FI945877A0 - Menetelmä proteiini C:n tuottamiseksi - Google Patents

Menetelmä proteiini C:n tuottamiseksi

Info

Publication number: FI945877A0
Authority: FI; Finland
Prior art keywords: cell lines; degrees centigrade; recombinant proteins; higher levels; producing protein
Prior art date: 1993-12-15

Application number

FI945877A

Other languages

English (en)

Swedish (sv)

Other versions

FI106385B (fi

FI945877L (fi

Inventor

Brian William Grinnell

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-15

Filing date

1994-12-14

Publication date

1994-12-14

1994-12-14 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1994-12-14 Publication of FI945877A0 publication Critical patent/FI945877A0/fi

1995-06-16 Publication of FI945877L publication Critical patent/FI945877L/fi

2001-01-31 Application granted granted Critical

2001-01-31 Publication of FI106385B publication Critical patent/FI106385B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2523/00—Culture process characterised by temperature

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Hematology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI945877A 1993-12-15 1994-12-14 Menetelmiä proteiini C:n tuottamiseksi FI106385B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/168,035 US5618714A (en)	1993-12-15	1993-12-15	Methods for producing protein C
US16803593		1993-12-15

Publications (3)

Publication Number	Publication Date
FI945877A0 true FI945877A0 (fi)	1994-12-14
FI945877L FI945877L (fi)	1995-06-16
FI106385B FI106385B (fi)	2001-01-31

Family

ID=22609820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI945877A FI106385B (fi)	1993-12-15	1994-12-14	Menetelmiä proteiini C:n tuottamiseksi

Country Status (28)

Country	Link
US (1)	US5618714A (fi)
EP (1)	EP0658626B1 (fi)
JP (1)	JP3662614B2 (fi)
KR (1)	KR950018454A (fi)
CN (1)	CN1107887A (fi)
AT (1)	ATE196165T1 (fi)
AU (1)	AU687914B2 (fi)
BR (1)	BR9404991A (fi)
CA (1)	CA2138101A1 (fi)
CO (1)	CO4340654A1 (fi)
CZ (2)	CZ315794A3 (fi)
DE (1)	DE69425809T2 (fi)
DK (1)	DK0658626T3 (fi)
ES (1)	ES2149244T3 (fi)
FI (1)	FI106385B (fi)
GR (1)	GR3034909T3 (fi)
HU (1)	HU219508B (fi)
IL (1)	IL111983A0 (fi)
NO (1)	NO944846L (fi)
NZ (1)	NZ270140A (fi)
PE (1)	PE42695A1 (fi)
PL (1)	PL176381B1 (fi)
PT (1)	PT658626E (fi)
RU (1)	RU2110574C1 (fi)
SI (1)	SI0658626T1 (fi)
UA (1)	UA26870C2 (fi)
YU (1)	YU73494A (fi)
ZA (1)	ZA949981B (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19724543A1 (de) *	1997-06-11	1998-12-17	Philips Patentverwaltung	Wechsler-Gerät für Informationsplatten
EP1998266A3 (en)	2001-02-19	2009-02-11	Merck Patent GmbH	Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity
US7344873B2 (en)	2002-03-29	2008-03-18	Merck & Co., Inc.	Methods of adenovirus production
US20070142272A1 (en) *	2003-01-24	2007-06-21	Zlokovic Berislav V	Neuroprotective activity of activated protein c independent of its anticoagulant activity
WO2006014839A2 (en) *	2004-07-23	2006-02-09	The University Of Rochester	Activated protein c inhibits undesirable effects of plasminogen activator in the brain
AU2006261555A1 (en) *	2005-06-23	2006-12-28	The University Of British Columbia	Coagulation factor lll polymorphisms associated with prediction of subject outcome and response to therapy
US20100041600A1 (en) *	2006-06-09	2010-02-18	Russel James A	Interferon gamma polymorphisms as indicators of subject outcome in critically ill subjects
CA2712057A1 (en) *	2008-01-15	2009-07-23	The University Of British Columbia	Protein c rs2069915 as a response predictor to survival and administration of activated protein c or protein c-like compound
WO2012068519A2 (en)	2010-11-19	2012-05-24	Sirius Genomics Inc.	Markers associated with response to activated protein c administration, and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4775624A (en) *	1985-02-08	1988-10-04	Eli Lilly And Company	Vectors and compounds for expression of human protein C
US4968626A (en) *	1985-08-15	1990-11-06	Board Of Reagents Of The University Of Washington	DNA sequence coding for protein C
US4959318A (en) *	1985-06-27	1990-09-25	Zymogenetics, Inc.	Expression of protein C
EP0245949B1 (en) *	1986-04-09	1997-10-29	Eli Lilly And Company	A method of using eukaryotic expression vectors comprising the bk virus enhancer
JPH01502080A (ja) *	1986-11-17	1989-07-27	ニュー・イングランド・メディカル・センター	組み換えビタミンｋ依存性蛋白質のガンマカルボキシル化の増強
US4992373A (en) *	1987-12-04	1991-02-12	Eli Lilly And Company	Vectors and compounds for direct expression of activated human protein C
ZA889497B (en) *	1987-12-28	1990-08-29	Lilly Co Eli	Vectors and compounds for expression of zymogen forms of human protein c
JPH0246296A (ja) *	1988-08-09	1990-02-15	Hoechst Japan Ltd	雑種プロテインｃ及びその製造方法
US4981952A (en) *	1988-10-04	1991-01-01	Eli Lilly And Company	Method for the purification of vitamin K-dependent proteins
CA1332049C (en) *	1988-10-07	1994-09-20	Eli Lilly And Company	Eukaryotic expression
JP3045307B2 (ja) *	1989-08-11	2000-05-29	ザイモジェネティクス，インコーポレイティド	活性化プロテインｃを生成するための細胞培養法
IL97312A (en) *	1990-02-23	1999-01-26	Lilly Co Eli	A method of generating a polypeptide in an eukaryotic vector AND recombinant surrogate cell containing an enhanced transcriptional control unit based on the primary late adenovirus coefficient
EP0530365A1 (en) *	1991-01-29	1993-03-10	Teijin Limited	Human protein c expression vector

1993
- 1993-12-15 US US08/168,035 patent/US5618714A/en not_active Expired - Lifetime
1994
- 1994-12-14 CA CA002138101A patent/CA2138101A1/en not_active Abandoned
- 1994-12-14 NO NO944846A patent/NO944846L/no not_active Application Discontinuation
- 1994-12-14 NZ NZ270140A patent/NZ270140A/en unknown
- 1994-12-14 SI SI9430347T patent/SI0658626T1/xx unknown
- 1994-12-14 ZA ZA949981A patent/ZA949981B/xx unknown
- 1994-12-14 PT PT94309314T patent/PT658626E/pt unknown
- 1994-12-14 UA UA94129175A patent/UA26870C2/uk unknown
- 1994-12-14 EP EP94309314A patent/EP0658626B1/en not_active Expired - Lifetime
- 1994-12-14 KR KR1019940034085A patent/KR950018454A/ko not_active Ceased
- 1994-12-14 FI FI945877A patent/FI106385B/fi active
- 1994-12-14 AT AT94309314T patent/ATE196165T1/de not_active IP Right Cessation
- 1994-12-14 RU RU94043769A patent/RU2110574C1/ru active
- 1994-12-14 DE DE69425809T patent/DE69425809T2/de not_active Expired - Lifetime
- 1994-12-14 BR BR9404991A patent/BR9404991A/pt not_active Application Discontinuation
- 1994-12-14 PE PE1994257065A patent/PE42695A1/es not_active Application Discontinuation
- 1994-12-14 DK DK94309314T patent/DK0658626T3/da active
- 1994-12-14 CZ CZ943157A patent/CZ315794A3/cs unknown
- 1994-12-14 CO CO94056544A patent/CO4340654A1/es unknown
- 1994-12-14 IL IL11198394A patent/IL111983A0/xx unknown
- 1994-12-14 AU AU80452/94A patent/AU687914B2/en not_active Ceased
- 1994-12-14 ES ES94309314T patent/ES2149244T3/es not_active Expired - Lifetime
- 1994-12-14 YU YU73494A patent/YU73494A/sh unknown
- 1994-12-14 HU HU9403600A patent/HU219508B/hu not_active IP Right Cessation
- 1994-12-15 CN CN94119106A patent/CN1107887A/zh active Pending
- 1994-12-15 PL PL94306291A patent/PL176381B1/pl unknown
- 1994-12-15 JP JP31160994A patent/JP3662614B2/ja not_active Expired - Fee Related
2000
- 2000-11-24 GR GR20000402615T patent/GR3034909T3/el not_active IP Right Cessation
2001
- 2001-06-22 CZ CZ20012322A patent/CZ290724B6/cs not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5618714A (en)	1997-04-08
CO4340654A1 (es)	1996-07-30
NO944846L (no)	1995-06-16
BR9404991A (pt)	1995-08-08
RU94043769A (ru)	1997-03-27
NZ270140A (en)	1996-05-28
EP0658626B1 (en)	2000-09-06
CN1107887A (zh)	1995-09-06
FI106385B (fi)	2001-01-31
CZ290724B6 (cs)	2002-10-16
FI945877L (fi)	1995-06-16
ATE196165T1 (de)	2000-09-15
AU8045294A (en)	1995-06-22
UA26870C2 (uk)	1999-12-29
CZ315794A3 (en)	1995-10-18
HU9403600D0 (en)	1995-02-28
PL176381B1 (pl)	1999-05-31
EP0658626A1 (en)	1995-06-21
YU73494A (sh)	1997-03-07
RU2110574C1 (ru)	1998-05-10
JP3662614B2 (ja)	2005-06-22
DE69425809T2 (de)	2001-02-01
HU219508B (hu)	2001-04-28
SI0658626T1 (en)	2001-02-28
ES2149244T3 (es)	2000-11-01
NO944846D0 (no)	1994-12-14
KR950018454A (ko)	1995-07-22
DE69425809D1 (de)	2000-10-12
GR3034909T3 (en)	2001-02-28
HUT69979A (en)	1995-09-28
PL306291A1 (en)	1995-06-26
PT658626E (pt)	2001-01-31
PE42695A1 (es)	1995-12-12
DK0658626T3 (da)	2000-10-16
ZA949981B (en)	1996-06-14
CA2138101A1 (en)	1995-06-16
IL111983A0 (en)	1995-03-15
AU687914B2 (en)	1998-03-05
JPH07222589A (ja)	1995-08-22

Publication	Publication Date	Title
ATE153068T1 (de)	1997-05-15	Interleukin-4-rezeptoren
NO975674L (no)	1998-02-06	Fremgangsmåte for å regulere sialyleringen av proteiner fremstilt av pattedyrceller i kultur
FI871908A0 (fi)	1987-04-29	Transformering av trichoderma-moegel.
EP0318296A3 (en)	1991-09-18	Interleukin-1 receptors
FI103987B1 (fi)	1999-10-29	Interleukiini-7
DE69016508D1 (de)	1995-03-16	Interleukin-7-Rezeptoren.
FI945877A0 (fi)	1994-12-14	Menetelmä proteiini C:n tuottamiseksi
NO175872C (no)	1994-12-21	Plasmidvektor, fremgangsmåte for fremstilling av peptider og myelomcelle
DE3888386D1 (de)	1994-04-21	Verfahren zur Herstellung von Proteinen.