FI93026B - In vitro diagnostiskt förfarande för att detektera periodontala sjukdomar - Google Patents
In vitro diagnostiskt förfarande för att detektera periodontala sjukdomar Download PDFInfo
- Publication number
- FI93026B FI93026B FI882122A FI882122A FI93026B FI 93026 B FI93026 B FI 93026B FI 882122 A FI882122 A FI 882122A FI 882122 A FI882122 A FI 882122A FI 93026 B FI93026 B FI 93026B
- Authority
- FI
- Finland
- Prior art keywords
- leukocyte esterase
- diagnostic
- sample
- leukocyte
- esterase
- Prior art date
Links
- 208000028169 periodontal disease Diseases 0.000 title claims abstract description 26
- 238000002405 diagnostic procedure Methods 0.000 title claims abstract description 16
- 238000000338 in vitro Methods 0.000 title claims description 18
- 108010000849 leukocyte esterase Proteins 0.000 claims abstract description 66
- 210000000214 mouth Anatomy 0.000 claims abstract description 19
- 241001465754 Metazoa Species 0.000 claims abstract description 7
- 150000002148 esters Chemical class 0.000 claims description 17
- 210000003296 saliva Anatomy 0.000 claims description 16
- PCKPVGOLPKLUHR-UHFFFAOYSA-N indoxyl Chemical group C1=CC=C2C(O)=CNC2=C1 PCKPVGOLPKLUHR-UHFFFAOYSA-N 0.000 claims description 11
- 210000000265 leukocyte Anatomy 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 4
- 208000007565 gingivitis Diseases 0.000 abstract description 27
- 239000012502 diagnostic product Substances 0.000 abstract description 21
- 241000282412 Homo Species 0.000 abstract description 8
- 239000012530 fluid Substances 0.000 abstract description 6
- 241000282414 Homo sapiens Species 0.000 abstract description 4
- 238000001727 in vivo Methods 0.000 abstract description 3
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 239000012876 carrier material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 description 31
- 239000000523 sample Substances 0.000 description 21
- 238000012360 testing method Methods 0.000 description 21
- 239000003153 chemical reaction reagent Substances 0.000 description 20
- 230000000694 effects Effects 0.000 description 17
- 239000000243 solution Substances 0.000 description 16
- 239000003795 chemical substances by application Substances 0.000 description 12
- 238000001514 detection method Methods 0.000 description 11
- 230000008859 change Effects 0.000 description 10
- 238000005259 measurement Methods 0.000 description 9
- 108090000371 Esterases Proteins 0.000 description 8
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- 208000008718 Pyuria Diseases 0.000 description 4
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- 238000004458 analytical method Methods 0.000 description 3
- 238000010931 ester hydrolysis Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000010408 sweeping Methods 0.000 description 3
- 239000001096 (4-ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol hydrochloride Substances 0.000 description 2
- NNKXWRRDHYTHFP-HZQSTTLBSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;hydron;dichloride Chemical compound Cl.Cl.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 NNKXWRRDHYTHFP-HZQSTTLBSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 2
- 108010051152 Carboxylesterase Proteins 0.000 description 2
- 102000013392 Carboxylesterase Human genes 0.000 description 2
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- 206010061218 Inflammation Diseases 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
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- 210000004027 cell Anatomy 0.000 description 2
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- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- 230000037123 dental health Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 150000001989 diazonium salts Chemical class 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 2
- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
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- 206010034674 peritonitis Diseases 0.000 description 2
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- 229960001811 quinine hydrochloride Drugs 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- XWNSFEAWWGGSKJ-UHFFFAOYSA-N 4-acetyl-4-methylheptanedinitrile Chemical compound N#CCCC(C)(C(=O)C)CCC#N XWNSFEAWWGGSKJ-UHFFFAOYSA-N 0.000 description 1
- DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 1
- GMVPRGQOIOIIMI-DODZYUBVSA-N 7-[(1R,2R,3R)-3-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid Chemical compound CCCCC[C@H](O)C=C[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DODZYUBVSA-N 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 206010018276 Gingival bleeding Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 101001099464 Homo sapiens Lactoperoxidase Proteins 0.000 description 1
- 102100038609 Lactoperoxidase Human genes 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 108700020962 Peroxidase Proteins 0.000 description 1
- 239000004153 Potassium bromate Substances 0.000 description 1
- 208000014151 Stomatognathic disease Diseases 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 208000008312 Tooth Loss Diseases 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
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- 244000309464 bull Species 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 239000003283 colorimetric indicator Substances 0.000 description 1
- ZAJNGDIORYACQU-UHFFFAOYSA-N decan-2-one Chemical compound CCCCCCCCC(C)=O ZAJNGDIORYACQU-UHFFFAOYSA-N 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
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- 239000012153 distilled water Substances 0.000 description 1
- 210000002256 epithelial attachment Anatomy 0.000 description 1
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- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
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- 238000000386 microscopy Methods 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229940094037 potassium bromate Drugs 0.000 description 1
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- 238000011321 prophylaxis Methods 0.000 description 1
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- 239000004328 sodium tetraborate Substances 0.000 description 1
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- 238000005507 spraying Methods 0.000 description 1
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- 239000008399 tap water Substances 0.000 description 1
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- 150000003522 tetracyclines Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical compound [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 238000005353 urine analysis Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/50—Indoles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Claims (5)
1. In vitro diagnostiskt förfarande för att detektera eller uppskatta närvaron av periodontala sjuk-5 domar hos mänskor eller lägre-stäende djur, kanne-t e c k n a t därav, att man tar ett salivprov frän mun-hälan eller ett prov frän det omräde av tandköttet som skall diagnostiseras och mäter mängden leukocytesteras som finns i provet.
2. Diagnostiskt förfarande enligt patentkrav 1, kännetecknat därav, att man vid mätningen av mängden leukocytesteras i saliven använder en ester som är hydrolyserbar av leukocytesteras.
3. Diagnostiskt förfarande enligt patentkrav 2, 15 kännetecknat därav, att man vid mätningen av mängden leukocytesteras i saliven använder en indoxylkar-bonsyraester, som är hydrolyserbar av leukocytesterase, varvid det bildas indoxyl.
4. Diagnostiskt förfarande enligt patentkrav 1, 20 kännetecknat därav, att man vid mätningen av mängden leukocytesteras i provet frän tandköttsomrädet använder en ester som är hydrolyserbar av leukocytesteras.
5. Diagnostiskt förfarande enligt patentkrav 4, - 25 kännetecknat därav, att det omfattar följande steg: (a) man stryker det omräde av tandköttet som skall diagnostiseras för att erhälla ett prov, varefter man (b) mäter mängden leukocytesteras i provet som 30 tagits frän tandköttsomrädet, genom att använda en in- doxylkarbonsyraester, som är hydrolyserbar av leukocytesterase, varvid det bildas indoxyl. «
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4723987 | 1987-05-07 | ||
| US07/047,239 US5051358A (en) | 1987-05-07 | 1987-05-07 | Diagnostic methods for detecting periodontal diseases |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI882122A0 FI882122A0 (sv) | 1988-05-06 |
| FI882122A7 FI882122A7 (sv) | 1988-11-08 |
| FI93026B true FI93026B (sv) | 1994-10-31 |
| FI93026C FI93026C (sv) | 1995-02-10 |
Family
ID=21947841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI882122A FI93026C (sv) | 1987-05-07 | 1988-05-06 | In vitro diagnostiskt förfarande för att detektera periodontala sjukdomar |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5051358A (sv) |
| EP (1) | EP0290217B1 (sv) |
| JP (1) | JPS6434299A (sv) |
| KR (1) | KR880013530A (sv) |
| AT (1) | ATE109836T1 (sv) |
| AU (1) | AU626523B2 (sv) |
| CA (1) | CA1320419C (sv) |
| DE (1) | DE3850998T2 (sv) |
| DK (1) | DK250888A (sv) |
| ES (1) | ES2056922T3 (sv) |
| FI (1) | FI93026C (sv) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0304871A3 (en) * | 1987-08-25 | 1990-01-17 | Dentsply Management Corp. | Dental diagnostic device and method |
| DE19651886A1 (de) * | 1996-12-13 | 1998-06-18 | Merck Patent Gmbh | Mittel und Verfahren zur Bestimmung von hydrolytischen Enzymen |
| US20040071594A1 (en) * | 2002-08-13 | 2004-04-15 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Oral self-assessment device |
| US7521200B2 (en) * | 2006-10-05 | 2009-04-21 | Michael Glogauer | Method for non-invasive rinse diagnosis and monitoring of periodontal diseases using colourimetric reagents |
| AU2011314366B2 (en) * | 2010-10-15 | 2016-03-03 | Nestec S. A. | Oral engagement assemblies |
| CN103282774B (zh) * | 2010-12-28 | 2015-08-05 | 狮王株式会社 | 口腔状态的判定方法及其所使用的分析用具、装置以及程序 |
| RU2702736C2 (ru) * | 2014-06-05 | 2019-10-10 | Колгейт-Палмолив Компани | Исследования при воспалении в полости рта |
| CN115667894A (zh) | 2020-04-30 | 2023-01-31 | 口腔科学国际公司 | 用于监测与牙周病相关联的口腔炎症的试剂盒和方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1128371A (en) * | 1965-10-04 | 1968-09-25 | Miles Lab | Diagnostic composition |
| US3691018A (en) * | 1970-10-28 | 1972-09-12 | Warner Lambert Co | Diagnostic method for periodontal disease |
| US3968011A (en) * | 1973-02-16 | 1976-07-06 | Alza Corporation | Test implement and test method for colorimetrically determining whether a female is fertile or pregnant |
| DE2836644A1 (de) * | 1978-08-22 | 1980-03-06 | Boehringer Mannheim Gmbh | Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten und dafuer geeignete chromogene |
| DE2905531A1 (de) * | 1979-02-14 | 1981-01-08 | Boehringer Mannheim Gmbh | Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten |
| US4499185A (en) * | 1982-05-17 | 1985-02-12 | Miles Laboratories, Inc. | Test for esterase activity in a liquid sample |
| IL74191A0 (en) * | 1984-01-31 | 1985-04-30 | Univ Illinois | Method and kit for determining periodontal disease |
| CA1252703A (en) * | 1984-02-27 | 1989-04-18 | Nutan B. Shah | Diagnostic saliva test for detecting periodontal disease |
| EP0176246A3 (en) * | 1984-08-27 | 1988-08-31 | JOHNSON & JOHNSON DENTAL PRODUCTS COMPANY | Method and kit for detecting the presence of gum disease |
| US4654298A (en) * | 1984-10-05 | 1987-03-31 | Abbott Laboratories | Method for detection of peritoneal inflammation or infection |
| US4717652A (en) * | 1984-10-05 | 1988-01-05 | Abbott Laboratories | Composition for detection of peritoneal inflammation or infection |
-
1987
- 1987-05-07 US US07/047,239 patent/US5051358A/en not_active Expired - Fee Related
-
1988
- 1988-05-03 ES ES88303975T patent/ES2056922T3/es not_active Expired - Lifetime
- 1988-05-03 DE DE3850998T patent/DE3850998T2/de not_active Expired - Fee Related
- 1988-05-03 EP EP88303975A patent/EP0290217B1/en not_active Expired - Lifetime
- 1988-05-03 AT AT88303975T patent/ATE109836T1/de not_active IP Right Cessation
- 1988-05-04 CA CA000565884A patent/CA1320419C/en not_active Expired - Fee Related
- 1988-05-06 DK DK250888A patent/DK250888A/da not_active Application Discontinuation
- 1988-05-06 AU AU15677/88A patent/AU626523B2/en not_active Ceased
- 1988-05-06 FI FI882122A patent/FI93026C/sv not_active IP Right Cessation
- 1988-05-07 KR KR1019880005304A patent/KR880013530A/ko not_active Ceased
- 1988-05-07 JP JP63111399A patent/JPS6434299A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR880013530A (ko) | 1988-12-21 |
| DK250888D0 (da) | 1988-05-06 |
| EP0290217A3 (en) | 1989-01-25 |
| AU1567788A (en) | 1988-11-10 |
| US5051358A (en) | 1991-09-24 |
| EP0290217A2 (en) | 1988-11-09 |
| JPS6434299A (en) | 1989-02-03 |
| CA1320419C (en) | 1993-07-20 |
| DE3850998T2 (de) | 1995-03-02 |
| FI882122A0 (sv) | 1988-05-06 |
| FI93026C (sv) | 1995-02-10 |
| ES2056922T3 (es) | 1994-10-16 |
| EP0290217B1 (en) | 1994-08-10 |
| ATE109836T1 (de) | 1994-08-15 |
| AU626523B2 (en) | 1992-08-06 |
| FI882122A7 (sv) | 1988-11-08 |
| DE3850998D1 (de) | 1994-09-15 |
| DK250888A (da) | 1988-11-08 |
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Owner name: THE PROCTER & GAMBLE COMPANY |