI941085A 1991-09-09 1992-09-02 O-heteroaryyli-, O-alkyyliheteroaryyli-, O-alkenyyliheteroaryyli- ja O-alkynyyliheteroaryylimakrolideja FI941085L (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75694691A 1991-09-09 1991-09-09
US07/921,851 US5252732A (en) 1991-09-09 1992-08-05 D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
PCT/US1992/007508 WO1993005058A1 (en) 1991-09-09 1992-09-02 O-heteroaryl, o-alkylheteroaryl, o-alkenylheteroaryl and o-alkynylheteroarylmacrolides

Publications (3)

Publication Number Publication Date
FI941085A0 FI941085A0 (fi) 1994-03-08
FI941085A7 FI941085A7 (fi) 1994-05-03
FI941085L true FI941085L (fi) 1994-05-03

Family

ID=27116312

Family Applications (1)

Application Number Title Priority Date Filing Date
FI941085A FI941085L (fi) 1991-09-09 1992-09-02 O-heteroaryyli-, O-alkyyliheteroaryyli-, O-alkenyyliheteroaryyli- ja O-alkynyyliheteroaryylimakrolideja

Country Status (21)

Country Link
US (2) US5252732A (fi)
EP (1) EP0532088B1 (fi)
JP (1) JPH0813819B2 (fi)
KR (1) KR930006030A (fi)
CN (1) CN1073443A (fi)
AT (1) ATE145915T1 (fi)
AU (1) AU647665B2 (fi)
BG (1) BG98639A (fi)
CA (1) CA2077331A1 (fi)
CZ (1) CZ53194A3 (fi)
DE (1) DE69215615T2 (fi)
FI (1) FI941085L (fi)
HU (1) HUT66855A (fi)
IL (1) IL103009A0 (fi)
MX (1) MX9205137A (fi)
NO (1) NO940805L (fi)
NZ (1) NZ244153A (fi)
RO (1) RO114331B1 (fi)
SK (1) SK26094A3 (fi)
WO (1) WO1993005058A1 (fi)
YU (1) YU89792A (fi)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5563172A (en) * 1991-09-05 1996-10-08 Abbott Laboratories Macrocyclic amide and urea immunomodulators
US5561137A (en) * 1991-09-05 1996-10-01 Abbott Laboratories Thio-heterocyclic macrolactam immunomodulators
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5310901A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
US5310903A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. Imidazolidyl rapamycin derivatives
US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
US5352783A (en) * 1993-06-09 1994-10-04 Merck & Co., Inc. Microbial transformation product having immunosuppressive activity
TW270114B (fi) * 1993-10-22 1996-02-11 Hoffmann La Roche
US5612350A (en) * 1993-11-30 1997-03-18 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
WO1995015328A1 (en) * 1993-11-30 1995-06-08 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
US5496831A (en) * 1994-05-13 1996-03-05 The General Hospital Corporation Inhibition of insulin-induced adiposis
US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
DE69525957T2 (de) 1994-10-26 2002-11-14 Novartis Ag Verwendung eines ungesättigten Fettalkohols
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
US5777105A (en) * 1995-08-24 1998-07-07 Merck & Co., Inc. Process for the preparation of imidazolyl macrolide immunosuppressants
CA2229718A1 (en) * 1995-08-24 1997-03-06 David J. Mathre Process for the preparation of imidazolyl macrolide immunosuppressants
US5877184A (en) * 1996-08-06 1999-03-02 Merck & Co., Inc. Macrolides having immunosuppressive activity
TR200002771T2 (tr) 1998-03-26 2001-02-21 Fujisawa Pharmaceutical Co.,Ltd. Devamlı salımı olan preparatlar
JP3732525B2 (ja) * 1998-04-27 2006-01-05 アステラス製薬株式会社 医薬組成物
GB9817064D0 (en) * 1998-08-05 1998-10-07 Fujisawa Pharmaceutical Co New use
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
CA2383451A1 (en) * 1999-08-24 2001-03-01 Ariad Gene Therapeutics, Inc. 28-epirapalogs
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP2407473A3 (en) * 2002-02-01 2012-03-21 ARIAD Pharmaceuticals, Inc Method for producing phosphorus-containing compounds
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
CA2552305A1 (en) * 2003-12-30 2005-07-14 Astellas Pharma Inc. Use of macrolides for treating or preventing airflow obstruction
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
AU2005284422A1 (en) * 2004-09-16 2006-03-23 Bayer Healthcare Ag Dermally applicable formulations for treating skin diseases in animals
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
EP1838316A4 (en) * 2005-01-20 2012-01-25 Array Biopharma Inc MACROCYCLIC ANALOGUES USEFUL FOR THE TREATMENT OF IMMUNOREGULATION DISORDERS AND RESPIRATORY DISEASES
CA2789097C (en) 2005-04-28 2017-02-21 Proteus Digital Health, Inc. Pharma-informatics system
US20090054667A1 (en) * 2005-08-10 2009-02-26 Replidyne, Inc. Transition metal catalyzed cross-coupling of 1-halo-1-haloalkene compounds
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
CN101583347A (zh) * 2006-11-14 2009-11-18 阿里亚德医药股份有限公司 口服制剂
WO2009089549A1 (en) * 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012054638A2 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the detection of analytes
EP2839038B1 (en) 2012-04-20 2019-01-16 T2 Biosystems, Inc. Compositions and methods for detection of candida species
JP6525971B2 (ja) 2013-06-11 2019-06-05 タカラ バイオ ユーエスエー， インコーポレイテッド タンパク質富化微細小胞、タンパク質富化微細小胞の作製方法及び使用方法
CN107106588B (zh) 2014-10-28 2020-08-11 山口晃史 用于改善妊娠状态的药剂及其使用
CA3011901A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
CN106074367A (zh) * 2016-07-20 2016-11-09 中山大学中山眼科中心 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法
CN112533599A (zh) 2018-08-10 2021-03-19 山口晃史 与母体和胎儿的关系中的体液免疫相关的疾病的治疗药
CN109467579B (zh) * 2018-11-01 2021-10-15 海南大学 一种具有免疫抑制活性的pks i型聚酮类化合物及其制备方法和应用
WO2020129348A1 (ja) 2018-12-18 2020-06-25 晃史 山口 不妊・不育症または妊娠状態を改善するための薬剤

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244592A (en) * 1962-06-09 1966-04-05 Arai Tadashi Ascomycin and process for its production
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
ATE120466T1 (de) * 1987-12-09 1995-04-15 Fisons Plc Makrozyklische verbindungen.
EP0356399A3 (en) * 1988-08-26 1991-03-20 Sandoz Ag Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them
KR920700212A (ko) * 1989-06-14 1992-02-19 쟝 크라머·한스 루돌프 하우스 헤테로원자-함유 트리사이클릭 화합물
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
US5064835A (en) * 1990-03-01 1991-11-12 Merck & Co., Inc. Hydroxymacrolide derivatives having immunosuppressive activity
GB9014136D0 (en) * 1990-06-25 1990-08-15 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
US5190950A (en) * 1990-06-25 1993-03-02 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
CA2044846A1 (en) * 1990-06-25 1991-12-26 Thomas R. Beattie Antagonists of immunosuppressive macrolides
GB2245891A (en) * 1990-07-09 1992-01-15 Fujisawa Pharmaceutical Co Tricyclo compounds
EP0543879A1 (en) * 1990-08-18 1993-06-02 FISONS plc Macrocyclic compounds
JPH04165249A (ja) * 1990-10-29 1992-06-11 Matsushita Electric Ind Co Ltd 多室型空気調和機
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
US5262533A (en) * 1991-05-13 1993-11-16 Merck & Co., Inc. Amino O-aryl macrolides having immunosuppressive activity
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity

Also Published As

Publication number Publication date
CZ53194A3 (en) 1994-08-17
DE69215615T2 (de) 1997-06-26
EP0532088B1 (en) 1996-12-04
DE69215615D1 (de) 1997-01-16
RO114331B1 (ro) 1999-03-30
WO1993005058A1 (en) 1993-03-18
HU9400686D0 (en) 1994-06-28
JPH0813819B2 (ja) 1996-02-14
NO940805D0 (no) 1994-03-08
NO940805L (no) 1994-05-06
ATE145915T1 (de) 1996-12-15
KR930006030A (ko) 1993-04-20
AU2282992A (en) 1993-03-11
NZ244153A (en) 1995-04-27
YU89792A (sh) 1996-01-08
MX9205137A (es) 1993-04-01
JPH06116274A (ja) 1994-04-26
SK26094A3 (en) 1994-08-10
CA2077331A1 (en) 1993-03-10
FI941085A0 (fi) 1994-03-08
FI941085A7 (fi) 1994-05-03
EP0532088A1 (en) 1993-03-17
IL103009A0 (en) 1993-02-21
CN1073443A (zh) 1993-06-23
HUT66855A (en) 1995-01-30
AU647665B2 (en) 1994-03-24
US5349061A (en) 1994-09-20
US5252732A (en) 1993-10-12
BG98639A (bg) 1995-03-31

Similar Documents

Publication Publication Date Title
FI941085A7 (fi) O-heteroaryyli-, O-alkyyliheteroaryyli-, O-alkenyyliheteroaryyli- ja O -alkynyyliheteroaryylimakrolideja
NL350021I1 (nl) 3-Aryl-4-hydroxy-delta3-dihydrofuranon- en 3-aryl-4-hydroxy-delta3-dihydrothiofenon-derivaten.
BR9202786A (pt) Tampao,e tampao curvo
FI922494L (fi) Pulverformig, enzymer innehaollande diskmedelskomposition foer automatiska diskmaskiner
FI925721L (fi) Transportabel medicinsk anordning, saerskild infusionsbehandlingsapparat
FI922493L (fi) Vattenfri, flytande, enzymer innehaollande diskmedelskomposition foer automatiska diskmaskiner
NO912589D0 (no) Anti-plakk og anti-tannsten tannpasta.
FI923314L (fi) Substituerade cyklopropylamino-1,3,5-triaziner
FI920472A0 (fi) Polymeriska skum.
DE69206078D1 (de) Einsetz- und Verbindungstechnik.
FI922451L (fi) Vaermehaerdande, pulveraktig belaeggningskomposition
FI922487L (fi) Foerbaettrad vattenfri, flytande, fosfatfri, enzymer innehaollande diskmedelskomposition foer automatiska diskmaskiner
FI922654L (fi) Saekringsanordning foer avtryckarmekanismer, isynnerhet foer eldvapen
DE69109404D1 (de) Fingerfräser.
FI934680A7 (fi) Aryylimorfoliini, valmistus ja käyttö
DE59102503D1 (de) Kanüle.
FI925411A0 (fi) Fartyg, speciellt handelsfartyg
ES1016723Y (es) Boligrafo-pulverizador mejorado.
FI921759L (fi) Lineaer viskoelastisk vattenhaltig flytande detergentkomposition, speciellt foer automatiska diskmaskiner
BR9205281A (pt) Pentapeptideos imuno-reguladores e neuro-reguladores
NO912551D0 (no) Jekkanordning.
FI911119A7 (fi) Utgivningsfoerraod.
NO922732D0 (no) 3,4-dehydropiperidinderivater
FR2703893B3 (fr) Oreiller.
FI922562L (fi) Optisk, reflekterande stjaernanordning