[go: up one dir, main page]

FI920992L - Foerfarande foer framstaellning av i industriell skala av ett standardiserat koncentrat av human von willebrand-faktor, vilket har synnerligen hoeg renhet och aer laempligt foer terapeutisk anvaendning - Google Patents

Foerfarande foer framstaellning av i industriell skala av ett standardiserat koncentrat av human von willebrand-faktor, vilket har synnerligen hoeg renhet och aer laempligt foer terapeutisk anvaendning Download PDF

Info

Publication number
FI920992L
FI920992L FI920992A FI920992A FI920992L FI 920992 L FI920992 L FI 920992L FI 920992 A FI920992 A FI 920992A FI 920992 A FI920992 A FI 920992A FI 920992 L FI920992 L FI 920992L
Authority
FI
Finland
Prior art keywords
foer
synnerligen
standardserat
renhet
laempligt
Prior art date
Application number
FI920992A
Other languages
English (en)
Other versions
FI106721B (fi
FI920992A0 (fi
Inventor
Miryana Burnouf-Radosevich
Thierry Burnouf
Original Assignee
Centre Regional De Transfusion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Regional De Transfusion filed Critical Centre Regional De Transfusion
Publication of FI920992A0 publication Critical patent/FI920992A0/fi
Publication of FI920992L publication Critical patent/FI920992L/fi
Application granted granted Critical
Publication of FI106721B publication Critical patent/FI106721B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI920992A 1991-03-08 1992-03-06 Menetelmä ihmisen standardisoidun, korkean puhtauden omaavan von Willebrand -tekijän konsentraatin valmistamiseksi FI106721B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9102804 1991-03-08
FR9102804A FR2673632A1 (fr) 1991-03-08 1991-03-08 Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique.

Publications (3)

Publication Number Publication Date
FI920992A0 FI920992A0 (fi) 1992-03-06
FI920992L true FI920992L (fi) 1992-09-09
FI106721B FI106721B (fi) 2001-03-30

Family

ID=9410505

Family Applications (1)

Application Number Title Priority Date Filing Date
FI920992A FI106721B (fi) 1991-03-08 1992-03-06 Menetelmä ihmisen standardisoidun, korkean puhtauden omaavan von Willebrand -tekijän konsentraatin valmistamiseksi

Country Status (29)

Country Link
US (1) US5408039A (fi)
EP (1) EP0503991B1 (fi)
JP (1) JP3435668B2 (fi)
AT (1) AT407115B (fi)
AU (1) AU645172B2 (fi)
BE (1) BE1004178A3 (fi)
BR (1) BR9200770A (fi)
CA (1) CA2062340C (fi)
CZ (1) CZ283633B6 (fi)
DE (2) DE69227055T2 (fi)
DK (1) DK0503991T3 (fi)
EE (1) EE03057B1 (fi)
EG (1) EG20300A (fi)
ES (1) ES2121830T3 (fi)
FI (1) FI106721B (fi)
FR (1) FR2673632A1 (fi)
HU (1) HU215098B (fi)
IL (1) IL101043A (fi)
IT (1) IT1256692B (fi)
LT (1) LT3175B (fi)
NL (1) NL300394I1 (fi)
NO (1) NO301278B1 (fi)
NZ (1) NZ241701A (fi)
PL (1) PL168353B1 (fi)
RU (1) RU2088590C1 (fi)
SA (1) SA92120446B1 (fi)
SK (1) SK279533B6 (fi)
UA (1) UA27732C2 (fi)
ZA (1) ZA921430B (fi)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
DE4435392B4 (de) * 1994-10-04 2008-02-07 Immuno Ag Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF
DE4437544A1 (de) * 1994-10-20 1996-04-25 Behringwerke Ag Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
DE19616540A1 (de) * 1995-11-10 1997-05-15 Immuno Ag Verwendung von von Willebrand-Faktor und pharmazeutische Zubereitung
US6005077A (en) * 1995-11-10 1999-12-21 Immuno Aktiengesellschaft Use of von willebrand factor and pharmaceutical formulation
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
US6068838A (en) * 1996-04-29 2000-05-30 Baxter Aktiengesellschaft Purified multimerase
AT404358B (de) 1997-02-04 1998-11-25 Immuno Ag Verfahren zur chromatographischen reinigung bzw. fraktionierung von von willebrand-faktor aus einem vwf-hältigen ausgangsmaterial
AT405403B (de) 1997-02-27 1999-08-25 Immuno Ag Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie
AT405485B (de) * 1997-05-28 1999-08-25 Immuno Ag Eine das vwf-propeptid enthaltende pharmazeutische präparation
PT1820516E (pt) 1999-02-22 2013-10-31 Baxter Int Novas formulações de factor viii isentas de albumina
EP1148063A1 (de) * 2000-04-18 2001-10-24 Octapharma AG Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung
RU2200028C2 (ru) * 2000-06-20 2003-03-10 Кировский НИИ гематологии и переливания крови Способ пломбировки пункционного канала после диагностической эндоскопической пункционной биопсии печени у больных гемофилией а
EP1593388A1 (en) * 2004-05-05 2005-11-09 ZLB Behring GmbH Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers
FR2874216B1 (fr) 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
DE102004044429B4 (de) * 2004-09-14 2009-04-30 Biotest Ag Verfahren zur Herstellung einer Zusammensetzung enthaltend von Willebrand Faktor
DE102004044419B4 (de) 2004-09-14 2010-04-15 Biotest Ag Verfahren zur Aufreinigung eines von Willebrand Faktors mittels Hydroxylapatit-Durchlaufchromatographie
ITLU20070007A1 (it) * 2007-05-07 2008-11-08 Kedrion Spa Processo cromatografico per l'ottenimento di un complesso fviii/vwf con differenti rapporti tra le due proteine da utilizzare nella terapia della emofilia a e nella malattia di von willebrand.
CA2690218C (en) 2007-06-13 2017-02-28 Csl Behring Gmbh Use of vwf stabilized fviii preparations and of vwf preparations without fviii for extravascular administration in the therapy and prophylactic treatment of bleeding disorders
FR2920429B1 (fr) * 2007-08-30 2012-10-05 Lfb Biotechnologies Procede de purification du facteur viii et du facteur von willebrand
EP2073015A1 (en) 2007-12-21 2009-06-24 CSL Behring GmbH Diagnostic in vitro method for assessing Von Willebrand Disease and bleeding risk associated with Von Willebrand Disease and acquired or congenital disorders of platelet function
US20100273206A1 (en) * 2007-12-21 2010-10-28 Manfred Rauh Diagnostic in vitro method for assessing von willebrand disease and increased bleeding risk associated with von willebrand disease and acquired or congenital disorders of platelet function
KR101648734B1 (ko) 2008-06-24 2016-08-18 체에스엘 베링 게엠베하 연장된 생체내 반감기를 갖는 인자 ｖｉｉｉ, 폰 빌레브란트 인자 또는 이들의 복합체
BRPI0921429B1 (pt) * 2008-11-07 2022-07-12 Takeda Pharmaceutical Company Limited Formulação farmacêutica liofilizada estável, e, método para preparar um fator liofilizado estável
IT1396528B1 (it) 2009-01-19 2012-12-14 Kedrion Spa Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn).
WO2011020866A2 (en) 2009-08-20 2011-02-24 Csl Behring Gmbh Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders
WO2012082933A1 (en) 2010-12-15 2012-06-21 Baxter International, Inc. Eluate collection using conductivity gradient
EP2768521B1 (en) 2011-10-18 2016-07-13 CSL Behring GmbH Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of factor viii
CN103889445A (zh) 2011-10-18 2014-06-25 德国杰特贝林生物制品有限公司 硫酸化糖胺聚糖用于改善因子viii的生物利用度的用途
DK2814502T3 (en) 2012-02-15 2017-12-18 Csl Behring Gmbh Von Willebrand Factor variants with improved Factor VIII binding affinity
EP2796145B1 (en) 2013-04-22 2017-11-01 CSL Ltd. A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
CN105705516B (zh) 2013-11-08 2019-11-01 杰特有限公司 浓缩von Willebrand因子或其络合物的方法
AU2015283822B2 (en) 2014-07-02 2019-10-03 CSL Behring Lengnau AG Modified von willebrand factor
US10626164B2 (en) 2014-07-25 2020-04-21 Csl Limited Purification of VWF
FR3034669B1 (fr) 2015-04-07 2020-02-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation du facteur von willebrand
EP3362464B1 (en) * 2015-10-15 2021-04-28 Plasma Technologies LLC Methods for extracting proteins from blood plasma
CA3010720A1 (en) 2016-01-07 2017-07-13 Csl Behring Recombinant Facility Ag Mutated truncated von willebrand factor
KR20180098404A (ko) 2016-01-07 2018-09-03 체에스엘 베링 리컴비넌트 퍼실리티 아게 돌연변이된 폰 빌레브란트 인자
CN105541997A (zh) * 2016-02-04 2016-05-04 江西博雅生物制药股份有限公司 一种高纯度和高活性血管性血友病因子的制备工艺
CN105622746A (zh) * 2016-02-04 2016-06-01 江西博雅生物制药股份有限公司 一种从冷沉淀提取凝血因子ⅷ的废料中提取人血管性血友病因子的制备工艺
CN105622747A (zh) * 2016-02-04 2016-06-01 江西博雅生物制药股份有限公司 一种vWF活性保护液
EP3488858A1 (en) 2017-11-27 2019-05-29 Laboratoire Français du Fractionnement et des Biotechnologies A von willebrand factor composition for use in treating a pathology mediated by angiogenesis
CN114249812B (zh) * 2020-09-22 2023-09-15 四川远大蜀阳药业有限责任公司 一种降低vWF制品中IgM含量的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61166542A (ja) * 1985-01-18 1986-07-28 Hitachi Chem Co Ltd 感光性組成物
US4970300A (en) * 1985-02-01 1990-11-13 New York University Modified factor VIII
US5006642A (en) * 1987-06-29 1991-04-09 Rhone-Poulenc Rorer Pharmaceuticals Inc. Purification of von Willebrand Factor by affinity chromatography
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus

Also Published As

Publication number Publication date
LTIP266A (en) 1994-07-15
AT407115B (de) 2000-12-27
CZ283633B6 (cs) 1998-05-13
FI106721B (fi) 2001-03-30
CA2062340A1 (fr) 1992-09-09
ITTO920189A0 (it) 1992-03-06
CS56892A3 (en) 1992-09-16
AU645172B2 (en) 1994-01-06
ATA43692A (de) 2000-05-15
RU2088590C1 (ru) 1997-08-27
EG20300A (fr) 1998-10-31
SK279533B6 (sk) 1998-12-02
EP0503991B1 (fr) 1998-09-23
FR2673632A1 (fr) 1992-09-11
AU1113192A (en) 1992-09-10
BR9200770A (pt) 1992-11-17
NO301278B1 (no) 1997-10-06
HU9200767D0 (en) 1992-05-28
DE69227055T2 (de) 1999-04-22
CA2062340C (fr) 2000-05-09
FR2673632B1 (fi) 1995-05-05
DE69227055D1 (de) 1998-10-29
DE122009000034I2 (de) 2011-06-16
FI920992A0 (fi) 1992-03-06
DE122009000034I1 (de) 2010-04-08
PL168353B1 (pl) 1996-02-29
EP0503991A1 (fr) 1992-09-16
ES2121830T3 (es) 1998-12-16
EE03057B1 (et) 1997-12-15
HUT63176A (en) 1993-07-28
BE1004178A3 (fr) 1992-10-06
JP3435668B2 (ja) 2003-08-11
NL300394I1 (nl) 2009-09-01
NO920867L (no) 1992-09-09
ITTO920189A1 (it) 1993-09-06
NO920867D0 (no) 1992-03-05
JPH0597696A (ja) 1993-04-20
DK0503991T3 (da) 1999-06-14
IT1256692B (it) 1995-12-12
ZA921430B (en) 1992-11-25
HU215098B (hu) 1998-09-28
US5408039A (en) 1995-04-18
IL101043A (en) 1997-02-18
NZ241701A (en) 1994-10-26
UA27732C2 (uk) 2000-10-16
SA92120446B1 (ar) 2004-05-04
IL101043A0 (en) 1992-11-15
PL293738A1 (en) 1992-09-21
LT3175B (en) 1995-02-27

Similar Documents

Publication Publication Date Title
FI920992L (fi) Foerfarande foer framstaellning av i industriell skala av ett standardiserat koncentrat av human von willebrand-faktor, vilket har synnerligen hoeg renhet och aer laempligt foer terapeutisk anvaendning
FI921168A0 (fi) Inhalator.
FI880624A0 (fi) Till intubationsroer kopplad spirometer och provtagningsfoerbindning i gasanalysator.
DE69110785D1 (de) Narkosemittelverdampfer.
FI890730L (fi) Foerfarande foer framstaellning av en metalliserad polyolefinfilm och den erhaollna filmen.
FI930906L (fi) Laekemedelsfrigoeringssystem foer minocyklin, vilket frigoer laekemedel stoetvis och aer avsedda foer administrering en gaong per dag
FI935189A7 (fi) Glasfiberarmerad plastbehaollare, foerfarande och anordning foet tillverkning av en saodan behaollare
FI934330L (fi) Xylanas, motsvarande rekombinant-dna-sekvens, ett innehaollande xylanassamt anvaendning av medlet
FI910722A0 (fi) Foerfarande foer hydrolysering av keratin.
FI935036A7 (fi) 1h-imidazol-1-yl-metyl-bensofuranderivat, daer imidazolylgruppen aer substituerade med cykloalkylgrupp
FI923143L (fi) Homogeniska, stabila och flytande vattenblandningar och anvaendning av naemnda blandningar foer framstaellning av dispersioner av i vatten oloesliga substanser
FI920732L (fi) 2-substituerade kinoliner, foerfarande foer framstaellning av dessa och anvaendning av dessa i laekemedel
FI924869L (fi) Kinolinderivat, foerfarande foer framstaellning av dessa och terapeutisk anvaendning av dessa
FI910854L (fi) Vektorer och foereningar foer expression av glykosyleringsmutanter av humant protein-c.
FI875710A7 (fi) Vindturbin och saekerhetsanordningar av den.
FI932045L (fi) Rullstol i vilken sitsen aer delad i laengsled
FI923278A7 (fi) Foerfarande foer sekvensning av signalbehandlingen naer ett digitalt, cellulaert radiosystem aer i foerbindelsetillstaond
FI894717A7 (fi) Anordning foer maetning av lokalt och tidsavhaengigt upptraedande svaga biomagnetiska faelt i kroppen hos en patient.
FI903288A0 (fi) Foerfarande och anlaeggning foer tillvaratagning av spillvaermet i den i pappersmaskinens papperstork avgaoende fuktiga torkluften.
FI896245A0 (fi) Foerfarande foer kontroll av parametrar hos den fasta fasen i en suspension och anordning foer detta.
FI875686A0 (fi) Uv-absorberande foereningar och kompositioner innehaollande dessa.
FI922491L (fi) Foerbaettrad, fosfat och enzymer innehaollande, pulverformig diskmedelskomposition foer automatiska diskmaskiner
FI920720A7 (fi) 4-pyrimidinonderivat, framstaellning av dessa och anvaendning av dessa iterapi
FI923279A7 (fi) Foerfarande foer sekvensning av signalbehandlingen naer ett digitalt, cellulaert radiosystem aer i ett begraensat foerbindelsetillstaond
FI922492L (fi) Fosfat och enzymer innehaollande, pulverformig diskmedelskomposition foer automatiska diskmaskiner