[go: up one dir, main page]

FI934000L - Nya estrar av bi- och tricykliska aminoalkoholer, deras framstaellning och deras anvaendning i laekemedel - Google Patents

Nya estrar av bi- och tricykliska aminoalkoholer, deras framstaellning och deras anvaendning i laekemedel Download PDF

Info

Publication number
FI934000L
FI934000L FI934000A FI934000A FI934000L FI 934000 L FI934000 L FI 934000L FI 934000 A FI934000 A FI 934000A FI 934000 A FI934000 A FI 934000A FI 934000 L FI934000 L FI 934000L
Authority
FI
Finland
Prior art keywords
och
deras
tricykliska
aminoalkoholer
estrar
Prior art date
Application number
FI934000A
Other languages
English (en)
Other versions
FI120235B (fi
FI934000A0 (fi
Inventor
Rolf Banholzer
Rudolf Bauer
Richard Reichl
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of FI934000L publication Critical patent/FI934000L/fi
Publication of FI934000A0 publication Critical patent/FI934000A0/fi
Application granted granted Critical
Publication of FI120235B publication Critical patent/FI120235B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
FI934000A 1991-03-15 1993-09-13 Uusien terapeuttisesti aktiivisten bi- ja trisyklisten aminoalkoholien estereiden valmistusmenetelmä FI120235B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4108393 1991-03-15
DE4108393A DE4108393A1 (de) 1991-03-15 1991-03-15 Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
PCT/EP1992/000489 WO1992016528A1 (de) 1991-03-15 1992-03-05 Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
EP9200489 1992-03-05

Publications (3)

Publication Number Publication Date
FI934000L true FI934000L (fi) 1993-09-13
FI934000A0 FI934000A0 (fi) 1993-09-13
FI120235B FI120235B (fi) 2009-08-14

Family

ID=6427349

Family Applications (1)

Application Number Title Priority Date Filing Date
FI934000A FI120235B (fi) 1991-03-15 1993-09-13 Uusien terapeuttisesti aktiivisten bi- ja trisyklisten aminoalkoholien estereiden valmistusmenetelmä

Country Status (26)

Country Link
US (1) US5654314A (fi)
EP (1) EP0579615B1 (fi)
JP (1) JP3352684B2 (fi)
KR (1) KR100307274B1 (fi)
AT (1) ATE202778T1 (fi)
AU (1) AU662128B2 (fi)
CA (1) CA2105575C (fi)
CZ (1) CZ281509B6 (fi)
DE (2) DE4108393A1 (fi)
DK (1) DK0579615T3 (fi)
ES (1) ES2160577T3 (fi)
FI (1) FI120235B (fi)
GR (1) GR3036792T3 (fi)
HU (1) HU224210B1 (fi)
IE (1) IE920815A1 (fi)
IL (1) IL101225A (fi)
MX (1) MX9201139A (fi)
NO (1) NO304266B1 (fi)
NZ (1) NZ241961A (fi)
PL (1) PL179673B1 (fi)
PT (1) PT100234B (fi)
SG (1) SG43037A1 (fi)
SK (1) SK281511B6 (fi)
UA (1) UA29406C2 (fi)
WO (1) WO1992016528A1 (fi)
ZA (1) ZA921875B (fi)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
IT1255323B (it) * 1992-07-08 1995-10-31 Fidia Spa Composti ad attivita' analgesica e nootropa
DE19921693A1 (de) 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
US7214687B2 (en) * 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
NZ522677A (en) * 2000-04-27 2004-10-29 Boehringer Ingelheim Pharma Novel, slow-acting betamimetics, a method for their production and their use as medicaments
US6761901B1 (en) * 2000-05-02 2004-07-13 Enzrel Inc. Liposome drug delivery
US6689760B1 (en) 2000-07-10 2004-02-10 Enzrel Inc. Anti-mycobacterial compositions
US6455073B1 (en) 2000-07-10 2002-09-24 Enzrel, Inc. Covalent microparticle-drug conjugates for biological targeting
AU2001271027B2 (en) 2000-07-11 2005-07-07 Msd K.K. Ester derivatives
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
DZ3477A1 (fi) * 2000-10-12 2002-04-18
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
DE10050995A1 (de) 2000-10-14 2002-04-18 Boehringer Ingelheim Pharma Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US6852728B2 (en) 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
DE10050994A1 (de) * 2000-10-14 2002-04-18 Boehringer Ingelheim Pharma Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
SK287414B6 (sk) * 2000-12-28 2010-09-07 Laboratorios Almirall, S.A. Chinuklidínové deriváty a kompozície s ich obsahom
US20030013675A1 (en) * 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
AU2003210477A1 (en) * 2002-01-09 2003-07-30 Enzrel, Inc. Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
DE10203741A1 (de) * 2002-01-31 2003-08-14 Boehringer Ingelheim Pharma Neue Fluorencarbonsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US7405224B2 (en) 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
DE10203749A1 (de) * 2002-01-31 2003-08-14 Boehringer Ingelheim Pharma Neue Anticholinergika, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE10203753A1 (de) * 2002-01-31 2003-08-14 Boehringer Ingelheim Pharma Neue Xanthencarbonsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US6696462B2 (en) 2002-01-31 2004-02-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for the preparation thereof, and pharmaceutical compositions
US6790856B2 (en) 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US20030229227A1 (en) * 2002-03-16 2003-12-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
DE10211700A1 (de) * 2002-03-16 2003-09-25 Boehringer Ingelheim Pharma Neue Difurylglykolsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7244415B2 (en) * 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
MXPA04009583A (es) * 2002-04-04 2005-01-11 Boehringer Ingelheim Pharma Nuevas formulaciones en polvo adecuadas para inhalacion.
US20030235538A1 (en) 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
DE10256317A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Arzneimittel enthaltend Betamimetika und ein neues Anticholinergikum
DE10216429A1 (de) 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Arzneimittel enthaltend Steroide und ein neues Anticholinergikum
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
ES2248767T3 (es) * 2002-04-12 2006-03-16 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO.KG Medicamento que contiene beta-mimeticos y un nuevo anticolinergico.
US7417051B2 (en) 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7094788B2 (en) 2002-04-13 2006-08-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
DE10216339A1 (de) * 2002-04-13 2003-10-23 Boehringer Ingelheim Pharma Neue Ester hydroxy-substituierter Stickstoffheterocyclen, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE10224091A1 (de) * 2002-05-31 2003-12-11 Boehringer Ingelheim Pharma Technisches Verfahren zur Herstellung von Tropenol
US20040048886A1 (en) * 2002-07-09 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on new anticholinergics and NK1 receptor antagonists
DE10255040A1 (de) * 2002-11-26 2004-06-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Carbaminsäureester mit anticholinerger Wirksamkeit
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
AU2004206846B2 (en) * 2003-01-16 2009-05-28 University Of Rochester Quaternary antimuscarinic compounds for the treatment of bladder diseases
ES2329133T3 (es) * 2003-05-28 2009-11-23 Theravance, Inc. Compuestos azabicicloalcanicos como antagonistas de receptores de muscarinicos.
US7273603B2 (en) * 2003-07-11 2007-09-25 Boehringer Ingelheim International Gmbh HFC solution formulations containing an anticholinergic
DE10345065A1 (de) 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
SI1677795T1 (sl) * 2003-10-14 2011-04-29 Glaxo Group Ltd Antagonisti muskarinskega acetilholinskega receptorja
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
US20050203088A1 (en) * 2004-01-09 2005-09-15 Boehringer Ingelheim International Gmbh Medicament combinations based on scopine- or tropene acid esters with EGFR-kinase inhibitors
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
US20080027094A1 (en) * 2004-08-30 2008-01-31 Ono Pharmaceutical Co., Ltd. Tropane Compounds and Pharmaceutical Compositions Comprising the Same as an Active Ingredient
DE102005001297A1 (de) * 2005-01-12 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
ES2298049B1 (es) * 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
EP1997819A1 (de) * 2007-05-25 2008-12-03 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopinestern
EP2100598A1 (en) * 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
PL2435024T3 (pl) * 2009-05-29 2017-01-31 Pearl Therapeutics, Inc. Dostarczanie substancji czynnych do dróg oddechowych oraz powiązane sposoby i systemy
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
CA2905542C (en) 2013-03-15 2022-05-03 Pearl Therapeutics, Inc. Methods and systems for conditioning of particulate crystalline materials
KR101823451B1 (ko) 2013-07-13 2018-01-30 베이징 에프에스웰컴 테크놀로지 디벨롭먼트 컴퍼니 리미티드 퀴논계 화합물, 이의 광학 이성질체 및 이의 제조 방법과 의약 용도

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2872452A (en) * 1959-02-03 N-carbocyclohexoxy- and certain n-car-
US2753288A (en) * 1953-01-12 1956-07-03 Upjohn Co Scopolamine lower-alkyl halide therapeutic composition
US2893996A (en) * 1957-10-14 1959-07-07 Grace W R & Co N-amino derivatives of tropine alkaloids
US3145211A (en) * 1962-01-04 1964-08-18 Sterling Drug Inc Tropyl esters of alpha-cycloalkylalkanoic acids
GB1107036A (en) * 1964-10-31 1968-03-20 Koninklijke Pharma Fab Nv Esters of dibenzocycloheptenyl-carboxylic acids
GB1223130A (en) * 1967-04-12 1971-02-24 Egyt Gyogyszervegyeszeti Gyar Tropine ester salts
US3808263A (en) * 1970-05-12 1974-04-30 Tanabe Seiyaku Co 6,6-dimethyl-9-alkyl-9-azabicyclo(3.3.1)nonan-3-ols
US3673195A (en) * 1970-05-25 1972-06-27 Tanabe Seiyaku Co Derivatives of 6,6,9-tri-lower alkyl-9-azabicyclo(3.3.1) nonan-3{60 -or 3{62 -ol
DE2026661A1 (de) * 1970-06-01 1971-12-16 C H Boehnnger Sohn, 6507 Ingelheim Tropan 3 öl Derivate und Verfahren zu deren Herstellung
FR2168881A1 (en) * 1972-01-25 1973-09-07 Synthelabo Tropanol 1-phenylcycloalkane carboxylic ester salts - spasmolytics and cholinergics
FR2208649A1 (en) * 1972-12-01 1974-06-28 Synthelabo 1-(2-Thienyl)cycloalkane carboxylic ester salts - with spasmolytic and anticholinergic activity
DE2540633A1 (de) * 1975-09-12 1977-04-28 Boehringer Sohn Ingelheim Neue quartaere n-beta-substituierte benzilsaeure-n-alkyl-nortropinester und verfahren zu deren herstellung
DE3320138A1 (de) * 1983-06-03 1984-12-06 Boehringer Ingelheim KG, 6507 Ingelheim Neues nortropinderivat, verfahren zu seiner herstellung und seine verwendung
IT1194343B (it) * 1983-07-26 1988-09-14 Valeas Spa Sali di endo-8,8-dialchil-8-azoniabiciclo (3.2.1) ottan-6,7-esso-epossi-3-alchilcarbossilati,processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo
DE3546218A1 (de) * 1985-12-27 1987-07-02 Madaus & Co Dr Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutisches mittel
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Also Published As

Publication number Publication date
NO933274L (no) 1993-11-12
SG43037A1 (en) 1997-10-17
PT100234A (pt) 1993-07-30
KR100307274B1 (ko) 2001-12-05
DK0579615T3 (da) 2001-09-17
CZ191793A3 (en) 1994-05-18
AU662128B2 (en) 1995-08-24
NO933274D0 (no) 1993-09-14
JP3352684B2 (ja) 2002-12-03
EP0579615B1 (de) 2001-07-04
IE920815A1 (en) 1992-09-23
HU224210B1 (hu) 2005-06-28
CZ281509B6 (cs) 1996-10-16
AU1345792A (en) 1992-10-21
ZA921875B (en) 1993-09-13
JPH06505718A (ja) 1994-06-30
MX9201139A (es) 1992-10-01
NZ241961A (en) 1995-07-26
IL101225A0 (en) 1992-11-15
NO304266B1 (no) 1998-11-23
SK281511B6 (sk) 2001-04-09
ATE202778T1 (de) 2001-07-15
CA2105575C (en) 2000-04-25
PL179673B1 (pl) 2000-10-31
ES2160577T3 (es) 2001-11-16
HU9302611D0 (en) 1993-12-28
EP0579615A1 (de) 1994-01-26
CA2105575A1 (en) 1992-09-16
PT100234B (pt) 1999-06-30
FI120235B (fi) 2009-08-14
HUT65132A (en) 1994-04-28
SK94993A3 (en) 1994-04-06
DE4108393A1 (de) 1992-09-17
US5654314A (en) 1997-08-05
WO1992016528A1 (de) 1992-10-01
FI934000A0 (fi) 1993-09-13
IL101225A (en) 1996-05-14
DE59209907D1 (de) 2001-08-09
UA29406C2 (uk) 2000-11-15
GR3036792T3 (en) 2002-01-31

Similar Documents

Publication Publication Date Title
FI934000L (fi) Nya estrar av bi- och tricykliska aminoalkoholer, deras framstaellning och deras anvaendning i laekemedel
FI930753L (fi) Nya fosfolipidderivat av nukleosider, deras framstaellning och deras anvaendning saosom antivirala laekemedel
FI922735A0 (fi) Nya behaollarsystem och vattenhaltiga kompositioner.
FI934438L (fi) Nya konjugater och foerfaranden foer samtidig detektering av flera ligander
FI925937L (fi) Nya polyamider och foeremaol erhaollna av dessa
FI935071L (fi) Nya perhydroisoindoler, deras framstaellning och dessa innehaollande farmaceutiska preparat
FI935421A7 (fi) Konstruktionsdel av plaot, byggnadspanel och byggnadsfoerfarande
FI912285L (fi) Nya bifunktionella kopplingsfoereningar, konjugat och foerfaranden foer framstaellning av dessa.
FI935189A7 (fi) Glasfiberarmerad plastbehaollare, foerfarande och anordning foet tillverkning av en saodan behaollare
FI923143L (fi) Homogeniska, stabila och flytande vattenblandningar och anvaendning av naemnda blandningar foer framstaellning av dispersioner av i vatten oloesliga substanser
FI920732L (fi) 2-substituerade kinoliner, foerfarande foer framstaellning av dessa och anvaendning av dessa i laekemedel
FI925946L (fi) Nya 2-sackarinylmetylaryl- och -aryloxiacetat anvaendbara som inhibitorer foer proteolytiska ensymer, kompositioner innehaollande dessa och anvaendning av dessa
FI925665L (fi) Nya pyridylderivat, dessa foereningar innehaollande laekemedel och foerfarande foer deras framstaellning
FI920349L (fi) Foerfarande foer framstaellning av nya tetrazolderivat och deras anvaendning.
FI932145L (fi) Nya b-karbolinderivat, deras framstaellning och anvaendning i laekemedel
FI924617A7 (fi) Anordning foer viktinstaellning av instaellning av sittyta och ryggstoed istolar, saerskilt byrosvaengstolar
FI925570L (fi) Nya i vatten oloesliga katjoniska kopolymerer, nya dispersioner och anvaendning av dessa vid bestrykning av papper
FI923755L (fi) Disulfider, foerfarande foer framstaellning av dessa och anvaendning av dessa
FI930716L (fi) Nya arylkarbonylaminoalkyldihydrooxopyridiner, framstaellning och anvaendning av dessa
FI921340L (fi) Nya tiazolidinon- och oxazolidinonderivat, deras framstaellning och anvaendning som utvidgare av blodkaerlen
FI935845L (fi) Formskiva, kontaktskikt och foerfarande foer tillverkning av formskivan
FI920720A7 (fi) 4-pyrimidinonderivat, framstaellning av dessa och anvaendning av dessa iterapi
FI913888L (fi) Nya farmaceutiska sammansaettningar och foerfarande foer framstaellning av desamma.
FI922428L (fi) Nya 2-amino-5-cyan-1,4-dihydropyridiner, foerfarande foer deras framstaellning och deras anvaendning i laekemedel
FI930293L (fi) Nya heteroaryloxi-b-karboliner, deras framstaellning och anvaendning i laekemedel

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 120235

Country of ref document: FI

MA Patent expired