FI921473L - Method for preparing therapeutically useful benzimidazole derivatives - Google Patents

Method for preparing therapeutically useful benzimidazole derivatives Download PDF

Info

Publication number: FI921473L
Authority: FI; Finland
Prior art keywords: therapeutically useful; benzimidazole derivatives; preparing therapeutically; useful benzimidazole; preparing
Prior art date: 1991-04-05

Application number

FI921473A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI921473A0 (en

FI99112B (en

FI99112C (en

Inventor

Maria Rosa Cuberes-Altisent

Constansa Jordi Frigola

Corominas Juan Pares

Original Assignee

Esteve Labor Dr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-05

Filing date

1992-04-03

Publication date

1992-10-06

1992-04-03 Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr

1992-04-03 Publication of FI921473A0 publication Critical patent/FI921473A0/en

1992-10-06 Publication of FI921473L publication Critical patent/FI921473L/en

1997-06-30 Publication of FI99112B publication Critical patent/FI99112B/en

1997-10-10 Application granted granted Critical

1997-10-10 Publication of FI99112C publication Critical patent/FI99112C/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Anesthesiology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

FI921473A 1991-04-05 1992-04-03 Process for the preparation of therapeutically useful benzimidazole derivatives FI99112C (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9104171A FR2674856B1 (en)	1991-04-05	1991-04-05	NOVEL NON - SEDATIVE ANTIHISTAMINS, DERIVATIVES OF BENZIMIDAZOLE, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS.

Publications (4)

Publication Number	Publication Date
FI921473A0 FI921473A0 (en)	1992-04-03
FI921473L true FI921473L (en)	1992-10-06
FI99112B FI99112B (en)	1997-06-30
FI99112C FI99112C (en)	1997-10-10

Family

ID=9411523

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI921473A FI99112C (en)	1991-04-05	1992-04-03	Process for the preparation of therapeutically useful benzimidazole derivatives

Country Status (28)

Country	Link
US (1)	US5214040A (en)
EP (1)	EP0507696B1 (en)
JP (1)	JP3060054B2 (en)
KR (1)	KR970011298B1 (en)
CN (1)	CN1028367C (en)
AT (1)	ATE126228T1 (en)
AU (1)	AU647904B2 (en)
BG (1)	BG60678B1 (en)
BR (1)	BR1100983A (en)
CA (1)	CA2065061A1 (en)
CZ (1)	CZ279506B6 (en)
DE (1)	DE69203911T2 (en)
DK (1)	DK0507696T3 (en)
ES (1)	ES2046110B1 (en)
FI (1)	FI99112C (en)
FR (1)	FR2674856B1 (en)
GR (1)	GR3017643T3 (en)
HU (1)	HU214316B (en)
IL (1)	IL101483A (en)
IS (1)	IS1639B (en)
MX (1)	MX9201556A (en)
NO (1)	NO179552C (en)
NZ (1)	NZ242208A (en)
PL (1)	PL167720B1 (en)
RO (1)	RO109198B1 (en)
RU (1)	RU2099336C1 (en)
TW (1)	TW208003B (en)
YU (1)	YU48826B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1264456B1 (en) *	1993-05-14	1996-09-23	Dompe Farmaceutici Spa	DERIVATIVES OF PHARMACOLOGICALLY ACTIVE 2- (BENZIMIDAZOL-2-IL) -1,3-DIAMINOPROPANE.
FR2727865B1 (en) *	1994-12-08	1997-07-18	Esteve Labor Dr	USE OF 2- (4- (AZOLYBUTYL) -PIPERAZINYL- (METHYL)) - BENZIMIDAZOLE DERIVATIVES AND THEIR SALTS FOR THE PREPARATION OF MEDICINAL PRODUCTS FOR THE TREATMENT OR PROPHYLAXIS OF ASTHMA
US5773616A (en) *	1995-02-15	1998-06-30	Neurogen Corporation	Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
AU4867496A (en) *	1995-02-15	1996-09-04	Neurogen Corporation	Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
FR2731618B1 (en) *	1995-03-14	1997-08-01	Esteve Labor Dr	TOPICAL OPHTHALMIC COMPOSITION COMPRISING A DERIVATIVE OF 2- (4- (AZOLYLBUTYL) -PIPERAZINYL-METHYL) -BENZIMIDAZOLE, IN PARTICULAR FOR THE TREATMENT OF ALLERGIC CONJUNCTIVITY
US6211199B1 (en)	1995-11-17	2001-04-03	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en)	1995-12-20	2002-07-23	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en)	1995-12-20	2001-02-27	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5932571A (en) *	1996-02-21	1999-08-03	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) *	1996-02-21	1999-12-07	Hoescht Marion Roussel, Inc.	Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) *	1996-02-21	1999-07-13	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
IL139828A0 (en) *	1998-05-22	2002-02-10	Avanir Pharmaceuticals	COMPOUNDS HAVING IgE AFFECTING PROPERTIES
TWI225488B (en) *	1999-12-21	2004-12-21	Janssen Pharmaceutica Nv	Derivatives of homopiperidinyl substituted benzimidazole analogues
CZ304346B6 (en) *	2000-01-19	2014-03-19	Cadila Healthcare Ltd.	Substituted pyrrole derivative exhibiting hypolipidemic and hypocholesteremic activity , process for its preparation and pharmaceutical composition containing thereof
CA2427156A1 (en) *	2000-10-31	2003-04-28	Basf Drucksysteme Gmbh	Use of hyperbranched polyurethanes for producing printing inks
IL157029A0 (en) *	2001-02-02	2004-02-08	Bristol Myers Squibb Co	Azaindoleoxoacetic piperazine derivatives and pharmaceutical compositions containing the same
WO2003060475A2 (en) *	2002-01-10	2003-07-24	Neurogen Corporation	Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazole analogues
RU2288917C2 (en) *	2002-04-19	2006-12-10	Фаэс Фарма, С.А.	POLYMORPH OF 4-[2-[4-[1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL]-PIPERIDINYL]ETHYL]-α,α-DIMETHYLBENZENEACETIC ACID, METHOD FOR ITS PREPARING, PHARMACEUTICAL PREPARATION BASED ON THEREOF AND ITS USING
MX2007002324A (en) *	2004-09-03	2007-05-11	Yuhan Corp	Pyrrolo[2,3-c]pyridine derivatives and processes for the preparation thereof.
CN101089000B (en)	2006-06-16	2011-01-05	北京大学	Spiro piperazine quaternary ammonium salt compound and its preparation method and application
KR20120026534A (en) *	2009-06-11	2012-03-19	시에나 바이오테크 에스.피.에이.	Hedgehog pathway antagonists and therapeutic applications thereof
CA2895285C (en) *	2012-12-27	2021-03-30	Alzprotect	Sulphate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4200641A (en) *	1976-12-21	1980-04-29	Janssen Pharmaceutica, N.V.	1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
DE3336409A1 (en) *	1983-10-06	1985-04-18	Ludwig Heumann & Co GmbH, 8500 Nürnberg	CHINAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US5010075A (en) *	1987-04-24	1991-04-23	Syntex Pharmaceuticals Ltd.	Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
CA1317939C (en) *	1987-07-01	1993-05-18	Janssen Pharmaceutica Naamloze Vennootschap	¬(bicyclic heterocyclyl)methyl and -hetero\| substituted hexahydro-1h-azepines and pyrrolidines
FR2665161B1 (en) *	1990-07-26	1992-11-27	Esteve Labor Dr	NOVEL BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS.

1991
- 1991-04-05 FR FR9104171A patent/FR2674856B1/en not_active Expired - Fee Related
1992
- 1992-03-31 TW TW081102419A patent/TW208003B/zh active
- 1992-03-31 YU YU33692A patent/YU48826B/en unknown
- 1992-04-01 RU SU925011426A patent/RU2099336C1/en active
- 1992-04-02 NZ NZ242208A patent/NZ242208A/en unknown
- 1992-04-02 AU AU13979/92A patent/AU647904B2/en not_active Ceased
- 1992-04-02 RO RO92-200447A patent/RO109198B1/en unknown
- 1992-04-02 IS IS3832A patent/IS1639B/en unknown
- 1992-04-03 US US07/863,208 patent/US5214040A/en not_active Expired - Fee Related
- 1992-04-03 DE DE69203911T patent/DE69203911T2/en not_active Expired - Fee Related
- 1992-04-03 NO NO921315A patent/NO179552C/en not_active IP Right Cessation
- 1992-04-03 EP EP92400940A patent/EP0507696B1/en not_active Expired - Lifetime
- 1992-04-03 BG BG96180A patent/BG60678B1/en unknown
- 1992-04-03 HU HU9201145A patent/HU214316B/en not_active IP Right Cessation
- 1992-04-03 ES ES09200813A patent/ES2046110B1/en not_active Expired - Lifetime
- 1992-04-03 KR KR1019920005583A patent/KR970011298B1/en not_active Expired - Fee Related
- 1992-04-03 IL IL10148392A patent/IL101483A/en not_active IP Right Cessation
- 1992-04-03 FI FI921473A patent/FI99112C/en active
- 1992-04-03 DK DK92400940.0T patent/DK0507696T3/en active
- 1992-04-03 CA CA002065061A patent/CA2065061A1/en not_active Abandoned
- 1992-04-03 AT AT92400940T patent/ATE126228T1/en not_active IP Right Cessation
- 1992-04-03 CZ CS921017A patent/CZ279506B6/en not_active IP Right Cessation
- 1992-04-03 MX MX9201556A patent/MX9201556A/en unknown
- 1992-04-03 PL PL92294101A patent/PL167720B1/en unknown
- 1992-04-04 CN CN92102353A patent/CN1028367C/en not_active Expired - Fee Related
- 1992-04-06 JP JP4084230A patent/JP3060054B2/en not_active Expired - Lifetime
1995
- 1995-10-04 GR GR950402756T patent/GR3017643T3/en unknown
1997
- 1997-05-14 BR BR1100983-7A patent/BR1100983A/en active IP Right Grant

Also Published As

Publication number	Publication date
IS1639B (en)	1997-03-25
RO109198B1 (en)	1994-12-30
DE69203911T2 (en)	1995-12-07
JP3060054B2 (en)	2000-07-04
YU33692A (en)	1995-03-27
IL101483A (en)	1995-12-08
NO179552B (en)	1996-07-22
TW208003B (en)	1993-06-21
FI921473A0 (en)	1992-04-03
NO921315D0 (en)	1992-04-03
AU1397992A (en)	1992-10-08
CA2065061A1 (en)	1992-10-06
IL101483A0 (en)	1992-12-30
BR1100983A (en)	1999-10-13
NO921315L (en)	1992-10-06
FI99112B (en)	1997-06-30
RU2099336C1 (en)	1997-12-20
ATE126228T1 (en)	1995-08-15
AU647904B2 (en)	1994-03-31
PL294101A1 (en)	1992-11-30
JPH0597846A (en)	1993-04-20
FI99112C (en)	1997-10-10
EP0507696A1 (en)	1992-10-07
NZ242208A (en)	1993-10-26
CN1028367C (en)	1995-05-10
CS101792A3 (en)	1992-10-14
KR970011298B1 (en)	1997-07-09
HUT60732A (en)	1992-10-28
DK0507696T3 (en)	1995-09-18
KR920019781A (en)	1992-11-20
GR3017643T3 (en)	1996-01-31
HU214316B (en)	1998-03-02
HU9201145D0 (en)	1992-06-29
BG96180A (en)	1993-12-24
MX9201556A (en)	1992-10-01
PL167720B1 (en)	1995-10-31
DE69203911D1 (en)	1995-09-14
ES2046110B1 (en)	1994-08-01
EP0507696B1 (en)	1995-08-09
US5214040A (en)	1993-05-25
FR2674856A1 (en)	1992-10-09
NO179552C (en)	1996-10-30
IS3832A (en)	1992-10-06
CZ279506B6 (en)	1995-05-17
FR2674856B1 (en)	1993-07-30
BG60678B1 (en)	1995-12-29
ES2046110A1 (en)	1994-01-16
YU48826B (en)	2002-03-18
CN1065460A (en)	1992-10-21

Publication	Publication Date	Title
FI921473L (en)	1992-10-06	Method for preparing therapeutically useful benzimidazole derivatives
FI905941A7 (en)	1991-06-07	Method for preparing therapeutically useful heterocyclic 2-acylaminothiazole derivatives
FI893433A7 (en)	1990-01-15	Method for preparing therapeutically useful heterocyclic compounds
FI890282L (en)	1989-07-21	Method for preparing therapeutically useful 23,24-didehydro-25-hydroxycalciferol derivatives
FI951591L (en)	1995-04-04	Method for preparing taxane derivatives
NO180749C (en)	1997-06-11	Analogous Process for Preparing Therapeutically Active Benzimidazole Substituted Derivatives
FI894217L (en)	1990-03-08	Method for preparing 1-adamantane derivatives
FI890842A7 (en)	1989-08-25	Method for preparing therapeutically useful stilbene derivatives
FI892182A7 (en)	1989-11-07	Method for preparing therapeutically useful chroman derivatives
FI943643A7 (en)	1994-08-05	Method for preparing taxane derivatives
FI913614L (en)	1992-02-01	Method for preparing therapeutically useful N-sulfonyl indoline derivatives
FI940769L (en)	1994-08-20	Process for preparing 2-aminoazole derivatives
FI930150L (en)	1993-01-14	Method for preparing therapeutically active indole derivatives
FI890283A7 (en)	1989-07-21	Method for preparing therapeutically useful 25-hydroxyvitamin D derivatives
FI894803L (en)	1990-04-12	Method for preparing therapeutically useful quinolinone derivatives
FI924642L (en)	1992-10-14	Method for preparing therapeutically active 3-indolylthioacetate derivatives
FI892948A7 (en)	1989-12-17	Method for preparing therapeutically useful chroman derivatives
FI923498A7 (en)	1993-02-07	Method for preparing 3-deoxymannosamine derivatives
FI890257A7 (en)	1989-07-21	Method for preparing therapeutically useful pyridine derivatives
FI940280L (en)	1994-01-20	Process for preparing demethylepipodophyllotoxin
FI893003L (en)	1989-12-21	Method for preparing novel therapeutically useful neplanosin derivatives
FI916058A7 (en)	1992-06-28	Method for preparing therapeutically active dihydrobenzofurancarboxamides
FI911420L (en)	1991-09-27	Method for preparing therapeutically useful compounds
FI911701L (en)	1991-10-11	Process for preparing therapeutically useful 2-substituted alkyl-3-carboxycarbapenems
FI893345A7 (en)	1990-01-12	Method for preparing novel therapeutically useful pyridazinone derivatives

Legal Events

Date	Code	Title	Description
1997-06-02	BB	Publication of examined application